{"ymdb_id":"YMDB00236","created_at":"2011-05-29T16:09:56.000Z","updated_at":"2016-09-08T18:35:13.000Z","name":"Succinic acid semialdehyde","cas":"692-29-5","state":"Solid","melting_point":"","description":"Succinic acid semialdehyde is an intermediate in the catabolism of gamma-aminobutyrate.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Bruce, R.; Sims, K.; Pitts, F. N., Jr.  Synthesis and purification of succinic semialdehyde.    Analytical Biochemistry  (1971),  41(1),  271-3.","chebi_id":"16265","hmdb_id":"HMDB01259","kegg_id":"C00232","pubchem_id":"1112","cs_id":"1080","foodb_id":null,"wikipedia_link":"Succinic semialdehyde","biocyc_id":"SUCC-S-ALD","iupac":"4-oxobutanoic acid","traditional_iupac":"succinic semialdehyde","logp":"-0.5570992196666666","pka":"17.53992018087323","alogps_solubility":"1.94e+02 g/l","alogps_logp":"-0.47","alogps_logs":"0.28","acceptor_count":"3","donor_count":"1","rotatable_bond_count":"3","polar_surface_area":"54.37","refractivity":"22.611600000000003","polarizability":"9.263882313671203","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-6.956114389966538","pka_strongest_acidic":"4.12725825924451","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-formylpropionic acid ethyl ester","3-Formylpropanoate","3-Formylpropanoic acid","3-Formylpropionic acid","4-Oxobutanoate","4-Oxobutanoic acid","beta-Formylpropionate","beta-Formylpropionic acid","Butanoic acid, 4-oxo- (9CI)","Butryaldehydate","Butryaldehydic acid","gamma-Oxybutyrate","gamma-Oxybutyric acid","Semi-aldehyde succinique","Semi-aldehyde succinique [French]","semialdehyde succinique","Succinaldehydate","Succinaldehydic acid","Succinate semialdehyde","Succinic acid semialdehyde","Succinic semialdehyde"],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"4-aminobutanoate degradation","kegg_map_id":null},{"name":"Glutamate Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":3888627,"citation":"Ramos, F., el Guezzar, M., Grenson, M., Wiame, J. M. (1985). \"Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae.\" Eur J Biochem 149:401-404."},{"pubmed_id":2653828,"citation":"Vissers, S., Andre, B., Muyldermans, F., Grenson, M. (1989). \"Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4-aminobutyric-acid-specific permease in Saccharomyces cerevisiae.\" Eur J Biochem 181:357-361."},{"pubmed_id":11031268,"citation":"Coleman, S. T., Fang, T. K., Rovinsky, S. A., Turano, F. J., Moye-Rowley, W. S. (2001). \"Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.\" J Biol Chem 276:244-250."}],"proteins":[{"created_at":"2011-05-24T20:44:30.000Z","updated_at":"2011-07-22T17:53:56.000Z","name":"Acetylornithine aminotransferase, mitochondrial","uniprot_id":"P18544","uniprot_name":"ARGD_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG8","num_residues":423,"molecular_weight":"46681.10156","theoretical_pi":"7.62","general_function":"Involved in transaminase activity","specific_function":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate","reactions":[{"id":1247,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2338,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M32795","genbank_protein_id":"171083","gene_card_id":"ARG8","chromosome_location":"chromosome 15","locus":"YOL140W","synonyms":["ACOAT"],"enzyme_classes":["2.6.1.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGTTTAAAAGATATTTATCCAGTACGTCATCAAGAAGATTTACAAGCATTTTAGAGGAAAAGGCCTTTCAAGTGACCACTTACTCTAGACCTGAAGATCTATGTATAACTAGAGGTAAAAATGCAAAGCTGTATGATGACGTGAATGGTAAAGAATATATCGATTTCACCGCAGGTATTGCGGTGACCGCATTAGGCCATGCAAATCCTAAAGTGGCAGAAATTCTGCACCATCAGGCTAACAAACTGGTTCATTCCTCCAACCTTTACTTCACTAAGGAATGTTTGGATTTAAGTGAAAAGATTGTTGAAAAGACCAAGCAATTCGGTGGTCAACACGACGCCTCAAGAGTATTTTTATGTAATTCTGGTACGGAAGCAAATGAAGCTGCTTTGAAGTTTGCAAAGAAACATGGTATAATGAAAAATCCTAGCAAGCAAGGCATTGTTGCATTTGAGAACTCTTTTCATGGCCGTACTATGGGCGCTTTATCTGTCACTTGGAATAGTAAATATAGAACTCCTTTTGGGGATTTGGTTCCCCATGTCTCATTCTTAAATTTGAATGACGAAATGACCAAACTACAAAGTTATATCGAGACCAAAAAGGACGAGATTGCTGGTTTAATTGTCGAGCCCATACAAGGTGAAGGTGGGGTTTTTCCCGTAGAAGTTGAAAAGCTAACCGGATTGAAGAAAATATGTCAAGATAATGATGTGATTGTCATTCATGATGAAATTCAATGCGGTTTGGGCCGTTCAGGTAAACTATGGGCTCATGCTTATTTACCAAGTGAGGCTCATCCGGATATTTTTACATCTGCCAAAGCATTGGGAAATGGCTTCCCCATCGCTGCCACCATCGTCAATGAAAAAGTTAATAATGCTTTGAGAGTTGGTGACCACGGCACCACGTATGGTGGTAATCCGCTGGCCTGTTCTGTAAGCAACTATGTTTTGGATACCATAGCAGACGAAGCTTTTTTGAAACAAGTCTCTAAGAAGAGTGATATCTTACAAAAGCGCTTGCGCGAAATTCAAGCCAAATATCCAAATCAAATAAAGACTATCAGAGGAAAAGGTTTGATGCTTGGTGCTGAGTTCGTCGAACCACCCACCGAGGTCATCAAAAAGGCCAGAGAATTGGGACTTTTGATCATTACCGCTGGTAAGAGTACCGTTAGATTTGTTCCCGCATTAACGATTGAAGACGAACTAATCGAAGAAGGGATGGATGCTTTTGAAAAGGCTATTGAAGCGGTTTACGCTTAA","protein_sequence":"MFKRYLSSTSSRRFTSILEEKAFQVTTYSRPEDLCITRGKNAKLYDDVNGKEYIDFTAGIAVTALGHANPKVAEILHHQANKLVHSSNLYFTKECLDLSEKIVEKTKQFGGQHDASRVFLCNSGTEANEAALKFAKKHGIMKNPSKQGIVAFENSFHGRTMGALSVTWNSKYRTPFGDLVPHVSFLNLNDEMTKLQSYIETKKDEIAGLIVEPIQGEGGVFPVEVEKLTGLKKICQDNDVIVIHDEIQCGLGRSGKLWAHAYLPSEAHPDIFTSAKALGNGFPIAATIVNEKVNNALRVGDHGTTYGGNPLACSVSNYVLDTIADEAFLKQVSKKSDILQKRLREIQAKYPNQIKTIRGKGLMLGAEFVEPPTEVIKKARELGLLIITAGKSTVRFVPALTIEDELIEEGMDAFEKAIEAVYA"},{"created_at":"2011-05-27T02:29:27.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","uniprot_id":"P07275","uniprot_name":"PUT2_YEAST","enzyme":true,"transporter":false,"gene_name":"PUT2","num_residues":575,"molecular_weight":"64434.60156","theoretical_pi":"7.0","general_function":"Involved in oxidoreductase activity","specific_function":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H","reactions":[{"id":1437,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1685,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1688,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1698,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1699,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2676,"direction":"\u003e","locations":"Mitochondrion inner membrane","altext":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3772,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006294","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane","genbank_gene_id":"M10029","genbank_protein_id":"172303","gene_card_id":"PUT2","chromosome_location":"chromosome 8","locus":"YHR037W","synonyms":["P5C dehydrogenase"],"enzyme_classes":["1.5.1.12"],"go_classes":[{"category":"Component","description":" cytoplasmic part"},{"category":"Component","description":" mitochondrial part"},{"category":"Component","description":" mitochondrial matrix"},{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" 1-pyrroline-5-carboxylate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGCTATCAGCAAGGTGCCTCAAATCTATATACTTCAAGAGATCTTTCTCACAACTGGGACACATCAAGCCCCCCAAGCACATAAGAAATGAACCTGTTAAGCCATTTAGAAACATAGACTTAAAAGACTGGGACTTACTGAGGGCTTCCTTGATGAAATTCAAAAGTTCTTCTTTAGAAGTGCCACTGGTCATCAATGGGGAAAGGATATATGACAATAATGAAAGAGCGCTTTTCCCGCAGACTAACCCTGCGAACCATCAACAAGTACTGGCAAACGTCACACAAGCCACGGAAAAAGATGTCATGAATGCTGTAAAAGCCGCCAAGGATGCCAAAAAGGATTGGTACAATCTACCGTTTTATGACAGATCTGCAATTTTTTTGAAAGCCGCTGACTTAATTTCCACCAAGTATCGTTATGACATGTTAGCTGCTACAATGCTGGGCCAGGGAAAAAATGTGTATCAGGCAGAAATCGACTGTATCACGGAATTATCTGACTTTTTTAGATACTATGTCAAGTATGCATCAGACTTGTATGCTCAACAACCCGTGAGTCGAGCGGATGGTACTTGGAATAAAGCTGAATACAGACCTTTAGAGGGATTTGTGTATGCTGTTTCACCATTCAACTTTACTGCTATTGCTGCAAACTTGATTGGGGCTCCAGCTTTGATGGGTAATACAGTTGTCTGGAAACCTTCACAAACCGCTGCCCTTTCAAATTACTTATTGATGACTGTTTTGGAAGAAGCGGGATTGCCAAAGGGTGTCATAAATTTCATTCTAGGTGATCCAGTTCAAGTTACTGACCAGGTATTAGCTGATAAAGATTTTGGTGCCTTGCATTTTACCGGTTCTACAAATGTCTTTAAGAGTTTGTATGGCAAAATACAAAGTGGCGTTGTTGAAGGGAAGTACAGAGATTACCCCCGTATTATTGGTGAGACAGGTGGTAAAAATTTCCATCTAGTTCACCCAAGTGCAAATATATCACATGCAGTACTCTCTACTATTAGAGGCACTTTCGAGTTCCAAGGCCAAAAGTGCTCTGCCGCTTCTAGGTTATATCTTCCAGAGTCAAAAAGTGAAGAATTCTTATCCGATATGTTTGGCATATTGCAGTCACAGAATGTTGTCCCAATGAACACATCCGCAAGTCCAATTTCTGGTGGGAATTTGCGGGGATTTATGGGTCCTGTCATCCATGAACAAAGTTTCGACAAATTAGTTAAAGTAATTGAAGATGCAAAGAAAGACCCCGAGTTGGAAATTCTTTACGGTGGACAATACGATAAAAGCCAAGGTTGGTTTGTCGGACCCACAGTCATAAAAGCCAAGAGACCAGATCATCCATATATGTCAACAGAATTTTTTGGCCCTATATTAACTGTTTACGAGTATCCAGATACGGAATTTAATGAAATCTGTGATATTATCGATAATACGAGTCAATACGCCTTAACTGGTGCTATTTTTGCCAAAGATCGTAAAGCAATTGAATACGCAGATGAGAAGTTGAAGTTTAGCGCAGGAAATTTCTACATAAATGATAAGTGTACTGGTGCCGTTGTTTCTCAGCAATGGTTTGGTGGCGCAAGAATGAGTGGTACCGACGGTAAGGCTGGTGGTCCAAACATTTTAAGCAGATTTGTCAGTATTAGAAACACAAAGGAGAGCTTCTACGAGTTGACTGATTTCAAATATCCATCGAATTATGAATAA","protein_sequence":"MLSARCLKSIYFKRSFSQLGHIKPPKHIRNEPVKPFRNIDLKDWDLLRASLMKFKSSSLEVPLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSGTDDKAGGPNILSRFVSIRNTKENFYELTDFKYPSNYE"},{"created_at":"2011-05-27T02:48:15.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"4-aminobutyrate aminotransferase","uniprot_id":"P17649","uniprot_name":"GATA_YEAST","enzyme":true,"transporter":false,"gene_name":"UGA1","num_residues":471,"molecular_weight":"52945.69922","theoretical_pi":"6.79","general_function":"Involved in 4-aminobutyrate transaminase activity","specific_function":"Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL)","reactions":[{"id":1192,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2695,"direction":"\u003e","locations":"Cytoplasm","altext":"4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3750,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006275","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692904","genbank_protein_id":"51013259","gene_card_id":"UGA1","chromosome_location":"chromosome 7","locus":"YGR019W","synonyms":["GABA aminotransferase","GABA-AT","Gamma-amino-N-butyrate transaminase","GABA transaminase"],"enzyme_classes":["2.6.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" 4-aminobutyrate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" gamma-aminobutyric acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTATTTGTGAACAATACTACCCAGAAGAGCCAACCAAACCAACTGTTAAGACCGAGTCCATTCCTGGTCCTGAATCCCAGAAGCAGTTAAAGGAACTGGGTGAAGTTTTTGACACAAGACCAGCATATTTTTTGGCTGATTATGAGAAATCTTTAGGTAACTATATCACTGATGTGGATGGGAACACATATTTGGATTTGTATGCCCAAATCTCTTCAATTGCACTTGGTTATAACAACCCTGCTTTGATCAAGGCAGCACAATCACCAGAAATGATCCGTGCTTTGGTCGACCGTCCTGCCTTAGGTAACTTCCCATCTAAGGATTTAGACAAGATATTGAAGCAAATATTGAAATCTGCGCCAAAGGGTCAAGATCACGTCTGGTCAGGGCTTTCCGGTGCAGATGCCAATGAATTAGCGTTCAAGGCTGCCTTTATTTATTACCGTGCCAAACAAAGGGGCTATGATGCCGATTTTTCTGAAAAGGAAAACTTGTCTGTCATGGACAATGACGCCCCTGGCGCCCCTCATCTTGCCGTACTATCGTTCAAGAGAGCGTTCCACGGTAGATTGTTTGCCTCCGGTTCCACAACTTGTTCTAAACCAATTCACAAGTTGGATTTCCCAGCCTTCCACTGGCCTCATGCTGAGTATCCATCTTACCAATACCCATTAGATGAAAATTCTGATGCAAACCGTAAAGAGGATGACCATTGCTTGGCCATTGTTGAAGAATTAATCAAAACCTGGTCTATTCCAGTTGCTGCCTTAATCATCGAACCAATTCAATCTGAGGGAGGTGATAACCACGCTTCTAAGTATTTCTTACAAAAGCTAAGAGACATTACCTTGAAGTATAACGTTGTCTACATCATAGATGAAGTGCAAACAGGTGTCGGAGCCACCGGTAAGCTATGGTGTCATGAGTACGCCGATATTCAACCACCTGTGGATTTAGTGACCTTTTCCAAGAAATTCCAAAGTGCAGGATATTTCTTCCACGACCCTAAATTCATTCCAAACAAACCATACAGACAATTCAACACATGGTGTGGTGAACCTGCAAGAATGATCATTGCAGGTGCCATTGGACAGGAAATCTCCGACAAGAAGTTGACTGAACAATGTTCAAGAGTAGGTGATTATTTGTTCAAGAAATTGGAGGGTTTGCAGAAGAAATACCCTGAAAACTTTCAAAACTTGAGAGGTAAAGGAAGAGGCACATTCATTGCCTGGGATTTGCCTACTGGTGAGAAGAGAGACTTACTATTGAAGAAATTGAAGTTGAATGGTTGCAACGTTGGTGGATGTGCAGTCCATGCAGTGAGATTAAGACCTTCATTAACATTCGAGGAGAAGCATGCTGATATCTTTATTGAAGCATTAGCCAAATCAGTTAATGAATTATGA","protein_sequence":"MSICEQYYPEEPTKPTVKTESIPGPESQKQLKELGEVFDTRPAYFLADYEKSLGNYITDVDGNTYLDLYAQISSIALGYNNPALIKAAQSPEMIRALVDRPALGNFPSKDLDKILKQILKSAPKGQDHVWSGLSGADANELAFKAAFIYYRAKQRGYDADFSEKENLSVMDNDAPGAPHLAVLSFKRAFHGRLFASGSTTCSKPIHKLDFPAFHWPHAEYPSYQYPLDENSDANRKEDDHCLAIVEELIKTWSIPVAALIIEPIQSEGGDNHASKYFLQKLRDITLKYNVVYIIDEVQTGVGATGKLWCHEYADIQPPVDLVTFSKKFQSAGYFFHDPKFIPNKPYRQFNTWCGEPARMIIAGAIGQEISDKKLTEQCSRVGDYLFKKLEGLQKKYPENFQNLRGKGRGTFIAWDLPTGEKRDLLLKKLKLNGCNVGGCAVHAVRLRPSLTFEEKHADIFIEALAKSVNEL"},{"created_at":"2011-05-27T05:25:59.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Succinate-semialdehyde dehydrogenase [NADP+]","uniprot_id":"P38067","uniprot_name":"UGA2_YEAST","enzyme":true,"transporter":false,"gene_name":"UGA2","num_residues":497,"molecular_weight":"54188.80078","theoretical_pi":"6.62","general_function":"Involved in oxidoreductase activity","specific_function":"Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H","reactions":[{"id":1988,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2771,"direction":"\u003e","locations":null,"altext":"Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3751,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006276","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z35875","genbank_protein_id":"4388565","gene_card_id":"UGA2","chromosome_location":"chromosome 2","locus":"YBR006W","synonyms":["SSDH"],"enzyme_classes":["1.2.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTTGAGTAAGTATTCTAAACCAACTCTAAACGACCCTAATTTATTCAGAGAATCTGGTTATATTGACGGAAAATGGGTTAAGGGCACTGACGAAGTTTTTGAGGTGGTAGACCCTGCTTCCGGCGAAATCATAGCAAGAGTTCCCGAACAACCAGTCTCCGTGGTTGAGGAAGCGATTGATGTTGCCTATGAAACTTTCAAGACGTACAAGAATACAACACCAAGAGAGAGGGCAAAGTGGCTCAGAAACATGTATAACTTAATGCTTGAAAATTTGGATGATCTGGCAACCATCATTACTTTAGAAAATGGTAAAGCTCTAGGGGAAGCTAAAGGAGAAATCAAATACGCGGCTTCGTATTTTGAGTGGTACGCCGAGGAAGCACCCCGTTTATATGGTGCTACTATTCAACCCTTGAACCCTCACAACAGAGTATTCACAATTAGGCAACCTGTTGGTGTATGCGGTATAATTTGTCCATGGAATTTTCCGAGCGCCATGATCACGAGAAAGGCCGCCGCTGCTTTAGCTGTGGGCTGCACAGTAGTCATCAAGCCAGACTCTCAAACGCCGCTATCTGCTTTAGCAATGGCATATTTGGCTGAAAAGGCAGGCTTTCCCAAGGGTTCGTTTAATGTTATTCTTTCACATGCCAACACACCAAAGCTTGGTAAAACATTATGTGAATCACCAAAAGTCAAGAAAGTTACTTTTACTGGTTCTACAAACGTCGGTAAAATCTTGATGAAACAATCTTCTTCTACTTTGAAGAAACTGTCTTTTGAGCTGGGTGGTAACGCCCCTTTCATAGTCTTTGAGGATGCCGATTTGGATCAAGCCTTGGAACAAGCCATGGCTTGTAAATTTAGGGGTTTGGGTCAAACATGTGTGTGCGCAAATAGACTTTACGTTCACTCATCCATAATTGATAAATTTGCGAAATTACTCGCGGAGAGGGTCAAAAAATTCGTAATTGGCCATGGTTTGGACCCAAAAACTACACATGGTTGTGTCATTAACTCCAGCGCTATTGAAAAAGTTGAAAGACATAAACAGGATGCCATTGATAAGGGAGCAAAAGTTGTGCTTGAAGGTGGACGTTTAACTGAGTTAGGTCCTAACTTTTATGCTCCAGTAATTTTGTCACACGTTCCCTCAACAGCTATTGTTTCCAAGGAGGAGACTTTTGGTCCATTATGTCCAATCTTTTCTTTTGATACTATGGAAGAAGTTGTCGGATATGCTAATGATACTGAGTTTGGTTTAGCAGCATATGTCTTTTCTAAAAATGTCAACACTTTATACACTGTGTCTGAAGCTTTGGAAACTGGTATGGTTTCATGTAATACAGGTGTTTTTTCGGATTGTTCTATACCATTTGGTGGTGTTAAAGAGTCAGGATTTGGAAGAGAAGGTTCGCTATATGGTATTGAAGATTACACTGTTTTGAAGACCATCACAATTGGGAATTTGCCAAACAGCATTTAA","protein_sequence":"MTLSKYSKPTLNDPNLFRESGYIDGKWVKGTDEVFEVVDPASGEIIARVPEQPVSVVEEAIDVAYETFKTYKNTTPRERAKWLRNMYNLMLENLDDLATIITLENGKALGEAKGEIKYAASYFEWYAEEAPRLYGATIQPLNPHNRVFTIRQPVGVCGIICPWNFPSAMITRKAAAALAVGCTVVIKPDSQTPLSALAMAYLAEKAGFPKGSFNVILSHANTPKLGKTLCESPKVKKVTFTGSTNVGKILMKQSSSTLKKLSFELGGNAPFIVFEDADLDQALEQAMACKFRGLGQTCVCANRLYVHSSIIDKFAKLLAERVKKFVIGHGLDPKTTHGCVINSSAIEKVERHKQDAIDKGAKVVLEGGRLTELGPNFYAPVILSHVPSTAIVSKEETFGPLCPIFSFDTMEEVVGYANDTEFGLAAYVFSKNVNTLYTVSEALETGMVSCNTGVFSDCSIPFGGVKESGFGREGSLYGIEDYTVLKTITIGNLPNSI"}]}