{"ymdb_id":"YMDB00164","created_at":"2011-05-29T16:03:00.000Z","updated_at":"2016-09-08T18:35:07.000Z","name":"Thiamine monophosphate","cas":"495-23-8","state":"Solid","melting_point":null,"description":"Thiamine monophosphate (ThMP) is one of the five known natural thiamine phosphate derivatives. Thiamine (vitamin B1) is the transport form of the vitamin, while the phosphorylated derivatives are the active forms. There is no known physiological role of thiamine monophosphate.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":"","location":"Cytoplasm; Extracellular","synthesis_reference":"Leder, Irwin G.  Enzymic synthesis of thiamine monophosphate.    Journal of Biological Chemistry  (1961),  236  3066-71. ","chebi_id":"37574","hmdb_id":"HMDB02666","kegg_id":"C01081","pubchem_id":"1131","cs_id":"2627905","foodb_id":null,"wikipedia_link":"Thiamine_monophosphate","biocyc_id":"THIAMINE-P","iupac":"3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(hydrogen phosphonooxy)ethyl]-4-methyl-1,3-thiazol-3-ium","traditional_iupac":"3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(hydrogen phosphonooxy)ethyl]-4-methyl-1,3-thiazol-3-ium","logp":"-5.696316403219863","pka":"6.712600648963036","alogps_solubility":"8.90e-02 g/l","alogps_logp":"-1.68","alogps_logs":"-3.65","acceptor_count":"6","donor_count":"2","rotatable_bond_count":"6","polar_surface_area":"125.27000000000001","refractivity":"83.15090000000001","polarizability":"31.956487685608256","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"5.507552519532389","pka_strongest_acidic":"1.6589988406382288","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Aneurin-monophosphorsaeureester","Aneurine monophosphate","Monofosfotiamina","Monophosphoric ester of thiamine","Monophosphothiamine","Monophosphothiaminum","Phosphothiaminum","Thiamin dihydrogenphosphate","thiamin monophosphate","Thiamin phosphate","Thiamine monophosphate","Thiamine monophosphate dihydrate","Thiamine monophosphic acid","thiamine phosphate","Tiamina monofosfato","TMP","tmp, thiamin phosphate"],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18028398,"citation":"Onozuka, M., Konno, H., Kawasaki, Y., Akaji, K., Nosaka, K. (2008). \"Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.\" FEMS Yeast Res 8:266-275."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-26T17:57:34.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Acid phosphatase PHO11","uniprot_id":"P35842","uniprot_name":"PPAB_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO11","num_residues":467,"molecular_weight":"52757.39844","theoretical_pi":"4.78","general_function":"Involved in acid phosphatase activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1245,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14442,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006956","source":"Smpdb"}],"signal_regions":"1-17","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"L28920","genbank_protein_id":"456155","gene_card_id":"PHO11","chromosome_location":"chromosome 1","locus":"YAR071W","synonyms":["P56"],"enzyme_classes":["3.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTGAAGTCAGCCGTTTATTCAATTTTAGCCGCTTCTTTGGTTAATGCAGGTACCATACCCCTCGGAAAGTTATCTGACATTGACAAAATCGGAACTCAAACGGAAATTTTCCCATTTTTGGGTGGTTCTGGGCCATACTACTCTTTCCCTGGTGATTATGGTATTTCTCGTGATTTGCCGGAAAGTTGTGAAATGAAGCAAGTGCAAATGGTTGGTAGACACGGTGAAAGATACCCCACTGTCAGCAAAGCCAAAAGTATCATGACAACATGGTACAAATTGAGTAACTATACCGGTCAATTCAGCGGAGCATTGTCTTTCTTGAACGATGACTACGAATTTTTCATTCGTGACACCAAAAACCTAGAAATGGAAACCACACTTGCCAATTCGGTCAATGTTTTGAACCCATATACCGGTGAGATGAATGCTAAGAGACACGCTCGTGATTTCTTGGCGCAATATGGCTACATGGTCGAAAACCAAACCAGTTTTGCCGTTTTTACGTCTAACTCGAACAGATGTCATGATACTGCCCAGTATTTCATTGACGGTTTGGGTGATAAATTCAACATATCCTTGCAAACCATCAGTGAAGCCGAGTCTGCTGGTGCCAATACTCTGAGTGCCCACCATTCGTGTCCTGCTTGGGACGATGATGTCAACGATGACATTTTGAAAAAATATGATACCAAATATTTGAGTGGTATTGCCAAGAGATTAAACAAGGAAAACAAGGGTTTGAATCTGACTTCAAGTGATGCAAACACTTTTTTTGCATGGTGTGCATATGAAATAAACGCTAGAGGTTACAGTGACATCTGTAACATCTTCACCAAAGATGAATTGGTCCGTTTCTCCTACGGCCAAGACTTGGAAACTTATTATCAAACGGGACCAGGCTATGACGTCGTCAGATCCGTCGGTGCCAACTTGTTCAACGCTTCAGTGAAACTACTAAAGGAAAGTGAGGTCCAGGACCAAAAGGTTTGGTTGAGTTTCACCCACGATACCGATATTCTGAACTATTTGACCACTATCGGCATAATCGATGACAAAAATAACTTGACCGCCGAACATGTTCCATTCATGGAAAACACTTTCCACAGATCCTGGTACGTTCCACAAGGTGCTCGTGTTTACACTGAAAAGTTCCAGTGTTCCAATGACACCTATGTTAGATACGTCATCAACGATGCTGTCGTTCCAATTGAAACCTGTTCTACTGGTCCAGGGTTCTCCTGTGAAATAAATGACTTCTACGACTATGCTGAAAAGAGAGTAGCCGGTACTGACTTCCTAAAGGTCTGTAACGTCAGCAGCGTCAGTAACTCTACTGAATTGACCTTTTTCTGGGACTGGAATACCAAGCACTACAACGACACTTTATTAAAACAGTAA","protein_sequence":"MLKSAVYSILAASLVNAGTIPLGKLSDIDKIGTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDDYEFFIRDTKNLEMETTLANSVNVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKFNISLQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDKNNLTAEHVPFMENTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNSTELTFFWDWNTKHYNDTLLKQ"},{"created_at":"2011-05-26T17:58:53.000Z","updated_at":"2011-07-22T17:53:56.000Z","name":"Repressible acid phosphatase","uniprot_id":"P00635","uniprot_name":"PPA5_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO5","num_residues":467,"molecular_weight":"52858.10156","theoretical_pi":"4.41","general_function":"Involved in acid phosphatase activity","specific_function":"Partially mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and NPP2","reactions":[{"id":1245,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14442,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006956","source":"Smpdb"}],"signal_regions":"1-17","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Secreted","genbank_gene_id":"V01320","genbank_protein_id":"4159","gene_card_id":"PHO5","chromosome_location":"chromosome 2","locus":"YBR093C","synonyms":["P60"],"enzyme_classes":["3.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTAAATCTGTTGTTTATTCAATTTTAGCCGCTTCTTTGGCCAATGCAGGTACCATTCCCTTAGGCAAACTAGCCGATGTCGACAAGATTGGTACCCAAAAATATATCTTCCCATTTTTGGGTGGTGCCGGACCATACTACTCTTTCCCTGGCGACTATGGTATTTCTCGTGATTTGCCTGAAGGTTGTGAAATGAAGCAACTGCAAATGGTTGGTAGGCATGGTGAAAGATACCCTACTGTCAGTCTGGCTAAGACTATCAAGAGTACATGGTATAAGTTGAGCAATTACACTCGTCAATTCAACGGCTCATTGTCATTCTTGAACGATGATTACGAGTTTTTCATCCGTGATGACGATGATTTGGAAATGGAAACCACTTTTGGGAACTCGGACGATGTTTTGAACCCATACACTGGTGAAATGAACGCCAAGAGACATGCTCGTGACTTCTTGGCTCAATACGGTTACATGGTCGAAAACCAAACCAGTTTCGCCGTTTTTACCTCTAATTCTAAGAGATGTCATGACACTGCTCAATATTTCATTGATGGTTTAGGTGACCAATTCAACATCACCTTGCAGACTGTCAGTGAAGCTGAATCCGCTGGTGCCAACACTTTGAGTGCTTGTAACTCATGTCCTGCCTGGGACTACGATGCCAATGATGACATTGTAAATGAATACGACACAACCTACTTGGATGACATTGCCAAGAGATTGAACAAGGAAAACAAGGGTTTGAACTTGACCTCAACTGACGCTAGTACTTTATTCTCGTGGTGTGCATTTGAAGTGAACGCCAAAGGTTACAGTGATGTCTGTGATATTTTCACCAAGGATGAATTAGTCCATTACTCCTACTACCAAGACTTGCAGACCTATTACCATGAAGGTCCAGGTTACGATATTATCAAGTCTGTCGGTTCCAACTTGTTCAATGCCTCAGTCAAATTATTAAAGCAAAGTGAGATTCAAGACCAAAAGGTTTGGTTGAGTTTTACCCACGATACCGATATCCTAAACTTTTTGACCACCGCTGGTATAATTGACGACAAAAACAACTTAACTGCCGAATACGTTCCATTCATGGGCAACACTTTCCACAGATCCTGGTACGTTCCTCAAGGTGCTCGTGTCTACACCGAAAAATTCCAATGTTCTAACGACACCTACGTCAGATACGTCATTAACGATGCTGTCGTTCCAATTGAAACCTGTTCCACTGGTCCAGGGTTCTCTTGTGAAATCAATGACTTCTACGACTATGCTGAAAAGAGAGTAGCCGGTACTGACTTCCTAAAGGTCTGTAACGTCAGCAGTGTCAGTAACGTCACCGAATTGACCTTCTACTGGGACTGGAATACTACTCACTACAATGATACCCTATTAAAACAATAA","protein_sequence":"MFKSVVYSILAASLANAGTIPLGKLADVDKIGTQKDIFPFLGGAGPYYSFPGDYGISRDLPEGCEMKQLQMVGRHGERYPTVSLAKTIKSTWYKLSNYTRQFNGSLSFLNDDYEFFIRDDDDLEMETTFANSDDVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSKRCHDTAQYFIDGLGDQFNITLQTVSEAESAGANTLSACNSCPAWDYDANDDIVNEYDTTYLDDIAKRLNKENKGLNLTSTDASTLFSWCAFEVNAKGYSDVCDIFTKDELVHYSYYQDLHTYYHEGPGYDIIKSVGSNLFNASVKLLKQSEIQDQKVWLSFTHDTDILNFLTTAGIIDDKNNLTAEYVPFMGNTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNSTELTFYWDWNTTHYNASLLRQ"},{"created_at":"2011-05-27T00:33:49.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Thiamine biosynthetic bifunctional enzyme","uniprot_id":"P41835","uniprot_name":"THI6_YEAST","enzyme":true,"transporter":false,"gene_name":"THI6","num_residues":540,"molecular_weight":"58058.19922","theoretical_pi":"5.74","general_function":"Involved in catalytic activity","specific_function":"Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole","reactions":[{"id":1646,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2003,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2621,"direction":"\u003e","locations":null,"altext":"2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2622,"direction":"\u003e","locations":null,"altext":"ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.","export":false,"pw_reaction_id":null,"source":null},{"id":14440,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006953","source":"Smpdb"},{"id":14441,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006954","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D31908","genbank_protein_id":"633125","gene_card_id":"THI6","chromosome_location":"chromosome 16","locus":"YPL214C","synonyms":["Thiamine-phosphate pyrophosphorylase","TMP pyrophosphorylase","TMP-PPASE","Hydroxyethylthiazole kinase","4-methyl-5-beta-hydroxyethylthiazole kinase","TH kinase","THZ kinase"],"enzyme_classes":["2.5.1.3","2.7.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" thiamin-phosphate diphosphorylase activity"},{"category":"Function","description":" hydroxyethylthiazole kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" thiamin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"}],"pfams":[{"name":"HK","identifier":"PF02110"},{"name":"TMP-TENI","identifier":"PF02581"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTATTTACTAAGGAAGAAGTTGATTACTCATTATATCTGGTTACAGATTCTACCATGCTTCCACCGGGAACTACTTTATGTTCTCAGGTTGAAGCTGGGTTGAAAAATGGTGTAACGCTAGTTCAAATCCGTGAAAAGGATATTGAAACAAAAAATTTCGTTGCAGAGGCTTTAGAAGTTCAAAAAATATGTAAGAAGTACAATGTTCCACTTATTATCAATGACCGTATAGACGTCGCTATGGCAATTGACGCCGATGGGGTTCATGTGGGCCAGGACGATATGCCAATCCCAATGGTAAGAAAACTTTTGGGCCCTTCTAAAATTCTTGGATGGAGTGTTGGTAAACCTTCGGAGGTAGAGACATTGGCTAAATGGGGGCCAGATATGGTAGATTATATTGGTGTTGGTACTCTTTTCCCTACATCAACAAAGAAAAATCCTAAGAAATCACCCATGGGTCCTCAAGGCGCCATTGCCATTTTGGATGCTTTGGAGGAATTTAAAGCTACATGGTGTAGAACCGTTGGTATTGGTGGTCTTCATCCTGACAATATTCAACGTGTGCTTTGTCAATGTGTTGCTTCAAATGGAAAGAGATCGTTGGATGGTATCTCTCTAGTCAGCGATATTATGGCCGCTCCAGATGCATGTGCAGCAACCAAGAGGTTGAGAGGCTTGTTAGATGCTACCAGATACCAATTTGTTGAGTGCGAGTTAAATAATACATTTCCGACCACAACTTCAATTCAAAACGTTATATCTCAAGTATCAAACAATCGTCCATTAGTGCAACATATCACCAATAAGGTTCATCAAAATTTTGGTGCCAATGTCACTCTAGCTTTAGGCTCATCTCCTATCATGTCTGAAATTGAAAGTGAAGTATCTGAACTAGCAAGAATCCCAAATGCTTCTTTACTGTTAAATACCGGATCAGTGGCACCTATTGAAATGCTAAAAGCCGCAATTAATGCTTATAATGAAGTAAATAGACCCATCACCTTTGACCCGGTCGGGTACAGCGCCACTGAAACAAGGCTCTGTCTAAACAACACTTTGCTCACTTACGGCCAATTTGCTTGTATAAAGGGCAATTGCAGTGAAATACTGTCTCTAGCCAAGTTAAATAACCATAAAATGAAGGGCGTCGACTCTAGCAGCGGCAAAACGAACATCGACACACTTGTGCGCGCTACACAAATTGTGGCATTCCAATACAGGACTGTTGCTGTTTGCACGGGTGAGTTTGATTGCGTTGCTGATGGTACTTTTGGAGGCGAATACAAACTTTCATCAGGAACAGAAGGAATAACCGCTGAAGATCTTCCATGTGTAATAATTGAAGATGGCCCAATTCCTATCATGGGTGACATCACTGCAAGTGGATGTTCACTTGGTTCTACAATTGCTTCCTTTATCGGTGGGTTAGATTCCACTGGAAAACTGTTTGATGCTGTGGTTGGTGCTGTCCTATTATACAAATCAGCTGGTAAGTTGGCTTCCACCCGTTGTCAAGGAAGTGGTTCATTCCATGTCGAATTGATTGACGCATTATATCAATTATTCCATGAAAATAAACCAGAAAAGTGGTCCGCTTCTTTGAAGAAATTCAAATAA","protein_sequence":"MVFTKEEVDYSLYLVTDSTMLPPGTTLCSQVEAGLKNGVTLVQIREKDIETKNFVAEALEVQKICKKYNVPLIINDRIDVAMAIDADGVHVGQDDMPIPMVRKLLGPSKILGWSVGKPSEVETLAKWGPDMVDYIGVGTLFPTSTKKNPKKSPMGPQGAIAILDALEEFKATWCRTVGIGGLHPDNIQRVLCQCVASNGKRSLDGISLVSDIMAAPDACAATKRLRGLLDATRYQFVECELNNTFPTTTSIQNVISQVSNNRPLVQHITNKVHQNFGANVTLALGSSPIMSEIESEVSELARIPNASLLLNTGSVAPIEMLKAAINAYNEVNRPITFDPVGYSATETRLCLNNTLLTYGQFACIKGNCSEILSLAKLNNHKMKGVDSSSGKTNIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFGGEYKLSSGTEGITAEDLPCVIIEDGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDAVVGAVLLYKSAGKLASTRCQGSGSFHVELIDALYQLFHENKPEKWSASLKKFK"},{"created_at":"2011-05-27T05:17:24.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Constitutive acid phosphatase","uniprot_id":"P24031","uniprot_name":"PPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO3","num_residues":467,"molecular_weight":"52776.10156","theoretical_pi":"4.21","general_function":"Involved in acid phosphatase activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1997,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1999,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14442,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006956","source":"Smpdb"}],"signal_regions":"1-17","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"X01080","genbank_protein_id":"758280","gene_card_id":"PHO3","chromosome_location":"chromosome 2","locus":"YBR092C","synonyms":[],"enzyme_classes":["3.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTAAATCTGTTGTTTATTCAATTTTAGCCGCTTCTTTGGCCAATGCAGGTACCATTCCCTTAGGCAAACTAGCCGATGTCGACAAGATTGGTACCCAAAAAGATATCTTCCCATTTTTGGGTGGTGCCGGACCATACTACTCTTTCCCTGGCGACTATGGTATTTCTCGTGATTTGCCTGAAGGTTGTGAAATGAAGCAACTGCAAATGGTTGGTAGACATGGTGAAAGATACCCTACTGTCAGTCTGGCTAAGACTATCAAGAGTACATGGTATAAGTTGAGCAATTACACTCGTCAATTCAACGGCTCATTGTCATTCTTGAACGATGATTACGAGTTTTTCATCCGTGATGACGATGATTTGGAAATGGAAACCACTTTTGCCAACTCGGACGATGTTTTGAACCCATACACTGGTGAAATGAACGCCAAGAGACATGCTCGTGACTTCTTGGCTCAATACGGTTACATGGTCGAAAACCAAACCAGTTTCGCCGTTTTTACCTCTAATTCTAAGAGATGTCATGACACTGCTCAATATTTCATTGATGGTTTAGGTGACCAATTCAACATCACCTTGCAGACTGTCAGTGAAGCTGAATCCGCTGGTGCCAACACTTTGAGTGCTTGTAACTCATGTCCTGCTTGGGACTACGATGCCAATGATGACATTGTAAATGAATACGACACAACCTACTTGGATGACATTGCCAAGAGATTGAACAAGGAAAACAAGGGTTTGAACTTGACCTCAACTGACGCTAGTACTTTATTCTCGTGGTGTGCATTTGAAGTGAACGCTAAAGGTTACAGTGATGTCTGTGATATTTTCACCAAGGATGAATTAGTCCATTACTCCTACTACCAAGACTTGCACACTTATTACCATGAGGGTCCAGGTTACGACATTATCAAGTCTGTCGGTTCCAACTTGTTCAATGCCTCAGTCAAATTATTAAAGCAAAGTGAGATTCAAGACCAAAAGGTTTGGTTGAGTTTTACCCACGATACCGATATCCTAAACTTTTTGACCACCGCTGGTATAATTGACGACAAAAACAACTTAACTGCCGAATACGTTCCATTCATGGGCAACACTTTCCACAGATCCTGGTACGTTCCTCAAGGTGCTCGTGTCTACACCGAAAAATTCCAATGTTCTAACGACACCTACGTCAGATACGTCATTAACGATGCTGTTGTTCCAATTGAAACCTGTTCCACTGGTCCAGGGTTCTCTTGTGAAATCAATGACTTCTACGACTATGCTGAAAAGAGAGTAGCCGGTACTGACTTCCTAAAGGTCTGTAACGTCAGCAGCGTCAGTAACTCTACTGAATTGACCTTCTACTGGGACTGGAACACTACTCATTACAACGCCAGTCTATTGAGACAATAG","protein_sequence":"MFKSVVYSVLAAALVNAGTIPLGELADVAKIGTQEDIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDDYEFFIRDDDDLEMETTFANSDNVLNPYTGEMDAKRHAREFLAQYGYMFENQTSFPIFAASSERVHDTAQYFIDGLGDQFNISLQTVSEAMSAGANTLSAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGYSDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQSETQDLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYVPFMGNTFHKSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNVTELTFYWDWNTTHYNDTLLKQ"},{"created_at":"2011-05-27T11:36:01.000Z","updated_at":"2011-05-27T15:01:33.000Z","name":"Acid phosphatase PHO12","uniprot_id":"P38693","uniprot_name":"PPAC_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO12","num_residues":467,"molecular_weight":"52699.30078","theoretical_pi":"4.77","general_function":"Involved in acid phosphatase activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14442,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006956","source":"Smpdb"}],"signal_regions":"1-17","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U00029","genbank_protein_id":"458917","gene_card_id":"PHO12","chromosome_location":"chromosome 8","locus":"YHR215W","synonyms":[],"enzyme_classes":["3.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTGAAGTCAGCCGTTTATTCAATTTTAGCCGCTTCTTTGGTTAATGCAGGTACCATACCCCTCGGAAAGTTATCTGACATTGACAAAATCGGAACTCAAACGGAAATTTTCCCATTTTTGGGTGGTTCTGGGCCATACTACTCTTTCCCTGGTGATTATGGTATTTCTCGTGATTTGCCGGAAAGTTGTGAAATGAAGCAAGTGCAAATGGTTGGTAGACACGGTGAAAGATACCCCACTGTCAGCAAAGCCAAAAGTATCATGACAACGTGGTACAAATTGAGTAACTATACCGGTCAATTCAGCGGAGCATTGTCTTTCTTGAACGATGACTACGAATTTTTCATTCGTGACACCAAAAACCTAGAAATGGAAACCACACTTGCCAATTCGGTCAATGTTTTGAACCCATATACCGGTGAGATGAATGCTAAGAGACACGCTCGTGATTTCTTGGCGCAATATGGCTACATGGTCGAAAACCAAACCAGTTTTGCCGTTTTTACGTCTAACTCGAACAGATGTCATGATACTGCCCAGTATTTCATTGACGGTTTGGGTGATAAATTCAACATATCCTTGCAAACCATCAGTGAAGCCGAGTCTGCTGGTGCCAATACTCTGAGTGCCCACCATTCGTGTCCTGCTTGGGACGATGATGTCAACGATGACATTTTGAAAAAATATGATACCAAATATTTGAGTGGTATTGCCAAGAGATTAAACAAGGAAAACAAGGGTTTGAATCTGACTTCAAGTGATGCAAACACTTTTTTTGCATGGTGTGCATATGAAATAAACGCTAGAGGTTACAGTGACATCTGTAACATCTTCACCAAAGATGAATTGGTCCGTTTCTCCTACGGCCAAGACTTGGAAACTTATTATCAAACGGGACCAGGCTATGACGTCGTCAGATCCGTCGGTGCCAACTTGTTCAACGCTTCAGTGAAACTACTAAAGGAAAGTGAGGTCCAGGACCAAAAGGTTTGGTTGAGTTTCACCCACGATACCGATATTCTGAACTATTTGACCACTATCGGCATAATCGATGACCAAAATAACTTGACCGCCGAACATGTTCCATTCATGGAAAACACTTTCCACAGATCCTGGTACGTTCCACAAGGTGCTCGTGTTTACACTGAAAAGTTCCAGTGTTCCAATGACACCTATGTTAGATACGTCATCAACGATGCTGTCGTTCCAATTGAAACCTGTTCTACTGGTCCAGGGTTCTCTTGTGAAATAAATGACTTCTACGGCTATGCTGAAAAGAGAGTAGCCGGTACTGACTTCCTAAAGGTCTGTAACGTCAGCAGCGTCAGTAACTCTACTGAATTGACCTTTTTCTGGGACTGGAATACCAAGCACTACAACGACACTTTATTAAAACAGTAA","protein_sequence":"MLKSAVYSILAASLVNAGTIPLGKLSDIDKIGTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDDYEFFIRDTKNLEMETTLANSVNVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKFNISLQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFMENTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYGYAEKRVAGTDFLKVCNVSSVSNSTELTFFWDWNTKHYNDTLLKQ"}]}