{"ymdb_id":"YMDB00101","created_at":"2011-05-29T15:56:49.000Z","updated_at":"2016-10-18T17:11:17.000Z","name":"Fumaric acid","cas":"110-17-8","state":"Solid","melting_point":"549 oC","description":"Fumaric acid is a precursor to L-malate in the Krebs tricarboxylic acid cycle. It is formed by the oxidation of succinate by succinate dehydrogenase. Fumarate is then converted to malate by fumarase.","experimental_water_solubility":"7 mg/mL at 25 oC [US EPA (1981)]","experimental_logp_hydrophobicity":"0.46 [HANSCH,C ET AL. (1995)]","location":"Cytoplasm;Extracellular;Mitochondrion","synthesis_reference":"Dong, Changsheng; Ma, Xinming.  Method for preparation of fumaric acid from the tail gas acid spray solution from oxidation of phthalic anhydride.    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2007),  5pp. ","chebi_id":"18012","hmdb_id":"HMDB00134","kegg_id":"C00122","pubchem_id":"723","cs_id":"24532688","foodb_id":null,"wikipedia_link":"Fumaric_acid","biocyc_id":"FUM","iupac":"(2E)-but-2-enedioic acid","traditional_iupac":"fumaric acid","logp":"-0.040914331333333324","pka":"4.412485134930334","alogps_solubility":"2.41e+01 g/l","alogps_logp":"0.21","alogps_logs":"-0.68","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"2","polar_surface_area":"74.6","refractivity":"24.607","polarizability":"9.352250335599845","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"3.545732417201611","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2E)-2-Butenedioic acid","(2E)-But-2-enedioate","(2E)-But-2-enedioic acid","(E)-2-Butenedioate","(E)-2-Butenedioic acid","(E)-2-butenedioic acid, ion(2-)","(E)-HO2CCH=CHCO2H","1, 2-Ethenedicarboxylic acid, trans-","1,2-Ethenedicarboxylic acid, trans-","1,2-Ethylenedicarboxylic acid, (E)","2-(E)-Butenedioate","2-(E)-Butenedioic acid","2-butenedioic acid","2-Butenedioic acid (E)-","2-Butenedioic acid, (E)-","Allomaleate","Allomaleic acid","Boletate","Boletic acid","Butenedioic acid, (E)-","Fumarate","Fumaric acid","Kyselina fumarova","Lichenate","Lichenic acid","sodium fumarate","trans-1,2-Ethylenedicarboxylate","trans-1,2-Ethylenedicarboxylic acid","trans-2-Butenedioate","trans-2-Butenedioic acid","trans-Butenedioate","trans-Butenedioic acid","Tumaric acid"],"pathways":[{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"growth_conditions":[{"growth_media":"Glucose limited aerobic culture","concentration":"0.85","concentration_units":"umol/g DW","error":"0.0"},{"growth_media":"Synthetic medium ","concentration":"685.0","concentration_units":"uM","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":2275532,"citation":"Peleg, Y., Rokem, J. S., Goldberg, I., Pines, O. (1990). \"Inducible overexpression of the FUM1 gene in Saccharomyces cerevisiae: localization of fumarase and efficient fumaric acid bioconversion to L-malic acid.\" Appl Environ Microbiol 56:2777-2783."},{"pubmed_id":9395087,"citation":"Palmieri, L., Lasorsa, F. M., De Palma, A., Palmieri, F., Runswick, M. J., Walker, J. E. (1997). \"Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate.\" FEBS Lett 417:114-118."},{"pubmed_id":10224250,"citation":"Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., McCammon, M. T. (1999). \"Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.\" Genetics 152:153-166."},{"pubmed_id":1409592,"citation":"Nagy, M., Lacroute, F., Thomas, D. (1992). \"Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.\" Proc Natl Acad Sci U S A 89:8966-8970."},{"pubmed_id":9587404,"citation":"Muratsubaki, H., Enomoto, K. (1998). \"One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene.\" Arch Biochem Biophys 352:175-181."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:59:21.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Adenylosuccinate lyase","uniprot_id":"Q05911","uniprot_name":"PUR8_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE13","num_residues":482,"molecular_weight":"54509.89844","theoretical_pi":"6.39","general_function":"Involved in catalytic activity","specific_function":"N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP","reactions":[{"id":1279,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1281,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2286,"direction":"\u003e","locations":null,"altext":"N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.","export":false,"pw_reaction_id":null,"source":null},{"id":2287,"direction":"\u003e","locations":null,"altext":"(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U19103","genbank_protein_id":"609416","gene_card_id":"ADE13","chromosome_location":"chromosome 12","locus":"YLR359W","synonyms":["ASL","Adenylosuccinase","ASase"],"enzyme_classes":["4.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" amidine-lyase activity"},{"category":"Function","description":" N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine ribonucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ADSL_C","identifier":"PF10397"},{"name":"Lyase_1","identifier":"PF00206"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGCCTGACTATGACAATTACACTACGCCATTGTCTTCTAGATATGCCTCCAAGGAAATGTCAGCAACGTTTTCTTTGAGAAACAGATTTTCCACATGGAGAAAACTATGGTTAAATTTGGCTATTGCTGAGAAGGAATTGGGCTTAACTGTTGTTACAGATGAAGCAATTGAGCAAATGCGCAAACACGTCGAAATCACTGATGATGAAATCGCAAAAGCTTCTGCTCAAGAAGCCATTGTAAGACATGATGTTATGGCACATGTTCATACATTTGGTGAAACTTGTCCGGCTGCTGCGGGTATCATTCACTTAGGTGCTACTTCCTGTTTCGTTACAGACAATGCTGATCTAATCTTTATTAGGGACGCCTACGATATTATTATTCCAAAACTTGTTAACGTCATCAACAGATTGGCTAAGTTTGCTATGGAATACAAGGATTTGCCTGTATTGGGTTGGACTCACTTTCAACCAGCACAATTAACGACCTTGGGTAAGAGAGCTACTTTATGGATACAAGAGCTATTGTGGGATTTGAGAAACTTTGAAAGAGCTAGAAACGATATCGGTCTACGTGGTGTTAAGGGTACTACTGGTACTCAGGCATCATTCTTGGCCTTATTCCATGGTAATCATGATAAAGTTGAAGCCCTTGACGAAAGAGTAACTGAATTATTAGGTTTCGATAAGGTATATCCAGTCACTGGTCAAACCTACTCAAGAAAAATTGACATTGACGTGTTGGCTCCTTTGTCTTCTTTTGCTGCTACTGCACACAAAATGGCTACTGACATAAGATTATTAGCCAACCTGAAGGAAGTTGAGGAACCTTTTGAGAAATCACAAATCGGATCCTCTGCTATGGCTTACAAGAGAAACCCAATGCGTTGTGAGAGAGTGTGCTCCTTGGCTAGACACTTAGGTTCCTTGTTTAGTGACGCCGTTCAAACTGCATCCGTTCAATGGTTCGAAAGAACTCTGGATGATTCTGCTATTAGAAGAATTTCTTTACCAAGTGCATTTTTAACCGCAGATATTCTATTATCTACTTTGTTGAACATCTCATCCGGTTTAGTTGTGTATCCAAAGGTTATCGAAAGGAGAATTAAGGGTGAACTACCTTTTATGGCTACTGAAAATATCATCATGGCTATGGTAGAAAAGAATGCCTCCAGACAAGAAGTACATGAGCGTATTAGAGTGCTCTCTCATCAAGCCGCAGCAGTAGTCAAGGAAGAAGGTGGGGAAAATGATTTAATTGAACGAGTAAAGAGGGATGAATTTTTCAAGCCTATCTGGGAAGAATTAGATTCTTTACTGGAACCATCCACTTTTGTTGGTAGAGCTCCACAACAAGTTGAGAAATTTGTTCAAAAAGACGTTAACAATGCTTTACAACCTTTCCAAAAGTACCTAAACGATGAACAAGTCAAGTTAAATGTTTAG","protein_sequence":"MPDYDNYTTPLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEITDDEIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKGTTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKMATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKFVQKDVNNALQPFQKYLNDEQVKLNV"},{"created_at":"2011-05-26T16:44:03.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Argininosuccinate lyase","uniprot_id":"P04076","uniprot_name":"ARLY_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG4","num_residues":463,"molecular_weight":"51988.69922","theoretical_pi":"5.48","general_function":"Involved in argininosuccinate lyase activity","specific_function":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine","reactions":[{"id":1327,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2441,"direction":"\u003e","locations":null,"altext":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.","export":false,"pw_reaction_id":null,"source":null},{"id":3738,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006263","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693155","genbank_protein_id":"51013761","gene_card_id":"ARG4","chromosome_location":"chromosome 8","locus":"YHR018C","synonyms":["ASAL","Arginosuccinase"],"enzyme_classes":["4.3.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" amidine-lyase activity"},{"category":"Function","description":" argininosuccinate lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" arginine biosynthetic process via ornithine"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Lyase_1","identifier":"PF00206"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGTCAGACGGCACTCAAAAACTATGGGGTGGGAGATTCACTGGTGAAACCGATCCTTTGATGCACCTTTACAATGCGTCTCTTCCGTATGATTATAAGATGTATAAGGCAGATTTAGAAGGAACTAAAGTATACACAGCGGGCTTGCAGAAGTTGGGTCTTCTAACGGAGACAGAATTGGCAAAGATCCATGAAGGTTTGGCTGAAATCAAAAAAGAATGGGACGCTGACAAATTTGTCCGTCATCCAAACGACGAGGATATCCATACTGCGAATGAAAGACGTCTTGGTGAACTAATTGGCCGCGATATTGCTGGTAAAGTCCACACCGGTAGATCCCGTAATGATCAAGTTGTTACCGATTTGAGAATATACTGTCGTGACATTGTCAATGACACCCTCTTTCCAGCTTTAAAGGGCTTGGTTGAAGTTCTAATTAAGAGGGCCGAAGGTGAGATAGATGTCTTAATGCCAGGCTACACACATTTACAAAGGGCACAACCTATTAGATGGTCTCATTGGTTGAGCTCTTATGCAACATACTTCACCGAAGATTACAAGAGACTGGGTCAAATACTACACAGATTGAATCAATCACCACTGGGTGCAGGCGCTCTTGCTGGTCATCCTTACGGCATTGATAGAGAATTTTTGGCTGAAGGTTTGGGTTTCAATAGTGTAATTGGTAACTCCTTGGTTGCTGTTTCTGATAGAGATTTCATCGTGGAGTTGATGTTTTGGGGAACTTTGTTCATGAACCATATTTCTCGTTTTGCTGAAGATTTGATTATATATTGTACAGCAGAATTTGGTTTCATACAGTTGAGCGACGCCTATTCAACAGGTTCTTCTTTAATGCCTCAGAAGAAGAATGCAGACTCGTTAGAGTTGTTAAGAGGTAAATCCGGTAGAGTATTTGGTGATCTGACAGGATTCTTGATGAGTTTGAAGGGTATCCCATCTACTTATGATAAAGACATGCAAGAAGACAAAGAGCCACTATTCGATTGCTTAACAACTGTAGAGCACTCCATGCTGATTGCCACAGGTGTTATTTCTACCTTAACTGTAAATAAGGAAAAGATGGAAGCTGCTCTCACGATGGATATGCTAGCTACCGACTTGGCAGATTACTTGGTCAGAAAGGGTGTTCCATTCAGAGAGACTCATCACATATCTGGTGAGTGTGTCGCTACTGCTGAAAGACTTGGTCTAAGCGGTATTGATAAATTAACCTTGGAGCAGTATCAAAAGATCGATTCGAGATTCGGACAAGATCTTTTTGAAACTTTTAACTTTGAACAAAGCGTTGAAAGACGAGATGCTACTGGTGGAACCGCTAAATCTGCTGTATTGAAGCAATTGGATAATTTGAAATCCCAATTAAATTAG","protein_sequence":"MSDGTQKLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIKKEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFPALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPLGAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYCTAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDKEPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGECVATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLKSQLN"},{"created_at":"2011-05-26T17:56:42.000Z","updated_at":"2011-05-26T17:56:42.000Z","name":"Fumarate reductase","uniprot_id":"P32614","uniprot_name":"FRDS_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":470,"molecular_weight":"50843.69922","theoretical_pi":"6.26","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2498,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm","altext":"Succinate + NAD(+) = fumarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"U18779","genbank_protein_id":"603632","gene_card_id":null,"chromosome_location":null,"locus":"YEL047C","synonyms":["FAD-dependent oxidoreductase FRDS","NADH","NADH-dependent fumarate reductase"],"enzyme_classes":["1.3.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTCTCTCTCTCCCGTTGTTGTTATTGGAACCGGTTTGGCCGGGCTGGCTGCTGCCAATGAATTGGTTAACAAGTATAACATCCCTGTAACCATCCTCGAAAAGGCTTCCTCGATCGGTGGGAACTCTATCAAGGCCTCCAGTGGTATTAACGGTGCTTGCACCGAGACTCAACGTCACTTCCACATCGAGGACTCCCCACGCTTATTTGAAGATGACACCATCAAGTCTGCTAAAGGTAAAGGTGTCCAAGAATTAATGGCTAAGTTGGCCAATGATTCTCCCCTGGCTATTGAATGGTTGAAAAACGAATTTGATTTGAAATTGGACCTATTGGCTCAATTGGGTGGCCACTCTGTGGCAAGAACTCACAGATCGTCTGGGAAGTTGCCTCCAGGTTTCGAAATTGTTTCTGCCTTATCTAACAATTTGAAGAAATTAGCTGAGACTAAACCAGAGTTAGTTAAGATTAACTTAGACAGTAAAGTCGTAGACATCCATGAAAAGGATGGCTCCATTTCTGCTGTAGTGTACGAGGACAAGAATGGCGAAAAGCACATGGTGAGTGCTAACGATGTCGTTTTTTGTTCTGGAGGGTTTGGCTTTTCTAAGGAAATGCTTAAAGAATACGCACCCGAACTGGTGAACTTGCCAACAACAAACGGGCAACAAACAACTGGTGATGGTCAAAGGCTTCTGCAGAAGTTAGGCGCTGATCTGATTGACATGGACCAAATTCAAGTTCATCCAACTGGGTTCATTGATCCAAATGACCGTAGCTCAAGCTGGAAATTCTTGGCTGCCGAATCCTTAAGAGGTCTTGGTGGTATCCTATTAAACCCTATTACCGGTAGAAGATTTGTCAACGAATTGACCACAAGAGATGTAGTCACTGCAGCTATTCAAAAGGTTTGTCCTCAAGAGGATAACAGAGCACTATTGGTTATGGGCGAAAAAATGTACACAGATTTGAAGAATAATTTAGATTTTTACATGTTCAAGAAACTTGTACAGAAATTGACATTATCTCAAGTTGTTTCTGAATATAATTTACCAATCACTGTCGCCCAATTATGCGAGGAATTGCAAACATACTCTTCCTTCACTACCAAGGCTGATCCGTTGGGACGTACCGTTATTCTCAACGAATTTGGCTCTGACGTTACTCCAGAAACTGTGGTTTTTATTGGTGAAGTAACACCGGTTGTCCATTTCACCATGGGTGGTGCTAGAATCAATGTCAAGGCTCAAGTCATTGGCAAGAACGACGAAAGGCTACTAAAAGGCCTGTACGCGGCCGGTGAAGTTTCTGGCGGTGTTCATGGCGCCAATAGGTTGGGTGGTTCAAGTTTGTTAGAATGCGTTGTCTTTGGGAGAACCGCAGCTGAATCTATTGCCAATGACCGCAAGTAA","protein_sequence":"MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK"},{"created_at":"2011-05-26T17:57:08.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Osmotic growth protein 1","uniprot_id":"P21375","uniprot_name":"OSM1_YEAST","enzyme":true,"transporter":false,"gene_name":"OSM1","num_residues":501,"molecular_weight":"55064.80078","theoretical_pi":"9.51","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3732,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006258","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Probable)","genbank_gene_id":"L26347","genbank_protein_id":"695798","gene_card_id":"OSM1","chromosome_location":"chromosome 10","locus":"YJR051W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[],"gene_sequence":"ATGATTAGATCTGTGAGAAGGGTTTTCATTTACGTCTCAATATTCGTATTGATAATAGTTTTGAAAAGAACATTAAGTGGCACAGATCAAACGTCAATGAAACAACCAGTGGTGGTCATTGGCTCTGGTTTGGCAGGCTTAACCACAAGTAATCGTCTCATTAGTAAATACAGAATTCCTGTTGTGCTTTTGGATAAGGCGGCTTCTATTGGTGGGAATTCTATAAAGGCTTCTAGTGGTATTAATGGTGCTCACACAGACACTCAACAAAATTTAAAGGTAATGGACACTCCCGAATTGTTTTTGAAAGATACTTTGCATTCGGCTAAAGGCAGAGGGGTTCCATCACTGATGGATAAGTTGACTAAGGAATCCAAGAGTGCTATCAGGTGGTTGCAAACAGAATTCGATTTGAAATTAGACCTCCTTGCGCAATTGGGCGGTCACTCTGTTCCAAGGACCCATAGATCTTCTGGCAAATTACCACCAGGTTTTGAAATCGTGCAAGCGTTATCAAAAAAACTAAAGGATATCTCTTCCAAAGATTCCAATCTCGTGCAGATTATGCTAAACAGTGAAGTAGTGGATATCGAGCTTGATAATCAAGGTCATGTTACTGGTGTAGTATATATGGACGAGAACGGAAACCGTAAAATCATGAAGTCACACCATGTCGTGTTTTGCTCAGGTGGATTTGGTTACTCTAAGGAAATGTTGAAAGAGTACTCACCAAATTTGATTCACTTGCCAACTACTAATGGCAAACAGACTACAGGTGATGGTCAAAAAATCCTTTCAAAGTTGGGTGCCGAATTGATTGATATGGATCAAGTGCAGGTACACCCTACCGGCTTCATTGATCCAAATGACCGTGAAAATAACTGGAAGTTTTTGGCTGCAGAGGCATTGAGGGGTTTAGGCGGCATCTTATTGCATCCCACCACTGGAAGAAGGTTTACAAATGAATTGAGCACCAGAGATACAGTAACCATGGAAATACAGTCTAAATGTCCGAAAAATGATAATAGAGCACTTTTGGTAATGAGCGACAAAGTCTACGAGAACTATACGAATAACATAAACTTTTATATGTCCAAAAACTTAATCAAAAAAGTGTCAATCAACGATCTGATCCGACAATATGACCTACAAACTACAGCTTCTGAACTGGTAACTGAACTGAAGAGCTATTCCGATGTTAATACTAAGGATACGTTTGATAGGCCATTGATTATCAATGCCTTTGATAAAGATATTTCGACTGAATCAACTGTTTATGTTGGGGAAGTTACACCAGTTGTTCATTTCACAATGGGTGGTGTGAAAATTAATGAGAAATCTCAGGTAATTAAGAAAAATTCGGAAAGCGTTCTATCTAATGGGATATTTGCTGCTGGTGAAGTTTCGGGTGGTGTTCATGGAGCCAACAGATTGGGTGGATCTAGTTTGTTAGAGTGTGTTGTCTTTGGAAAGACAGCTGCGGATAACATAGCAAAATTGTACTGA","protein_sequence":"MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY"},{"created_at":"2011-05-26T18:04:17.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial","uniprot_id":"Q00711","uniprot_name":"DHSA_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH1","num_residues":640,"molecular_weight":"70228.79688","theoretical_pi":"7.53","general_function":"Involved in electron carrier activity","specific_function":"Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M86746","genbank_protein_id":"172557","gene_card_id":"SDH1","chromosome_location":"chromosome 11","locus":"YKL148C","synonyms":["Flavoprotein subunit of complex II","FP"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGCTATCGCTAAAAAAATCAGCGCTCTCCAAGTTGACTTTGCTCAGAAACACAAGAACATTTACATCGTCAGCTTTGGTGCGCCAAACGCAGGGCTCTGTAAACGGTTCCGCGTCCAGATCTGCAGACGGGAAGTACCACATAATAGATCACGAGTATGACTGTGTGGTAATCGGTGCCGGTGGTGCCGGCCTTAGAGCGGCCTTTGGTCTTGCCGAGGCGGGCTACAAGACTGCTTGTATATCCAAGCTTTTCCCCACCAGATCCCACACTGTTGCTGCTCAGGGTGGTATCAATGCCGCTCTGGGAAATATGCACAAGGATAACTGGAAATGGCATATGTACGATACTGTGAAAGGATCTGATTGGCTAGGTGACCAGGACTCCATCCATTACATGACCAGGGAAGCGCCCAAATCGATCATTGAACTGGAACACTATGGTGTTCCTTTTTCAAGAACTGAAAACGGTAAGATCTACCAAAGAGCCTTTGGTGGTCAGACCAAGGAGTACGGTAAGGGTGCTCAGGCCTATAGAACATGCGCTGTCGCAGACAGGACAGGACATGCTCTTTTACACACGCTTTATGGCCAAGCTTTAAGACATGACACACATTTCTTTATTGAGTACTTTGCCCTCGATCTGTTGACCCATAATGGCGAGGTCGTTGGTGTCATCGCTTATAATCAGGAAGACGGTACCATCCACAGATTCAGAGCACACAAGACCATTATTGCCACTGGTGGCTATGGTAGAGCATACTTCTCTTGTACCTCTGCTCACACATGTACGGGTGACGGTAATGCCATGGTTTCGCGTGCTGGTTTCCCCTTGCAAGATTTAGAGTTTGTTCAATTCCATCCTTCAGGTATATATGGGTCTGGTTGCTTAATCACTGAAGGTGCTCGTGGTGAAGGTGGTTTTTTGGTTAATTCTGAAGGTGAAAGATTCATGGAACGTTACGCTCCTACGGCCAAGGATCTAGCTTGTAGAGATGTCGTTTCCAGAGCAATCACCATGGAGATCAGAGAAGGCAGAGGTGTTGGTAAGAAAAAGGACCACATGTACTTACAATTGAGCCATCTACCTCCGGAAGTTCTAAAGGAAAGATTGCCAGGTATCTCTGAAACAGCAGCCATTTTTGCTGGTGTAGACGTCACTAAGGAACCTATTCCCATTATTCCTACCGTCCACTATAACATGGGTGGTATTCCCACGAAGTGGAATGGTGAGGCATTAACCATTGATGAAGAAACTGGCGAAGACAAGGTTATTCCCGGTTTAATGGCTTGTGGTGAAGCCGCTTGTGTTTCTGTCCATGGTGCCAATAGATTAGGTGCCAATTCCTTGTTGGATCTTGTTGTCTTTGGTCGTGCTGTTGCCCATACGGTTGCTGACACTTTACAGCCTGGGTTGCCACACAAACCACTACCTTCTGATTTGGGTAAAGAATCCATCGCAAACTTGGATAAACTAAGAAATGCTAATGGTTCAAGATCTACGGCAGAAATTAGAATGAATATGAAACAAACTATGCAAAAGGATGTTTCCGTCTTTAGAACACAATCATCTTTAGATGAAGGTGTTCGGAACATTACTGCAGTAGAGAAGACCTTTGATGATGTGAAGACGACCGATAGATCAATGATCTGGAATTCTGACTTGGTTGAAACTCTGGAGCTACAGAACTTATTAACCTGTGCCTCCCAAACAGCTGTTTCCGCTGCTAATAGAAAGGAATCCCGTGGTGCTCATGCAAGAGAGGATTATCCAAATAGAGATGACGAACATTGGATGAAGCATACATTATCCTGGCAAAAGGACGTCGCTGCCCCAGTGACTTTGAAATACAGAAGGGTTATCGATCACACTTTGGACGAAAAGGAATGTCCTTCCGTACCTCCAACTGTAAGAGCCTACTAA","protein_sequence":"MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY"},{"created_at":"2011-05-26T18:04:53.000Z","updated_at":"2011-05-26T18:04:53.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial","uniprot_id":"P47052","uniprot_name":"DHSX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":634,"molecular_weight":"69382.0","theoretical_pi":"7.4","general_function":"Involved in electron carrier activity","specific_function":"Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z49320","genbank_protein_id":"1008175","gene_card_id":null,"chromosome_location":null,"locus":"YJL045W","synonyms":["Flavoprotein subunit of complex II","FP","SDH1b"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGTTATCTTTGAAAAAAGGAATAACAAAATCATACATCTTGCAAAGAACTTTCACTTCTTCCTCTGTTGTTCGTCAAATTGGGGAAGTGAAATCTGAATCGAAACCGCCGGCCAAATATCATATTATCGACCATGAATATGATTGTGTGGTGGTAGGCGCTGGCGGTGCAGGTTTAAGAGCAGCTTTCGGTTTGGCTGAAGCTGGATACAAGACTGCTTGTTTATCCAAGTTGTTTCCAACAAGGTCACATACTGTGGCTGCTCAGGGTGGAATTAATGCTGCGCTGGGAAATATGCATCCAGATGATTGGAAATCGCACATGTACGACACTGTCAAGGGTTCTGACTGGCTCGGAGACCAAGATGCAATCCATTACATGACAAGAGAAGCACCTAAGTCTGTCATTGAACTAGAACATTACGGTATGCCCTTTTCGAGGACTGAAGATGGAAGGATTTACCAGAGAGCATTTGGGGGACAATCCAAAGATTTTGGTAAAGGTGGACAGGCCTATAGGACTTGTGCGGTGGCAGATAGAACAGGTCACGCAATGCTTCATACATTGTATGGACAAGCGCTGAAAAATAATACACACTTCTTTATTGAATACTTTGCAATGGATTTGTTGACCCATAATGGCGAGGTTGTGGGTGTCATTGCCTATAATCAGGAGGACGGTACAATTCACAGATTCAGAGCACATAAGACCGTCATCGCGACAGGCGGATACGGTAGAGCTTACTTCTCTTGCACTTCTGCTCACACTTGTACAGGTGACGGTAATGCTATGGTTTCTCGCGCTGGATTTCCACTAGAGGATTTAGAATTTGTTCAATTTCATCCGTCAGGAATTTATGGGTCTGGCTGCCTAATCACTGAAGGTGCCCGTGGTGAGGGTGGATTTTTATTGAATTCTGAAGGAGAAAGGTTTATGGAACGCTATGCTCCTACTGCCAAGGACTTGGCAAGCAGGGATGTTGTTTCCAGAGCAATCACCATGGAAATCAGGGCTGGCAGAGGTGTCGGGAAAAACAAGGATCATATCCTTTTACAATTAAGCCATCTACCACCTGAGGTACTAAAGGAAAGGCTACCGGGAATATCTGAAACAGCTGCTGTCTTTGCGGGTGTCGATGTCACCCAGGAGCCAATTCCTGTCTTGCCAACTGTCCATTATAATATGGGAGGCATTCCCACAAAATGGACTGGTGAAGCATTGACCATTGACGAGGAAACTGGAGAGGATAAGGTCATCCCAGGATTGATGGCGTGTGGTGAAGCTGCTTGCGTATCGGTTCATGGAGCGAACAGATTAGGCGCTAACTCACTACTGGATTTAGTCGTTTTCGGTCGCGCCGTTGCAAATACCATTGCTGACACATTACAGCCTGGCTTGCCTCATAAGCCATTGGCTTCAAACATCGGGCACGAGTCAATTGCTAATTTGGATAAAGTAAGAAATGCTCGCGGCTCACTGAAAACCTCTCAAATCAGGTTGAACATGCAAAGGACAATGCAAAAAGATGTTTCTGTTTTCAGGACGCAAGACACTCTAGATGAAGGTGTTAGAAATATTACTGAAGTGGACAAGACATTTGAGGATGTGCACGTTTCTGATAAGTCAATGATCTGGAATTCTGATCTCGTAGAAACTCTGGAATTGCAAAATTTACTTACTTGTGCCACACAAACGGCTGTTTCTGCTTCCAAAAGAAAGGAGTCTCGTGGTGCTCATGCGAGAGAGGACTATGCAAAAAGAGATGATGTGAATTGGAGAAAGCACACATTATCATGGCAAAAGGGGACATCAACACCTGTAAAAATCAAGTACAGGAATGTAATCGCACATACTTTAGATGAGAATGAATGCGCCCCAGTCCCTCCAGCTGTCAGATCCTATTAA","protein_sequence":"MLSLKKGITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRDDVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"},{"created_at":"2011-05-26T19:25:57.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Fumarate hydratase, mitochondrial","uniprot_id":"P08417","uniprot_name":"FUMH_YEAST","enzyme":true,"transporter":false,"gene_name":"FUM1","num_residues":488,"molecular_weight":"53151.5","theoretical_pi":"8.4","general_function":"Involved in fumarate hydratase activity","specific_function":"(S)-malate = fumarate + H(2)O","reactions":[{"id":1553,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2565,"direction":"\u003e","locations":"Mitochondrion matrix. Cytoplasm.","altext":"(S)-malate = fumarate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":3702,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003284","source":"Smpdb"},{"id":3733,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006259","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YFM","cellular_location":"Mitochondrion matrix. Cytoplasm.","genbank_gene_id":"J02802","genbank_protein_id":"171523","gene_card_id":"FUM1","chromosome_location":"chromosome 16","locus":"YPL262W","synonyms":["Fumarase"],"enzyme_classes":["4.2.1.2"],"go_classes":[{"category":"Component","description":" tricarboxylic acid cycle enzyme complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" fumarate hydratase activity"},{"category":"Process","description":" fumarate metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" dicarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Lyase_1","identifier":"PF00206"},{"name":"FumaraseC_C","identifier":"PF10415"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAGATTTACCAATTGTAGTTGCAAGACTTTCGTAAAATCGTCATATAAGCTTAATATAAGAAGAATGAACTCCTCGTTCAGAACTGAAACCGATGCATTTGGTGAGATACACGTGCCTGCTGATAAGTACTGGGGTGCCCAAACTCAAAGATCCTTTCAAAACTTCAAGATTGGTGGCGCTCGTGAAAGAATGCCATTGCCTTTGGTGCATGCATTTGGTGTTTTGAAGAAATCTGCCGCGATTGTGAATGAGTCTCTGGGGGGATTGGATCCCAAGATCTCCAAGGCTATTCAACAGGCCGCTGACGAAGTGGCTTCTGGTAAGCTAGACGACCACTTTCCATTGGTTGTTTTCCAAACGGGTTCCGGTACCCAGTCTAACATGAACGCTAATGAAGTTATTTCCAATCGTGCCATTGAGATCCTAGGAGGCAAGATTGGATCTAAACAAGTCCATCCAAACAATCATTGCAACCAATCTCAATCATCCAATGATACTTTCCCCACTGTCGTGCATATCGCTGCCAGTTTGCAAATTCAAAACGAGTTGATACCTGAGTTGACCAATTTAAAGAACGCCCTTGAAGCCAAATCCAAGGAATTTGACCATATTGTGAAGATCGGTAGAACACACTTGCAAGATGCCACGCCTTTGACACTAGGTCAAGAGTTTTCCGGTTACGTGCAACAAGTTGAGAACGGTATCCAAAGAGTGGCACATTCTTTGAAAACATTGAGTTTCCTGGCACAAGGTGGTACTGCCGTTGGTACAGGGTTGAACACCAAGCCCGGATTCGATGTCAAGATAGCCGAGCAAATTTCCAAAGAAACTGGACTAAAGTTTCAAACCGCCCCTAATAGGTTCGAGGCTTTGGCTGCTCACGACGCCATTGTCGAATGTAGCGGTGCTCTAAACACCCTTGCTTGTTCTCTTTTCAAAATAGCGCAAGATATAAGATACTTAGGGTCCGGGCCACGTTGCGGCTACCATGAACTAATGCTGCCAGAGAATGAACCAGGTTCCTCAATCATGCCTGGTAAAGTTAACCCAACCCAAAACGAGGCATTGACTCAAGTGTGTGTGCAAGTCATGGGTAACAATGCAGCTATCACGTTTGCCGGCTCTCAAGGTCAATTCGAGTTAAATGTCTTCAAGCCAGTCATGATCGTCAATCTATTGAATTCGATCAGGTTAATTACTGATGCCGCATATTCATTTAGAGTGCACTGTGTTGAAGGTATCAAAGCCAATGAGCCTCGTATTCATGAGTTGTTGACTAAATCTTTAATGTTAGTCACCGCTTTGAACCCTAAGATCGGTTATGATGCCGCTTCCAAGGTCGCCAAGAATGCTCATAAGAAGGGCATTACCTTGAAGGAAAGTGCATTGGAATTGGGTGTATTGACTGAAAAGGAATTTGATGAATGGGTTGTTCCTGAACACATGCTAGGTCCTAAATAA","protein_sequence":"MLRFTNCSCKTFVKSSYKLNIRRMNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEVASGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQVHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAEQISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK"},{"created_at":"2011-05-27T07:14:15.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Dihydroorotate dehydrogenase","uniprot_id":"P28272","uniprot_name":"PYRD_YEAST","enzyme":true,"transporter":false,"gene_name":"URA1","num_residues":314,"molecular_weight":"34800.60156","theoretical_pi":"5.85","general_function":"Involved in catalytic activity","specific_function":"In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors","reactions":[{"id":1453,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1454,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1554,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2803,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + O(2) = orotate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2804,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + a quinone = orotate + a quinol","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585637","genbank_protein_id":"45719878","gene_card_id":"URA1","chromosome_location":"chromosome 11","locus":"YKL216W","synonyms":["DHOD","DHODase","DHOdehase","Dihydroorotate oxidase"],"enzyme_classes":["1.3.3.1","1.3.5.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" dihydroorotate oxidase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"},{"category":"Function","description":" dihydroorotate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" pyrimidine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" pyrimidine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" UMP biosynthetic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"}],"pfams":[{"name":"DHO_dh","identifier":"PF01180"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGACAGCCAGTTTAACTACCAAGTTCTTGAACAATACCTATGAAAACCCATTTATGAATGCATCCGGTGTTCATTGCATGACTACACAAGAATTAGATGAATTAGCAAACTCTAAAGCTGGCGCATTCATTACAAAGAGTGCTACAACCTTAGAAAGAGAAGGTAACCCTGAACCACGTTACATTTCTGTCCCTCTAGGCAGTATCAACTCCATGGGTTTACCAAACGAAGGTATCGACTACTATTTGTCCTATGTATTAAACCGTCAAAAGAATTATCCTGATGCACCTGCTATTTTCTTCTCAGTTGCTGGTATGAGCATTGATGAAAATTTAAATTTGTTGAGGAAAATCCAAGATAGCGAATTCAACGGTATTACCGAGTTAAACTTGTCTTGTCCTAATGTGCCTGGGAAACCACAAGTTGCTTATGACTTTGACTTGACAAAGGAAACCTTGGAAAAGGTTTTTGCCTTTTTCAAAAAACCTCTTGGTGTCAAGTTGCCTCCTTATTTTGATTTTGCCCATTTTGATATCATGGCAAAAATATTGAACGAGTTCCCATTAGCTTATGTCAACTCTATCAATAGTATAGGAAATGGTCTTTTCATTGATGTGGAGAAGGAGAGTGTAGTAGTGAAGCCAAAGAATGGTTTCGGGGGTATTGGAGGTGAATATGTTAAGCCAACCGCGCTCGCCAATGTTCGTGCATTTTACACTCGTTTGAGACCTGAAATCAAAGTTATCGGTACAGGTGGAATTAAGTCCGGTAAGGATGCATTTGAACATCTTCTATGTGGTGCCTCTATGCTACAGATTGGTACAGAATTACAAAAAGAGGGCGTCAAGATTTTTGAACGTATCGAAAAAGAATTAAAAGACATAATGGAAGCTAAGGGTTATACATCCATAGATCAGTTCCGTGGGAAGTTGAACAGCATTTAA","protein_sequence":"MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI"},{"created_at":"2011-05-27T09:03:42.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"Succinate/fumarate mitochondrial transporter","uniprot_id":"P33303","uniprot_name":"SFC1_YEAST","enzyme":false,"transporter":true,"gene_name":"SFC1","num_residues":322,"molecular_weight":"35340.10156","theoretical_pi":"10.31","general_function":"Involved in binding","specific_function":"Transports cytoplasmic succinate, derived from isocitrate by the action of isocitrate lyase in the cytosol, into the mitochondrial matrix in exchange for fumarate","reactions":[],"signal_regions":"None","transmembrane_regions":"11-31;68-88;114-134;177-193;219-235;278-295","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"AY692924","genbank_protein_id":"51013299","gene_card_id":"SFC1","chromosome_location":"chromosome 10","locus":"YJR095W","synonyms":["Regulator of acetyl-CoA synthase activity"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCTCAAAAAAAGAAGGCTTCCCATCCAGCCATCAATCTCATGGCTGGCGGCACAGCAGGTTTATTTGAAGCATTGTGTTGTCATCCTTTAGATACAATTAAGGTGAGAATGCAAATATACAGACGGGTAGCTGGTATTGAACATGTTAAACCCCCAGGATTTATTAAAACTGGGCGTACCATTTATCAAAAAGAAGGTTTCTTGGCTCTGTATAAAGGTCTAGGTGCTGTGGTCATCGGTATTATACCTAAGATGGCAATCCGTTTCTCGTCTTATGAATTCTATAGAACCTTATTGGTTAACAAGGAATCAGGAATTGTGTCTACCGGTAATACTTTTGTTGCTGGTGTTGGGGCTGGTATCACCGAAGCTGTTCTTGTCGTGAACCCGATGGAAGTTGTAAAGATTAGGTTACAAGCTCAGCATTTAACTCCGAGTGAGCCAAATGCTGGTCCTAAATATAACAACGCCATTCATGCAGCCTACACTATTGTCAAAGAAGAAGGTGTTTCTGCCTTATATAGAGGCGTTTCCTTAACTGCGGCAAGGCAAGCAACTAATCAGGGTGCTAACTTCACAGTTTATTCTAAACTGAAGGAGTTTTTGCAGAATTACCATCAGATGGATGTCCTACCTTCATGGGAAACTTCTTGCATAGGTTTGATTTCGGGTGCTATTGGGCCGTTTTCCAACGCTCCATTGGATACTATAAAGACAAGGCTGCAAAAGGATAAGTCCATCTCATTGGAAAAACAGTCCGGTATGAAGAAAATCATAACCATTGGTGCTCAACTACTGAAAGAAGAAGGTTTTAGAGCTTTGTACAAGGGTATTACCCCAAGAGTGATGAGGGTGGCTCCAGGTCAGGCTGTCACCTTTACCGTTTATGAATATGTAAGGGAGCATTTAGAAAATTTGGGTATATTCAAGAAGAATGACACACCAAAGCCAAAGCCATTAAAGTAG","protein_sequence":"MSQKKKASHPAINLMAGGTAGLFEALCCHPLDTIKVRMQIYRRVAGIEHVKPPGFIKTGRTIYQKEGFLALYKGLGAVVIGIIPKMAIRFSSYEFYRTLLVNKESGIVSTGNTFVAGVGAGITEAVLVVNPMEVVKIRLQAQHLTPSEPNAGPKYNNAIHAAYTIVKEEGVSALYRGVSLTAARQATNQGANFTVYSKLKEFLQNYHQMDVLPSWETSCIGLISGAIGPFSNAPLDTIKTRLQKDKSISLEKQSGMKKIITIGAQLLKEEGFRALYKGITPRVMRVAPGQAVTFTVYEYVREHLENLGIFKKNDTPKPKPLK"}]}