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One carbon pool by folate

SourceIDPathway
KEGG00670 Map00670

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00079Dihydrofolic acid
4033-27-6
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H21N7O6
443.4133
Thumb
YMDB00080N10-Formyl-THF
2800-34-2
(2S)-2-[(4-{N-[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acidC20H23N7O7
473.4393
Thumb
YMDB00139Tetrahydrofolic acid
135-16-0
2-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB001765,10-Methenyltetrahydrofolic acid
7444-29-3
C20H21N7O6
455.424
Thumb
YMDB002385-Methyltetrahydrofolic acid
134-35-0
(2R)-2-[(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC20H25N7O6
459.4558
Thumb
YMDB002605,10-Methylene-THF
31690-11-6
2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB00298N5-Formyl-THF
58-05-9
2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC20H23N7O7
473.4393
Thumb
YMDB004835,6,7,8-Tetrahydrofolic acid
135-16-0
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB00515(6R)-5,10-Methenyltetrahydrofolic acid(6aR)-3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-1H,2H,5H,6H,6aH,7H,8H-10λ⁵-imidazo[1,5-f]pteridin-10-yliumC20H22N7O6
456.432
Thumb
YMDB005165-Formyltetrahydrofolic acid
58-05-9
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC20H23N7O7
473.4393
Thumb
YMDB0051710-Formyltetrahydrofolic acid
2800-34-2
(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acidC20H23N7O7
473.4393
Thumb
YMDB00848(6R)-5,10-methylenetetrahydrofolic acid
3432-99-3
(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB008795,10-Methenyltetrahydrofolate
7444-29-3
3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-1H,4H,5H,6H,6aH,7H,8H-10λ⁵-imidazo[1,5-f]pteridin-10-yliumC20H22N7O6
456.432
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P04161ADE8
YDR408C
Phosphoribosylglycinamide formyltransferaseEnzyme
P37291SHM2
YLR058C
Serine hydroxymethyltransferase, cytosolicEnzyme
P37292SHM1
YBR263W
Serine hydroxymethyltransferase, mitochondrialEnzyme
P07807DFR1
YOR236W
Dihydrofolate reductaseEnzyme
P06785TMP1
YOR074C
Thymidylate synthaseEnzyme
P09440MIS1
YBR084W
C-1-tetrahydrofolate synthase, mitochondrialEnzyme
P32785FMT1
YBL013W
Methionyl-tRNA formyltransferase, mitochondrialEnzyme
P07245ADE3
YGR204W
C-1-tetrahydrofolate synthase, cytoplasmicEnzyme
P48015GCV1
YDR019C
Aminomethyltransferase, mitochondrialEnzyme
P40099FAU1
YER183C
5-formyltetrahydrofolate cyclo-ligaseEnzyme
Q02046MTD1
YKR080W
Methylenetetrahydrofolate dehydrogenase [NAD+]Enzyme
P46151MET12
YPL023C
Methylenetetrahydrofolate reductase 1Enzyme
P53128MET13
YGL125W
Methylenetetrahydrofolate reductase 2Enzyme