Glutamate Metabolism

Source	ID	Pathway
PathWhiz	PW002376

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00002	L-Glutamine 56-85-9	(2S)-2-amino-4-carbamoylbutanoic acid	C₅H₁₀N₂O₃ 146.1445
YMDB00003	Urea 57-13-6	urea	CH₄N₂O 60.0553
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00143	NADH 58-68-4	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid	C₂₁H₂₉N₇O₁₄P₂ 665.441
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00236	Succinic acid semialdehyde 692-29-5	4-oxobutanoic acid	C₄H₆O₃ 102.0886
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00338	Succinic acid 110-15-6	butanedioic acid	C₄H₆O₄ 118.088
YMDB00353	Ornithine 70-26-8	(2S)-2,5-diaminopentanoic acid	C₅H₁₂N₂O₂ 132.161
YMDB00423	Ammonium 14798-03-9	azanium	H₄N 18.0385
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00592	L-Arginine 74-79-3	(2S)-2-amino-5-carbamimidamidopentanoic acid	C₆H₁₄N₄O₂ 174.201
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00912	Carbon dioxide 124-38-9	methanedione	CO₂ 44.0095
YMDB00918	l-Glutamic-gamma-semialdehyde 496-92-4	(2S)-2-amino-5-oxopentanoic acid	C₅H₉NO₃ 131.1299
YMDB16233	4-(Glutamylamino) butanoate	(2S)-2-amino-4-[(3-carboxypropyl)carbamoyl]butanoic acid	C₉H₁₆N₂O₅ 232.2337

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
Q12680	GLT1 YDL171C	Glutamate synthase [NADH]	Enzyme	L-Glutamine NAD NADH Oxoglutaric acid L-Glutamic acid NAD(+) hydron
P00812	CAR1 YPL111W	Arginase	Enzyme	Urea Ornithine L-Arginine water
P33327	GDH2 YDL215C	NAD-specific glutamate dehydrogenase	Enzyme	Ammonia NAD NADH Oxoglutaric acid L-Glutamic acid NAD(+) Ammonium hydron water
P39708	GDH3 YAL062W	NADP-specific glutamate dehydrogenase 2	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P07262	GDH1 YOR375C	NADP-specific glutamate dehydrogenase 1	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P17649	UGA1 YGR019W	4-aminobutyrate aminotransferase	Enzyme	Oxoglutaric acid Succinic acid semialdehyde L-Glutamic acid gamma-Aminobutyric acid 4-(Glutamylamino) butanoate
P38067	UGA2 YBR006W	Succinate-semialdehyde dehydrogenase [NADP+]	Enzyme	Succinic acid semialdehyde Succinic acid NADPH NADP hydron water succinate semialdehyde
Q04792	GAD1 YMR250W	Glutamate decarboxylase	Enzyme	Beta-Alanine L-Glutamic acid gamma-Aminobutyric acid Taurine hydron L-Aspartic acid Carbon dioxide Hypotaurine 3-Sulfinoalanine Cysteic acid 4-(Glutamylamino) butanoate
P07991	CAR2 YLR438W	Ornithine aminotransferase	Enzyme	Oxoglutaric acid L-Glutamic acid Ornithine l-Glutamic-gamma-semialdehyde
P32872		Aldehyde dehydrogenase 2, mitochondrial		Ubiquinone Q1 NAD NADH 1-Pyrroline-5-carboxylic acid L-Glutamic acid L-Proline hydron water l-Glutamic-gamma-semialdehyde QH(2)