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Identification |
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Name | Isocitrate dehydrogenase [NADP], mitochondrial |
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Synonyms | - IDH
- IDP
- NADP(+)-specific ICDH
- Oxalosuccinate decarboxylase
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Gene Name | IDP1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in magnesium ion binding |
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Specific Function | Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH |
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Cellular Location | Mitochondrion |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00026 | Isocitric acid | Show | YMDB00153 | Oxoglutaric acid | Show | YMDB00210 | Oxalosuccinic acid | Show | YMDB00426 | NADPH | Show | YMDB00427 | NADP | Show | YMDB00862 | hydron | Show | YMDB00912 | Carbon dioxide | Show |
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GO Classification | Component |
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Not Available | Function |
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metal ion binding | oxidoreductase activity | magnesium ion binding | oxidoreductase activity, acting on CH-OH group of donors | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | isocitrate dehydrogenase activity | NAD or NADH binding | isocitrate dehydrogenase (NADP+) activity | binding | nucleotide binding | ion binding | cation binding | Process |
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oxidation reduction | organic acid metabolic process | oxoacid metabolic process | carboxylic acid metabolic process | metabolic process | cellular metabolic process | isocitrate metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 4 |
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Locus | YDL066W |
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Gene Sequence | >1287 bp
ATGAGTATGTTATCTAGAAGATTATTTTCCACCTCTCGCCTTGCTGCTTTCAGTAAGATT
AAGGTCAAACAACCCGTTGTCGAGTTGGACGGTGATGAAATGACCCGTATCATTTGGGAT
AAGATCAAGAAGAAATTGATTCTACCCTACTTGGACGTAGATTTGAAGTACTACGACTTA
TCTGTCGAATCTCGTGACGCCACCTCCGACAAGATTACTCAGGATGCTGCTGAGGCGATC
AAGAAGTATGGTGTTGGTATCAAATGTGCCACCATCACTCCTGATGAAGCTCGTGTGAAG
GAATTCAACCTGCACAAGATGTGGAAATCTCCTAATGGTACCATCAGAAACATTCTCGGC
GGTACAGTGTTTAGAGAGCCCATTGTGATTCCTAGAATTCCTAGACTGGTCCCACGTTGG
GAAAAACCAATCATTATTGGAAGACACGCCCACGGTGATCAATATAAAGCTACGGACACA
CTGATCCCAGGCCCAGGATCTTTGGAACTGGTCTACAAGCCATCCGACCCTACGACTGCT
CAACCACAAACTTTGAAAGTGTATGACTACAAGGGCAGTGGTGTGGCCATGGCCATGTAC
AATACTGACGAATCCATCGAAGGGTTTGCTCATTCGTCTTTCAAGCTGGCCATTGACAAA
AAGCTAAATCTTTTCTTGTCAACCAAGAACACTATTTTGAAGAAATATGACGGTCGGTTC
AAAGACATTTTCCAAGAAGTTTATGAAGCTCAATATAAATCCAAATTCGAACAACTAGGG
ATCCACTATGAACACCGTTTAATTGATGATATGGTCGCTCAAATGATAAAATCTAAAGGT
GGCTTTATCATGGCGCTAAAGAACTATGACGGTGATGTCCAATCTGACATCGTCGCTCAA
GGATTTGGCTCCTTAGGTTTGATGACTTCTATCTTAGTTACACCAGACGGTAAAACTTTC
GAAAGTGAAGCTGCTCATGGTACCGTGACAAGACATTATAGAAAGTACCAAAAGGGTGAA
GAAACTTCTACAAACTCCATTGCATCCATTTTCGCGTGGTCGAGAGGTCTATTGAAGAGA
GGTGAATTGGACAATACTCCTGCTTTGTGTAAATTTGCCAATATTTTGGAATCCGCCACT
TTGAACACAGTTCAGCAAGACGGTATCATGACGAAGGACTTGGCTTTGGCTTGCGGTAAC
AACGAAAGATCTGCTTATGTTACCACAGAAGAATTTTTGGATGCCGTTGAAAAAAGACTA
CAAAAAGAAATCAAGTCGATCGAGTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 428 |
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Protein Molecular Weight | 48189.89844 |
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Protein Theoretical pI | 9.17 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Isocitrate dehydrogenase [NADP], mitochondrial
MSMLSRRLFSTSRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDL
SVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILG
GTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTA
QPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRF
KDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQ
GFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKR
GELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRL
QKEIKSIE |
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References |
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External Links | |
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General Reference | - Haselbeck, R. J., McAlister-Henn, L. (1991). "Isolation, nucleotide sequence, and disruption of the Saccharomyces cerevisiae gene encoding mitochondrial NADP(H)-specific isocitrate dehydrogenase." J Biol Chem 266:2339-2345.1989987
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
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