{"ymdb_id":"YMDB00898","created_at":"2011-05-29T19:02:42.000Z","updated_at":"2016-09-08T18:36:02.000Z","name":"dGDP","cas":"3493-09-2","state":"Solid","melting_point":"","description":"Deoxyguanosine diphosphate (dGDP) is a derivative of the common nucleotide deoxyguanosine triphosphate (dGTP) which is used in DNA synthesis. It differs from dGTP by having one less phosphate group.","experimental_water_solubility":"5.5 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":"nucleus;cytoplasm","synthesis_reference":"Klenow, Hans; Lichtler, Eleanor; Andersen, Bjorn.  Adenine deoxyriboside polyphosphates.    Acta Chemica Scandinavica  (1956),  10  159-60","chebi_id":"28862","hmdb_id":"HMDB00960","kegg_id":"C00361","pubchem_id":"644","cs_id":"24785204","foodb_id":null,"wikipedia_link":null,"biocyc_id":"DGDP","iupac":"[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid","traditional_iupac":"dGDP","logp":"-2.518337817879012","pka":"3.211180454774107","alogps_solubility":"3.60e+00 g/l","alogps_logp":"-1.45","alogps_logs":"-2.07","acceptor_count":"11","donor_count":"6","rotatable_bond_count":"6","polar_surface_area":"228.04999999999995","refractivity":"84.85619999999997","polarizability":"34.98723478823068","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"0.44204991344968037","pka_strongest_acidic":"1.791789653298578","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["2'-Deoxy-GDP","2'-deoxyguanosine-5'-diphosphate","5'-dGDP","Deoxyguanosine 5'-diphosphate","Deoxyguanosine diphosphate","deoxyguanosine-diphosphate","dGDP"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16240436,"citation":"Bao, J., Ryu, D. D. (2006). \"Cloning of deoxynucleoside monophosphate kinase genes and biosynthesis of deoxynucleoside diphosphates.\" Biotechnol Bioeng 93:572-580."}],"proteins":[{"created_at":"2011-05-26T16:56:27.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase small chain 1","uniprot_id":"P09938","uniprot_name":"RIR2_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR2","num_residues":399,"molecular_weight":"46147.0","theoretical_pi":"4.9","general_function":"Involved in oxidoreductase activity","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SMQ","cellular_location":"Nucleus.","genbank_gene_id":"M17221","genbank_protein_id":"172448","gene_card_id":"RNR2","chromosome_location":"chromosome 10","locus":"YJL026W","synonyms":["Ribonucleotide reductase R2 subunit 1","Ribonucleotide reductase small subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" deoxyribonucleoside diphosphate metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" nucleoside diphosphate metabolic process"}],"pfams":[{"name":"Ribonuc_red_sm","identifier":"PF00268"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGCCTAAAGAGACCCCTTCCAAAGCTGCTGCCGATGCATTGTCCGACTTGGAAATCAAAGATTCCAAGTCCAACCTTAACAAGGAATTGGAGACATTGAGAGAGGAAAACAGAGTAAAGTCAGACATGCTTAAGGAGAAATTGAGCAAGGACGCTGAAAATCACAAGGCTTACTTGAAATCTCATCAAGTTCACCGTCACAAACTTAAGGAAATGGAAAAGGAGGAACCTTTGTTGAATGAAGACAAGGAGAGAACTGTTCTTTTCCCTATCAAGTACCATGAAATCTGGCAAGCCTACGAAGCTTCTTTCTGGACCGCTGAAACCGCTGAAGAAATTGATTTGTCTAAGGATATCCATGACTGGAACAACAGAATGAACGAAAACGAGAGATTTTTCATTTCCAGAGTTCTTGCCTTTTTCGCCGCTTCTGACGGTATTGTTAATGAAAACTTGGTTGAAAACTTCTCCACCGAAGTCCAAATTCCAGAGGCAAAGAGTTTCTACGGTTTCCAAATCATGATTGAAAATATTCACTCTGAAACTTACTCCTTGTTGATCGATACTTACATCAAGGACCCTAAAGAAAGTGAATTCTTGTTCAATGCCATTCACACCATCCCAGAAATCGGTGAGAAGGCCGAATGGGCTTTAAGATGGATTCAAGACGCTGACGCCTTGTTTGGTGAAAGACTAGTTGCCTTTGCCTCCATTGAAGGTGTCTTTTTCTCCGGTTCCTTTGCCTCCATTTTCTGGTTGAAAAAGAGAGGTATGATGCCCGGTTTAACCTTTTCCAACGAATTGATCTGTAGAGACGAAGGTTTGCACACCGACTTTGCATGCTTGTTGTTCGCCCATTTGAAGAACAAACCAGACCCAGCCATTGTTGAAAAAATTGTCACCGAGGCTGTGGAAATTGAACAAAGATACTTCTTGGACGCCTTACCAGTTGCTTTGCTAGGTATGAACGCTGACTTAATGAACCAATACGTTGAGTTCGTCGCCGACAGACTGTTGGTTGCTTTCGGTAACAAGAAATACTACAAGGTCGAAAACCCCTTCGATTTCATGGAAAACATCTCCTTGGCCGGTAAGACCAACTTCTTCGAAAAGAGAGTTTCTGACTACCAAAAGGCTGGTGTTATGTCCAAGTCGACTAAGCAAGAAGCCGGTGCTTTCACCTTCAACGAAGACTTTTAA","protein_sequence":"MPKETPSKAAADALSDLEIKDSKSNLNKELETLREENRVKSDMLKEKLSKDAENHKAYLKSHQVHRHKLKEMEKEEPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNADLMNQYVEFVADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQEAGAFTFNEDF"},{"created_at":"2011-05-26T16:57:01.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Nucleoside diphosphate kinase","uniprot_id":"P36010","uniprot_name":"NDK_YEAST","enzyme":true,"transporter":false,"gene_name":"YNK1","num_residues":153,"molecular_weight":"17166.59961","theoretical_pi":"9.05","general_function":"Involved in nucleoside diphosphate kinase activity","specific_function":"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage","reactions":[{"id":1786,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1787,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1788,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1789,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1790,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1791,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1792,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1793,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1794,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2454,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion intermembrane space.","altext":"ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion intermembrane space.","genbank_gene_id":"AY558263","genbank_protein_id":"45270416","gene_card_id":"YNK1","chromosome_location":"chromosome 11","locus":"YKL067W","synonyms":["NDK","NDP kinase"],"enzyme_classes":["2.7.4.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" nucleoside diphosphate kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" CTP biosynthetic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" pyrimidine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" UTP biosynthetic process"},{"category":"Process","description":" GTP biosynthetic process"}],"pfams":[{"name":"NDK","identifier":"PF00334"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTCTAGTCAAACAGAAAGAACTTTTATTGCGGTAAAACCAGATGGTGTCCAGAGGGGCTTAGTATCTCAAATTCTATCTCGTTTTGAAAAAAAAGGTTACAAACTAGTTGCTATTAAATTAGTTAAAGCGGATGATAAATTACTAGAGCAACATTACGCAGAGCATGTTGGTAAACCATTTTTCCCAAAGATGGTATCCTTTATGAAGTCTGGTCCCATTTTGGCCACGGTCTGGGAGGGAAAAGATGTGGTTAGACAAGGAAGAACTATTCTTGGTGCTACTAATCCTTTGGGCAGTGCACCAGGTACCATTAGAGGTGATTTCGGTATTGACCTAGGCAGAAACGTCTGTCACGGCAGTGATTCTGTTGATAGCGCTGAACGTGAAATCAATTTGTGGTTTAAGAAGGAAGAGTTAGTTGATTGGGAATCTAATCAAGCTAAGTGGATTTATGAATGA","protein_sequence":"MSSQTERTFIAVKPDGVQRGLVSQILSRFEKKGYKLVAIKLVKADDKLLEQHYAEHVGKPFFPKMVSFMKSGPILATVWEGKDVVRQGRTILGATNPLGSAPGTIRGDFGIDLGRNVCHGSDSVDSAEREINLWFKKEELVDWESNQAKWIYE"},{"created_at":"2011-05-26T16:58:03.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase large chain 1","uniprot_id":"P21524","uniprot_name":"RIR1_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR1","num_residues":888,"molecular_weight":"99560.20313","theoretical_pi":"6.1","general_function":"Involved in oxidation-reduction process","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":14262,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006740","source":"Smpdb"},{"id":14274,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006749","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18813","genbank_protein_id":"603306","gene_card_id":"RNR1","chromosome_location":"chromosome 5","locus":"YER070W","synonyms":["Ribonucleotide reductase R1 subunit 1","Ribonucleotide reductase large subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" ribonucleoside-diphosphate reductase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" DNA metabolic process"},{"category":"Process","description":" DNA replication"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ATP-cone","identifier":"PF03477"},{"name":"Ribonuc_red_lgC","identifier":"PF02867"},{"name":"Ribonuc_red_lgN","identifier":"PF00317"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTACGTTTATAAAAGAGACGGTCGTAAAGAACCTGTCCAATTCGATAAGATTACCGCTCGTATATCACGCTTATGCTATGGTTTAGATCCAAAACATATCGACGCCGTTAAGGTCACCCAACGTATCATTTCTGGTGTCTATGAAGGTGTCACAACAATCGAACTAGACAACTTAGCCGCTGAAACATGCGCTTATATGACTACTGTTCATCCAGATTACGCCACCCTAGCGGCCAGAATTGCCATTTCTAATTTACATAAACAAACCACAAAACAATTTTCTAAGGTTGTCGAAGATCTTTATAGATACGTCAATGCTGCTACTGGTAAGCCCGCTCCCATGATCTCTGATGATGTCTACAATATTGTCATGGAAAACAAGGATAAATTGAACTCCGCAATTGTCTATGACAGAGATTTTCAGTACAGTTATTTTGGTTTTAAAACTTTGGAACGTTCTTATTTACTAAGAATCAACGGTCAAGTGGCCGAACGTCCACAACATTTAATTATGAGAGTCGCACTAGGCATCCACGGTAGAGATATCGAGGCTGCTTTAGAAACGTATAACTTGATGTCTCTAAAATATTTTACTCACGCCTCTCCAACGTTGTTCAATGCCGGTACTCCAAAACCTCAAATGTCCTCTTGTTTCTTGGTTGCCATGAAGGAGGACTCTATCGAGGGGATTTACGACACCTTGAAGGAATGTGCTTTGATTTCCAAAACTGCTGGTGGTATTGGTCTACATATCCATAACATTCGTTCAACTGGTTCTTACATTGCTGGTACAAACGGTACTTCTAACGGTTTAATTCCTATGATTCGTGTTTTCAATAACACTGCCCGTTATGTTGACCAGGGTGGTAATAAAAGACCTGGTGCGTTTGCCCTTTACCTGGAACCATGGCATGCTGATATATTTGATTTTATTGATATTAGGAAGAACCACGGTAAAGAGGAAATTCGTGCAAGAGATTTGTTCCCTGCTCTATGGATTCCTGATCTTTTCATGAAGCGTGTCGAAGAAAATGGGACCTGGACATTATTCTCTCCAACATCAGCTCCTGGTTTAAGCGATTGTTACGGTGACGAGTTTGAGGCTCTATATACCCGCTACGAGAAAGAAGGTCGTGGTAAGACTATCAAAGCCCAAAAATTATGGTATTCCATTTTGGAAGCTCAAACTGAAACTGGTACACCTTTCGTTGTTTACAAGGATGCTTGTAACAGAAAATCTAATCAAAAAAACTTAGGTGTCATCAAGTCATCAAACTTATGCTGTGAAATTGTTGAATACTCAGCTCCAGATGAAACTGCTGTTTGTAACTTGGCTTCCGTTGCCTTACCAGCATTCATTGAAACTTCTGAGGATGGTAAGACTTCCACATACAACTTCAAAAAATTACATGAAATTGCTAAAGTTGTTACTCGTAATTTAAACAGAGTCATTGATCGTAATTACTACCCTGTTGAAGAAGCGAGAAAATCCAATATGAGACATAGACCAATTGCTTTGGGTGTTCAAGGTCTCGCTGACACTTTCATGCTGTTACGTTTGCCATTTGATTCTGAGGAAGCCCGTTTGCTAAATATCCAAATCTTTGAAACTATTTATCATGCCTCCATGGAAGCTTCTTGTGAACTAGCTCAGAAGGACGGTCCATACGAAACTTTCCAAGGATCTCCTGCTTCTCAAGGTATACTACAGTTTGATATGTGGGACCAAAAACCCTACGGCATGTGGGATTGGGACACCTTAAGAAAAGATATCATGAAGCATGGTGTTAGAAATTCCTTGACCATGGCACCAATGCCTACTGCATCCACATCCCAAATATTGGGTTATAATGAATGTTTCGAACCAGTCACTTCCAATATGTACTCCCGTCGTGTCTTATCCGGTGAATTCCAGGTTGTGAACCCTTACTTACTGCGTGACTTGGTTGATTTAGGTATTTGGGATGAGGGTATGAAACAGTATCTGATTACACAAAATGGCTCCATTCAAGGCTTACCAAACGTTCCACAAGAATTGAAGGACTTATACAAGACTGTTTGGGAAATTTCACAAAAGACTATCATTAACATGGCAGCCGATCGTTCTGTCTATATTGATCAATCTCATTCTTTGAATTTGTTCTTACGTGCCCCAACTATGGGTAAACTAACAAGTATGCATTTTTACGGATGGAAGAAGGGATTGAAGACCGGTATGTACTATTTGAGAACCCAAGCTGCATCTGCTGCAATTCAATTTACTATTGATCAGAAGATTGCGGATCAAGCTACAGAAAACGTTGCTGATATTTCCAACTTGAAGCGTCCATCATATATGCCTTCCAGTGCAAGCTACGCTGCCAGCGATTTCGTGCCCGCAGCTGTGACTGCAAACGCAACTATTCCATCTCTAGATAGCTCCTCGGAAGCTTCAAGAGAGGCATCTCCAGCTCCAACAGGTAGCCACTCATTAACTAAAGGAATGGCAGAATTAAACGTTCAAGAGTCTAAGGTAGAAGTTCCTGAAGTACCTGCCCCAACTAAGAATGAAGAAAAAGCTGCCCCCATCGTTGATGATGAGGAAACCGAGTTCGACATTTACAACTCTAAGGTTATAGCATGTGCTATTGATAACCCAGAAGCTTGTGAAATGTGTTCGGGTTAA","protein_sequence":"MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEASREASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSKVIACAIDNPEACEMCSG"},{"created_at":"2011-05-27T00:02:34.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Guanylate kinase","uniprot_id":"P15454","uniprot_name":"KGUA_YEAST","enzyme":true,"transporter":false,"gene_name":"GUK1","num_residues":187,"molecular_weight":"20637.19922","theoretical_pi":"7.34","general_function":"Involved in protein binding","specific_function":"Essential for recycling GMP and indirectly, cGMP","reactions":[{"id":1443,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1622,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1623,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2618,"direction":"\u003e","locations":null,"altext":"ATP + GMP = ADP + GDP.","export":false,"pw_reaction_id":null,"source":null},{"id":14313,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006812","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1EX7","cellular_location":null,"genbank_gene_id":"L04683","genbank_protein_id":"171625","gene_card_id":"GUK1","chromosome_location":"chromosome 4","locus":"YDR454C","synonyms":["GMP kinase"],"enzyme_classes":["2.7.4.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" guanylate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"}],"pfams":[{"name":"Guanylate_kin","identifier":"PF00625"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCGTCCTATCGTAATTTCTGGCCCAAGTGGTACAGGTAAATCTACACTGTTGAAGAAATTGTTCGCTGAATACCCAGATTCTTTCGGGTTTAGTGTTTCATCCACTACTAGAACCCCAAGAGCTGGCGAAGTAAACGGTAAGGACTATAACTTTGTCTCCGTAGATGAATTCAAATCTATGATTAAGAACAATGAATTCATTGAATGGGCGCAATTCTCCGGTAACTACTATGGTAGTACTGTCGCTTCCGTCAAACAAGTCAGTAAATCTGGTAAGACTTGTATTTTAGATATTGATATGCAGGGTGTCAAATCTGTCAAGGCTATCCCAGAGTTAAATGCCAGGTTTTTGTTTATTGCTCCACCATCGGTCGAGGATTTGAAAAAAAGATTAGAAGGTAGAGGTACGGAGACCGAAGAATCCATCAACAAGAGGTTAAGCGCCGCTCAAGCTGAATTGGCATATGCTGAGACAGGTGCCCATGACAAAGTTATTGTCAATGATGATTTGGACAAGGCCTACAAGGAATTGAAGGATTTTATCTTTGCAGAAAAATGA","protein_sequence":"MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK"}]}