{"ymdb_id":"YMDB00003","created_at":"2011-05-29T15:47:29.000Z","updated_at":"2016-09-08T18:34:53.000Z","name":"Urea","cas":"57-13-6","state":"Solid","melting_point":"132 oC","description":"Urea is a highly soluble organic compound formed by the deamination of amino acids. It is the principal end product of protein catabolism.","experimental_water_solubility":"545 mg/mL at 25 oC [YALKOWSKY,SH (1989)]","experimental_logp_hydrophobicity":"-2.11 [HANSCH,C ET AL. (1995)]","location":"extracellular;cytoplasm","synthesis_reference":"Leuthardt, F.; Glasson, B.  Biological synthesis of urea.    Verhandl. Ver. schweiz. Physiol.  (1942),  21  25-7. ","chebi_id":"16199","hmdb_id":"HMDB00294","kegg_id":"C00086","pubchem_id":"1176","cs_id":"1143","foodb_id":null,"wikipedia_link":"Urea","biocyc_id":"UREA","iupac":"urea","traditional_iupac":"urea","logp":"-1.3638338616666665","pka":null,"alogps_solubility":"4.12e+02 g/l","alogps_logp":"-1.78","alogps_logs":"0.84","acceptor_count":"1","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"69.11","refractivity":"13.1426","polarizability":"5.102881409078858","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.3686972237578967","pka_strongest_acidic":"15.731965106806726","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Alphadrate","Aqua care HP","Aquacare HP","ARF","b-I-K","Basodexan","beta-I-K","Bromisovalum","Bubber shet","Calmurid","Calmurid HC","Carbaderm","Carbamide","Carbamide resin","Carbamimic acid","Carbamimidic acid","Carbonyl diamide","Carbonyl diamine","Carbonyldiamide","Carbonyldiamine","Carmol","Carmol HC","e927b","H2NC(O)NH2","Harnstoff","Helicosol","Hyanit","Isourea","Karbamid","Keratinamin","Keratinamin kowa","Mocovina","Onychomal","Panafil","Pastaron","U-cort","ur","URE","Urea","Urea perhydrate","Ureaphil","Uree","Ureophil","Urepeal","Urevert","Varioform II"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":20100286,"citation":"Navarathna, D. H., Harris, S. D., Roberts, D. D., Nickerson, K. W. (2010). \"Evolutionary aspects of urea utilization by fungi.\" FEMS Yeast Res 10:209-213."},{"pubmed_id":6370999,"citation":"Eisenstein, E., Osborne, J. C. Jr, Chaiken, I. M., Hensley, P. (1984). \"Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae.\" J Biol Chem 259:5139-5145."},{"pubmed_id":4604238,"citation":"Lawther, R. P., Riemer, E., Chojnacki, B., Cooper, T. G. (1974). \"Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.\" J Bacteriol 119:461-468."}],"proteins":[{"created_at":"2011-05-24T19:43:43.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Urea amidolyase","uniprot_id":"P32528","uniprot_name":"DUR1_YEAST","enzyme":true,"transporter":false,"gene_name":"DUR1","num_residues":1835,"molecular_weight":"201830.0","theoretical_pi":"5.3","general_function":"Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor","specific_function":"Hydrolysis of urea to ammonia and CO(2)","reactions":[{"id":1312,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2035,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2266,"direction":"\u003e","locations":null,"altext":"ATP + urea + HCO(3)(-) = ADP + phosphate + urea-1-carboxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":2267,"direction":"\u003e","locations":null,"altext":"Urea-1-carboxylate + H(2)O = 2 CO(2) + 2 NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M64926","genbank_protein_id":"173122","gene_card_id":"DUR1","chromosome_location":null,"locus":"YBR208C","synonyms":["Urea carboxylase","Allophanate hydrolase"],"enzyme_classes":["6.3.4.6","3.5.1.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" carbon-nitrogen ligase activity, with glutamine as amido-N-donor"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Amidase","identifier":"PF01425"},{"name":"AHS1","identifier":"PF02682"},{"name":"AHS2","identifier":"PF02626"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGACAGTTAGTTCCGATACAACTGCTGAAATATCGTTAGGTTGGTCAATCCAAGACTGGATTGATTTCCACAAGTCATCAAGCTCCCAGGCTTCACTAAGGCTTCTTGAATCACTACTAGACTCTCAAAATGTTGCGCCAGTCGATAATGCGTGGATATCGCTAATTTCAAAGGAAAATTTACTGCACCAATTCCAAATTTTAAAGAGCAGAGAAAATAAAGAAACTCTACCTCTCTACGGTGTCCCTATTGCTGTTAAGGACAACATCGACGTTAGAGGTCTACGCACCACCGCTGCATGTCCATCCTTTGCATATGAGCCTTCCAAAGACTCTAAAGTAGTAGAACTACTAAGAAATGCAGGTGCAATAATCGTGGGTAAGACAAACTTGGACCAATTTGCCACAGGATTAGTCGGCACACGGTCTCCATATGGGAAAACACCTTGCGCTTTTAGCAAAGAGCATGTATCTGGTGGTTCCTCCGCTGGGTCAGCATCGGTGGTCGCCAGAGGTATCGTACCAATTGCATTGGGTACTGATACAGCAGGTTCTGGTAGAGTCCCAGCCGCCTTGAACAACCTGATTGGCCTAAAGCCAACAAAGGGCGTCTTTTCCTGTCAAGGTGTAGTTCCCGCTTGTAAATCTTTAGACTGCGTCTCCATCTTTGCATTAAACCTAAGTGATGCTGAACGCTGCTTCCGCATCATGTGCCAGCCAGATCCTGATAATGATGAATATTCTAGACCCTATGTTTCCAACCCAAAGAAAAATTTTTCAAGCAATGTAACGATTGCTATTCCTAAAAATATCCCATGGTATGGTGAAACCAAGAATCCTGTACTGTTTTCCAATGCTGTCGAAAATCTATCAAGAACGGGCGCTAACGTCATAGAAATTGATTTTGAGCCTCTTTTAGAGTTAGCTCGCTGTTTATACGAAGGTACTTGGGTGGCCGAGCGTTATCAAGCTATTCAATCGTTTTTGGACAGTAAACCACCAAAGGAATCTTTGGACCCTACTGTTATTTCAATTATAGAAGGGGCCAAGAAATACAGTGCAGTAGACTGCTTCAGTTTTGAATACAAAAGACAAGGCATCTTGCAAAAAGTGAGACGACTTCTCGAATCAGTCGATGTCTTGTGTGTGCCCACATGTCCCTTAAATCCTACTATGCAACAAGTTGCGGATGAACCAGTCCTAGTCAATTCAAGACAAGGCACATGGACTAATTTTGTCAACTTGGCAGATTTGGCAGCCCTTGCTGTTCCCGCAGGGTTCCGAGACGATGGTTTGCCAAATGGTATTACTTTAATCGGTAAAAAATTCACAGATTACGCACTATTAGAGTTGGCTAACCGCTATTTCCAAAATATGTTCCCCAACGGTTCCAGAACATACGGTACTTTTACCTCTTCTTCAGTAAAGCCAGCAAACGATCAATTAGTGGGACCAGACTATGACCCATCTACGTCCATAAAATTGGCTGTTGTCGGTGCACATCTTAAGGGTCTGCCTCTACATTGGCAATTGGAAAAGGTCAATGCAACATATTTATGTACAACAAAAACATCAAAAGCTTACCAGCTTTTTGCTTTGCCCAAAAATGGACCAGTTTTAAAACCTGGTTTGAGAAGAGTTCAAGATAGCAATGGCTCTCAAATCGAATTAGAAGTGTACAGTGTTCCAAAAGAACTGTTCGGTGCTTTTATTTCCATGGTTCCTGAACCATTGGGAATAGGTTCAGTGGAGTTAGAATCTGGTGAATGGATCAAATCCTTTATTTGTGAAGAATCTGGTTACAAAGCCAAAGGTACAGTTGATATCACAAAGTATGGTGGATTTAGAGCATATTTTGAAATGTTGAAGAAAAAAGAGTCCCAAAAGAAGAAGTTATTTGATACCGTGTTAATTGCCAATAGAGGTGAAATTGCCGTTCGTATTATCAAGACATTAAAAAAATTGGGTATTAGATCAGTTGCAGTTTATTCCGACCCTGATAAATATTCTCAACACGTTACTGATGCAGATGTTTCTGTACCCCTTCATGGCACAACCGCAGCCCAAACTTATTTAGACATGAATAAGATCATAGATGCCGCTAAGCAAACTAATGCACAGGCCATTATTCCTGGTTATGGTTTCTTGTCGGAAAATGCGGATTTTTCTGATGCGTGCACCAGTGCTGGCATTACCTTTGTTGGTCCTTCGGGAGATATTATCAGAGGTTTAGGGTTAAAACATTCTGCTAGACAGATTGCACAGAAGGCTGGCGTTCCTCTAGTGCCAGGCTCTTTGCTTATCACATCAGTTGAAGAGGCTAAGAAAGTCGCAGCGGAATTGGAATACCCAGTTATGGTGAAGTCAACTGCTGGTGGCGGTGGTATTGGTTTGCAGAAAGTCGATTCTGAAGAGGACATCGAGCATATTTTTGAGACTGTGAAACATCAAGGTGAAACATTTTTCGGTGACGCTGGTGTATTTCTGAAACGGTTTATCGAAAATGCCAGGCATGTTGAAGTCCAACTTATGGGAGATGGTTTTGGTAAGGCCATTGCTTTGGGCGAACGTGATTGTTCTTTACAGCGTCGTAACCAAAAAGTTATCGAAGAAACTCCTGCACCAAATTTGCCAGAAAAGACGAGGTTGGCGTTAAGAAAGGCAGCTGAAAGTTTGGGATCTTTATTGAATTACAAGTGTGCTGGTACGGTTGAATTTATTTACGATGAGAAAAAGGACGAGTTTTACTTTTTAGAAGTTAATACAAGATTACAAGTTGAACATCCAATAACAGAAATGGTTACAGGGTTAGACTTGGTCGAGTGGATGATCAGGATTGCCGCTAATGATGCACCTGATTTTGATTCTACAAAGGTAGAAGTCAATGGGGTTTCAATGGAGGCACGTTTATATGCTGAAAATCCATTGAAAAATTTCAGACCTTCTCCAGGTTTACTTGTCGATGTGAAATTTCCTGATTGGGCAAGAGTGGATACTTGGGTTAAGAAAGGTACTAATATTTCTCCCGAATATGATCCAACATTGGCCAAAATTATCGTTCATGGGAAAGACCGTGATGATGCAATTTCCAAGTTAAATCAAGCGTTAGAAGAAACAAAAGTTTACGGATGTATTACTAACATTGACTACCTGAAGTCTATCATTACCAGTGATTTCTTTGCTAAAGCAAAAGTTTCTACAAACATTTTGAACTCTTATCAATATGAGCCTACCGCCATCGAAATTACTTTGCCCGGTGCACACACTAGTATTCAGGATTACCCCGGTAGAGTTGGGTACTGGAGAATTGGTGTTCCGCCCTCTGGTCCAATGGACGCATATTCGTTTAGATTGGCGAACAGAATTGTTGGTAATGACTACAGGACTCCTGCCATTGAAGTAACGTTGACTGGTCCATCCATCGTTTTCCATTGTGAAACTGTCATTGCCATTACTGGTGGTACCGCTCTATGTACATTAGACGGCCAAGAAATTCCCCAACACAAACCGGTCGAAGTTAAGAGGGGATCTACTTTATCCATTGGCAAGTTGACAAGCGGCTGTAGAGCATACTTAGGTATCAGGGGTGGCATTGATGTGCCTAAATACTTGGGCTCTTATTCTACTTTCACTCTAGGAAATGTCGGTGGATACAATGGAAGGGTGCTAAAACTTGGAGACGTACTATTCTTACCAAGCAATGAAGAAAATAAATCAGTTGAGTGCCTTCCACAGAATATTCCTCAATCATTAATTCCTCAAATTTCCGAAACTAAGGAATGGAGAATTGGTGTAACATGTGGTCCCCATGGGTCTCCAGATTTTTTTAAACCTGAGTCCATCGAAGAATTTTTCAGTGAGAAGTGGAAGGTTCATTACAACTCCAATAGATTTGGTGTCCGTTTGATTGGACCTAAACCTAAGTGGGCAAGAAGTAATGGTGGTGAAGGTGGTATGCATCCTTCAAACACTCACGATTACGTTTATTCTCTGGGTGCAATTAATTTCACGGGTGATGAGCCAGTTATTATTACTTGCGATGGTCCTTCCTTAGGTGGTTTTGTGTGTCAAGCTGTTGTCCCAGAAGCAGAACTGTGGAAGGTTGGACAGGTTAAACCCGGTGATTCCATTCAGTTTGTGCCACTTTCTTACGAAAGCTCGAGATCCTTAAAGGAATCTCAGGAAGTTGCAATTAAATCATTGGATGGTACTAAGTTAAGGCGCTTAGACTCTGTTTCAATTTTACCATCATTCGAAACGCCTATTCTTGCACAAATGGAAAAAGTGAATGAGCTTTCACCAAAGGTTGTATACAGACAAGCAGGTGATCGTTATGTTTTGGTGGAATACGGTGATAATGAAATGAATTTTAATATTTCCTATAGAATTGAATGCCTGATCTCCCTTGTGAAAAAGAATAAGACTATTGGTATTGTTGAAATGTCCCAAGGTGTTAGATCTGTGTTGATAGAATTTGATGGTTACAAAGTCACTCAAAAAGAATTGCTTAAAGTATTGGTGGCATATGAAACAGAAATCCAGTTTGATGAAAATTGGAAGATAACTTCTAATATAATAAGATTACCGATGGCTTTCGAAGACTCGAAGACTTTGGCATGTGTTCAAAGGTATCAAGAAACAATTCGTTCGTCTGCTCCATGGTTGCCAAATAACGTTGATTTCATTGCCAATGTAAATGGAATTTCAAGGAATGAAGTTTATGATATGTTGTATTCTGCCAGATTTATGGTTTTAGGTTTAGGTGATGTCTTCCTAGGGTCGCCTTGTGCTGTTCCATTAGATCCTCGTCACAGATTTTTGGGAAGCAAGTACAACCCAAGTAGAACATATACAGAAAGAGGTGCAGTCGGTATTGGCGGTATGTATATGTGCATATATGCTGCTAACAGTCCTGGTGGGTACCAATTAGTGGGTAGAACAATACCAATTTGGGACAAACTATGTCTGGCCGCATCTTCTGAGGTTCCGTGGTTGATGAACCCATTTGACCAAGTCGAATTTTACCCAGTTTCTGAAGAAGATTTGGATAAAATGACTGAAGATTGTGATAATGGTGTTTATAAAGTCAATATCGAAAAGAGTGTTTTTGATCATCAAGAATACTTGAGATGGATCAACGCAAACAAAGATTCCATCACAGCATTCCAGGAGGGCCAGCTTGGTGAAAGAGCAGAGGAATTTGCCAAATTGATTCAAAATGCAAACTCTGAACTAAAAGAAAGTGTCACAGTCAAACCTGACGAGGAAGAAGACTTCCCAGAAGGTGCAGAAATTGTATATTCTGAGTATTCTGGGCGTTTTTGGAAATCCATAGCATCTGTTGGAGATGTTATTGAAGCAGGTCAAGGGCTACTAATTATTGAAGCCATGAAAGCGGAAATGATTATATCCGCTCCTAAATCGGGTAAGATTATCAAGATTTGCCATGGCAATGGTGATATGGTTGATTCTGGTGACATAGTGGCCGTCATAGAGACATTGGCATGA","protein_sequence":"MTVSSDTTAEISLGWSIQDWIDFHKSSSSQASLRLLESLLDSQNVAPVDNAWISLISKENLLHQFQILKSRENKETLPLYGVPIAVKDNIDVRGLPTTAACPSFAYEPSKDSKVVELLRNAGAIIVGKTNLDQFATGLVGTRSPYGKTPCAFSKEHVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGVFSCQGVVPACKSLDCVSIFALNLSDAERCFRIMCQPDPDNDEYSRPYVSNPLKKFSSNVTIAIPKNIPWYGETKNPVLFSNAVENLSRTGANVIEIDFEPLLELARCLYEGTWVAERYQAIQSFLDSKPPKESLDPTVISIIEGAKKYSAVDCFSFEYKRQGILQKVRRLLESVDVLCVPTCPLNPTMQQVADEPVLVNSRQGTWTNFVNLADLAALAVPAGFRDDGLPNGITLIGKKFTDYALLELANRYFQNIFPNGSRTYGTFTSSSVKPANDQLVGPDYDPSTSIKLAVVGAHLKGLPLHWQLEKVNATYLCTTKTSKAYQLFALPKNGPVLKPGLRRVQDSNGSQIELEVYSVPKELFGAFISMVPEPLGIGSVELESGEWIKSFICEESGYKAKGTVDITKYGGFRAYFEMLKKKESQKKKLFDTVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVSVPLHGTTAAQTYLDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSARQIAQKAGVPLVPGSLLITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIFETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETPAPNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLDLVEWMIRIAANDAPDFDSTKVEVNGVSMEARLYAENPLKNFRPSPGLLVDVKFPDWARVDTWVKKGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKVSTNILNSYQYEPTAIEITLPGAHTSIQDYPGRVGYWRIGVPPSGPMDAYSFRLANRIVGNDYRTPAIEVTLTGPSIVFHCETVIAITGGTALCTLDGQEIPQHKPVEVKRGSTLSIGKLTSGCRAYLGIRGGIDVPKYLGSYSTFTLGNVGGYNGRVLKLGDVLFLPSNEENKSVECLPQNIPQSLIPQISETKEWRIGVTCGPHGSPDFFKPESIEEFFSEKWKVHYNSNRFGVRLIGPKPKWARSNGGEGGMHPSNTHDYVYSLGAINFTGDEPVIITCDGPSLGGFVCQAVVPEAELWKVGQVKPGDSIQFVPLSYESSRSLKESQDVAIKSLDGTKLRRLDSVSILPSFETPILAQMEKVNELSPKVVYRQAGDRYVLVEYGDNEMNFNISYRIECLISLVKKNKTIGIVEMSQGVRSVLIEFDGYKVTQKELLKVLVAYETEIQFDENWKITSNIIRLPMAFEDSKTLACVQRYQETIRSSAPWLPNNVDFIANVNGISRNEVYDMLYSARFMVLGLGDVFLGSPCAVPLDPRHRFLGSKYNPSRTYTERGAVGIGGMYMCIYAANSPGGYQLVGRTIPIWDKLCLAASSEVPWLMNPFDQVEFYPVSEEDLDKMTEDCDNGVYKVNIEKSVFDHQEYLRWINANKDSITAFQEGQLGERAEEFAKLIQNANSELKESVTVKPDEEEDFPEGAEIVYSEYSGRFWKSIASVGDVIEAGQGLLIIEAMKAEMIISAPKSGKIIKICHGNGDMVDSGDIVAVIETLA"},{"created_at":"2011-05-24T19:44:14.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Allantoicase","uniprot_id":"P25335","uniprot_name":"ALLC_YEAST","enzyme":true,"transporter":false,"gene_name":"DAL2","num_residues":343,"molecular_weight":"38713.5","theoretical_pi":"6.33","general_function":"Involved in allantoicase activity","specific_function":"Utilization of purines as secondary nitrogen sources, when primary sources are limiting","reactions":[{"id":1310,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2268,"direction":"\u003e","locations":"Cytoplasmic","altext":"Allantoate + H(2)O = (S)-ureidoglycolate + urea.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SG3","cellular_location":"Cytoplasmic","genbank_gene_id":"M64720","genbank_protein_id":"171368","gene_card_id":"DAL2","chromosome_location":"chromosome 9","locus":"YIR029W","synonyms":["Allantoate amidinohydrolase"],"enzyme_classes":["3.5.3.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"},{"category":"Function","description":" allantoicase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Allantoicase","identifier":"PF03561"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAAGTTTTTTAGTTTGGCAGATGAGGCAGAATTTAAGTCAATAATCATTTCAAAAAACAAAGCAGTAGATGTTATAGGATCTAAGTTAGGTGGTCAAGTGGTTTCTTTTTCAGATGAATGGTTTGCTTCTGCTGAAAATTTAATTCAGCCAACTGCTCCTATAAGGGATCCTACCAGATTTGTTCATTCAGGCGCATGGTACGACGGCTGGGAAACACGAAGACATAATGAGATGGAATACGATTGGGTTATCATCAAGATGGGAGTCGCTGCTGCCCATATTATTGGTGGTGAAATTGACACTGCGTTTTTCAATGGTAATCATGCACCATTTGTATCAATAGAGGCGCTCTATGACGAGGGCGAAGAAGGTAATATAGTGGAAGATGACTCGCGTTGGGTTGAGATTGTTGAGAAATTTGAGTGTGGTCCTTCGCAAAGGCATCTTTTCGTTAGAGGCAACGGCCTTACTAAAGAAAGGTTTACTCACATCAAGCTGAAGATGTACCCCGATGGAGGAATCGCCAGATTTAGATTATACGGAAGAGTTGTTCCTCCAGAACTCAAAACGAAGGATCATATAATTGACTTGGCTTATGTTTGCAATGGTGCTGTCGCTTTAAAGTATTCTGACCAACACTTCGGTTCAGTTGATAATTTGCTACTGCCAGGTCGAGGTCATGATATGTCGGACGGCTGGGAAACCAAAAGATCGAGACAACCAGGTCATACTGATTGGGCGGTAATTCAACTGGGCAGGGAGTCTTCTTTCATTGAGAAGATTATTGTTGATACGGCACACTTCAGGGGGAACTTCCCTCAGTTCATTACCGTGGAAGGTTGCTTGAAGGAGTCAGAATCAAGTGAGAACACTGGTGAAGGAACATGGGTAGAGCTAGTTGGTAAGTCAAAGACGGGGCCTGACAAAGAACATGTGTATGAAATACGTAAGAGTATAAGAGTCTCCCATGTCAAATTAACGATTATTCCAGATGGAGGAGTGAAAAGAATAAGAGTTTGGGGGTACTGA","protein_sequence":"MKFFSLADEAEFKSIIISKNKAVDVIGSKLGGQVVSFSDEWFASAENLIQPTAPIRDPTRFVHSGAWYDGWETRRHNEMEYDWVIIKMGVAAAHIIGGEIDTAFFNGNHAPFVSIEALYDEGEEGNIVEDDSRWVEIVEKFECGPSQRHLFVRGNGLTKERFTHIKLKMYPDGGIARFRLYGRVVPPELKTKDHIIDLAYVCNGAVALKYSDQHFGSVDNLLLPGRGHDMSDGWETKRSRQPGHTDWAVIQLGRESSFIEKIIVDTAHFRGNFPQFITVEGCLKESESSENTGEGTWVELVGKSKTGPDKEHVYEIRKSIRVSHVKLTIIPDGGVKRIRVWGY"},{"created_at":"2011-05-24T19:44:45.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Arginase","uniprot_id":"P00812","uniprot_name":"ARGI_YEAST","enzyme":true,"transporter":false,"gene_name":"CAR1","num_residues":333,"molecular_weight":"35661.60156","theoretical_pi":"5.38","general_function":"Involved in arginase activity","specific_function":"L-arginine + H(2)O = L-ornithine + urea","reactions":[{"id":1326,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2269,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-arginine + H(2)O = L-ornithine + urea.","export":false,"pw_reaction_id":null,"source":null},{"id":3740,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006267","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M10110","genbank_protein_id":"171161","gene_card_id":"CAR1","chromosome_location":"chromosome 16","locus":"YPL111W","synonyms":[],"enzyme_classes":["3.5.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"},{"category":"Function","description":" arginase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Arginase","identifier":"PF00491"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAAACAGGACCTCATTACAACTACTACAAAAATCGCGAATTGTCCATCGTTCTGGCTCCATTCAGCGGCGGTCAGGGTAAGCTTGGTGTCGAGAAGGGCCCTAAATACATGCTTAAGCATGGTCTGCAAACAAGCATAGAGGATTTGGGCTGGTCTACGGAATTAGAGCCCTCAATGGACGAGGCCCAATTTGTGGGAAAGTTGAAAATGGAGAAGGACTCCACAACTGGGGGTTCCTCTGTTATGATAGACGGTGTCAAGGCTAAAAGAGCAGATTTGGTTGGTGAAGCCACCAAGTTGGTGTACAACTCCGTGTCGAAAGTGGTCCAGGCGAACAGATTCCCCTTGACCTTGGGTGGTGATCATTCAATAGCCATTGGTACTGTATCCGCGGTTTTGGACAAATACCCCGATGCTGGTCTTTTATGGATAGACGCCCACGCTGATATAAACACCATAGAAAGCACCCCCTCTGGAAACTTGCACGGCTGTCCCGTGTCATTCCTAATGGGTTTGAACAAGGATGTCCCACATTGTCCCGAGTCGCTCAAATGGGTTCCAGGCAACTTGAGCCCAAAAAAGATCGCGTATATTGGGTTGAGAGATGTTGATGCCGGAGAAAAGAAAATCTTGAAAGATCTGGGTATCGCCGCCTTTTCCATGTACCACGTTGACAAATACGGCATCAACGCTGTCATTGAAATGGCAATGAAAGCCGTGCACCCAGAAACAAACGGTGAAGGTCCCATTATGTGCTCCTATGACGTCGATGGTGTAGACCCATTATACATTCCTGCTACAGGTACTCCAGTGAGAGGTGGGTTGACCTTGAGAGAAGGTCTTTTCTTGGTGGAAAGATTGGCCGAATCCGGTAATTTAATTGCGCTAGACGTTGTTGAATGTAACCCTGATCTGGCTATTCATGATATCCATGTTTCAAACACCATCTCTGCAGGTTGCGCCATTGCAAGGTGTGCATTGGGTGAAACCTTATTGTAG","protein_sequence":"METGPHYNYYKNRELSIVLAPFSGGQGKLGVEKGPKYMLKHGLQTSIEDLGWSTELEPSMDEAQFVGKLKMEKDSTTGGSSVMIDGVKAKRADLVGEATKLVYNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPDAGLLWIDAHADINTIESTPSGNLHGCPVSFLMGLNKDVPHCPESLKWVPGNLSPKKIAYIGLRDVDAGEKKILKDLGIAAFSMYHVDKYGINAVIEMAMKAVHPETNGEGPIMCSYDVDGVDPLYIPATGTPVRGGLTLREGLFLVERLAESGNLIALDVVECNPDLAIHDIHVSNTISAGCAIARCALGETLL"},{"created_at":"2011-05-24T19:45:11.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Urea active transporter","uniprot_id":"P33413","uniprot_name":"DUR3_YEAST","enzyme":false,"transporter":true,"gene_name":"DUR3","num_residues":735,"molecular_weight":"80616.10156","theoretical_pi":"5.36","general_function":"Involved in transporter activity","specific_function":"Required for active transport of urea","reactions":[],"signal_regions":"None","transmembrane_regions":"15-35;86-106;131-151;167-187;190-210;254-274;296-316;344-364;404-424;426-446;455-475;497-517;619-639;651-671","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY693170","genbank_protein_id":"51013791","gene_card_id":"DUR3","chromosome_location":"chromosome 8","locus":"YHL016C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"SSF","identifier":"PF00474"}],"pathways":[],"gene_sequence":"ATGGGAGAATTTAAACCTCCGCTACCTCAAGGCGCTGGGTACGCTATTGTATTGGGCCTAGGGGCCGTATTTGCAGGAATGATGGTTTTGACCACTTATTTACTGAAACGTTATCAAAAGGAAATCATCACAGCAGAAGAATTCACCACCGCCGGTAGATCTGTAAAAACCGGCTTAGTGGCTGCAGCCGTGGTTTCTAGTTGGATCTGGTGTTCTACATTGTTAACGTCGTCAACAAAGGAATATGCAGACGGTATATTTGGCGGTTATGCGTACGCTGCTGGCGCATGCTTCCAAATTATTGCATTCGCAATTTTGGCAATTAAAACCAAGCAAATGGCTCCCAATGCGCACACATATTTAGAATTAGTGAGAACAAGATATGGTAAGATCGGCCATGGTTGCTACTTGTTTTATGCCATCGCGACGAATATTTTAGTCACTTCAATGCTTTTAACTTCAGGTTCTGCTGTCTTTAGTGATTTAACCGGGATGAACACTATCGCATCATGTTTTTTACTGCCTGTGGGTGTTGTTGTTTATACTCTATTTGGTGGGATTAAAGCAACTTTCTTAACGGACTATATGCACACATGTGTCATTATCATCATTGTCCTCGTATTTGCCTTTAAAGTTTATGCGACTAGTGATGTTTTAGGCTCACCGGGAAAAGTTTATGACTTAGTTCGTGAAGCCGCCAAGAGGCATCCAGTAGACGGTAACTATCAGGGTGAATATATGACCATGACATCCAAATCCGCTGGTATTTTATTAATTATTAACCTGATTGGAAATTTCGGCACCGTTTTCCTTGATAATGGTTATTGGAATAAAGCGATTTCTGCTAGTCCCGCAGCGAGTTTGAAAGCATATGCCATCGGTGGGTTAGCATGGTTTGCAGTACCTTCTTTGATTTCATTGACCATGGGATTAGCATGTCTTGCGGTGGAAACGTCTCCGAACTTCCCCACCTATCCTGATCCACTTACTTCGTTCCAGGCAAATTCTGGGTTAGTCTTGCCGGCAGCTGCAATTGCTATCATGGGTAAGGGGGGTGCTGTGGCATCGCTGCTAATGATTTTCATGGCCGTCACATCTGCTATGTCTGCTGAACTAATTGCCGTTTCATCTGTTTTCACTTACGATATCTATAGAGAATATATTGATCCTCGTGCAAGCGGTAAGAAATTGATTTACACATCACACGTTGCTTGTATCTTTTTTGGTCTTGCCATGAGTGGATTTTCGGTTGGTTTATACTATGGTGGTATTTCTATGGGTTATATCTATGAAATGATGGGTATAATTATTAGTAGTGCAGTATTACCTGTCGTTTTGACCTTATGTTCCAAAGACATGAATTTGGTGGCCGCTGTAGTGTCGCCTATTTTGGGCACAGGACTGGCTATAATGTCATGGCTTGTCTGTACCAAATCCCTTTATAAAGAATTGACCGTGGATACTACGTTCATGGATTATCCAATGTTAACAGGTAACTTGGTGGCTTTGCTATCACCAGCCATTTTTATTCCTATTTTAACGTATGTGTTTAAGCCACAAAATTTTGACTGGGAGAAAATGAAAGATATTACTAGAGTTGACGAAACTGCAGAGTTAGTTCAGGCTGACCCTGATATCCAGCTTTACGATGCTGAAGCTAACGATAAGGAACAAGAAGAAGAAACAAATTCTCTGGTCTCAGATAGTGAAAAAAACGATGTTAGAGTAAATAATGAAAAATTGATTGAGCCTAACCTTGGTGTTGTAATAAGTAATGCCATTTTTCAAGAAGATGACACACAGTTACAAAATGAATTAGACGAAGAACAAAGAGAACTAGCACGTGGTTTAAAAATTGCATACTTCCTATGTGTTTTTTTCGCTTTGGCATTTTTGGTAGTTTGGCCCATGCCCATGTATGGTTCCAAATATATCTTCAGTAAAAAATTCTTTACCGGTTGGGTTGTTGTGATGATCATCTGGCTTTTTTTCAGTGCGTTTGCCGTTTGTATTTATCCACTCTGGGAAGGTAGGCATGGTATATATACCACTTTGCGAGGCCTTTACTGGGATCTATCTGGTCAAACTTATAAATTAAGGGAATGGCAAAATTCGAACCCACAAGATCTGCATGTAGTAACAAGCCAAATTAGTGCGAGAGCACATAGACAATCATCACATTTCGGACAAGTTGATGAAATAATTTAG","protein_sequence":"MGEFKPPLPQGAGYAIVLGLGAVFAGMMVLTTYLLKRYQKEIITAEEFTTAGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIFGGYAYAAGACFQIIAFAILAIKTKQMAPNAHTYLELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATSDVLGSPGKVYDLVREAAKRHPVDGNYQGEYMTMTSKSAGILLIINLIGNFGTVFLDNGYWNKAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVETSPNFPTYPDPLTSFQANSGLVLPAAAIAIMGKGGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRASGKKLIYTSHVACIFFGLAMSGFSVGLYYGGISMGYIYEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSPILGTGLAIMSWLVCTKSLYKELTVDTTFMDYPMLTGNLVALLSPAIFIPILTYVFKPQNFDWEKMKDITRVDETAELVQADPDIQLYDAEANDKEQEEETNSLVSDSEKNDVRVNNEKLIEPNLGVVISNAIFQEDDTQLQNELDEEQRELARGLKIAYFLCVFFALAFLVVWPMPMYGSKYIFSKKFFTGWVVVMIIWLFFSAFAVCIYPLWEGRHGIYTTLRGLYWDLSGQTYKLREWQNSNPQDLHVVTSQISARAHRQSSHFGQVDEII"}]}