{"ymdb_id":"YMDB00226","created_at":"2011-05-29T16:08:55.000Z","updated_at":"2016-10-18T17:11:21.000Z","name":"L-Asparagine","cas":"70-47-3","state":"Solid","melting_point":"234-235 oC","description":"Asparagine (abbreviated as Asn or N) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a polar amino acid, because of the hydrophilic nature of its alkyl-amide or alkyl-carboxamide side chain. Asparagine can be considered the amide of aspartic acid The precursor to asparagine is oxaloacetate. Oxaloacetate is converted to aspartate using a transaminase enzyme. The enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. Glutamine donates an ammonium group, which reacts with beta-aspartyl-AMP to form asparagine and free AMP. Aspartate is a glucogenic amino acid. L-asparaginase hydrolyzes the amide group to form aspartate and ammonium. A transaminase converts the aspartate to oxaloacetate, which can then be metabolized in the citric acid cycle or gluconeogenesis. A reaction between asparagine and reducing sugars or reactive carbonyls produces acrylamide (acrylic amide) in food when heated to sufficient temperature. These products occur in baked goods such as French fries, potato chips, and roasted coffee.","experimental_water_solubility":"29.4 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.82 [CHMELIK,J ET AL. (1991)]","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":"Wang, Fangda.  Preparation of L-b-asparagine.    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2005),     8 pp.","chebi_id":"17196","hmdb_id":"HMDB00168","kegg_id":"C00152","pubchem_id":"6267","cs_id":"6031","foodb_id":null,"wikipedia_link":"Asparagine","biocyc_id":"ASN","iupac":"(2S)-2-amino-3-carbamoylpropanoic acid","traditional_iupac":"L-asparagine","logp":"-4.287830841089268","pka":"16.09048069675879","alogps_solubility":"1.68e+02 g/l","alogps_logp":"-3.36","alogps_logs":"0.10","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"106.41","refractivity":"28.354899999999997","polarizability":"11.677080187792834","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"8.433487205020553","pka_strongest_acidic":"1.9985390993927763","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-Asparagine","(S)-2,4-Diamino-4-oxobutanoate","(S)-2,4-Diamino-4-oxobutanoic acid","(S)-Asparagine","2-Aminosuccinamate","2-Aminosuccinamic acid","a-Aminosuccinamate","a-Aminosuccinamic acid","Agedoite","alpha Amminosuccinamate","alpha Amminosuccinamic acid","alpha-Aminosuccinamate","alpha-Aminosuccinamic acid","Altheine","Asn","Asparagine","Asparagine acid","Asparamide","Aspartamate","Aspartamic acid","Aspartic acid amide","Aspartic acid b-amide","Aspartic acid beta amide","B2,4-(S)-diamino-4-oxo-utanoate","B2,4-(S)-diamino-4-oxo-utanoic acid","L-2,4-Diamino-4-oxobutanoate","L-2,4-Diamino-4-oxobutanoic acid","l-Asparagine","L-Aspartamine","L-b-Asparagine","L-beta-Asparagine"],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Asparagine metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YEB media with 0.5 mM glucose","concentration":"427.0","concentration_units":"\u0026#181;M","error":"21.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"820.0","concentration_units":"\u0026#181;M","error":"116.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"4.7","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":8660458,"citation":"Zhu, X., Garrett, J., Schreve, J., Michaeli, T. (1996). \"GNP1, the high-affinity glutamine permease of S. cerevisiae.\" Curr Genet 30:107-114."}],"proteins":[{"created_at":"2011-05-24T19:32:56.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 3","uniprot_id":"P36062","uniprot_name":"AVT3_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT3","num_residues":692,"molecular_weight":"75458.70313","theoretical_pi":"8.69","general_function":"Amino acid transport and metabolism","specific_function":"Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine","reactions":[],"signal_regions":"None","transmembrane_regions":"302-322;329-349;374-394;412-432;443-463;483-503;519-539;561-581;607-627;630-650;665-685","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z28146","genbank_protein_id":"486252","gene_card_id":"AVT3","chromosome_location":"chromosome 11","locus":"YKL146W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGAATGGAAAAGAGGTTTCAAGTGGCTCTGGAAGAACGCAGAGCAACAACAACAAAAAAAATAACAACGGAGGCAGTACAGGAATCTCGCATGCGTCTGGCTCACCTTTAACGGACGGCAACGGTGGCAATAGCAACGGTAATAGTAGAAGTAGAAGCAGAAGTAGAAAATCTAGTGGAACTACAGGTGGTTTGCTAAAAAAGCCGCCGCTGCTTGTGAACAATGAAGCGGTGCATGCTAGCGTACCCGACGCGTCGCACACTTCCTGTAACAATGGCACGCTTGAAGTGAGCATAAATAACCCTGAGCCACATGTGGTAGATGCCGTGGCACGCCACTTGATAAGAAACCCGAGTAACAGCCTACAATTGCAAGGCGGAGACATTACAAGAGATCTGTATAAGTGGACAAACGACCATCCTTCATCACCATCGCAGTATCAGTACCCAAGTCAACCTGCACTTTCCACCTCAATACCTTCACAAGCGCCCTCATTCTCGAATCGTAAAAGGTCTATGAGCTTTTCTGCCGCTTCTATAGCATCTTCCTCTCACCTTAACAACAACTCGGAGGCGAATGGGAATCCTCTAGCGGCAATAGGCCTGGCGCCCGCACCGATGACGCACGAAGAAATCAGGGCTCCTGGTGGATTCAGAAGATCTTTTATAATACAGAAGCGCAGGAAACATAACGTTGATGCGCCCATACCGAATTTTTTCACCAGGAACTTTATTGAATTTTTGACCTTGTATGGCCACTTCGCTGGTGAAGATTTATCGGAAGAAGAGGAGGAGGAGGAAGAAACTGAAGAGGAGCCAGAGGAGGAAGCTTTGGAAACGGAAAGCACCCAGCTAGTTTCTCGTGAACACGGGCGCCATCCTCACAAATCATCTACGGTAAAGGCGGTGCTGCTCTTGTTAAAGTCATTTGTTGGGACAGGTGTGCTTTTCCTACCAAAGGCTTTCCATAACGGTGGTTGGGGATTTAGCGCCCTTTGTCTACTCTCGTGTGCCCTCATTTCTTATGGATGTTTCGTATCATTGATTACCACCAAGGACAAAGTAGGCGTAGATGGGTACGGTGACATGGGTCGTATACTATATGGGCCCAAAATGAAATTTGCCATTCTTTCGTCTATCGCCTTGTCACAAATCGGGTTTTCTGCTGCATACACTGTTTTCACTGCAACTAATTTGCAGGTCTTTTCTGAAAATTTCTTCCATTTGAAACCGGGCAGCATCAGTCTAGCCACCTATATCTTTGCACAAGTACTCATCTTTGTCCCACTATCTTTGACAAGAAACATAGCCAAGTTAAGTGGGACCGCGTTAATAGCAGATCTATTTATTCTACTGGGATTGGTTTATGTTTACGTTTACTCCATTTATTATATTGCTGTTAATGGTGTCGCATCCGATACAATGCTTATGTTCAATAAAGCGGACTGGTCGTTGTTCATCGGTACCGCCATATTCACCTTTGAAGGTATAGGCCTACTTATCCCCATTCAGGAGTCAATGAAACACCCGAAGCATTTCCGGCCATCGTTGTCCGCGGTGATGTGTATCGTGGCAGTGATTTTCATATCATGTGGTCTCTTATGCTATGCCGCTTTTGGATCTGACGTGAAAACTGTTGTTTTATTGAATTTTCCGCAGGACACTTCCTATACTCTCACTGTTCAATTACTGTATGCATTAGCCATTTTGTTATCCACGCCGTTGCAGCTATTTCCCGCGATACGTATTTTGGAAAACTGGACTTTTCCCTCAAATGCATCTGGTAAATACAACCCGAAAGTCAAATGGTTGAAAAACTATTTCCGTTGCGCTATTGTCGTCCTGACATCTATCCTCGCTTGGGTAGGCGCCAACGATTTGGACAAATTTGTATCACTGGTAGGCTCCTTCGCGTGTATCCCATTGATCTACATATACCCGCCATTGTTGCACTATAAGGCGTCCATCTTATCTGGAACCTCGAGAGCCAGGCTTCTTTTAGATTTAATCGTCATAGTATTTGGAGTTGCTGTCATGGCCTACACGTCATGGCAGACGATTAAAATGTGGAGCCAGTAA","protein_sequence":"MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSGTTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSNSLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASIASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFFTRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGYGDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFGSDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGTSRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ"},{"created_at":"2011-05-24T19:33:19.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 1","uniprot_id":"P47082","uniprot_name":"AVT1_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT1","num_residues":602,"molecular_weight":"65345.30078","theoretical_pi":"8.2","general_function":"Amino acid transport and metabolism","specific_function":"Required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine. Requires ATP for function","reactions":[],"signal_regions":"None","transmembrane_regions":"209-231;241-261;287-307;322-342;345-365;390-410;430-450;467-487;518-538;544-564;581-601","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"X87611","genbank_protein_id":"854573","gene_card_id":"AVT1","chromosome_location":"chromosome 10","locus":"YJR001W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGCCTGAGCAAGAACCATTGAGTCCCAATGGCCGTAAGCGCTCTGAGGTTCACTATATCTCAATCCCATTGAACAGAGGTTCCGCATTCTCACCAGATGATTCTGTATCACAGTTTCAGTCTGACGGGTTCATGACACGTAGGCAATCCATATTGGACCATCCTGTGGGCTCATTTAAGGGAGTTAATTCTTTAAGTCGATTTGCGACTTCGTTGAGGAGAGCCAATTCGTTTCGTAATATCGAGCTAAATGCGGATAATGAAAGATCCTTTTTCAAAGAGAGTAACGATGAAACCTACGATCCGGATACTTTAGCACCAGCTTTGGACGGTAGAAGATTATCAGTAACTTTAAATAATGCTGGTCGCCCGCGCATTACTAATTTGGCTAACAACGATAGAGTTAGTACAGCCAGCATGGCTATTCACGATGATGATTATGGGTCCATCCAAAATTCAACAATTGGGGATTCTGGGTCAATATTACGCCCTACTGCCTCCTTAACAGAAATGATGAGTGGTGGAGCGGGGAGAAGGTTTACAAATAATGACATGGATTCAATTGTAGTGAAGAGAGTGGAGGGTGTAGATGGTAAGGTAGTAACTCTTCTTGCTGGTCAGTCGACCGCTCCACAGACCATATTCAACTCAATCAATGTACTGATTGGTATTGGGCTCCTGGCGTTACCTCTTGGTTTGAAATACGCCGGCTGGGTTATAGGACTTACTATGCTTGCAATCTTCGCCTTAGCGACATTTTGTACTGCTGAACTTTTGTCTAGGTGCCTAGATACAGATCCAACTTTGATATCTTACGCGGACTTGGGATATGCAGCATTTGGTACAAAAGGGCGCGCACTAATTTCTGCTCTTTTCACACTTGACCTACTGGGTAGTGGGGTGTCCTTGGTGATTCTCTTCGGAGATTCTTTAAATGCTCTATTTCCTCAATACTCCACCACTTTTTTCAAAATAGTTTCATTTTTTATCGTTACACCCCCGGTTTTTATACCATTGAGTGTTCTATCTAATATCTCGCTTCTGGGAATCCTTTCAACAACCGGAACTGTGCTAGTCATTTGCTGCTGCGGACTATACAAGTCGTCTTCTCCAGGTTCATTAGTTAATCCGATGGAAACGAGCATGTGGCCGATAGATCTAAAGCATCTCTGTTTATCTATAGGTTTATTGAGTGCCTGCTGGGGAGGACATGCGGTTTTTCCCAACTTAAAGACAGATATGAGGCATCCAGATAAATTTAAAGACTGTTTGAAAACTACCTATAAGATAACATCGGTTACGGACATAGGTACTGCAGTTATTGGCTTTTTGATGTTTGGAAATCTTGTTAAAGATGAAATTACTAAGAACGTTTTGCTGACGGAGGGATATCCAAAATTCGTTTATGGTCTGATTTCAGCGCTTATGACTATCATTCCTATCGCAAAGACCCCATTGAACGCAAGACCTATCGTTTCTGTATTGGACGTTCTGATGAATGTGCAACACATAGATGAAGCGGCCAGCGCCATAAAAAGAAGAGCTGCGAAAGGCCTTCAAGTATTCAATAGGATCTTTATTAATGTTGTCTTCGTTTTGATAGCTATTAATTTCCCTGAATTTGATAAGATTATCGCATTTCTGGGGGCCGGTTTGTGTTTTACAATTTGCCTAATTTTGCCGTGTTGGTTCTATTTAAGATTGTGCAAGACAACAATCAAACCATGGGAGAGAGTGGCTTGTCACGTAACCATATGTATTAGTGTCGTGTTGTCCACATTAGGTGTTGGTGCTGCAATTATTTCATAA","protein_sequence":"MPEQEPLSPNGRKRSEVHYISIPLNRGSAFSPDDSVSQFQSDGFMTRRQSILDHPVGSFKGVNSLSRFATSLRRANSFRNIELNADNERSFFKESNDETYDPDTLAPALDGRRLSVTLNNAGRPRITNLANNDRVSTASMAIHDDDYGSIQNSTIGDSGSILRPTASLTEMMSGGAGRRFTNNDMDSIVVKRVEGVDGKVVTLLAGQSTAPQTIFNSINVLIGIGLLALPLGLKYAGWVIGLTMLAIFALATFCTAELLSRCLDTDPTLISYADLGYAAFGTKGRALISALFTLDLLGSGVSLVILFGDSLNALFPQYSTTFFKIVSFFIVTPPVFIPLSVLSNISLLGILSTTGTVLVICCCGLYKSSSPGSLVNPMETSMWPIDLKHLCLSIGLLSACWGGHAVFPNLKTDMRHPDKFKDCLKTTYKITSVTDIGTAVIGFLMFGNLVKDEITKNVLLTEGYPKFVYGLISALMTIIPIAKTPLNARPIVSVLDVLMNVQHIDEAASAIKRRAAKGLQVFNRIFINVVFVLIAINFPEFDKIIAFLGAGLCFTICLILPCWFYLRLCKTTIKPWERVACHVTICISVVLSTLGVGAAIIS"},{"created_at":"2011-05-24T19:35:50.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Asparagine synthetase [glutamine-hydrolyzing] 1","uniprot_id":"P49089","uniprot_name":"ASNS1_YEAST","enzyme":true,"transporter":false,"gene_name":"ASN1","num_residues":572,"molecular_weight":"64469.60156","theoretical_pi":"6.02","general_function":"Involved in asparagine synthase (glutamine-hydrolyzing) activity","specific_function":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate","reactions":[{"id":1330,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2261,"direction":"\u003e","locations":"","altext":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3711,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006184","source":"Smpdb"},{"id":3712,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006185","source":"Smpdb"},{"id":3731,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006256","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U40829","genbank_protein_id":"1066479","gene_card_id":"ASN1","chromosome_location":"chromosome 16","locus":"YPR145W","synonyms":["Glutamine-dependent asparagine synthetase 1"],"enzyme_classes":["6.3.5.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" asparagine synthase (glutamine-hydrolyzing) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic process"},{"category":"Process","description":" asparagine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Asn_synthase","identifier":"PF00733"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Asparagine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTGTGGTATTTTCGCCGCTTTCAGGCACGAAGACGTGCATAGATATAAGCCAAAGGCTCTACAACTATCAAAAAGAATCAGACACCGTGGTCCAGATTGGTCCGGTAATGCTATCAAGAACTCCACTATATTTGTTCATGAAAGACTAGCCATTGTCGGTGTGGAATCCGGTGCTCAACCAATTACTTCTTCAGACGGAGAGTACATGCTATGTGTTAACGGTGAAATCTACAACCACATTCAATTAAGAGAAGAATGCGCAGACTACGAGTTTGGAACACTGAGTGACTGTGAGCCTATCATCCCAATGTACTTAAAGCACGATATCGACGCTCCTAAGTACTTGGATGGTATGTTTGCTTGGACTCTTTACGACGCTAAACAAGATCGTATTGTGGCAGCCAGAGACCCAATCGGTATTACGACATTATATATGGGACGCTCTTCCGCTTCTCCAAAGACCGTTTATTTTGCATCCGAACTAAAATGTTTGACTGACGACTGTGACACTATCACTGCATTCCCACCGGGCCACGTATACGATTCTAAGACTGACAAGATCACCCGTTACTTCACACCAGATTGGCTGGACGAAAAACGCATTCCTTCCACCCCAATAGATTACATGGCAATTAGACACTCCTTAGAAAAAGCCGTTAGAAAGAGATTAATGGCCGAAGTCCCATACGGTGTTCTATTGTCGGGTGGTTTGGACTCCTCTTTAATCGCTTCCATTGCTGCCCGTGAAACTGCAAAGGCCACTAACGATGTCGAACCATCAACTTACGATAGTAAGGCAAGACATCTAGCAGGTATCGACGATGACGGTAAGCTACACACTGCTGGTTGGACAAGTCTCCATTCCTTTGCCATCGGTTTACCAAATGCTCCAGATTTGCAAGCCGCAAGAAAGGTTGCCAAATTCATCGGCTCTATTCATCATGAACACACCTTTACATTACAAGAAGGTTTGGATGCTTTGGACGACGTGATCTACCATTTGGAAACTTACGACGTTACCACTATCAGAGCTTCCACTCCAATGTTCTTACTATCCAGAAAGATTAAGGCCCAAGGGGTCAAGATGGTTCTTTCCGGTGAAGGTTCCGATGAAATCTTCGGTGGTTATCTATATTTCGCACAAGCTCCTTCTGCGGCAGAATTTCACACTGAATCCGTGCAACGTGTCAAGAACTTGCATTTGGCAGATTGTTTGAGAGCTAACAAGTCTACGATGGCTTGGGGTCTAGAAGCTCGTGTTCCATTCTTAGACAGAGAATTTTTGCAATTGTGTATGAACATCGATCCAAATGAAAAGATGATTAAACCAAAGGAAGGACGTATTGAAAAGTACATTCTAAGGAAGGCATTCGACACCACAGGAGAACCAGATGCTAAGCCATATTTACCAGAAGAAATTTTATGGAGACAAAAAGAACAATTTTCCGACGGTGTTGGTTACTCCTGGATCGACGGATTAAAAGATACCGCCGAAGCAGTCATTTCAGATGAAATGTTTGCCAGTCCAAAGGCCGAATGGGGTAGTGACATTCCAACCACAAAAGAGGCTTTCTGGTACAGACTAAAATTCGATGCTTTGTTCCCTCAAAAGACCGTGGCTGACACCGTTATGAGATGGATTCCAAAGGCCGACTGGGGTTGTGCTGAAGATCCTTCTGGTAGATATGCCCAAATTCATGAAAAACATATCGAATAA","protein_sequence":"MCGIFAAFRHEDVHRYKPKALQLSKRIRHRGPDWSGNAIKNSTIFVHERLAIVGVESGAQPITSSDGEYMLCVNGEIYNHIQLREECADYEFGTLSDCEPIIPMYLKHDIDAPKYLDGMFAWTLYDAKQDRIVAARDPIGITTLYMGRSSASPKTVYFASELKCLTDDCDTITAFPPGHVYDSKTDKITRYFTPDWLDEKRIPSTPIDYMAIRHSLEKAVRKRLMAEVPYGVLLSGGLDSSLIASIAARETAKATNDVEPSTYDSKARHLAGIDDDGKLHTAGWTSLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDREFLQLCMNIDPNEKMIKPKEGRIEKYILRKAFDTTGEPDAKPYLPEEILWRQKEQFSDGVGYSWIDGLKDTAEAVISDEMFASPKAEWGSDIPTTKEAFWYRLKFDALFPQKTVADTVMRWIPKADWGCAEDPSGRYAQIHEKHIE"},{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:38:06.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"High-affinity glutamine permease","uniprot_id":"P48813","uniprot_name":"GNP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GNP1","num_residues":663,"molecular_weight":"73597.39844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn","reactions":[],"signal_regions":"None","transmembrane_regions":"155-175;178-198;220-240;265-285;290-310;343-363;382-402;433-453;482-502;507-527;561-581;591-611","pdb_id":null,"cellular_location":"Mitochondrion membrane; Multi-pass membrane protein","genbank_gene_id":"U21643","genbank_protein_id":"833812","gene_card_id":"GNP1","chromosome_location":"chromosome 4","locus":"YDR508C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACGCTTGGTAATAGACGCCATGGGCGGAATAATGAGGGAAGCTCTAATATGAATATGAATCGTAACGACCTTGACGATGTTTCCCATTACGAGATGAAGGAAATACAACCAAAGGAAAAACAAATTGGCTCTATAGAACCGGAAAATGAAGTAGAATATTTTGAAAAAACAGTGGAAAAAACCATTGAAAATATGGAATATGAAGGTGAACATCATGCATCTTACTTACGGAGGTTCATTGACTCGTTTAGAAGAGCGGAAGGCTCGCATGCAAATTCCCCAGACTCGAGCAACTCTAATGGGACTACTCCTATATCCACAAAAGATTCCAGCTCTCAATTGGACAATGAGTTGAATCGGAAGAGCTCATACATCACTGTTGATGGTATTAAACAGTCACCACAAGAACAAGAACAGAAACAAGAAAATTTGAAAAAGAGTATAAAGCCCCGTCATACGGTGATGATGTCCCTAGGGACTGGTATTGGTACTGGTTTGCTGGTCGGTAACTCCAAAGTTTTGAACAATGCAGGTCCGGGTGGTTTGATCATTGGTTATGCTATTATGGGTAGTTGTGTTTACTGTATTATTCAAGCTTGTGGTGAATTAGCGGTTATATACAGTGATTTGATTGGTGGATTTAATACATATCCTTTGTTTTTGGTCGACCCTGCACTTGGCTTTTCTGTTGCTTGGCTTTTTTGCTTACAATGGCTATGTGTTTGTCCTCTAGAATTGGTCACTGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTTTTCGTTGTTATCTTCTACGTACTAATCGTTGTTATCAACGTTTTTGGAGCTAAGGGTTATGCAGAGGCAGATTTCTTCTTCAATTGTTGTAAAATTCTGATGATAGTTGGATTTTTCATTCTCGCCATTATTATTGATTGTGGTGGTGCAGGTACCGATAGTTACATAGGTAGCAAATATTGGCGTGATCCCGGAGCCTTCCGTGGTGATACACCCATCCAGAGGTTCAAAGGTGTCGTTGCCACATTTGTCACAGCAGCGTTCGCCTTTGGTATGAGTGAACAGCTGGCTATGACTGCCAGTGAACAATCCAATCCAAGAAAGGCTATTCCATCGGCGGCAAAGAAAATGATTTATAGAATTCTGTTTGTGTTCTTGGCGTCTTTAACGTTAGTTGGTTTCCTTGTACCTTACACCTCAGATCAATTGCTAGGGGCCGCAGGTTCAGCCACTAAAGCGTCGCCCTACGTCATCGCTGTCTCCTCTCATGGTGTTCGTGTGGTTCCTCATTTCATAAACGCTGTCATCCTGTTGTCTGTTCTTTCCGTTGCTAACGGTGCCTTCTATACCAGTTCTCGTATTTTGATGTCGTTGGCCAAACAAGGTAATGCACCCAAATGTTTCGATTACATCGATAGGGAAGGTAGACCTGCTGCTGCTATGCTTGTCAGTGCATTATTTGGTGTCATTGCATTCTGTGCCTCATCTAAAAAGGAAGAGGACGTTTTCACCTGGTTGTTAGCAATCTCCGGTTTGTCTCAATTATTCACGTGGATTACCATTTGTTTGTCTCACATTAGGTTTAGAAGAGCTATGAAAGTGCAAGGAAGGTCCTTAGGAGAGGTTGGTTATAAATCTCAAGTCGGTGTCTGGGGGTCGGCTTACGCTGTCCTTATGATGGTGTTAGCTTTAATCGCCCAATTTTGGGTTGCCATTGCCCCAATTGGTGGAGGAGGTAAGTTAAGTGCCCAATCATTTTTTGAGAATTATTTGGCTATGCCAATCTGGATTGCTTTATACATCTTTTACAAAGTTTGGAAAAAAGATTGGAGTTTATTCATTCCCGCTGATAAAGTAGACTTAGTTTCTCATAGAAACATCTTTGATGAAGAATTATTAAAACAAGAAGATGAAGAATATAAAGAGAGATTAAGAAACGGACCATACTGGAAAAGAGTTCTTGATTTCTGGTGTTAA","protein_sequence":"MTLGNRRHGRNNEGSSNMNMNRNDLDDVSHYEMKEIQPKEKQIGSIEPENEVEYFEKTVEKTIENMEYEGEHHASYLRRFIDSFRRAEGSHANSPDSSNSNGTTPISTKDSSSQLDNELNRKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNNAGPGGLIIGYAIMGSCVYCIIQACGELAVIYSDLIGGFNTYPLFLVDPALGFSVAWLFCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVVIFYVLIVVINVFGAKGYAEADFFFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQRFKGVVATFVTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFLASLTLVGFLVPYTSDQLLGAAGSATKASPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDYIDREGRPAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQGRSLGEVGYKSQVGVWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPIWIALYIFYKVWKKDWSLFIPADKVDLVSHRNIFDEELLKQEDEEYKERLRNGPYWKRVLDFWC"},{"created_at":"2011-05-24T19:38:40.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Asparagine synthetase [glutamine-hydrolyzing] 2","uniprot_id":"P49090","uniprot_name":"ASNS2_YEAST","enzyme":true,"transporter":false,"gene_name":"ASN2","num_residues":572,"molecular_weight":"64592.5","theoretical_pi":"5.69","general_function":"Involved in asparagine synthase (glutamine-hydrolyzing) activity","specific_function":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate","reactions":[{"id":1330,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2261,"direction":"\u003e","locations":"","altext":"ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3712,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006185","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X83099","genbank_protein_id":"642347","gene_card_id":"ASN2","chromosome_location":"chromosome 7","locus":"YGR124W","synonyms":["Glutamine-dependent asparagine synthetase 2"],"enzyme_classes":["6.3.5.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" asparagine synthase (glutamine-hydrolyzing) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic process"},{"category":"Process","description":" asparagine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Asn_synthase","identifier":"PF00733"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Asparagine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTGTGGTATCTTTGCAGCCTTCAAGCATGAAGATATTCACAACTTCAAACCAAAAGCTCTACAACTATCTAAAAAAATCAGACACCGTGGCCCAGATTGGTCAGGAAATGCCGTTATGAATTCCACCATTTTCGTTCACGAGAGGTTGGCTATTGTTGGTTTAGACTCCGGTGCCCAGCCAATCACTTCAGCTGATGGCGAATATATGCTTGGCGTTAATGGTGAGATCTACAACCACATCCAACTAAGGGAGATGTGCTCTGATTACAAGTTTCAAACTTTCAGTGACTGTGAACCCATCATACCGTTATATTTGGAACATGATATCGATGCTCCAAAATATCTGGACGGTATGTTCGCATTTTGTCTGTATGATTCCAAGAAAGACCGTATTGTCGCTGCAAGAGACCCTATCGGTGTTGTCACTTTATACATGGGGCGTTCTTCTCAGTCTCCAGAGACCGTTTATTTTGCCTCCGAATTAAAATGTCTAACTGACGTTTGTGACAGTATCATTTCGTTCCCTCCTGGTCATGTCTACGATTCTGAAACGGACAAGATTACTCGTTACTTTACCCCAGACTGGTTGGATGAAAAGCGTATCCCATCCACCCCAGTTGACTACCATGCTATCAGACACAGTTTAGAAAAGGCCGTTAGAAAGAGGCTAATGGCTGAAGTTCCATACGGTGTTCTTCTATCCGGTGGGCTGGACTCTTCTTTGATTGCTGCGATTGCTGCTCGTGAAACGGAAAAAGCTAATGCTGATGCTAACGAAGACAACAATGTTGACGAGAAGCAACTTGCAGGTATCGATGACCAAGGCCATCTACACACATCCGGTTGGTCTCGTTTGCATTCGTTTGCGATTGGTCTACCAAATGCACCTGATTTACAAGCGGCTAGAAAAGTCGCCAAATTCATTGGTTCTATCCACCATGAACACACTTTTACATTACAAGAAGGTTTGGATGCTTTGGACGACGTGATCTACCATTTGGAAACTTACGACGTTACCACTATCAGAGCTTCTACACCAATGTTCTTACTATCTAGAAAGATTAAGGCCCAAGGTGTCAAAATGGTTCTTTCTGGTGAAGGCTCGGACGAAATATTCGGTGGCTATCTATATTTCGCACAAGCACCTTCTGCTGCAGAATTTCACACCGAATCTGTGCAACGTGTCAAGAACTTGCATTTGGCAGATTGTTTGAGAGCTAATAAGTCCACGATGGCTTGGGGTCTAGAAGCTCGTGTTCCCTTCTTAGACAAAGACTTTTTGCAGCTATGTATGAACATTGATCCAAATGAAAAGATGATCAAGCCAAAGGAAGGACGTATCGAAAAATACATTTTAAGAAAGGCATTCGACACTACAGATGAACCAGATGTTAAGCCATACCTACCTGAAGAAATCTTATGGAGACAAAAGGAACAATTTTCCGATGGTGTTGGCTACTCATGGATTGACGGCCTAAGAGACACTGCTGAAAGGGCCATTTCTGACGCCATGTTTGCCAATCCAAAGGCTGATTGGGGCGACGATATTCCAACCACCAAAGAAGCTTACTGGTACAGGCTGAAGTTTGATGCTTGGTTTCCTCAAAAGACTGCGGCAGACACTGTCATGAGATGGATTCCAAAGGCCGATTGGGGTTGTGCCGAAGATCCTTCAGGTAGATACGCCAAAATACACGAAAAGCACGTCAGTGCTTAA","protein_sequence":"MCGIFAAFKHEDIHNFKPKALQLSKKIRHRGPDWSGNAVMNSTIFVHERLAIVGLDSGAQPITSADGEYMLGVNGEIYNHIQLREMCSDYKFQTFSDCEPIIPLYLEHDIDAPKYLDGMFAFCLYDSKKDRIVAARDPIGVVTLYMGRSSQSPETVYFASELKCLTDVCDSIISFPPGHVYDSETDKITRYFTPDWLDEKRIPSTPVDYHAIRHSLEKAVRKRLMAEVPYGVLLSGGLDSSLIAAIAARETEKANADANEDNNVDEKQLAGIDDQGHLHTSGWSRLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDKDFLQLCMNIDPNEKMIKPKEGRIEKYILRKAFDTTDEPDVKPYLPEEILWRQKEQFSDGVGYSWIDGLRDTAERAISDAMFANPKADWGDDIPTTKEAYWYRLKFDAWFPQKTAADTVMRWIPKADWGCAEDPSGRYAKIHEKHVSA"},{"created_at":"2011-05-24T19:39:09.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 4","uniprot_id":"P50944","uniprot_name":"AVT4_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT4","num_residues":713,"molecular_weight":"80025.0","theoretical_pi":"9.73","general_function":"Amino acid transport and metabolism","specific_function":"Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine","reactions":[],"signal_regions":"None","transmembrane_regions":"243-263;302-322;327-347;374-394;411-431;439-459;484-504;516-536;562-582;622-642;649-669;693-711","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z50161","genbank_protein_id":"929852","gene_card_id":"AVT4","chromosome_location":"chromosome 14","locus":"YNL101W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGGTCACTAACAATGGAGATGGTGAGCACCTTGGGATCCGAAGAAACGGAAATTTAAGGCATCCTTCCAATAATATGAAAATTCCCAGAAGGGCTCAATCAACAGTTCTCAATTCAAACCCATTTTATAGTAGGAAGTATTCTATGTCTACCTTAACGCCGAGGGATATATGTCGAAGCGTTGATTCTAGAGTATTTGTGGATATGTCTTCTCCCAATTTTCAGACTCTGGAGGATCCCCACAGAGATGAGATTATAAACAGTGTACGGCTTAACTACTTGAACAGTAGCAAAAGAAGTTCCGTCTCTCATGGAAATGAAGCAATCCCTAGGGTTAATCCGACTAAGAATTCTTCAGCAAGTACCATAGCTGCAGCAAATGTTGATAGTGATGACGATGAGACTAACCTGAGTAGCGCTGGAGGCGACATAACGCATGATATTTACAAGTTGGTTAAAGCAGAGGATCCTAAACGGCTCAGACGCCCTCGGTCCATGGAAAATGTAACACCTAAAATTGAGCACCATACTAAATTGTCATCAGCAAGTGGTTTAAATGTCCCCGGTGGCTTCAGAAGGGAATTTATTGTCAACAAAAAAAGGCAAGAACATCAATTAAATGATTCCGCTAGCTCAGACTTCACTTCGCATGAAAGCGATTCGATTAACCAGTCATCTCCATCTTCTAACCAAGATATCGATAAGGTCCCCTTTTTAACAAGAAACTTTTTGGAATTTCTATACGTGTTTGGACATTTTGCTGGTGAATCCTTCGAGGATGATTTTATCCCTGATAGCTCAAACATGATGATACGCGGAGAAGATGAAAGGAGTGCATTGCTGTCTCGGCCTGACCATATGAAAGTATTACCTTCAGCCAAAGGTACGACTTCGACAAAGAAGGTTTTTTTGATATTGCTTAAATCTTTCATTGGAACTGGCGTTTTATTTTTACCTAATGCCTTTCATAATGGTGGTTTGTTTTTCTCAGTAAGTATGCTGGCCTTTTTTGGAATTTATTCATACTGGTGTTACTACATATTGGTGCAGGCCAAATCTTCATGCGGTGTATCCTCCTTTGGTGATATTGGTTTAAAACTGTATGGACCTTGGATGAGAATAATAATTCTTTTCTCCCTAGTAATAACTCAAGTTGGATTCTCTGGAGCTTATATGATATTTACTGCAAAAAATTTACAAGCTTTTCTTGATAACGTATTCCATGTGGGCGTCCTACCTTTATCTTACCTGATGGTCTTTCAAACGATCATTTTTATTCCACTTTCGTTTATTAGAAACATTTCGAAATTGTCACTACCATCTTTACTAGCAAATTTTTTCATCATGGCTGGTTTAGTCATTGTCATTATTTTTACAGCCAAAAGGTTGTTTTTTGACCTGATGGGGACCCCAGCAATGGGTGTCGTCTATGGCTTAAATGCAGACCGTTGGACGCTGTTTATCGGGACGGCAATATTTGCTTTCGAAGGAATCGGGTTAATTATTCCTGTTCAAGACTCAATGAGAAATCCTGAAAAATTTCCTTTAGTACTTGCTTTGGTGATTCTAACGGCAACCATACTTTTCATTTCCATAGCTACATTGGGATATTTGGCATACGGCTCAAATGTTCAAACGGTTATACTGTTGAACTTACCTCAAAGTAACATTTTTGTAAACTTAATCCAGCTGTTCTATTCCATCGCAATTATGTTGTCCACACCTTTGCAGTTGTTTCCAGCTATTAAAATTATTGAAAATAAGTTTTTTCCAAAGTTCACTAAAATATATGTCAAGCACGATGATCTAACAACAAGAGTCGAATTACGTCCTAATTCAGGAAAGCTGAACTGGAAAATTAAATGGCTGAAGAACTTTATTCGTTCTATAATCGTAATCATTGTTGTATCAATTGCTTACTTTGGGTCTGATAATTTAGACAAGTTCGTTTCAGTTATAGGATCCCTCGCCTGTATTCCTTTGGTATATATATACCCATCGATGCTGCATTTACGGGGCAATAGCCTTCCAGAGACTAAAGGGGAATTTTGGAGATTCAAACCAATGTTAGATACCATTTTAATTTTCTTCGGTATTGCAAGCATGCTTTATACGTCTTACCAGAGTATATTCGGTGTCTAG","protein_sequence":"MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYSRKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSVSHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRLRRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSIFGV"},{"created_at":"2011-05-24T19:39:43.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Dicarboxylic amino acid permease","uniprot_id":"P53388","uniprot_name":"DIP5_YEAST","enzyme":false,"transporter":true,"gene_name":"DIP5","num_residues":608,"molecular_weight":"68096.70313","theoretical_pi":"9.17","general_function":"Involved in transport","specific_function":"Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine","reactions":[],"signal_regions":"None","transmembrane_regions":"91-111;120-142;157-177;202-222;232-252;286-306;323-343;373-393;424-444;455-475;502-522;531-551","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X95802","genbank_protein_id":"1213234","gene_card_id":"DIP5","chromosome_location":"chromosome 16","locus":"YPL265W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAAGATGCCTCTAAAGAAGATGTTTACCAGCACGTCTCCTCGTAACTCTTCTTCTCTTGACAGTGATCATGACGCTTACTATTCGAAACAAAATCCTGACAATTTCCCTGTAAAGGAGCAAGAAATCTATAACATTGACCTGGAAGAAAACAATGTGTCCTCTCGTTCATCCACCTCTACATCACCTTCAGCAAGGGACGACTCTTTCGCAGTTCCAGATGGTAAAGACGAAAACACGCGGTTGAGGAAAGATTTAAAGGCAAGACATATTTCTATGATCGCCATTGGTGGTTCATTAGGTACAGGTCTGCTTATAGGTACAGGTACCGCCTTATTGACGGGTGGTCCGGTTGCGATGTTAATTGCATATGCCTTTGTCGGCCTTTTAGTCTTTTACACCATGGCCTGTCTTGGTGAAATGGCTTCTTACATTCCATTGGATGGTTTTACAAGTTATGCCTCACGTTACGTGGATCCTGCATTAGGTTTTGCTATTGGTTATACTTACCTTTTCAAATATTTCATCTTACCTCCCAACCAACTTACTGCTGCTGCTTTGGTCATTCAATATTGGATCAGCAGAGACCGTGTTAACCCTGGTGTGTGGATTACTATATTCTTGGTTGTTATTGTCGCTATCAATGTCGTCGGTGTAAAATTCTTTGGTGAATTTGAATTTTGGTTGTCCAGTTTCAAAGTCATGGTAATGTTGGGTCTAATCCTGTTACTATTTATTATTATGCTTGGTGGAGGTCCTAACCATGACCGCCTAGGGTTTAGATACTGGCGTGATCCTGGTGCGTTCAAAGAATATTCGACGGCTATCACTGGTGGTAAAGGTAAATTTGTTTCGTTCGTTGCTGTTTTCGTTTACAGTCTTTTCAGTTACACGGGTATTGAATTGACAGGTATCGTTTGTTCTGAAGCTGAGAATCCAAGAAAAAGTGTTCCAAAGGCAATTAAATTGACAGTTTACCGTATCATTGTTTTTTACCTATGCACCGTTTTCCTTTTGGGTATGTGCGTTGCATACAATGACCCTCGTTTACTTTCCACAAAAGGTAAGAGTATGTCTGCTGCGGCATCTCCATTCGTGGTTGCCATTCAAAACTCAGGTATTGAAGTCTTACCTCATATCTTCAATGCTTGTGTCTTGGTTTTCGTTTTCAGTGCTTGTAACTCAGATTTGTACGTTTCTTCCAGAAATTTATATGCGTTGGCAATTGATGGTAAAGCGCCAAAGATCTTCGCTAAGACAAGTAGATGGGGTGTTCCTTACAATGCTTTAATACTCTCCGTGCTGTTTTGTGGCTTGGCGTACATGAATGTGTCTTCAGGATCAGCAAAGATTTTCAACTACTTTGTTAACGTTGTTTCTATGTTCGGAATCTTGAGTTGGATCACCATTTTAATTGTTTACATCTACTTCGATAAAGCCTGCCGTGCTCAAGGGATTGACAAATCAAAATTTGCTTATGTCGCTCCTGGCCAACGTTATGGTGCTTATTTTGCTTTATTCTTCTGCATTTTGATTGCTTTAATCAAAAACTTCACTGTTTTCCTAGGTCATAAATTTGATTATAAAACATTCATCACCGGGTATATTGGCCTGCCTGTCTATATCATTTCTTGGGCTGGTTACAAATTGATATACAAAACCAAAGTGATAAAGTCTACCGACGTGGATTTGTACACATTTAAGGAAATATACGATAGAGAAGAAGAAGAGGGAAGAATGAAGGACCAAGAAAAGGAAGAGCGTTTAAAAAGTAACGGTAAAAATATGGAGTGGTTCTATGAAAAATTTTTGGGTAATATCTTCTAG","protein_sequence":"MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T18:10:35.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"L-asparaginase 2","uniprot_id":"P11163","uniprot_name":"ASPG2_YEAST","enzyme":true,"transporter":false,"gene_name":"ASP3-1","num_residues":362,"molecular_weight":"38686.19922","theoretical_pi":"4.44","general_function":"Involved in asparaginase activity","specific_function":"L-asparagine + H(2)O = L-aspartate + NH(3)","reactions":[{"id":1695,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2513,"direction":"\u003e","locations":"Cytoplasm;Secreted, cell wall","altext":"L-asparagine + H(2)O = L-aspartate + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"1-25","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Secreted, cell wall","genbank_gene_id":"AY557957","genbank_protein_id":"45269806","gene_card_id":"ASP3-1","chromosome_location":"chromosome 12","locus":"YLR155C","synonyms":["L-asparaginase II","L-asparagine amidohydrolase II","ASP II"],"enzyme_classes":["3.5.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" asparaginase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Asparaginase","identifier":"PF00710"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"}],"gene_sequence":"ATGAGATCTTTAAATACCCTTTTACTTTCTCTCTTTGTCGCAATGTCCAGTGGTGCTCCACTACTAAAAATTCGTGAAGAGAAGAATTCTCCTTTGCCATCAATCAAAATTTTTGGTACCGGCGGTACTATCGCTTCCAAGGGTTCGACAAGTGCAACAACGGCGGGTTATAGCGTGGGATTAACCGTAAATGATTTAATAGAAGCCGTCCCATCTTTAGCTGAGAAGGCAAATCTGGACTATCTTCAAGTGTCTAACGTTGGTTCAAATTCTTTAAACTATACGCATCTGATCCCATTGTATCACGGTATCTCCGAGGCACTAGCCTCTGATGACTACGCTGGTGCGGTTGTCACTCATGGGACCGACACTATGGAGGAGACAGCTTTCTTCTTAGATTTGACCATAAATTCAGAGAAGCCAGTATGTATCGCAGGCGCTATGCGTCCAGCCACTGCCACGTCTGCTGATGGCCCAATGAATTTATATCAAGCAGTGTCTATTGCTGCTTCTGAGAAATCACTGGGTCGTGGCACGATGATCACTCTAAACGATCGTATTGCCTCTGGGTTTTGGACAACGAAAATGAATGCCAACTCTTTAGATACATTCAGAGCGGATGAACAGGGATATTTAGGTTACTTTTCAAATGATGACGTGGAGTTTTACTACCCACCAGTCAAGCCAAATGGATGGCAATTTTTTGACATTTCCAACCTCACAGACCCTTCGGAAATTCCAGAAGTCATTATTCTGTACTCCTATCAAGGCTTGAATCCTGAGCTAATAGTAAAGGCCGTCAAGGACCTGGGCGCAAAAGGTATCGTGTTGGCGGGTTCTGGAGCTGGTTCCTGGACTGCTACGGGTAGTATTGTAAACGAACAACTTTATGAAGAGTATGGTATACCAATTGTTCACAGCAGAAGAACAGCAGATGGTACAGTTCCTCCAGATGATGCCCCAGAGTACGCCATTGGATCTGGCTACCTAAACCCTCAAAAATCGCGTATTTTGCTACAATTATGTTTGTACTCCGGCTACGGCATGGATCAGATTAGGTCTGTTTTTTCTGGCGTCTACGGTGGTTAA","protein_sequence":"MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG"},{"created_at":"2011-05-26T18:12:58.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"L-asparaginase 1","uniprot_id":"P38986","uniprot_name":"ASPG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ASP1","num_residues":381,"molecular_weight":"41394.80078","theoretical_pi":"5.08","general_function":"Involved in asparaginase activity","specific_function":"L-asparagine + H(2)O = L-aspartate + NH(3)","reactions":[{"id":1694,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2513,"direction":"\u003e","locations":"Cytoplasm;Secreted, cell wall","altext":"L-asparagine + H(2)O = L-aspartate + NH(3).","export":false,"pw_reaction_id":null,"source":null},{"id":3715,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006187","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U32517","genbank_protein_id":"914995","gene_card_id":"ASP1","chromosome_location":"chromosome 4","locus":"YDR321W","synonyms":["L-asparaginase I","L-asparagine amidohydrolase I","ASP I"],"enzyme_classes":["3.5.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"},{"category":"Function","description":" asparaginase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" asparagine metabolic 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