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Porphyrin and chlorophyll metabolism

SourceIDPathway
KEGG00860 Map00860

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00016Glycine
56-40-6
2-aminoacetic acidC2H5NO2
75.0666
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YMDB00041Heme
14875-96-8
C34H32FeN4O4
616.487
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YMDB00055Protoporphyrin IX
553-12-8
3-[20-(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(21),2,4,6,8(23),9,11,13,15,17,19-undecaen-4-yl]propanoic acidC34H34N4O4
562.6582
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YMDB000835-Aminolevulinic acid
106-60-5
5-amino-4-oxopentanoic acidC5H9NO3
131.1299
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YMDB00084Coproporphyrinogen III
2624-63-7
3-[9,14,20-tris(2-carboxyethyl)-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acidC36H44N4O8
660.7566
Thumb
YMDB00145Hydroxymethylbilane
73023-76-4
3-(2-{[4-(2-carboxyethyl)-5-{[4-(2-carboxyethyl)-5-{[4-(2-carboxyethyl)-3-(carboxymethyl)-1H-pyrrol-2-yl]methyl}-3-(carboxymethyl)-1H-pyrrol-2-yl]methyl}-3-(carboxymethyl)-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-5-(hydroxymethyl)-1H-pyrrol-3-yl)propanoic acidC40H46N4O17
854.8098
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YMDB00156Protoporphyrinogen IX
7412-77-3
3-[20-(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acidC34H40N4O4
568.7058
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YMDB00194Iron(3+)
20074-52-6
iron(3+) ionFe
55.845
Thumb
YMDB00214L-Threonine
72-19-5
(2S,3R)-2-amino-3-hydroxybutanoic acidC4H9NO3
119.1192
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YMDB00249Sirohydrochlorin
65207-12-7
3-[(4S,5S,9S,10S)-9,15,19-tris(2-carboxyethyl)-5,10,14,20-tetrakis(carboxymethyl)-5,10-dimethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(21),2,6,8(23),11,13,15,17,19-nonaen-4-yl]propanoic acidC42H46N4O16
862.8318
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YMDB00267Uroporphyrinogen III
1976-85-8
3-[9,14,20-tris(2-carboxyethyl)-5,10,15,19-tetrakis(carboxymethyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acidC40H44N4O16
836.7946
Thumb
YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
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YMDB00379Iron(2+)
15438-31-0
λ²-iron(2+) ionFe
55.845
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YMDB00401Porphobilinogen
487-90-1
3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acidC10H14N2O4
226.2292
Thumb
YMDB00882Heme A
57560-10-8
4,20-bis(2-carboxyethyl)-15-ethenyl-5-formyl-10-[(4E,8E)-1-hydroxy-5,9,13-trimethyltetradeca-4,8,12-trien-1-yl]-9,14,19-trimethyl-2lambda5,22,23lambda5,25-tetraaza-1-ferraoctacyclo[11.9.1.1^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16(23),17,19,21(24)-undecaene-2,23-bis(ylium)C49H56FeN4O6
852.837
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YMDB00968Siroheme
52553-42-1
3-[(4S,5S,9S,10S,11Z,16Z)-9,15,19-tris(2-carboxyethyl)-5,10,14,20-tetrakis(carboxymethyl)-5,10-dimethyl-21,23,24,25-tetraaza-22-ferrahexacyclo[9.9.3.1³,⁶.1¹³,¹⁶.0⁸,²³.0¹⁸,²¹]pentacosa-1(20),2,6(25),7,11,13(24),14,16,18-nonaen-4-yl]propanoic acidC42H44FeN4O16
916.661
Thumb
YMDB00977Precorrin-2
82542-92-5
3-[(4S,5S,6Z,9S,10S,11Z)-9,15,19-tris(2-carboxyethyl)-5,10,14,20-tetrakis(carboxymethyl)-5,10-dimethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),2,6,8(23),11,13,15,18-octaen-4-yl]propanoic acidC42H48N4O16
864.8477
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YMDB00987Protoheme IX
14875-96-8
3-[(12Z)-20-(2-carboxyethyl)-10,15-diethenyl-5,9,14,19-tetramethyl-21,23,24,25-tetraaza-22-ferrahexacyclo[9.9.3.1³,⁶.1¹³,¹⁶.0⁸,²³.0¹⁸,²¹]pentacosa-1,3(25),4,6,8,10,12,14,16(24),17,19-undecaen-4-yl]propanoic acidC34H32FeN4O4
616.487
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YMDB010685-aminolevulinate
106-60-5
5-amino-4-oxopentanoateC5H8NO3
130.1219
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P09950HEM1
YDR232W
5-aminolevulinate synthase, mitochondrialEnzyme
P36150MET1
YKR069W
Uroporphyrinogen-III C-methyltransferaseEnzyme
P06182CYC3
YAL039C
Cytochrome c heme lyaseEnzyme
P16622HEM15
YOR176W
Ferrochelatase, mitochondrialEnzyme
P40012HEM14
YER014W
Protoporphyrinogen oxidaseEnzyme
P05373HEM2
YGL040C
Delta-aminolevulinic acid dehydrataseEnzyme
P11353HEM13
YDR044W
Coproporphyrinogen-III oxidaseEnzyme
P32347HEM12
YDR047W
Uroporphyrinogen decarboxylaseEnzyme
Q07923LOT6
YLR011W
NAD(P)H-dependent FMN reductase LOT6Enzyme
P28789HEM3
YDL205C
Porphobilinogen deaminaseEnzyme
P48525MSE1
YOL033W
Glutamyl-tRNA synthetase, mitochondrialEnzyme
P15807MET8
YBR213W
Siroheme biosynthesis protein MET8Enzyme
P06174HEM4
YOR278W
Uroporphyrinogen-III synthaseEnzyme
Q07540YFH1
YDL120W
Frataxin homolog, mitochondrialEnzyme
P46655GUS1
YGL245W
Glutamyl-tRNA synthetase, cytoplasmicEnzyme