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Thiamine metabolism
Source | ID | Pathway |
---|---|---|
KEGG | 00730 |
Pathway Metabolites
YMDB ID | Name CAS Number | IUPAC Name | Formula Weight | Structure |
---|---|---|---|---|
YMDB00016 | Glycine 56-40-6 | 2-aminoacetic acid | C2H5NO2 75.0666 | |
YMDB00046 | L-Cysteine 52-90-4 | (2R)-2-amino-3-sulfanylpropanoic acid | C3H7NO2S 121.158 | |
YMDB00065 | 5-Aminoimidazole ribonucleotide 25635-88-5 | {[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C8H14N3O7P 295.1864 | |
YMDB00115 | D-Glyceraldehyde 3-phosphate 142-10-9 | (2-hydroxy-3-oxopropoxy)phosphonic acid | C3H7O6P 170.0578 | |
YMDB00117 | 4-amino-2-methyl-5-diphosphomethylpyrimidine | ({hydroxy[(6-imino-2-methyl-1,6-dihydropyrimidin-5-yl)methoxy]phosphoryl}oxy)phosphonic acid | C6H11N3O7P2 299.115 | |
YMDB00118 | 4-amino-5-hydroxymethyl-2-methylpyrimidine 73-67-6 | (4-amino-2-methylpyrimidin-5-yl)methanol | C6H9N3O 139.1552 | |
YMDB00128 | 4-amino-2-methyl-5-phosphomethylpyrimidine | [(6-imino-2-methyl-1,6-dihydropyrimidin-5-yl)methoxy]phosphonic acid | C6H10N3O4P 219.1351 | |
YMDB00164 | Thiamine monophosphate 495-23-8 | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(hydrogen phosphonooxy)ethyl]-4-methyl-1,3-thiazol-3-ium | C12H17N4O4PS 344.327 | |
YMDB00175 | Pyruvic acid 127-17-3 | 2-oxopropanoic acid | C3H4O3 88.0621 | |
YMDB00220 | Thiamine 59-43-8 | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium | C12H17N4OS 265.355 | |
YMDB00319 | 4-Methyl-5-(2-phosphonooxyethyl)thiazole | [2-(4-methyl-1,3-thiazol-5-yl)ethoxy]phosphonic acid | C6H10NO4PS 223.187 | |
YMDB00364 | L-Tyrosine 60-18-4 | (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | C9H11NO3 181.1885 | |
YMDB00381 | Thiamine pyrophosphate 154-87-0 | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium | C12H19N4O7P2S 425.314 | |
YMDB00492 | 5-Amino-1-(5-phospho-D-ribosyl)imidazole 25635-88-5 | {[(2R,3S,4R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C8H14N3O7P 295.1864 | |
YMDB00706 | 5-(2-Hydroxyethyl)-4-methylthiazole 137-00-8 | 2-(4-methyl-1,3-thiazol-5-yl)ethan-1-ol | C6H9NOS 143.207 | |
YMDB00774 | Thiamine(1+) monophosphate 532-40-1 | C12H18N4O4PS 345.334 | ||
YMDB00775 | Thiamine triphosphate | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium | C12H20N4O10P3S 505.294 | |
YMDB00793 | Toxopyrimidine 73-67-6 | C6H9N3O 139.1552 | ||
YMDB01053 | pyruvate 127-17-3 | C3H3O3 87.0541 |
Pathway Proteins
Uniprot ID | Gene Name Locus | Name | Type | Metabolites |
---|---|---|---|---|
P25374 | NFS1 YCL017C | Cysteine desulfurase, mitochondrial | Enzyme | |
P35202 | THI80 YOR143C | Thiamine pyrophosphokinase | Enzyme | |
Q08975 | THI21 YPL258C | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 | Enzyme | |
Q08224 | THI20 YOL055C | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 | Enzyme |
|
P41835 | THI6 YPL214C | Thiamine biosynthetic bifunctional enzyme | Enzyme |