You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Identification
Name5-aminolevulinate synthase, mitochondrial
Synonyms
  • 5-aminolevulinic acid synthase
  • Delta-ALA synthase
  • Delta-aminolevulinate synthase
Gene NameHEM1
Enzyme Class
Biological Properties
General FunctionInvolved in 5-aminolevulinate synthase activity
Specific FunctionSuccinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Cellular LocationMitochondrion matrix
SMPDB Pathways
Biosynthesis of unsaturated fatty acids (docosanoyl)PW002408 ThumbThumb?image type=greyscaleThumb?image type=simple
Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)PW002404 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycine, serine and threonine metabolismec00260 Map00260
Porphyrin and chlorophyll metabolismec00860 Map00860
SMPDB ReactionsNot Available
KEGG Reactions
Glycine + hydron + Succinyl-CoA5-Aminolevulinic acid + Carbon dioxide + Coenzyme A
Metabolites
YMDB IDNameView
YMDB00016GlycineShow
YMDB00045Coenzyme AShow
YMDB000835-Aminolevulinic acidShow
YMDB00514Succinyl-CoAShow
YMDB00862hydronShow
YMDB00912Carbon dioxideShow
GO Classification
Component
Not Available
Function
cofactor binding
pyridoxal phosphate binding
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
catalytic activity
acyltransferase activity
transferase activity
N-acyltransferase activity
N-succinyltransferase activity
5-aminolevulinate synthase activity
binding
transferase activity, transferring nitrogenous groups
Process
metabolic process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
tetrapyrrole biosynthetic process
Gene Properties
Chromosome Locationchromosome 4
LocusYDR232W
Gene Sequence>1647 bp ATGCAACGCTCCATTTTTGCGAGGTTCGGTAACTCCTCTGCCGCTGTTTCCACACTGAAT AGGCTGTCCACGACAGCCGCACCACATGCGAAAAATGGCTATGCCACCGCTACTGGTGCT GGTGCCGCTGCTGCCACTGCCACAGCGTCATCAACACATGCAGCAGCAGCAGCAGCCGCT GCTGCCAACCATTCCACCCAGGAGTCGGGTTTCGATTACGAAGGCCTGATAGATTCCGAA CTGCAGAAGAAAAGACTTGACAAATCGTACAGATATTTCAACAATATCAACCGATTGGCC AAGGAGTTCCCCCTAGCTCATCGCCAGAGAGAGGCGGACAAGGTCACCGTTTGGTGTTCC AACGACTATTTAGCACTTTCCAAGCACCCTGAGGTATTGGACGCCATGCATAAAACTATC GACAAGTATGGTTGTGGTGCCGGTGGTACAAGAAACATTGCTGGCCATAACATCCCCACT TTGAATCTGGAAGCCGAATTGGCCACTTTACACAAGAAGGAAGGTGCCTTAGTTTTTTCG TCATGTTACGTAGCCAACGATGCCGTCTTATCCCTACTGGGTCAAAAGATGAAGGACTTG GTGATTTTCTCCGACGAACTCAACCATGCGTCCATGATTGTCGGTATTAAGCATGCTAAC GTAAAAAAACACATTTTCAAACATAATGACTTGAACGAATTGGAACAACTGCTCCAGTCA TACCCCAAATCCGTTCCTAAACTAATTGCTTTCGAATCAGTATATTCTATGGCCGGTTCA GTGGCCGACATAGAAAAAATTTGCGACTTGGCCGACAAATACGGTGCTTTGACCTTCTTG GATGAAGTACATGCGGTCGGCCTGTACGGCCCTCACGGTGCAGGTGTTGCAGAACATTGT GATTTTGAAAGTCACCGTGCAAGTGGTATTGCTACCCCAAAGACCAATGACAAGGGCGGC GCGAAGACTGTGATGGACCGTGTCGACATGATCACCGGCACTTTAGGTAAGTCTTTCGGT AGCGTAGGTGGCTACGTCGCAGCCTCTAGGAAATTGATCGATTGGTTCAGATCGTTTGCA CCTGGTTTCATTTTCACCACGACTTTACCACCTTCAGTTATGGCAGGCGCTACCGCAGCA ATTAGATACCAACGTTGCCACATCGACCTAAGAACCTCGCAACAGAAACATACCATGTAC GTAAAGAAAGCTTTCCATGAGTTGGGCATTCCAGTTATTCCAAATCCTTCTCATATCGTC CCAGTGTTGATTGGTAATGCTGATTTGGCTAAGCAAGCTTCTGACATCTTAATCAATAAG CATCAAATCTACGTACAAGCTATCAACTTCCCTACGGTTGCTCGCGGTACCGAAAGATTG AGAATTACCCCAACGCCAGGTCACACCAACGATTTATCTGACATCTTAATCAATGCAGTT GATGATGTGTTCAATGAGCTACAGTTACCACGTGTCAGAGACTGGGAAAGCCAAGGTGGC TTATTGGGTGTTGGAGAGAGCGGATTTGTGGAAGAGTCTAACTTATGGACATCAAGCCAA CTATCTTTAACTAATGACGACTTGAACCCTAATGTTAGAGACCCCATCGTTAAACAACTA GAGGTTTCTAGTGGTATCAAGCAGTAA
Protein Properties
Pfam Domain Function
Protein Residues548
Protein Molecular Weight59361.69922
Protein Theoretical pI7.56
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>5-aminolevulinate synthase, mitochondrial MQRSIFARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAA AANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCS NDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFS SCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQS YPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHC DFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFA PGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIV PVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAV DDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIVKQL EVSSGIKQ
References
External Links
ResourceLink
Saccharomyces Genome Database HEM1
Uniprot IDP09950
Uniprot NameHEM1_YEAST
GenBank Gene IDM26329
Genebank Protein ID171662
General Reference
  • Urban-Grimal, D., Volland, C., Garnier, T., Dehoux, P., Labbe-Bois, R. (1986). "The nucleotide sequence of the HEM1 gene and evidence for a precursor form of the mitochondrial 5-aminolevulinate synthase in Saccharomyces cerevisiae." Eur J Biochem 156:511-519.3516694
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Keng, T., Guarente, L. (1987). "Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression." Proc Natl Acad Sci U S A 84:9113-9117.3321068
  • Keng, T., Alani, E., Guarente, L. (1986). "The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix." Mol Cell Biol 6:355-364.3023841
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106