{"ymdb_id":"YMDB00562","created_at":"2011-05-29T18:31:23.000Z","updated_at":"2016-09-08T18:35:37.000Z","name":"5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","cas":"3031-94-5","state":"Solid","melting_point":null,"description":"5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (AICAR) is an intermediate in inosine-5'-phosphate (IMP) biosynthesis.  AICAR is also known to postively regulate both the purine and phosphate metabolic pathways. Accumulation of AICAR is toxic for yeast cells. [PMID: 19528318]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Schmitt, Laurent; Caperelli, Carol A.  Enantiospecific synthesis of carbocyclic aminoimidazole carboxamide ribonucleotide (C-AICAR), succinoaminoimidazole carboxamide ribonucleotide (C-SAICAR), and a new intermediate for SAICAR analogs.    Nucleosides \u0026 N","chebi_id":"18406","hmdb_id":"HMDB01517","kegg_id":"C04677","pubchem_id":"65110","cs_id":"58620","foodb_id":null,"wikipedia_link":"AICA ribonucleotide","biocyc_id":"AICAR","iupac":"{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"aica ribonucleotide","logp":"-4.81241299868757","pka":"6.266347985457528","alogps_solubility":"2.79e+00 g/l","alogps_logp":"-2.16","alogps_logs":"-2.08","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"5","polar_surface_area":"203.37999999999997","refractivity":"69.1421","polarizability":"28.56573109900927","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.804279678031426","pka_strongest_acidic":"1.2245998962218518","bioavailability":"0","number_of_rings":"2","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxamide","1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide","5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","5-Amino-4-imidazole carboxamide ribonucleotide","5-amino-4-imidazolecarboxamide ribotide","5-aminoimidazole-4-carboxamide ribotide","5-phospho-ribosyl-5-amino-4-imidazole carboxamide","5-phosphoribosyl-4-carbamoyl-5-aminoimidazole","5-phosphoribosyl-5-amino-4-imidazolecarboxamide","5'-P-ribosyl-5-amino-4-imidazole carboxamide","5'-Phospho-ribosyl-5-amino-4-imidazole carboxamide","5'-phosphoribosyl-5-amino-4-imidazole carboxamide","5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide","AICA ribonucleotide","aicar","aminoimidazole carboxamide ribonucleotide","Z-nucleotide"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":19528318,"citation":"Pinson, B., Vaur, S., Sagot, I., Coulpier, F., Lemoine, S., Daignan-Fornier, B. (2009). \"Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways.\" Genes Dev 23:1399-1407."}],"proteins":[{"created_at":"2011-05-24T19:27:04.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Imidazole glycerol phosphate synthase hisHF","uniprot_id":"P33734","uniprot_name":"HIS5_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS7","num_residues":552,"molecular_weight":"61067.60156","theoretical_pi":"5.15","general_function":"Involved in catalytic activity","specific_function":"IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR","reactions":[{"id":1653,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2255,"direction":"\u003e","locations":null,"altext":"5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":4161,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006457","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OX6","cellular_location":null,"genbank_gene_id":"X69815","genbank_protein_id":"395155","gene_card_id":"HIS7","chromosome_location":"chromosome 2","locus":"YBR248C","synonyms":["IGP synthase","IGPS","ImGP synthase","Glutamine amidotransferase","Cyclase"],"enzyme_classes":["2.4.2.-","4.1.3.-"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" imidazoleglycerol-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"His_biosynth","identifier":"PF00977"}],"pathways":[{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCCGGTCGTTCACGTGATTGACGTTGAAAGTGGTAACCTACAGTCACTAACCAATGCAATTGAGCATTTAGGTTACGAAGTACAACTGGTGAAATCACCAAAGGATTTTAACATATCAGGCACGTCAAGATTGATTTTGCCTGGTGTCGGAAATTATGCCCATTTCGTCGACAATTTATTTAATAGAGGATTCGAAAAGCCGATAAGAGAATACATTGAATCTGGAAAACCAATAATGGGAATTTGCGTCGGGCTACAAGCGCTCTTTGCCGGTTCCGTGGAAAGCCCTAAGAGTACGGGTCTGAACTACATTGATTTTAAGTTGTCCAGGTTCGATGATTCAGAAAAGCCAGTACCAGAAATAGGTTGGAATTCTTGCATTCCCTCGGAAAACCTATTCTTTGGATTGGATCCATACAAGAGGTACTATTTCGTCCATTCTTTTGCTGCCATTCTGAATTCAGAAAAGAAAAAAAACCTAGAAAATGACGGTTGGAAAATTGCAAAAGCTAAGTACGGTTCAGAGGAATTTATTGCGGCAGTCAACAAGAATAATATATTCGCTACTCAGTTCCATCCTGAAAAATCAGGTAAAGCTGGTTTGAACGTCATTGAGAATTTTTTGAAGCAACAAAGTCCTCCGATTCCAAACTATAGTGCGGAAGAGAAGGAACTCTTAATGAATGACTATTCAAATTATGGTCTAACACGCAGAATTATTGCTTGTCTTGATGTACGTACTAATGACCAAGGTGATTTGGTGGTTACTAAAGGTGATCAATACGATGTACGTGAAAAAAGTGATGGTAAAGGTGTTAGAAACCTTGGTAAGCCTGTTCAGTTGGCACAGAAATATTACCAACAGGGTGCGGATGAAGTAACATTTTTGAATATAACTTCTTTTAGAGATTGTCCTTTGAAGGATACTCCGATGCTAGAGGTTCTGAAACAAGCCGCAAAGACAGTCTTTGTTCCATTGACAGTCGGTGGGGGGATCAAGGATATTGTCGATGTTGATGGAACCAAAATACCTGCTTTAGAAGTTGCAAGTCTATACTTCAGATCTGGTGCTGATAAAGTATCGATCGGTACGGATGCAGTCTATGCAGCCGAAAAATACTACGAGTTGGGTAACAGAGGAGATGGAACGTCACCAATAGAGACAATCTCGAAAGCATACGGTGCTCAGGCAGTTGTTATTTCTGTCGACCCTAAGAGAGTATATGTAAATTCACAAGCAGATACGAAGAACAAAGTCTTCGAGACAGAATATCCGGGCCCCAATGGAGAGAAATACTGCTGGTACCAATGTACAATCAAAGGTGGAAGAGAATCTAGAGACCTTGGTGTGTGGGAATTAACAAGGGCATGTGAAGCTCTAGGTGCTGGGGAGATTTTATTGAACTGCATAGACAAGGATGGCTCTAATTCTGGTTATGATCTGGAATTGATAGAACATGTTAAAGATGCGGTCAAGATTCCCGTCATTGCATCCAGTGGCGCCGGTGTACCCGAACATTTCGAAGAGGCCTTCCTAAAGACCCGCGCAGATGCTTGCTTGGGTGCAGGTATGTTCCACAGAGGTGAATTCACTGTTAACGATGTAAAGGAGTATTTACTAGAGCACGGATTAAAGGTTAGAATGGATGAAGAGTAA","protein_sequence":"MPVVHVIDVESGNLQSLTNAIEHLGYEVQLVKSPKDFNISGTSRLILPGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQALFAGSVESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPSENLFFGLDPYKRYYFVHSFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKSGKAGLNVIENFLKQQSPPIPNYSAEEKELLMNDYSNYGLTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVKEYLLEHGLKVRMDEE"},{"created_at":"2011-05-24T19:59:21.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Adenylosuccinate lyase","uniprot_id":"Q05911","uniprot_name":"PUR8_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE13","num_residues":482,"molecular_weight":"54509.89844","theoretical_pi":"6.39","general_function":"Involved in catalytic activity","specific_function":"N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP","reactions":[{"id":1279,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1281,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2286,"direction":"\u003e","locations":null,"altext":"N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.","export":false,"pw_reaction_id":null,"source":null},{"id":2287,"direction":"\u003e","locations":null,"altext":"(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U19103","genbank_protein_id":"609416","gene_card_id":"ADE13","chromosome_location":"chromosome 12","locus":"YLR359W","synonyms":["ASL","Adenylosuccinase","ASase"],"enzyme_classes":["4.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" amidine-lyase activity"},{"category":"Function","description":" N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine ribonucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"}],"pfams":[{"name":"ADSL_C","identifier":"PF10397"},{"name":"Lyase_1","identifier":"PF00206"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"}],"gene_sequence":"ATGCCTGACTATGACAATTACACTACGCCATTGTCTTCTAGATATGCCTCCAAGGAAATGTCAGCAACGTTTTCTTTGAGAAACAGATTTTCCACATGGAGAAAACTATGGTTAAATTTGGCTATTGCTGAGAAGGAATTGGGCTTAACTGTTGTTACAGATGAAGCAATTGAGCAAATGCGCAAACACGTCGAAATCACTGATGATGAAATCGCAAAAGCTTCTGCTCAAGAAGCCATTGTAAGACATGATGTTATGGCACATGTTCATACATTTGGTGAAACTTGTCCGGCTGCTGCGGGTATCATTCACTTAGGTGCTACTTCCTGTTTCGTTACAGACAATGCTGATCTAATCTTTATTAGGGACGCCTACGATATTATTATTCCAAAACTTGTTAACGTCATCAACAGATTGGCTAAGTTTGCTATGGAATACAAGGATTTGCCTGTATTGGGTTGGACTCACTTTCAACCAGCACAATTAACGACCTTGGGTAAGAGAGCTACTTTATGGATACAAGAGCTATTGTGGGATTTGAGAAACTTTGAAAGAGCTAGAAACGATATCGGTCTACGTGGTGTTAAGGGTACTACTGGTACTCAGGCATCATTCTTGGCCTTATTCCATGGTAATCATGATAAAGTTGAAGCCCTTGACGAAAGAGTAACTGAATTATTAGGTTTCGATAAGGTATATCCAGTCACTGGTCAAACCTACTCAAGAAAAATTGACATTGACGTGTTGGCTCCTTTGTCTTCTTTTGCTGCTACTGCACACAAAATGGCTACTGACATAAGATTATTAGCCAACCTGAAGGAAGTTGAGGAACCTTTTGAGAAATCACAAATCGGATCCTCTGCTATGGCTTACAAGAGAAACCCAATGCGTTGTGAGAGAGTGTGCTCCTTGGCTAGACACTTAGGTTCCTTGTTTAGTGACGCCGTTCAAACTGCATCCGTTCAATGGTTCGAAAGAACTCTGGATGATTCTGCTATTAGAAGAATTTCTTTACCAAGTGCATTTTTAACCGCAGATATTCTATTATCTACTTTGTTGAACATCTCATCCGGTTTAGTTGTGTATCCAAAGGTTATCGAAAGGAGAATTAAGGGTGAACTACCTTTTATGGCTACTGAAAATATCATCATGGCTATGGTAGAAAAGAATGCCTCCAGACAAGAAGTACATGAGCGTATTAGAGTGCTCTCTCATCAAGCCGCAGCAGTAGTCAAGGAAGAAGGTGGGGAAAATGATTTAATTGAACGAGTAAAGAGGGATGAATTTTTCAAGCCTATCTGGGAAGAATTAGATTCTTTACTGGAACCATCCACTTTTGTTGGTAGAGCTCCACAACAAGTTGAGAAATTTGTTCAAAAAGACGTTAACAATGCTTTACAACCTTTCCAAAAGTACCTAAACGATGAACAAGTCAAGTTAAATGTTTAG","protein_sequence":"MPDYDNYTTPLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEITDDEIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKGTTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKMATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKFVQKDVNNALQPFQKYLNDEQVKLNV"},{"created_at":"2011-05-26T17:52:10.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE17","uniprot_id":"P38009","uniprot_name":"PUR92_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE17","num_residues":592,"molecular_weight":"65262.60156","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":14239,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006682","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"Z49273","genbank_protein_id":"809579","gene_card_id":"ADE17","chromosome_location":"chromosome 13","locus":"YMR120C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"gene_sequence":"ATGGCCAATTACACAAAAACCGCAATCCTATCCGTCTATGACAAGACAGGTCTACTTGATTTAGCCAGAGGCCTCATCGAGAAGAACGTTCGTATTCTCGCCTCCGGTGGTACTGCTCGTATGATTCGTGACGCTGGTTTTCCAATCGAAGACGTTTCTGCTATCACACATGCCCCAGAAATGTTGGGAGGTAGAGTGAAAACTTTACATCCTGCCGTTCATGGTGGTATCCTTGCTAGGGACATCGATAGCGATGAGAAAGACTTGAAGGAACAGCACATTGAAAAAGTCGATTATGTCGTTTGTAACCTATACCCATTCAAAGAAACTGTTGCTAAGGTGGGTGTGACTATTCCAGAAGCAGTAGAAGAAATTGATATTGGTGGTGTTACTCTATTAAGAGCAGCTGCTAAGAACCATGCTAGAGTCACTATTTTATCTGATCCAAAGGACTACTCCGAATTTTTAAGTGAATTATCCAGTAATGGTGAAATCTCTCAAGATTTGAGAAACAGATTGGCATTAAAGGCTTTCGAACACACTGCCGATTATGATGCTGCAATTTCAGATTTCTTCAGGAAACAATACTCTGAAGGTCAAGCTCAAATTACTCTACGTTATGGTGCCAATCCACACCAAAAGCCGGCTCAAGCTTACGTCAGTCAACAAGACAGTTTACCTTTCAAAGTCCTATGTGGTTCACCAGGTTACATTAATTTGTTGGATGCTCTAAATTCCTGGCCCCTGGTTAAGGAATTATCCGCCTCGTTGAATTTACCAGCAGCAGCATCGTTCAAGCATGTATCACCAGCTGGTGCCGCTGTGGGTATCCCATTGTCTGATGTTGAAAAGCAAGTTTATTTTGTTGCCGACATTGAAAACTTATCTCCCCTGGCATGTGCCTATGCTAGGGCCCGTGGTGCTGATAGAATGTCTTCCTTTGGTGATTGGATTGCTCTTTCCAACATAGTTGATGTTCCAACAGCTAAGATCATATCTAGAGAAGTTTCTGATGGTGTTATTGCCCCAGGTTATGAGCCTGAGGCGTTGGCCATTCTATCCAAGAAGAAGGGAGGTAAGTACTGCATATTACAAATTGATCCAAACTATGTTCCAGAAGCTGTCGAAAGAAGACAAGTATACGGTGTGACTTTGGAACAAAAGAGAAACGATGCCATAATCAATCAATCAACTTTCAAAGAAATTGTTTCTCAAAATAAAAATCTCACTGAACAAGCCATAATTGATTTAACGGTTGCCACCATTGCTATTAAATATACTCAATCTAATTCCGTATGTTATGCTAGAAATGGTATGGTTGTCGGATTGGGTGCAGGTCAACAATCTAGAATCCATTGTACAAGATTAGCTGGTGATAAGGCTGATAATTGGTGGTTCAGACAACACCCTAGAGTTTTGGAGATTAAATGGGCTAAAGGCGTCAAGAGACCAGAAAAATCTAATGCTATCGATTTATTCGTAACCGGCCAAATTCCAACAGAAGAACCAGAATTGTCTGAATACCAATCGAAGTTCGAGGAGATTCCAAAACCATTTACTCCAGAAGAAAGAAAGGAATGGTTGAGTAAATTAACCAACGTTTCTTTGTCATCGGATGCATTTTTCCCATTCCCAGACAATGTTTACAGAGCAGTTAAATCCGGTGTCAAATACATTGCCGCTCCATCTGGTTCTGTCATGGACAAGGTTGTATTTTCAGCTGCCGATTCATTCGATTTGGTTTACGTAGAGAACCCAATCCGTTTGTTCCACCATTAG","protein_sequence":"MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH"},{"created_at":"2011-05-26T17:52:41.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE16","uniprot_id":"P54113","uniprot_name":"PUR91_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE16","num_residues":591,"molecular_weight":"65281.80078","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U62402","genbank_protein_id":"1480728","gene_card_id":"ADE16","chromosome_location":"chromosome 12","locus":"YLR028C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGGCAAATATACCAAGACTGCGATCTTGTCAGTTTATGATAAGACAGGTTTATTAGACTTAGCCAAGGGATTGGTAGAGAACAATGTTCGTATCCTAGCATCCGGTGGTACGGCCAACATGGTCAGAGAAGCTGGTTTTCCGGTCGACGATGTTTCTTCAATTACGCATGCACCAGAAATGCTAGGGGGTAGAGTCAAGACTCTTCACCCTGCTGTGCATGCAGGTATTCTTGCCAGAAATTTAGAGGGCGATGAAAAAGATTTAAAAGAGCAGCACATTGATAAGGTGGATTTTGTTGTATGTAATCTATATCCGTTCAAAGAAACTGTGGCTAAAATTGGTGTTACAGTTCAAGAAGCTGTAGAGGAGATCGACATTGGCGGTGTGACTTTGTTGAGAGCAGCCGCAAAGAACCATTCCAGAGTGACTATTCTTTCAGACCCTAATGACTATTCTATCTTTCTGCAAGACCTGTCTAAGGACGGTGAAATTTCTCAGGATTTAAGAAATAGATTTGCACTTAAGGCGTTTGAACATACGGCCGATTATGATGCGGCCATTTCTGACTTTTTCAGGAAACAGTACTCCGAAGGGAAAGCCCAATTACCGCTAAGATATGGTTGTAATCCCCACCAAAGACCTGCACAAGCTTATATCACTCAGCAGGAGGAGTTGCCCTTCAAAGTGCTCTGCGGTACACCAGGATATATAAATCTTTTGGATGCCTTGAACTCATGGCCCTTAGTGAAAGAGTTATCTGCATCATTGAACTTGCCTGCGGCAGCATCGTTCAAGCACGTTTCTCCAGCAGGTGCTGCTGTGGGACTTCCATTATCCGATGTGGAAAGACAAGTTTATTTTGTGAATGATATGGAGGATTTATCACCATTGGCATGCGCATACGCTAGGGCCCGTGGTGCAGATAGGATGTCATCCTTTGGTGATTTCATTGCATTGTCCAATATTGTAGATGTCGCCACTGCAAAAATCATCTCTAAAGAAGTTTCCGATGGTGTTATTGCTCCAGGGTATGAACCAGAGGCATTGAATATACTATCTAAGAAGAAAAACGGAAAATACTGTATTTTACAAATCGATCCAAACTATGTTCCTGGCCAAATGGAATCCCGAGAGGTTTTTGGCGTAACGTTACAACAGAAGAGAAACGATGCGATCATAAACCAATCCACTTTCAAAGAAATTGTCTCCAAAAACAAAGCACTCACCGAGCAAGCCGTTATCGATCTAACTGTTGCTACGCTGGTTTTAAAATACACACAATCAAATTCTGTTTGCTACGCAAAGAATGGTATGGTTGTGGGGCTTGGGGCCGGCCAACAATCGCGTATACACTGTACCAGATTAGCTGGTGACAAGACGGACAACTGGTGGTTGAGACAACATCCAAAGGTTTTGAACATGAAGTGGGCCAAGGGAATTAAGAGAGCGGACAAGTCGAATGCGATTGATCTTTTTGTTACAGGGCAAAGAATAGAAGGCCCGGAAAAGGTGGATTACGAAAGCAAATTTGAAGAAGTCCCTGAACCTTTCACCAAAGAAGAAAGACTAGAATGGTTAAGCAAATTAAACAATGTATCGTTATCATCCGATGCGTTCTTTCCCTTCCCAGACAACGTTTATAGAGCTGTGCAGTCTGGTGTAAAGTTCATCACGGCTCCTTCGGGGTCTGTCATGGACAAAGTTGTCTTCCAAGCGGCGGATTCATTTGATATCGTCTACGTGGAGAACCCAATTCGTTTATTCCACCACTAA","protein_sequence":"MGKYTKTAILSVYDKTGLLDLAKGLVENNVRILASGGTANMVREAGFPVDDVSSITHAPEMLGGRVKTLHPAVHAGILARNLEGDEKDLKEQHIDKVDFVVCNLYPFKETVAKIGVTVQEAVEEIDIGGVTLLRAAAKNHSRVTILSDPNDYSIFLQDLSKDGEISQDLRNRFALKAFEHTADYDAAISDFFRKQYSEGKAQLPLRYGCNPHQRPAQAYITQQEELPFKVLCGTPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVERQVYFVNDMEDLSPLACAYARARGADRMSSFGDFIALSNIVDVATAKIISKEVSDGVIAPGYEPEALNILSKKKNGKYCILQIDPNYVPGQMESREVFGVTLQQKRNDAIINQSTFKEIVSKNKALTEQAVIDLTVATLVLKYTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDKTDNWWLRQHPKVLNMKWAKGIKRADKSNAIDLFVTGQRIEGPEKVDYESKFEEVPEPFTKEERLEWLSKLNNVSLSSDAFFPFPDNVYRAVQSGVKFITAPSGSVMDKVVFQAADSFDIVYVENPIRLFHH"}]}