{"ymdb_id":"YMDB16233","created_at":"2016-09-12T18:26:19.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"4-(Glutamylamino) butanoate","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-2-amino-4-[(3-carboxypropyl)carbamoyl]butanoic acid","traditional_iupac":"glugaba","logp":"-3.8525560376446113","pka":"4.370224218501651","alogps_solubility":"1.21e+01 g/l","alogps_logp":"-3.37","alogps_logs":"-1.28","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"8","polar_surface_area":"129.72","refractivity":"53.5456","polarizability":"23.130464491248325","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.312092334792249","pka_strongest_acidic":"2.2953777937671016","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Glutamate Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T02:48:15.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"4-aminobutyrate aminotransferase","uniprot_id":"P17649","uniprot_name":"GATA_YEAST","enzyme":true,"transporter":false,"gene_name":"UGA1","num_residues":471,"molecular_weight":"52945.69922","theoretical_pi":"6.79","general_function":"Involved in 4-aminobutyrate transaminase activity","specific_function":"Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL)","reactions":[{"id":1192,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2695,"direction":"\u003e","locations":"Cytoplasm","altext":"4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3750,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006275","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692904","genbank_protein_id":"51013259","gene_card_id":"UGA1","chromosome_location":"chromosome 7","locus":"YGR019W","synonyms":["GABA aminotransferase","GABA-AT","Gamma-amino-N-butyrate transaminase","GABA transaminase"],"enzyme_classes":["2.6.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" 4-aminobutyrate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" gamma-aminobutyric acid metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTATTTGTGAACAATACTACCCAGAAGAGCCAACCAAACCAACTGTTAAGACCGAGTCCATTCCTGGTCCTGAATCCCAGAAGCAGTTAAAGGAACTGGGTGAAGTTTTTGACACAAGACCAGCATATTTTTTGGCTGATTATGAGAAATCTTTAGGTAACTATATCACTGATGTGGATGGGAACACATATTTGGATTTGTATGCCCAAATCTCTTCAATTGCACTTGGTTATAACAACCCTGCTTTGATCAAGGCAGCACAATCACCAGAAATGATCCGTGCTTTGGTCGACCGTCCTGCCTTAGGTAACTTCCCATCTAAGGATTTAGACAAGATATTGAAGCAAATATTGAAATCTGCGCCAAAGGGTCAAGATCACGTCTGGTCAGGGCTTTCCGGTGCAGATGCCAATGAATTAGCGTTCAAGGCTGCCTTTATTTATTACCGTGCCAAACAAAGGGGCTATGATGCCGATTTTTCTGAAAAGGAAAACTTGTCTGTCATGGACAATGACGCCCCTGGCGCCCCTCATCTTGCCGTACTATCGTTCAAGAGAGCGTTCCACGGTAGATTGTTTGCCTCCGGTTCCACAACTTGTTCTAAACCAATTCACAAGTTGGATTTCCCAGCCTTCCACTGGCCTCATGCTGAGTATCCATCTTACCAATACCCATTAGATGAAAATTCTGATGCAAACCGTAAAGAGGATGACCATTGCTTGGCCATTGTTGAAGAATTAATCAAAACCTGGTCTATTCCAGTTGCTGCCTTAATCATCGAACCAATTCAATCTGAGGGAGGTGATAACCACGCTTCTAAGTATTTCTTACAAAAGCTAAGAGACATTACCTTGAAGTATAACGTTGTCTACATCATAGATGAAGTGCAAACAGGTGTCGGAGCCACCGGTAAGCTATGGTGTCATGAGTACGCCGATATTCAACCACCTGTGGATTTAGTGACCTTTTCCAAGAAATTCCAAAGTGCAGGATATTTCTTCCACGACCCTAAATTCATTCCAAACAAACCATACAGACAATTCAACACATGGTGTGGTGAACCTGCAAGAATGATCATTGCAGGTGCCATTGGACAGGAAATCTCCGACAAGAAGTTGACTGAACAATGTTCAAGAGTAGGTGATTATTTGTTCAAGAAATTGGAGGGTTTGCAGAAGAAATACCCTGAAAACTTTCAAAACTTGAGAGGTAAAGGAAGAGGCACATTCATTGCCTGGGATTTGCCTACTGGTGAGAAGAGAGACTTACTATTGAAGAAATTGAAGTTGAATGGTTGCAACGTTGGTGGATGTGCAGTCCATGCAGTGAGATTAAGACCTTCATTAACATTCGAGGAGAAGCATGCTGATATCTTTATTGAAGCATTAGCCAAATCAGTTAATGAATTATGA","protein_sequence":"MSICEQYYPEEPTKPTVKTESIPGPESQKQLKELGEVFDTRPAYFLADYEKSLGNYITDVDGNTYLDLYAQISSIALGYNNPALIKAAQSPEMIRALVDRPALGNFPSKDLDKILKQILKSAPKGQDHVWSGLSGADANELAFKAAFIYYRAKQRGYDADFSEKENLSVMDNDAPGAPHLAVLSFKRAFHGRLFASGSTTCSKPIHKLDFPAFHWPHAEYPSYQYPLDENSDANRKEDDHCLAIVEELIKTWSIPVAALIIEPIQSEGGDNHASKYFLQKLRDITLKYNVVYIIDEVQTGVGATGKLWCHEYADIQPPVDLVTFSKKFQSAGYFFHDPKFIPNKPYRQFNTWCGEPARMIIAGAIGQEISDKKLTEQCSRVGDYLFKKLEGLQKKYPENFQNLRGKGRGTFIAWDLPTGEKRDLLLKKLKLNGCNVGGCAVHAVRLRPSLTFEEKHADIFIEALAKSVNEL"},{"created_at":"2011-05-27T05:45:58.000Z","updated_at":"2011-05-29T05:06:42.000Z","name":"Glutamate decarboxylase","uniprot_id":"Q04792","uniprot_name":"DCE_YEAST","enzyme":true,"transporter":false,"gene_name":"GAD1","num_residues":585,"molecular_weight":"65989.5","theoretical_pi":"6.61","general_function":"Involved in glutamate decarboxylase activity","specific_function":"L-glutamate = 4-aminobutanoate + CO(2)","reactions":[{"id":1571,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2782,"direction":"\u003e","locations":null,"altext":"L-glutamate = 4-aminobutanoate + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3747,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006274","source":"Smpdb"},{"id":3748,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006857","source":"Smpdb"},{"id":3749,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006858","source":"Smpdb"},{"id":14214,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006653","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z48639","genbank_protein_id":"732928","gene_card_id":"GAD1","chromosome_location":"chromosome 13","locus":"YMR250W","synonyms":["GAD"],"enzyme_classes":["4.1.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" glutamate decarboxylase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamate metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"Pyridoxal_deC","identifier":"PF00282"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Taurine and hypotaurine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTACACAGGCACGGTTCTAAGCAGAAGAACTTCGAGAATATCGCTGGAAAAGTTGTCCACGACCTTGCAGGTCTGCAATTGCTTTCTAACGACGTTCAAAAATCCGCTGTCCAAAGTGGTCATCAAGGATCGAACAATATGAGAGATACTTCGTCTCAGGGCATGGCTAATAAGTATTCAGTTCCAAAAAAGGGACTACCTGCTGATTTGTCTTACCAACTGATTCATAATGAATTAACACTTGATGGTAATCCGCATTTGAACCTTGCCAGTTTCGTGAACACTTTTACCACTGATCAGGCAAGGAAATTGATTGATGAAAATTTGACCAAAAATCTTGCTGACAATGATGAATATCCGCAATTAATTGAGCTAACTCAGCGTTGTATTTCTATGCTAGCTCAATTATGGCACGCTAATCCCGATGAAGAACCAATAGGCTGTGCCACCACAGGTTCTAGTGAGGCAATCATGTTGGGTGGACTCGCCATGAAAAAAAGATGGGAACACAGAATGAAGAATGCTGGTAAAGATGCTTCCAAGCCGAACATTATAATGTCTTCTGCGTGCCAAGTGGCATTAGAGAAGTTTACGAGATATTTTGAAGTGGAATGCCGATTGGTTCCGGTATCCCACAGAAGCCATCATATGCTTGACCCAGAGTCGTTATGGGATTATGTAGATGAGAACACTATTGGCTGTTTTGTAATTTTAGGAACCACCTACACTGGCCATTTGGAAAATGTAGAGAAAGTTGCAGATGTCTTGTCCCAAATTGAGGCCAAGCATCCTGATTGGAGCAATACTGATATTCCAATCCATGCGGATGGCGCTTCAGGTGGGTTTATTATCCCATTTGGCTTTGAAAAAGAGCACATGAAAGCTTATGGCATGGAACGTTGGGGGTTCAACCATCCGCGTGTGGTTAGTATGAACACTAGTGGTCATAAGTTTGGCTTAACCACTCCCGGTCTGGGTTGGGTGCTATGGAGAGATGAATCCTTACTGGCTGATGAATTGAGATTCAAACTAAAGTACCTCGGTGGCGTGGAAGAAACTTTCGGTTTGAATTTTTCAAGACCTGGATTTCAAGTTGTCCATCAATACTTCAATTTTGTTTCTCTAGGCCATTCAGGGTATAGAACACAATTCCAAAATTCTCTATTTGTTGCAAGAGCGTTTTCTTTCGAATTATTGAATTCGTCAAAATTGCCCGGATGCTTTGAAATTGTTAGCAGTATCCATGAAAGCATTGAGAACGATTCCGCCCCTAAGTCAGTTAAAGACTATTGGGAACACCCCCAGGCTTACAAACCAGGTGTACCGCTGGTAGCCTTCAAATTGTCCAAGAAATTCCACGAAGAATATCCAGAAGTGCCACAAGCAATCCTTTCCTCTTTACTGAGAGGTAGGGGTTGGATAATACCAAATTACCCACTACCAAAGGCAACGGATGGATCCGATGAGAAGGAGGTATTAAGAGTGGTTTTCAGATCGGAGATGAAGTTGGATTTAGCACAGTTGTTGATCGTTGACATCGAGAGTATCTTGACAAAGTTGATTCATAGTTACGAAAAGGTTTGTCATCATATAGAACTTGCCTCTGAGCAAACTCCAGAGCGCAAGAGTTCGTTCATCTACGAAATGTTGCTGGCATTGGCATCTCCACAAGATGACATCCCAACGCCGGATGAAATCGAAAAGAAAAATAAGCTAAAGGAAACAACAACGAGAAACTATAGAGGAACATGTTGA","protein_sequence":"MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQGSNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC"}]}