{"ymdb_id":"YMDB00052","created_at":"2011-05-29T15:52:07.000Z","updated_at":"2016-09-08T18:34:57.000Z","name":"Argininosuccinic acid","cas":"2387-71-5","state":"Solid","melting_point":null,"description":"Arginosuccinic acid is a basic amino acid. It is used as a precursor for arginine in the urea cycle or citrulline-NO cycle.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Hagino, Koji; Nakanishi, Toshihide.  Fermentative production of L-arginosuccinic acid.    Jpn. Kokai Tokkyo Koho  (1980),     3 pp.","chebi_id":"15682","hmdb_id":"HMDB00052","kegg_id":"C03406","pubchem_id":"439998","cs_id":"17215918","foodb_id":null,"wikipedia_link":"Argininosuccinic_acid","biocyc_id":null,"iupac":"(2S)-2-{N'-[(4S)-4-amino-4-carboxybutyl]carbamimidamido}butanedioic acid","traditional_iupac":"argininosuccinic acid","logp":"-5.803854917241661","pka":"3.2332188556928654","alogps_solubility":"4.56e-01 g/l","alogps_logp":"-3.25","alogps_logs":"-2.80","acceptor_count":"10","donor_count":"7","rotatable_bond_count":"9","polar_surface_area":"185.82999999999998","refractivity":"75.3116","polarizability":"27.598868203245992","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"12.386778734858158","pka_strongest_acidic":"2.1362975685976218","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-(N(omega)-L-arginine)succinate","2-(N(omega)-L-arginine)succinic acid","2-(N(omega)-L-arginino)succinate","2-(N(omega)-L-arginino)succinic acid","2-(Nw-L-arginino)butanedioate","2-(Nw-L-arginino)butanedioic acid","Argininosuccinate","Argininosuccinic acid","Arginosuccinate","Arginosuccinic acid","ASA","L-Argininosuccinate","L-Argininosuccinic acid","L-Arginosuccinate","L-Arginosuccinic acid","N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartate","N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartic acid","N-(L-arginino) succinate","N-(L-arginino) succinic acid","N-(L-Arginino)succinate","N-(L-Arginino)succinic acid","N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartate","N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartic acid","N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartate","N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartic acid","N(omega)-(L-arginino)succinate","N(omega)-(L-arginino)succinic acid"],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":11553611,"citation":"Abadjieva, A., Pauwels, K., Hilven, P., Crabeel, M. (2001). \"A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase.\" J Biol Chem 276:42869-42880."}],"proteins":[{"created_at":"2011-05-26T16:43:33.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Argininosuccinate synthase","uniprot_id":"P22768","uniprot_name":"ASSY_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG1","num_residues":420,"molecular_weight":"46939.30078","theoretical_pi":"5.4","general_function":"Involved in argininosuccinate synthase activity","specific_function":"In yeast, as can have a catabolic function since it allows efficient utilization of citrulline via arginine and the reactions involved in the arginase pathway","reactions":[{"id":1328,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2440,"direction":"\u003e","locations":null,"altext":"ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.","export":false,"pw_reaction_id":null,"source":null},{"id":3736,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006261","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M35237","genbank_protein_id":"171085","gene_card_id":"ARG1","chromosome_location":"chromosome 15","locus":"YOL058W","synonyms":["Citrulline--aspartate ligase"],"enzyme_classes":["6.3.4.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" argininosuccinate synthase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"Arginosuc_synth","identifier":"PF00764"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGTCTAAGGGAAAAGTTTGTTTGGCTTATTCTGGTGGTTTAGATACCTCCGTCATTTTGGCTTGGCTACTAGACCAGGCTACGGAAGTTGTAGCTTTCATGGCTAATGTAGGGCAAGAAGAAGATTTCGATGCCGCCAAGGTTTTGGCCTTGAAGATCGGTGCCTGCAAGTTCGTTTGTGGTGGATTGTCTGAAGATTTTGTCAAGGATATTCTATTCCCAGCTGTACAGGTCAACGCTGTGTACGAAGACGTTTATCTGTTGGGTACCTCTTTGGCAAGACCTGTTATTGCCAAAGCCCAAATTGACGTCGCTAAACAGGAGGGCTGTTTCGCGGTCTCTCATGGTTGTACCGGCAAAGGTAATGATCAAATCAGATTCGAATTGTCATTTTACGCTCTGAAGCCAGACGTTAAGTGTATTACACCATGGAGAATGCCTGAATTTTTCGAAAGATTTGCTGGCAGAAAGGATTTGTTAGACTATGCTGCACAAAAGGGTATTTTTGTCGCCCAAACCAAGGCCAAGCCATGGTCTACTGACGAAAACCAAGCCCACATTTCTTACGAGGCAGGTATCTTGGAAGACCCAGATACCACCCCACCAAAGGACATGTGGAAATTGATCGTCGATCCAATGGATGCTCCGGACCAACCACAAGATTTGACCATTGACTTTGAACGTGGTCTTCCAGTCAAGTTGACCTACACCGACAACAAGACTTCCAAGGAAGTTTCCGTTACCAAGCCTTTGGATGTTTTCTTGGCCGCATCCAACTTAGCAAGGGCCAACGGTGTTGGTAGAATCGATATTGTAGAAGATCGTTACATTAACTTGAAATCCAGAGGTTGTTACGAACAGGCTCCATTGACTGTTTTGAGAAAAGCTCATGTTGATTTGGAAGGTTTGACTTTAGACAAAGAAGTCCGTCAATTGAGAGACTCATTGGTCACTCCAAACTACTCCAGATTGATATATAACGGTTTCCTACTTCACCCAGAGTGTGAGTACATCAGATCTATGATCCAACCATCCCAAAATAGCGTTAACGGTACTGTCAGGGTTAGACTGTATAAGGGTAACGTCATCATTCTGGGCAGATCTACAAAGACTGAAAAGTTGTACGATCCGACAGAATCCTCTATGGATGAGTTGACCGGTTTCTTACCTACCGATACCACCGGTTTCATTGCCATCCAGGCCATTAGAATTAAAAAATACGGTGAATCCAAAAAAACCAAAGGTGAAGAGTTGACTTTGTAA","protein_sequence":"MSKGKVCLAYSGGLDTSVILAWLLDQGYEVVAFMANVGQEEDFDAAKEKALKIGACKFVCVDCREDFVKDILFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGNDQIRFELSFYALKPDVKCITPWRMPEFFERFAGRKDLLDYAAQKGIPVAQTKAKPWSTDENQAHISYEAGILEDPDTTPPKDMWKLIVDPMDAPDQPQDLTIDFERGLPVKLTYTDNKTSKEVSVTKPLDVFLAASNLARANGVGRIDIVEDRYINLKSRGCYEQAPLTVLRKAHVDLEGLTLDKEVRQLRDSFVTPNYSRLIYNGFLLHPECEYIRSMIQPSQNSVNGTVRVRLYKGNVIILGRSTKTEKLYDPTESSMDELTGFLPTDTTGFIAIQAIRIKKYGESKKTKGEELTL"},{"created_at":"2011-05-26T16:44:03.000Z","updated_at":"2011-07-22T17:54:12.000Z","name":"Argininosuccinate lyase","uniprot_id":"P04076","uniprot_name":"ARLY_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG4","num_residues":463,"molecular_weight":"51988.69922","theoretical_pi":"5.48","general_function":"Involved in argininosuccinate lyase activity","specific_function":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine","reactions":[{"id":1327,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2441,"direction":"\u003e","locations":null,"altext":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.","export":false,"pw_reaction_id":null,"source":null},{"id":3738,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006263","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693155","genbank_protein_id":"51013761","gene_card_id":"ARG4","chromosome_location":"chromosome 8","locus":"YHR018C","synonyms":["ASAL","Arginosuccinase"],"enzyme_classes":["4.3.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" argininosuccinate lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" amidine-lyase activity"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" arginine biosynthetic process via ornithine"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Lyase_1","identifier":"PF00206"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGTCAGACGGCACTCAAAAACTATGGGGTGGGAGATTCACTGGTGAAACCGATCCTTTGATGCACCTTTACAATGCGTCTCTTCCGTATGATTATAAGATGTATAAGGCAGATTTAGAAGGAACTAAAGTATACACAGCGGGCTTGCAGAAGTTGGGTCTTCTAACGGAGACAGAATTGGCAAAGATCCATGAAGGTTTGGCTGAAATCAAAAAAGAATGGGACGCTGACAAATTTGTCCGTCATCCAAACGACGAGGATATCCATACTGCGAATGAAAGACGTCTTGGTGAACTAATTGGCCGCGATATTGCTGGTAAAGTCCACACCGGTAGATCCCGTAATGATCAAGTTGTTACCGATTTGAGAATATACTGTCGTGACATTGTCAATGACACCCTCTTTCCAGCTTTAAAGGGCTTGGTTGAAGTTCTAATTAAGAGGGCCGAAGGTGAGATAGATGTCTTAATGCCAGGCTACACACATTTACAAAGGGCACAACCTATTAGATGGTCTCATTGGTTGAGCTCTTATGCAACATACTTCACCGAAGATTACAAGAGACTGGGTCAAATACTACACAGATTGAATCAATCACCACTGGGTGCAGGCGCTCTTGCTGGTCATCCTTACGGCATTGATAGAGAATTTTTGGCTGAAGGTTTGGGTTTCAATAGTGTAATTGGTAACTCCTTGGTTGCTGTTTCTGATAGAGATTTCATCGTGGAGTTGATGTTTTGGGGAACTTTGTTCATGAACCATATTTCTCGTTTTGCTGAAGATTTGATTATATATTGTACAGCAGAATTTGGTTTCATACAGTTGAGCGACGCCTATTCAACAGGTTCTTCTTTAATGCCTCAGAAGAAGAATGCAGACTCGTTAGAGTTGTTAAGAGGTAAATCCGGTAGAGTATTTGGTGATCTGACAGGATTCTTGATGAGTTTGAAGGGTATCCCATCTACTTATGATAAAGACATGCAAGAAGACAAAGAGCCACTATTCGATTGCTTAACAACTGTAGAGCACTCCATGCTGATTGCCACAGGTGTTATTTCTACCTTAACTGTAAATAAGGAAAAGATGGAAGCTGCTCTCACGATGGATATGCTAGCTACCGACTTGGCAGATTACTTGGTCAGAAAGGGTGTTCCATTCAGAGAGACTCATCACATATCTGGTGAGTGTGTCGCTACTGCTGAAAGACTTGGTCTAAGCGGTATTGATAAATTAACCTTGGAGCAGTATCAAAAGATCGATTCGAGATTCGGACAAGATCTTTTTGAAACTTTTAACTTTGAACAAAGCGTTGAAAGACGAGATGCTACTGGTGGAACCGCTAAATCTGCTGTATTGAAGCAATTGGATAATTTGAAATCCCAATTAAATTAG","protein_sequence":"MSDGTQKLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIKKEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFPALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPLGAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYCTAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDKEPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGECVATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLKSQLN"}]}