{"ymdb_id":"YMDB00718","created_at":"2011-05-29T18:46:22.000Z","updated_at":"2016-09-08T18:35:49.000Z","name":"1-pyrroline-3-hydroxy-5-carboxylic acid","cas":null,"state":null,"melting_point":null,"description":"1-Pyrroline-3-hydroxy-5-carboxylic acid is an intermediate in 4-hydroxyproline degradation pathway. [Biocyc HYDROXYPRODEG-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"27391","hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":"1030","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"4-hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid","traditional_iupac":"pyrroline-hydroxy-carboxylate","logp":"-1.4545071951925133","pka":"14.25483703022578","alogps_solubility":"3.39e+01 g/l","alogps_logp":"-1.10","alogps_logs":"-0.58","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"1","polar_surface_area":"69.89","refractivity":"28.8459","polarizability":"11.595062277388251","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"2.5899435587205386","pka_strongest_acidic":"3.7212230695209163","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(3R,5S)-1-Pyrroline-3-hydroxy-5-carboxylate","1-(p-Nitrophenoxy)-2,3-epoxypropane","1,2-Epoxy-3-(p-nitrophenoxy)propane","2, 3-Epoxy-1-(p-nitrophenoxy)propane","3-hydroxy-l-1-pyrroline-5-carboxylate","Glycidyl 4-nitrophenyl ether","Glycidylnitrophenyl ether","L-1-pyrroline 3-hydroxy-5-carboxylate","L-1-Pyrroline-3-hydroxy-5-carboxylate","L-Delta1-pyrroline 3-hydroxy-5-carboxylate","Oxirane, {[(4-nitrophenoxy)methyl]-}","p-Nitrophenol glycidyl ether","p-Nitrophenyl glycidyl ether","Propane, 1, 2-epoxy-3-(p-nitrophenoxy)-","pyrroline-hydroxy-carboxylate"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-27T02:29:27.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","uniprot_id":"P07275","uniprot_name":"PUT2_YEAST","enzyme":true,"transporter":false,"gene_name":"PUT2","num_residues":575,"molecular_weight":"64434.60156","theoretical_pi":"7.0","general_function":"Involved in oxidoreductase activity","specific_function":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H","reactions":[{"id":1437,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1685,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1688,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1698,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1699,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2676,"direction":"\u003e","locations":"Mitochondrion inner membrane","altext":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3772,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006294","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane","genbank_gene_id":"M10029","genbank_protein_id":"172303","gene_card_id":"PUT2","chromosome_location":"chromosome 8","locus":"YHR037W","synonyms":["P5C dehydrogenase"],"enzyme_classes":["1.5.1.12"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasmic part"},{"category":"Component","description":" mitochondrial part"},{"category":"Component","description":" mitochondrial matrix"},{"category":"Component","description":" cell part"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" 1-pyrroline-5-carboxylate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGCTATCAGCAAGGTGCCTCAAATCTATATACTTCAAGAGATCTTTCTCACAACTGGGACACATCAAGCCCCCCAAGCACATAAGAAATGAACCTGTTAAGCCATTTAGAAACATAGACTTAAAAGACTGGGACTTACTGAGGGCTTCCTTGATGAAATTCAAAAGTTCTTCTTTAGAAGTGCCACTGGTCATCAATGGGGAAAGGATATATGACAATAATGAAAGAGCGCTTTTCCCGCAGACTAACCCTGCGAACCATCAACAAGTACTGGCAAACGTCACACAAGCCACGGAAAAAGATGTCATGAATGCTGTAAAAGCCGCCAAGGATGCCAAAAAGGATTGGTACAATCTACCGTTTTATGACAGATCTGCAATTTTTTTGAAAGCCGCTGACTTAATTTCCACCAAGTATCGTTATGACATGTTAGCTGCTACAATGCTGGGCCAGGGAAAAAATGTGTATCAGGCAGAAATCGACTGTATCACGGAATTATCTGACTTTTTTAGATACTATGTCAAGTATGCATCAGACTTGTATGCTCAACAACCCGTGAGTCGAGCGGATGGTACTTGGAATAAAGCTGAATACAGACCTTTAGAGGGATTTGTGTATGCTGTTTCACCATTCAACTTTACTGCTATTGCTGCAAACTTGATTGGGGCTCCAGCTTTGATGGGTAATACAGTTGTCTGGAAACCTTCACAAACCGCTGCCCTTTCAAATTACTTATTGATGACTGTTTTGGAAGAAGCGGGATTGCCAAAGGGTGTCATAAATTTCATTCTAGGTGATCCAGTTCAAGTTACTGACCAGGTATTAGCTGATAAAGATTTTGGTGCCTTGCATTTTACCGGTTCTACAAATGTCTTTAAGAGTTTGTATGGCAAAATACAAAGTGGCGTTGTTGAAGGGAAGTACAGAGATTACCCCCGTATTATTGGTGAGACAGGTGGTAAAAATTTCCATCTAGTTCACCCAAGTGCAAATATATCACATGCAGTACTCTCTACTATTAGAGGCACTTTCGAGTTCCAAGGCCAAAAGTGCTCTGCCGCTTCTAGGTTATATCTTCCAGAGTCAAAAAGTGAAGAATTCTTATCCGATATGTTTGGCATATTGCAGTCACAGAATGTTGTCCCAATGAACACATCCGCAAGTCCAATTTCTGGTGGGAATTTGCGGGGATTTATGGGTCCTGTCATCCATGAACAAAGTTTCGACAAATTAGTTAAAGTAATTGAAGATGCAAAGAAAGACCCCGAGTTGGAAATTCTTTACGGTGGACAATACGATAAAAGCCAAGGTTGGTTTGTCGGACCCACAGTCATAAAAGCCAAGAGACCAGATCATCCATATATGTCAACAGAATTTTTTGGCCCTATATTAACTGTTTACGAGTATCCAGATACGGAATTTAATGAAATCTGTGATATTATCGATAATACGAGTCAATACGCCTTAACTGGTGCTATTTTTGCCAAAGATCGTAAAGCAATTGAATACGCAGATGAGAAGTTGAAGTTTAGCGCAGGAAATTTCTACATAAATGATAAGTGTACTGGTGCCGTTGTTTCTCAGCAATGGTTTGGTGGCGCAAGAATGAGTGGTACCGACGGTAAGGCTGGTGGTCCAAACATTTTAAGCAGATTTGTCAGTATTAGAAACACAAAGGAGAGCTTCTACGAGTTGACTGATTTCAAATATCCATCGAATTATGAATAA","protein_sequence":"MLSARCLKSIYFKRSFSQLGHIKPPKHIRNEPVKPFRNIDLKDWDLLRASLMKFKSSSLEVPLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSGTDDKAGGPNILSRFVSIRNTKENFYELTDFKYPSNYE"},{"created_at":"2011-05-27T02:32:56.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Pyrroline-5-carboxylate reductase","uniprot_id":"P32263","uniprot_name":"P5CR_YEAST","enzyme":true,"transporter":false,"gene_name":"PRO3","num_residues":286,"molecular_weight":"30131.59961","theoretical_pi":"5.17","general_function":"Involved in oxidoreductase activity","specific_function":"L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H","reactions":[{"id":1700,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1701,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1931,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2679,"direction":"\u003e","locations":null,"altext":"L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3718,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006234","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M57886","genbank_protein_id":"172243","gene_card_id":"PRO3","chromosome_location":"chromosome 5","locus":"YER023W","synonyms":["P5C reductase","P5CR"],"enzyme_classes":["1.5.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" pyrroline-5-carboxylate reductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"F420_oxidored","identifier":"PF03807"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Proline Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTACACATTGGCAATTTTAGGCTGCGGTGTTATGGGCCAAGCACTTCTTTCCGCCATTTATAATGCTCCAAAGGCGGCTGATGAAACTGCTGCTGCATTTTACCCTTCCAAAATTATCACATGTAACCATGATGAACCTAGTGCACAACAAGTTACCGATCTAGTTGAGACATTCGACGAATCTCCTAACGGTATTAAAGTCGAAAGCACTTACGGTCACAACGTGAGCGCTGTCGAAGAAGCTTCTGTAGTTCTTCTTGGTACCAAGCCATTTTTGGCCGAAGAAGTGTTGAATGGTGTGAAGAGCGTCATTGGGGGAAAGCTACTTATTTCCCTGGCTGCTGGCTGGACAATTGACCAATTGAGTCAATACACTAGCACTGTTTGCCGTGTTATGACGAACACACCTGCCAAGTACGGATATGGTTGTGCGGTGGTGTCCTACTCAGCTGATGTTTCCAAAGAGCAAAAGCCACTGGTCAACGAATTGATTAGCCAAGTTGGTAAATACGTTGAGCTTCCAGAAAAGAACATGGATGCTGCTACGGCTTTAGTCGGTTCAGGCCCCGCTTTTGTTCTCTTGATGTTAGAATCCTTGATGGAGAGTGGGTTGAAATTGGGAATCCCATTACAAGAGAGTAAGGAGTGTGCCATGAAAGTTCTAGAAGGAACAGTGAAGATGGTTGAGAAAAGCGGTGCTCATCCATCCGTTTTAAAGCATCAAGTTTGCACACCAGGTGGTACAACTATTGCCGGGTTGTGCGTAATGGAAGAAAAGGGCGTCAAGAGCGGTATTATCAATGGTGTTGAAGAGGCAGCCCGTGTTGCGTCACAATTAGGCCAAAAGAAGAAATAG","protein_sequence":"MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK"}]}