{"ymdb_id":"YMDB00190","created_at":"2011-05-29T16:05:22.000Z","updated_at":"2016-09-08T18:35:09.000Z","name":"Sphingosine","cas":"123-78-4","state":"Solid","melting_point":"81 oC","description":"Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain which forms a primary part of sphingolipids. Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. Sphingosine is generated by a ceramidase in the ceramide degradation pathway. Ceramidases have been well characterized from human, yeast and a number of other organisms. [Biocyc PWY-6483]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Nuclear Envelope, Plasma Membrane","synthesis_reference":"Obayashi, Michio; Schlosser, Manfred. An efficient synthesis of (2S,3R)- and (2S,3S)-sphingosine. Chemistry Letters (1985), (11), 1715-18.","chebi_id":"46964","hmdb_id":"HMDB00252","kegg_id":"C00319","pubchem_id":"31270","cs_id":"23937169","foodb_id":null,"wikipedia_link":"Sphingosine","biocyc_id":"SPHINGOSINE","iupac":"(4E)-2-aminooctadec-4-ene-1,3-diol","traditional_iupac":"sphingosine","logp":"4.5665800486666654","pka":"15.19039459699287","alogps_solubility":"3.90e-03 g/l","alogps_logp":"5.15","alogps_logs":"-4.89","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"15","polar_surface_area":"66.48","refractivity":"91.892","polarizability":"39.38492659222692","formal_charge":"0","physiological_charge":"1","pka_strongest_basic":"9.234294901231742","pka_strongest_acidic":"14.116140546669914","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(-)-D-erythro-Sphingosine","(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol","(2S,3R)-Sphingosine","(4E)-Sphingenine","[R-[R*,S*-(E)]]-2-amino-4-Octadecene-1,3-diol","4-Sphingenine","4-trans-Sphingenine"],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."}],"proteins":[{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"},{"created_at":"2011-05-26T19:42:27.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 4","uniprot_id":"Q12246","uniprot_name":"LCB4_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB4","num_residues":624,"molecular_weight":"69638.60156","theoretical_pi":"6.39","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"Z75078","genbank_protein_id":"1420417","gene_card_id":"LCB4","chromosome_location":"chromosome 15","locus":"YOR171C","synonyms":["LCB kinase 4","Sphinganine kinase 4"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGGTGGTGCAGAAAAAACTTAGGGCTATCTTGACCGATGAAGGTGTATTGATCAAATCGCAATCACACCATATGTTCAATAAGCATGGTCAACTCAGAAGCGGAGATTCTTTATCCTTGTTGAGCTGCTTGTCCTGTCTGGATGATGGAACTTTGAGCTCTGATGGAGGTTCTTTTGATGAGGATGATTCCCTGGAACTGTTGCCTCTTAATACTACCATTCCGTTCAACAGAATTTTGAACGCAAAATATGTGAATGTCGGTCAGAAAGGCTTCAATAATGGCAAAATTTCTTCGAATCCTTTTCAAACGGAAAATCTGAGTTCTTCGTCTGAAAATGACGACGTTGAGAATCATAGTTTGAGCAATGATAAGGCTCCTGTAAGCGAATCACAGTCATTTCCCAAAAAAGACAAGTGGGATACAAAAACGAACACTGTGAAGGTGTCTCCCGATGATTCACAGGATAACTCACCATCTTTAGGGATAAAAGATAATCAACAGTTAATTGAGTTAACTTTTGCTGTACCCAAGGGCCATGATGTTATACCACAAAAATTAACCTTGTTAATAGATCACGTTTCTAGGAAATCGAGAGCAAATACCGGAGAGGAGAACATTTCTTCTGGTACTGTGGAAGAAATCCTGGAAAAAAGTTATGAAAATTCCAAGAGAAACAGATCGATATTAGTCATTATTAATCCCCACGGTGGTAAAGGTACTGCTAAAAATTTATTCCTGACAAAAGCAAGGCCAATACTAGTGGAAAGTGGCTGCAAAATAGAAATTGCATACACAAAATATGCCCGTCACGCCATCGATATTGCCAAAGATTTAGATATCAGCAAATACGATACCATTGCATGTGCCTCGGGTGATGGTATTCCATACGAAGTAATTAATGGGCTTTATAGAAGACCCGACAGAGTGGATGCGTTCAATAAACTAGCCGTAACTCAGCTACCTTGCGGTTCAGGAAATGCTATGAGCATTTCATGTCATTGGACAAATAACCCATCGTACGCCGCTCTGTGCCTTGTCAAATCCATTGAAACAAGAATAGACTTAATGTGTTGTTCCCAACCTTCTTATATGAACGAATGGCCAAGATTATCCTTTTTGAGTCAGACGTACGGCGTTATTGCAGAATCTGATATTAACACTGAATTCATCAGATGGATGGGTCCCGTTAGGTTTAATTTGGGTGTAGCATTCAACATTATCCAAGGTAAGAAATATCCCTGCGAAGTTTTCGTCAAATATGCTGCCAAATCTAAAAAGGAATTAAAAGTTCATTTCTTAGAAAATAAAGATAAAAACAAAGGATGTTTAACCTTCGAACCAAATCCTAGCCCAAACTCTTCGCCGGATTTACTATCTAAAAACAATATCAACAACAGTACAAAAGATGAACTTTCACCGAATTTTCTCAACGAGGACAACTTTAAATTAAAGTATCCGATGACGGAACCAGTACCTAGAGACTGGGAGAAAATGGATTCAGAGCTAACTGATAACTTAACAATCTTTTACACAGGGAAAATGCCGTATATTGCTAAGGACACCAAATTTTTTCCCGCTGCTTTACCAGCGGATGGTACCATTGATTTAGTCATAACGGATGCAAGAATCCCAGTGACAAGAATGACACCAATTTTATTATCCTTGGATAAAGGTTCTCATGTATTAGAGCCAGAAGTTATTCACTCAAAAATATTGGCTTATAAGATTATACCAAAAGTGGAGTCAGGTTTATTTTCAGTGGATGGTGAAAAGTTTCCTTTGGAACCCTTGCAAGTGGAAATAATGCCCATGTTATGCAAGACGTTGCTAAGGAATGGTAGATATATCGATACAGAGTTTGAATCCATGTAG","protein_sequence":"MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM"},{"created_at":"2011-05-26T19:54:39.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"Sphingoid long chain base kinase 5","uniprot_id":"Q06147","uniprot_name":"LCB5_YEAST","enzyme":true,"transporter":false,"gene_name":"LCB5","num_residues":687,"molecular_weight":"77564.60156","theoretical_pi":"6.86","general_function":"Involved in diacylglycerol kinase activity","specific_function":"Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance","reactions":[{"id":1975,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1976,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2584,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + sphinganine = ADP + sphinganine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2585,"direction":"\u003e","locations":" Peripheral membrane protein. Golgi apparatus membrane;Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein;Cell membrane; Peripheral membrane protein. Late endosome membrane","altext":"ATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Peripheral membrane protein","genbank_gene_id":"U17244","genbank_protein_id":"577178","gene_card_id":"LCB5","chromosome_location":"chromosome 12","locus":"YLR260W","synonyms":["LCB kinase 5","Sphinganine kinase 5"],"enzyme_classes":["2.7.1.91"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" diacylglycerol kinase activity"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" cell surface receptor linked signaling pathway"},{"category":"Process","description":" G-protein coupled receptor protein signaling pathway"},{"category":"Process","description":" activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway"}],"pfams":[{"name":"DAGK_cat","identifier":"PF00781"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACTTTGAAACCTTCAAAGAGACGTAAGGGCAGGTCTCGCCATTCCAGGAAGAAGCAAATAACGTCAGCGATACTGACTGAGGAAGGAATAATGATCAAGGCAAAACCATCAAGTCCTTACACATACGCAAATAGAATGGCAGATAAACGAAGTCGCAGCAGCATTGACAACATCAGTAGAACTAGCTTTCAAAGCAACATCAGTAGAACTAGCTTTCAAAGCAACAGTGATAACAACAGTATATTTGAAACGGCTTCACTAATTAGCTGTGTTACCTGTTTAAGCGATACTGATACAATAGACAGATCGGAAACATCGACAACGGATACAAGTAAAGATGATCTTTCTGCTAATCCAAAACTTCATTATCCTTCGGTGAATGGTCAATTGCCAGCAAACACCGTTATCCCCTATGGACGAATTCTGGATGCCAGATACATTGAAAAGGAACCTCTGCATTATTATGATGCCAATTCATCACCCAGTTCACCTTTAAGCAGCTCAATGAGTAACATTAGTGAAAAGTGTGATCTTGATGAATTAGAGTCTTCCCAAAAAAAAGAAAGGAAGGGCAACTCGCTATCGCGAGGAAGTAACAGTAGTAGTAGCCTCCTGACTTCCAGATCTCCTTTTACGAAACTAGTAGAGGTTATATTTGCTAGGCCAAGACGGCATGACGTTGTACCCAAAAGGGTTTCATTGTATATTGACTATAAACCCCATTCATCTTCTCACTTAAAAGAAGAAGATGACTTGGTTGAGGAGATTTTAAAGAGAAGCTACAAAAACACTAGAAGGAACAAATCCATATTTGTGATCATTAATCCGTTTGGTGGTAAAGGTAAGGCGAAAAAACTGTTTATGACAAAGGCAAAGCCGTTACTATTAGCAAGTCGGTGTTCCATAGAAGTGGTTTATACAAAATACCCTGGTCATGCTATAGAGATCGCGCGGGAAATGGATATTGACAAATATGACACTATTGCTTGCGCTTCGGGAGATGGCATTCCTCATGAGGTGATCAATGGGTTATACCAAAGGCCTGATCATGTCAAAGCATTCAACAATATCGCCATTACAGAAATTCCATGCGGATCAGGTAACGCAATGAGCGTATCCTGCCACTGGACAAACAATCCTTCGTACTCAACTTTATGCTTAATTAAATCGATAGAGACTAGAATTGATTTGATGTGTTGTTCGCAGCCTTCTTATGCAAGAGAGCACCCAAAGTTATCATTTTTAAGTCAAACATATGGTCTCATTGCAGAAACTGACATAAACACTGAATTTATTAGATGGATGGGACCTGCAAGGTTTGAATTGGGTGTAGCCTTCAATATCATACAAAAAAAAAAATATCCTTGTGAGATATATGTAAAGTATGCTGCCAAATCAAAAAACGAGTTAAAAAATCATTACCTGGAACACAAAAATAAAGGGTCGTTAGAATTCCAGCATATTACTATGAACAAAGATAACGAGGATTGTGATAATTACAATTACGAAAATGAATACGAAACCGAAAACGAAGATGAAGATGAAGATGCGGATGCGGATGACGAAGACTCCCACTTGATATCTCGTGATCTGGCAGATTCTAGTGCTGATCAAATTAAAGAGGAAGATTTCAAAATAAAATATCCATTAGATGAAGGTATCCCTAGTGACTGGGAAAGATTGGATCCTAATATTTCGAACAACCTAGGTATCTTCTATACGGGTAAAATGCCATATGTGGCTGCTGACACTAAATTCTTTCCGGCAGCGCTTCCTTCAGATGGTACAATGGATATGGTTATCACCGATGCAAGAACCTCGTTGACGAGGATGGCACCAATCCTGCTGGGACTAGATAAGGGTTCCCATGTTTTACAACCGGAAGTCTTACACTCTAAAATTTTGGCATACAAGATAATACCAAAGCTAGGGAACGGCTTGTTCTCTGTCGATGGCGAGAAATTTCCTCTAGAGCCCCTTCAAGTCGAAATTATGCCACGCTTATGCAAGACGTTACTGAGAAATGGCCGTTATGTGGACACAGATTTCGATTCTATGTGA","protein_sequence":"MTLKPSKRRKGRSRHSRKKQITSAILTEEGIMIKAKPSSPYTYANRMADKRSRSSIDNISRTSFQSNISRTSFQSNSDNNSIFETASLISCVTCLSDTDTIDRSETSTTDTSKDDLSANPKLHYPSVNGQLPANTVIPYGRILDARYIEKEPLHYYDANSSPSSPLSSSMSNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLVEVIFARPRRHDVVPKRVSLYIDYKPHSSSHLKEEDDLVEEILKRSYKNTRRNKSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACASGDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVSCHWTNNPSYSTLCLIKSIETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYPCEIYVKYAAKSKNELKNHYLEHKNKGSLEFQHITMNKDNEDCDNYNYENEYETENEDEDEDADADDEDSHLISRDLADSSADQIKEEDFKIKYPLDEGIPSDWERLDPNISNNLGIFYTGKMPYVAADTKFFPAALPSDGTMDMVITDARTSLTRMAPILLGLDKGSHVLQPEVLHSKILAYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRLCKTLLRNGRYVDTDFDSM"}]}