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Sphingolipid metabolism

SourceIDPathway
PathWhizPW002479 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG00600 Map00600

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00045Coenzyme A
85-61-0
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC21H36N7O16P3S
767.534
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YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
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YMDB00112L-Serine
56-45-1
(2S)-2-amino-3-hydroxypropanoic acidC3H7NO3
105.0926
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YMDB00125O-Phosphoethanolamine
1071-23-4
(2-aminoethoxy)phosphonic acidC2H8NO4P
141.063
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YMDB001833-Dehydrosphinganine
16105-69-4
(2S)-2-amino-1-hydroxyoctadecan-3-oneC18H37NO2
299.4919
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YMDB00190Sphingosine
123-78-4
(4E)-2-aminooctadec-4-ene-1,3-diolC18H37NO2
299.4919
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YMDB00191Phosphorylcholine
3616-04-4
[2-(trimethylazaniumyl)ethoxy]phosphonic acidC5H15NO4P
184.1507
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YMDB00285Phytosphingosine
554-62-1
(2S,3S,4R)-2-aminooctadecane-1,3,4-triolC18H39NO3
317.5072
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YMDB00299Sphinganine 1-phosphate
19794-97-9
{[(2S,3R)-2-amino-3-hydroxyoctadecyl]oxy}phosphonic acidC18H40NO5P
381.4877
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YMDB00301Palmityl-CoA
1763-10-6
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC37H66N7O17P3S
1005.943
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YMDB00327Sphinganine
764-22-7
(2S,3R)-2-aminooctadecane-1,3-diolC18H39NO2
301.5078
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YMDB00358Calcium(2+)
7440-70-2
calcium(2+) ionCa
40.078
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YMDB00363Pyridoxal 5'-phosphate
54-47-7
[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acidC8H10NO6P
247.1419
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YMDB00395Palmitaldehyde
629-80-1
hexadecanalC16H32O
240.4247
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YMDB00426NADPH
53-57-6
{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209
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YMDB00427NADP
53-59-8
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H29N7O17P3
744.4129
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YMDB00514Succinyl-CoA
604-98-8
4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acidC25H40N7O19P3S
867.607
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YMDB00527palmitoyl-CoA
1763-10-6
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC37H66N7O17P3S
1005.943
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YMDB00532decanoyl-CoA
1264-57-9
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(decanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC31H54N7O17P3S
921.783
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YMDB00862hydron
12408-02-5
hydronH
1.00794
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YMDB00890water
7732-18-5
waterH2O
18.0153
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YMDB00900oxygen
7782-44-7
oxidanoneO2
31.9988
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YMDB00907phosphate
14265-44-2
phosphoric acidO4P
94.9714
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YMDB00912Carbon dioxide
124-38-9
methanedioneCO2
44.0095
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YMDB00914ADP
58-64-0
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
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YMDB01099(2S,3S,4R)-2-aminoicosane-1,3,4-triol(2S,3S,4R)-2-aminoicosane-1,3,4-triolC20H43NO3
345.5603
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YMDB011014-Hydroxysphinganine
554-62-1
(2S,3S,4R)-2-aminooctadecane-1,3,4-triolC18H39NO3
317.5072
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YMDB01520Magnesium
7439-95-4
magnesium(2+) ionMg
24.305
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YMDB01527Zinc
7440-66-6
zinc(2+) ionZn
65.409
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YMDB01546SM C18:0
85187-10-6
C41H84N2O6P
732.0892
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YMDB16113Sphingosine 1-phosphate{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acidC18H38NO5P
379.4718
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YMDB16182Ceramide (d18:1/18:0)N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamideC36H71NO3
565.9538
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YMDB16188DihydroceramideN-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]formamideC19H39NO3
329.5179
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YMDB16189Galactosylglycerol(2R,3R,4S,5R,6R)-2-(2,3-dihydroxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triolC9H18O8
254.2344
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YMDB16195PC(15:0/18:2(9Z,12Z))trimethyl(2-{[(2R)-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]-3-(pentadecanoyloxy)propyl phosphonato]oxy}ethyl)azaniumC41H78NO8P
744.0337
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YMDB16243Ferrocytochrome9-(2-carboxyethyl)-5-(2-carboxylatoethyl)-15-ethenyl-4,10,14,19,20-pentamethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1,3,5,7,9,11(23),12,14,16(22),17,19-undecaen-21-ide ironC33H32FeN4O4
604.489
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YMDB16255ferricytochrome c5-hydroxy-1,6,6,11,15-pentamethyl-14-[(5E)-6-methyl-7-{[3,4,5-trihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}hept-5-en-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-17-oneC42H68O13
780.993
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P25045LCB1
YMR296C
Serine palmitoyltransferase 1Enzyme
P38703LAG1
YHL003C
Sphingosine N-acyltransferase LAG1Enzyme
P40970LCB2
YDR062W
Serine palmitoyltransferase 2Enzyme
P28496LAC1
YKL008C
Sphingosine N-acyltransferase LAC1Enzyme
Q12246LCB4
YOR171C
Sphingoid long chain base kinase 4Enzyme
Q06147LCB5
YLR260W
Sphingoid long chain base kinase 5Enzyme
Q05567DPL1
YDR294C
Sphingosine-1-phosphate lyaseEnzyme
P38342TSC10
YBR265W
3-ketodihydrosphingosine reductase TSC10Enzyme
P38992SUR2
YDR297W
Sphingolipid C4-hydroxylase SUR2Enzyme
Q04396LPP1
YDR503C
Lipid phosphate phosphatase 1Enzyme
Q05521DPP1
YDR284C
Diacylglycerol pyrophosphate phosphatase 1Enzyme