Alanine, aspartate and glutamate metabolism

Source	ID	Pathway
KEGG	00250

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00002	L-Glutamine 56-85-9	(2S)-2-amino-4-carbamoylbutanoic acid	C₅H₁₀N₂O₃ 146.1445
YMDB00012	Adenylsuccinic acid 19046-78-7	2-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acid	C₁₄H₁₈N₅O₁₁P 463.2934
YMDB00027	Ureidosuccinic acid 13184-27-5	(2S)-2-(carbamoylamino)butanedioic acid	C₅H₈N₂O₅ 176.1274
YMDB00044	Glucosamine 6-phosphate 3616-42-0	{[(2R,3S,4R,5R,6S)-5-amino-3,4,6-trihydroxyoxan-2-yl]methoxy}phosphonic acid	C₆H₁₄NO₈P 259.151
YMDB00052	Argininosuccinic acid 2387-71-5	(2S)-2-{N'-[(4S)-4-amino-4-carboxybutyl]carbamimidamido}butanedioic acid	C₁₀H₁₈N₄O₆ 290.2731
YMDB00067	5-Phosphoribosylamine 14050-66-9	{[(2R,3S,4R,5R)-5-amino-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₅H₁₂NO₇P 229.125
YMDB00082	Carbamoylphosphate 590-55-6	(carbamoyloxy)phosphonic acid	CH₄NO₅P 141.0199
YMDB00091	Ammonia 7664-41-7	ammonia	H₃N 17.0305
YMDB00101	Fumaric acid 110-17-8	(2E)-but-2-enedioic acid	C₄H₄O₄ 116.0722
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00154	L-Alanine 56-41-7	(2S)-2-aminopropanoic acid	C₃H₇NO₂ 89.0932
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00226	L-Asparagine 70-47-3	(2S)-2-amino-3-carbamoylpropanoic acid	C₄H₈N₂O₃ 132.1179
YMDB00235	Oxalacetic acid 328-42-7	2-oxobutanedioic acid	C₄H₄O₅ 132.0716
YMDB00236	Succinic acid semialdehyde 692-29-5	4-oxobutanoic acid	C₄H₆O₃ 102.0886
YMDB00243	1-Pyrroline-5-carboxylic acid 2906-39-0	3,4-dihydro-2H-pyrrole-2-carboxylic acid	C₅H₇NO₂ 113.1146
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00335	gamma-Aminobutyric acid 56-12-2	4-aminobutanoic acid	C₄H₉NO₂ 103.1198
YMDB00338	Succinic acid 110-15-6	butanedioic acid	C₄H₆O₄ 118.088
YMDB00419	1-Pyrroline-5-carboxylate		C₅H₆NO₂ 112.1066
YMDB00593	(N(omega)-L-arginino)succinic acid 2387-71-5	2-{3-[(4S)-4-amino-4-carboxybutyl]carbamimidamido}butanedioic acid	C₁₀H₁₈N₄O₆ 290.2731
YMDB00871	N6-(1,2-Dicarboxyethyl)-AMP 19046-78-7	(2S)-2-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acid	C₁₄H₁₈N₅O₁₁P 463.2934
YMDB00874	2-oxoglutaramic acid 18465-19-5		C₅H₇NO₄ 145.1134
YMDB00896	L-Aspartic acid 56-84-8	(2S)-2-aminobutanedioic acid	C₄H₇NO₄ 133.1027
YMDB00992	succinate semialdehyde 692-29-5		C₄H₆O₃ 102.0886
YMDB01008	N-Carbamoyl-L-aspartate 13184-27-5		C₅H₆N₂O₅ 174.1115
YMDB01038	fumarate(2-) 110-17-8		C₄H₂O₄ 114.0563
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
A2P2R3	YMR084W	Putative glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	Enzyme	L-Glutamine Glucosamine 6-phosphate Fructose 6-phosphate L-Glutamic acid
P14742	GFA1 YKL104C	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	Enzyme	L-Glutamine Glucosamine 6-phosphate Fructose 6-phosphate L-Glutamic acid Beta-D-Fructose 6-phosphate
P07258	CPA1 YOR303W	Carbamoyl-phosphate synthase arginine-specific small chain	Enzyme	L-Glutamine Carbamoylphosphate Adenosine triphosphate L-Glutamic acid Carbonic acid phosphate ADP
P07259	URA2 YJL130C	Protein URA1	Enzyme	L-Glutamine Ureidosuccinic acid Carbamoylphosphate Adenosine triphosphate L-Glutamic acid Carbonic acid hydron water L-Aspartic acid phosphate ADP N-Carbamoyl-L-aspartate Hydrogen carbonate
P03965	CPA2 YJR109C	Carbamoyl-phosphate synthase arginine-specific large chain	Enzyme	L-Glutamine Carbamoylphosphate Adenosine triphosphate L-Glutamic acid Carbonic acid hydron water phosphate ADP
P32288	GLN1 YPR035W	Glutamine synthetase	Enzyme	L-Glutamine Ammonia Adenosine triphosphate L-Glutamic acid Ammonium hydron phosphate ADP
P49089	ASN1 YPR145W	Asparagine synthetase [glutamine-hydrolyzing] 1	Enzyme	L-Glutamine Adenosine monophosphate Adenosine triphosphate Pyrophosphate L-Asparagine L-Glutamic acid Ammonium hydron water L-Aspartic acid
Q12680	GLT1 YDL171C	Glutamate synthase [NADH]	Enzyme	L-Glutamine NAD NADH Oxoglutaric acid L-Glutamic acid NAD(+) hydron
P49090	ASN2 YGR124W	Asparagine synthetase [glutamine-hydrolyzing] 2	Enzyme	L-Glutamine Adenosine monophosphate Adenosine triphosphate Pyrophosphate L-Asparagine L-Glutamic acid Ammonium hydron water L-Aspartic acid
P04046	ADE4 YMR300C	Amidophosphoribosyltransferase	Enzyme	L-Glutamine 5-Phosphoribosylamine Pyrophosphate L-Glutamic acid Phosphoribosyl pyrophosphate water
P80210	ADE12 YNL220W	Adenylosuccinate synthetase	Enzyme	Adenylsuccinic acid Guanosine diphosphate Inosinic acid GTP hydron L-Aspartic acid phosphate
Q05911	ADE13 YLR359W	Adenylosuccinate lyase	Enzyme	Adenylsuccinic acid Adenosine monophosphate Fumaric acid Phosphoribosyl formamidocarboxamide SAICAR (2S)-2-[5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide N6-(1,2-Dicarboxyethyl)-AMP
P43567	AGX1 YFL030W	Alanine--glyoxylate aminotransferase 1	Enzyme	Glycine Glyoxylic acid L-Alanine Pyruvic acid
P22768	ARG1 YOL058W	Argininosuccinate synthase	Enzyme	Argininosuccinic acid Citrulline Adenosine monophosphate Adenosine triphosphate Pyrophosphate (N(omega)-L-arginino)succinic acid hydron L-Aspartic acid
P04076	ARG4 YHR018C	Argininosuccinate lyase	Enzyme	Argininosuccinic acid Fumaric acid L-Arginine (N(omega)-L-arginino)succinic acid
P33327	GDH2 YDL215C	NAD-specific glutamate dehydrogenase	Enzyme	Ammonia NAD NADH Oxoglutaric acid L-Glutamic acid NAD(+) Ammonium hydron water
P11163	ASP3-1 YLR155C	L-asparaginase 2	Enzyme	Ammonia L-Asparagine Ammonium water L-Aspartic acid
P39708	GDH3 YAL062W	NADP-specific glutamate dehydrogenase 2	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P38986	ASP1 YDR321W	L-asparaginase 1	Enzyme	Ammonia L-Asparagine Ammonium water L-Aspartic acid
P07262	GDH1 YOR375C	NADP-specific glutamate dehydrogenase 1	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P07275	PUT2 YHR037W	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	Enzyme	NAD NADH Succinic acid semialdehyde 1-Pyrroline-5-carboxylic acid L-Glutamic acid Succinic acid NAD(+) NADPH NADP 1-pyrroline-3-hydroxy-5-carboxylic acid erythro-4-hydroxy-L-glutamic acid L-4-hydroxyglutamic semialdehyde trans-4-hydroxy-L-proline hydron water l-Glutamic-gamma-semialdehyde
Q01802	AAT1 YKL106W	Aspartate aminotransferase, mitochondrial	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
P23542	AAT2 YLR027C	Aspartate aminotransferase, cytoplasmic	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
P52892	ALT2 YDR111C	Probable alanine aminotransferase	Enzyme	Oxoglutaric acid L-Alanine Pyruvic acid L-Glutamic acid
P17649	UGA1 YGR019W	4-aminobutyrate aminotransferase	Enzyme	Oxoglutaric acid Succinic acid semialdehyde L-Glutamic acid gamma-Aminobutyric acid 4-(Glutamylamino) butanoate
P52893	ALT1 YLR089C	Probable alanine aminotransferase, mitochondrial	Enzyme	Oxoglutaric acid L-Alanine Pyruvic acid L-Glutamic acid
P38067	UGA2 YBR006W	Succinate-semialdehyde dehydrogenase [NADP+]	Enzyme	Succinic acid semialdehyde Succinic acid NADPH NADP hydron water succinate semialdehyde
Q04792	GAD1 YMR250W	Glutamate decarboxylase	Enzyme	Beta-Alanine L-Glutamic acid gamma-Aminobutyric acid Taurine hydron L-Aspartic acid Carbon dioxide Hypotaurine 3-Sulfinoalanine Cysteic acid 4-(Glutamylamino) butanoate