{"ymdb_id":"YMDB00210","created_at":"2011-05-29T16:07:09.000Z","updated_at":"2016-09-08T18:35:11.000Z","name":"Oxalosuccinic acid","cas":"1948-82-9","state":"Solid","melting_point":"","description":"Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates. [Wikipedia]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"Mitochondrion","synthesis_reference":"Takeda, Isao; Iguchi, Takashi.  Fermentative production of oxalosuccinic acid from hydrocarbons.    Jpn. Tokkyo Koho  (1972),     3 pp.","chebi_id":"7815","hmdb_id":"HMDB03974","kegg_id":"C05379","pubchem_id":"972","cs_id":"947","foodb_id":null,"wikipedia_link":"Oxalosuccinic_acid","biocyc_id":"OXALO-SUCCINATE","iupac":"1-oxopropane-1,2,3-tricarboxylic acid","traditional_iupac":"oxalosuccinate","logp":"-0.37458442233333333","pka":"3.4363481700589906","alogps_solubility":"7.47e+00 g/l","alogps_logp":"-0.55","alogps_logs":"-1.41","acceptor_count":"7","donor_count":"3","rotatable_bond_count":"5","polar_surface_area":"128.96999999999997","refractivity":"35.1747","polarizability":"14.948859457050037","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-9.959494974326967","pka_strongest_acidic":"2.377884943609863","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Oxalosuccinate","Oxalosuccinic acid"],"pathways":[{"name":"Citrate cycle (TCA 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NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2336,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14886,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007077","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693154","genbank_protein_id":"51013759","gene_card_id":"IDP3","chromosome_location":"chromosome 14","locus":"YNL009W","synonyms":["IDH","IDP","NADP(+)-specific ICDH","Oxalosuccinate decarboxylase"],"enzyme_classes":["1.1.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" isocitrate dehydrogenase (NADP+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic 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Its probably critical function is the production of NADPH","reactions":[{"id":1676,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2335,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2336,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14884,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007075","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"M57229","genbank_protein_id":"171749","gene_card_id":"IDP1","chromosome_location":"chromosome 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NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14885,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007076","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U17246","genbank_protein_id":"577204","gene_card_id":"IDP2","chromosome_location":"chromosome 12","locus":"YLR174W","synonyms":["IDH","IDP","NADP(+)-specific ICDH","Oxalosuccinate decarboxylase"],"enzyme_classes":["1.1.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" isocitrate dehydrogenase (NADP+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" isocitrate metabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Nitrogen 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