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Identification
YMDB IDYMDB00297
NameS-Adenosylmethionine
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionS-Adenosyl-L-methionine (SAM) is a common co-substrate involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase [EC 2.5.1.6]. SAM is involved in transmethylation, transsulfuration, and aminopropylation metabolic pathways.
Structure
Thumb
Synonyms
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • Active methionine
  • Ademetionine
  • adenosylmethionine
  • AdoMet
  • Donamet
  • L-S-Adenosylmethionine
  • S-(5'-Adenosyl)-L-methionine
  • S-(5'-deoxyadenosin-5'-yl)-L-methionine
  • S-adenosyl methionine
  • S-Adenosyl-L-methionine
  • S-Adenosyl-L-Methionine Disulfate Tosylate
  • S-adenosyl-methionine
  • S-Adenosylmethionine
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • SAM
  • SAMe
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulphonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • [1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium
  • [1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • [1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • S-Adenosyl-L-methionine disulphate tosylate
  • ASTA medica brand OF ademetionine tosilate disulfate
  • S Adenosylmethionine sulfate tosylate
  • S-Adenosylmethionine sulfate tosylate
  • Sulfate tosylate, S-adenosylmethionine
  • Ademetionine europharma brand
  • Amet, S
  • Europharma brand OF ademetionine
  • Gumbaral
  • Knoll brand OF brand OF ademetionine tosilate disulfate
  • S Adenosylmethionine
  • S Amet
  • Samyr
  • Tosylate, S-adenosylmethionine sulfate
  • S Adenosyl L methionine
  • SAM-e
CAS number29908-03-0
WeightAverage: 399.445
Monoisotopic: 399.145063566
InChI KeyMEFKEPWMEQBLKI-XCPQSEKJSA-O
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8-,10-,11-,14-,27?/m1/s1
IUPAC Name[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium
Traditional IUPAC NameSAMe
Chemical FormulaC15H23N6O5S
SMILES[H]OC(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])[S+](C([H])([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
Chemical Taxonomy
Description belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
Class5'-deoxyribonucleosides
Sub Class5'-deoxy-5'-thionucleosides
Direct Parent5'-deoxy-5'-thionucleosides
Alternative Parents
Substituents
  • 5'-deoxy-5'-thionucleoside
  • Methionine or derivatives
  • N-glycosyl compound
  • Glycosyl compound
  • Pentose monosaccharide
  • 6-aminopurine
  • Alpha-amino acid
  • L-alpha-amino acid
  • Alpha-amino acid or derivatives
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Hydroxy fatty acid
  • Thia fatty acid
  • N-substituted imidazole
  • Fatty acyl
  • Monosaccharide
  • Imidolactam
  • Pyrimidine
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Amino acid or derivatives
  • 1,2-diol
  • Amino acid
  • Secondary alcohol
  • Oxacycle
  • Azacycle
  • Carboxylic acid derivative
  • Carboxylic acid
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organopnictogen compound
  • Alcohol
  • Carbonyl group
  • Organic oxygen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Primary aliphatic amine
  • Amine
  • Organonitrogen compound
  • Organic cation
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Physical Properties
StateSolid
Charge1
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility1.19 g/LALOGPS
logP-2ALOGPS
logP-5.3ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)1.71ChemAxon
pKa (Strongest Basic)9.41ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area182.63 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity96.23 m³·mol⁻¹ChemAxon
Polarizability40.37 ųChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • extracellular
  • mitochondrion
  • endoplasmic reticulum
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB Pathways
Biotin BiosynthesisPW002380 ThumbThumb?image type=greyscaleThumb?image type=simple
Cholesterol biosynthesis and metabolism CE(10:0)PW002545 ThumbThumb?image type=greyscaleThumb?image type=simple
Cholesterol biosynthesis and metabolism CE(12:0)PW002548 ThumbThumb?image type=greyscaleThumb?image type=simple
Cholesterol biosynthesis and metabolism CE(14:0)PW002544 ThumbThumb?image type=greyscaleThumb?image type=simple
Cholesterol biosynthesis and metabolism CE(16:0)PW002550 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Arginine and proline metabolismec00330 Map00330
Cysteine and methionine metabolismec00270 Map00270
Lipoic acid metabolismec00785 Map00785
Steroid biosynthesisec00100 Map00100
beta-Alanine metabolismec00410 Map00410
SMPDB ReactionsNot Available
KEGG Reactions
2-Hexaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone + S-Adenosylhomocysteine + hydron
3-Isopropylmalate + S-AdenosylmethionineS-Adenosylhomocysteine + 3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate
hydron + S-AdenosylmethionineS-Adenosylmethioninamine + Carbon dioxide
8-Amino-7-oxononanoic acid + S-AdenosylmethionineS-adenosyl-4-methylthio-2-oxobutanoic acid + 7,8-diaminononanoic acid
zymosterol + oxygen + S-Adenosylmethioninewater + S-Adenosylhomocysteine + hydron + ergosta-5,7,22,24(28)-tetraen-3beta-ol
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Cherest, H., Eichler, F., Robichon-Szulmajster, H. (1969). "Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae." J Bacteriol 97:328-336.5764336
  • Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). "A complete inventory of all enzymes in the eukaryotic methionine salvage pathway." FEBS J 275:4111-4120.18625006
Synthesis Reference:Lin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25.
External Links:
ResourceLink
CHEBI ID15414
HMDB IDHMDB01185
Pubchem Compound ID1079
Kegg IDC00019
ChemSpider ID21865164
FOODB IDFDB031152
WikipediaS-Adenosyl_methionine
BioCyc IDS-ADENOSYLMETHIONINE

Enzymes

General function:
Involved in methyltransferase activity
Specific function:
Required for the methylation step in diphthamide biosynthesis
Gene Name:
DPH5
Uniprot ID:
P32469
Molecular weight:
33847.0
Reactions
3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine → 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine.
General function:
Involved in methyltransferase activity
Specific function:
Siroheme synthase involved in methionine biosynthesis
Gene Name:
MET1
Uniprot ID:
P36150
Molecular weight:
66124.70313
Reactions
S-adenosyl-L-methionine + uroporphyrinogen III → S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 → S-adenosyl-L-homocysteine + precorrin-2.
General function:
Involved in methyltransferase activity
Specific function:
Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway
Gene Name:
COQ3
Uniprot ID:
P27680
Molecular weight:
36330.60156
Reactions
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate → S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.
S-adenosyl-L-methionine + 3-demethylubiquinone-n → S-adenosyl-L-homocysteine + ubiquinone-n.
S-adenosyl-L-methionine + 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol → S-adenosyl-L-homocysteine + ubiquinol.
General function:
Involved in catalytic activity
Specific function:
Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine
Gene Name:
BIO2
Uniprot ID:
P32451
Molecular weight:
41883.80078
Reactions
Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine → biotin + 2 L-methionine + 2 5'-deoxyadenosine.
General function:
Involved in transaminase activity
Specific function:
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
Gene Name:
BIO3
Uniprot ID:
P50277
Molecular weight:
53708.39844
Reactions
S-adenosyl-L-methionine + 8-amino-7-oxononanoate → S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM1
Uniprot ID:
P10659
Molecular weight:
41818.0
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)
Gene Name:
LIP5
Uniprot ID:
P32875
Molecular weight:
46246.80078
Reactions
Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine → protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine.
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation
Gene Name:
TMT1
Uniprot ID:
P32643
Molecular weight:
34768.0
Reactions
S-adenosyl-L-methionine + trans-aconitate → S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate.
General function:
Involved in adenosylmethionine decarboxylase activity
Specific function:
S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine
Gene Name:
SPE2
Uniprot ID:
P21182
Molecular weight:
46232.0
Reactions
S-adenosyl-L-methionine → (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2).
General function:
Involved in methyltransferase activity
Specific function:
Converts DDMQH2 into DMQH2
Gene Name:
COQ5
Uniprot ID:
P49017
Molecular weight:
34684.19922
Reactions
S-adenosyl-L-methionine + 2-polyprenyl-6-methoxy-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol.
General function:
Involved in methyltransferase activity
Specific function:
tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (m2U44) in tRNA(Ser)
Gene Name:
TRM44
Uniprot ID:
Q02648
Molecular weight:
64854.60156
Reactions
S-adenosyl-L-methionine + uridine(44) in tRNA → S-adenosyl-L-homocysteine + 2'-O-methyluridine(44) in tRNA.
General function:
Involved in [cytochrome c]-lysine N-methyltransferase a
Specific function:
Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)
Gene Name:
CTM1
Uniprot ID:
P38818
Molecular weight:
68283.60156
Reactions
S-adenosyl-L-methionine + [cytochrome c]-L-lysine → S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine.
General function:
Involved in methyltransferase activity
Specific function:
N6-methyltransferase that methylates adenosine residues of some mRNAs and is essential to activate sporulation. N6- methyladenosine (m6A), which is present at internal sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2
Gene Name:
IME4
Uniprot ID:
P41833
Molecular weight:
69395.39844
Reactions
S-adenosyl-L-methionine + m(7)G(5')pppAm → S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am.
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs
Gene Name:
TRM10
Uniprot ID:
Q12400
Molecular weight:
34520.19922
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine.
General function:
Involved in tRNA (adenine-N1-)-methyltransferase activity
Specific function:
Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency
Gene Name:
GCD14
Uniprot ID:
P46959
Molecular weight:
43919.30078
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methyladenine.
General function:
Involved in RNA binding
Specific function:
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs
Gene Name:
TRM1
Uniprot ID:
P15565
Molecular weight:
64051.80078
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(2)-methylguanine.
General function:
Involved in RNA binding
Specific function:
Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin
Gene Name:
NCL1
Uniprot ID:
P38205
Molecular weight:
77878.0
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine.
General function:
Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Specific function:
Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins
Gene Name:
STE14
Uniprot ID:
P32584
Molecular weight:
27887.40039
Reactions
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine → S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
General function:
Involved in methyltransferase activity
Specific function:
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
Gene Name:
TRM7
Uniprot ID:
P38238
Molecular weight:
34700.19922
Reactions
S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization
Gene Name:
TGS1
Uniprot ID:
Q12052
Molecular weight:
36526.80078
Reactions
S-adenosyl-L-methionine + m(7)G(5')pppR-RNA → S-adenosyl-L-homocysteine + m(2,7)G(5')pppR-RNA.
S-adenosyl-L-methionine + m(2,7)G(5')pppR-RNA → S-adenosyl-L-homocysteine + m(2,2,7)G(5')pppR-RNA.
General function:
Involved in RNA binding
Specific function:
Specifically methylates guanosine-18 in various tRNAs
Gene Name:
TRM3
Uniprot ID:
Q07527
Molecular weight:
165046.0
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine.
General function:
Involved in methyltransferase activity
Specific function:
Specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signature
Gene Name:
TRM13
Uniprot ID:
Q12383
Molecular weight:
54094.5
Reactions
S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
General function:
Involved in methyltransferase activity
Specific function:
Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20
Gene Name:
HSL7
Uniprot ID:
P38274
Molecular weight:
95152.5
Reactions
S-adenosyl-L-methionine + arginine-[histone] → S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
General function:
Involved in methyltransferase activity
Specific function:
Specifically methylates the uridine in position 2791 of mitochondrial 21S rRNA in the fully assembled mitochondrial large ribosomal subunit
Gene Name:
MRM2
Uniprot ID:
P53123
Molecular weight:
37423.10156
Reactions
S-adenosyl-L-methionine + uridine(2791)-2'-O in 21S rRNA → S-adenosyl-L-homocysteine + 2'-O-methyluridine(2791)-2'-O in 21S rRNA.
General function:
Involved in tRNA (guanine-N7-)-methyltransferase activity
Specific function:
Methyltransferase that catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity
Gene Name:
TRM8
Uniprot ID:
Q12009
Molecular weight:
33391.19922
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(7)-methylguanine.
General function:
Involved in nicotinamide N-methyltransferase activity
Specific function:
Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination
Gene Name:
NNT1
Uniprot ID:
Q05874
Molecular weight:
29632.30078
Reactions
S-adenosyl-L-methionine + nicotinamide → S-adenosyl-L-homocysteine + 1-methylnicotinamide.
General function:
Involved in phosphatidylethanolamine N-methyltransferas
Specific function:
S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
Gene Name:
PEM1
Uniprot ID:
P05374
Molecular weight:
101203.0
Reactions
S-adenosyl-L-methionine + phosphatidylethanolamine → S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.
General function:
Involved in identical protein binding
Specific function:
Specifically methylates guanosine-37 in various tRNAs. Not dependent on the nature of the nucleoside 5' of the target nucleoside
Gene Name:
TRM5
Uniprot ID:
P38793
Molecular weight:
56514.0
Reactions
S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine.
General function:
Involved in N-methyltransferase activity
Specific function:
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid
Gene Name:
OPI3
Uniprot ID:
P05375
Molecular weight:
23150.09961
Reactions
S-adenosyl-L-methionine + phospholipid olefinic fatty acid → S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.
General function:
Involved in methyltransferase activity
Specific function:
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation
Gene Name:
SPB1
Uniprot ID:
P25582
Molecular weight:
96484.0
Reactions
S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.
S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol
Gene Name:
ERG6
Uniprot ID:
P25087
Molecular weight:
43430.5
Reactions
S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol → S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM2
Uniprot ID:
P19358
Molecular weight:
42255.5
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in RNA methyltransferase activity
Specific function:
Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation
Gene Name:
TRM2
Uniprot ID:
P33753
Molecular weight:
72851.79688
Reactions
S-adenosyl-L-methionine + tRNA containing uridine at position 54 → S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54.