{"ymdb_id":"YMDB00117","created_at":"2011-05-29T15:58:35.000Z","updated_at":"2016-09-08T18:35:03.000Z","name":"4-amino-2-methyl-5-diphosphomethylpyrimidine","cas":null,"state":null,"melting_point":null,"description":"4-Amino-2-methyl-5-diphosphomethylpyrimidine is an intermediate in thiamine biosynthesis. [Biocyc THISYNARA-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"16629","hmdb_id":null,"kegg_id":"C04752","pubchem_id":"217","cs_id":"212","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"({hydroxy[(6-imino-2-methyl-1,6-dihydropyrimidin-5-yl)methoxy]phosphoryl}oxy)phosphonic acid","traditional_iupac":"[hydroxy((4-imino-2-methyl-3H-pyrimidin-5-yl)methoxy)phosphoryl]oxyphosphonic acid","logp":"-2.3882973783585157","pka":"3.3174428510223133","alogps_solubility":"6.42e+00 g/l","alogps_logp":"-0.59","alogps_logs":"-1.67","acceptor_count":"8","donor_count":"5","rotatable_bond_count":"5","polar_surface_area":"161.53","refractivity":"69.6993","polarizability":"23.48431432022145","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"1.7078904884347232","pka_strongest_acidic":"2.6101858140652507","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(4-amino-2-methylpyrimidin-5-yl)methyl diphosphate","2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate","4-Amino-2-methyl-5-diphosphomethylpyrimidine"],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10383756,"citation":"Llorente, B., Fairhead, C., Dujon, B. (1999). \"Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway.\" Mol Microbiol 32:1140-1152."}],"proteins":[{"created_at":"2011-05-26T20:54:30.000Z","updated_at":"2011-05-27T15:01:10.000Z","name":"Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21","uniprot_id":"Q08975","uniprot_name":"THI21_YEAST","enzyme":true,"transporter":false,"gene_name":"THI21","num_residues":551,"molecular_weight":"61333.69922","theoretical_pi":"5.77","general_function":"Involved in phosphomethylpyrimidine kinase activity","specific_function":"Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probaby that of HMP to HMP- P","reactions":[{"id":1650,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1877,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2601,"direction":"\u003e","locations":"","altext":"ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":2602,"direction":"\u003e","locations":"","altext":"ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":14435,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006949","source":"Smpdb"},{"id":14436,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006950","source":"Smpdb"},{"id":14437,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006951","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z73614","genbank_protein_id":"1370532","gene_card_id":"THI21","chromosome_location":"chromosome 16","locus":"YPL258C","synonyms":["Hydroxymethylpyrimidine kinase","HMP kinase","Hydroxymethylpyrimidine phosphate kinase","HMP-P kinase","HMP-phosphate kinase","HMPP kinase"],"enzyme_classes":["2.7.1.49","2.7.4.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphomethylpyrimidine kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" thiamin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"}],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"},{"name":"TENA_THI-4","identifier":"PF03070"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACCTATTCTACAGTTAATATTAATACACCTCCACCATATCTCGCTTTGGCCAGCAATGAAAAATTACCCACAGTTTTGTCTATTGCTGGAACAGATCCAAGCGGTGGTGCTGGTGTTGAAGCAGATGTGAAAACTATCACTGCACACAGATGCTATGCTATGACATGCATCACTGCTTTGAATGCTCAAACTCCAGTTAAAGTATACAGCATTAATAACACGCCAAAGGAAGTAGTTTCCCAAATTTTGGACGCCAATTTACAAGACATGAAATGTGACGTCATCAAGACTGGCATGCTTACGACAGCTGCTATCGAGGTTTTGCACGAAAAACTGCTGCAGCTCGGCGAAAATAGACCTAAGCTAGTAGTTGACCCAGTCCTTGTTGCTACTTCAGGCTCTTCTTTAGCTGGAAAGGATATAGCCAGTTTAATTACGGAGAAAATCGCACCTTTTGCTGACATTTTGACTCCTAACATTCCGGAGTGTTTCAAACTGTTAGGTGAAGACAGAGAAATAAGCAAATTGCGAGACATTTTCGAAGTCGCAAAAGACCTTGCCAAAATCACCAAGTGTTCCAATATTTTGGTTAAAGGTGGTCACATTCCATGGAATGATGAAGAAGGAAAGTACATCACTGATGTCCTTTACTTAGGGGCCGAACAAAGGTTTATAACCTTCAAGGGTAATTTTGTTAATACAACCCACACTCATGGTACCGGGTGCACCCTAGCTTCCGCCATTGCATCAAATTTGGCTCGCGGTTATTCCCTTCCCCAATCCGTTTATGGCGGTATTGAGTACGTCCAAAATGCGGTGGCCATTGGCTGCGATGTCACGAAAGAGACTGTTAAGGACAACGGGCCAATTAATCATGTCTACGCCATCGAAATTCCATTAGAAAAAATGCTCAGTGACGAATGTTTCACTGCATCAGATGCCGTACACAAAAAGCCAGTCAAAAGTTCTCTTAACAAAATCCCTGGAGGAAGTTTCTATAAATATCTGATAAATCACCCTAAAGTTAAGCCCCACTGGGACTCCTATGTGAACCATGATTTTGTTAGAAAAGTAGCAGACGGTTCCTTAGAGCCTAAGAAGTTCCAATTTTTTATCGAACAAGATTACCTGTACTTAGTCAATTATGCCAGGATTTCCTGCATCGCGGGTAGTAAATCCCCGTGTCTTGAAGACCTGGAGAAAGAGCTAGTTATTGTCGAATGCGTTCGTAATGGGCTTTGCCAACATGAAAGGAGATTAAGGGAGGAATTTGGAATTAAGGATCCCGACTACTTACAAAAGATTCAAAGAGGTCCTGCATTAAGGGCTTACTGTCGTTACTTTAATGATGTTTCCAGAAGAGGTAACTGGCAGGAGTTAGTTATAGCTCTTAATCCTTGCTTAATGGGCTATGTTCACGCTTTGACCAAGATCAAGGATGAAGTAACTGCAGCAGAAGGCTCCGTTTACCGTGAATGGTGTGAAACTTACTCATCGTCATGGTGCCACGAAGCTATGCTTGAAGGCGAAAAGCTGTTGAATCACATCTTGGAAACATACCCTCCAGAAAAACTTGATACACTGGTCACAATATATGCTGAAGTTTGTGAATTGGAAGCTAACTTCTGGACCGCCGCTCTAGAATATGAATGA","protein_sequence":"MTYSTVNINTPPPYLALASNEKLPTVLSIAGTDPSGGAGVEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVSQILDANLQDMKCDVIKTGMLTTAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIASLITEKIAPFADILTPNIPECFKLLGEDREISKLRDIFEVAKDLAKITKCSNILVKGGHIPWNDEEGKYITDVLYLGAEQRFITFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAIEIPLEKMLSDECFTASDAVHKKPVKSSLNKIPGGSFYKYLINHPKVKPHWDSYVNHDFVRKVADGSLEPKKFQFFIEQDYLYLVNYARISCIAGSKSPCLEDLEKELVIVECVRNGLCQHERRLREEFGIKDPDYLQKIQRGPALRAYCRYFNDVSRRGNWQELVIALNPCLMGYVHALTKIKDEVTAAEGSVYREWCETYSSSWCHEAMLEGEKLLNHILETYPPEKLDTLVTIYAEVCELEANFWTAALEYE"},{"created_at":"2011-05-26T21:07:14.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Hydroxymethylpyrimidine/phosphomethylpyrimidine 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4-amino-2-methyl-5-diphosphomethylpyrimidine.","export":false,"pw_reaction_id":null,"source":null},{"id":2603,"direction":"\u003e","locations":null,"altext":"thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.","export":false,"pw_reaction_id":null,"source":null},{"id":14435,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006949","source":"Smpdb"},{"id":14436,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006950","source":"Smpdb"},{"id":14437,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006951","source":"Smpdb"},{"id":14438,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006952","source":"Smpdb"},{"id":14439,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006955","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692780","genbank_protein_id":"51013011","gene_card_id":"THI20","chromosome_location":"chromosome 15","locus":"YOL055C","synonyms":["Hydroxymethylpyrimidine kinase","HMP 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metabolic process"}],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"},{"name":"TENA_THI-4","identifier":"PF03070"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACCTATTCTACAGTTAGCATCAACACGCCTCCACCATATCTTACTTTAGCCTGCAACGAAAAGTTGCCAACAGTTTTATCCATTGCTGGAACAGATCCAAGTGGTGGAGCCGGTATCGAAGCTGATGTCAAAACTATCACAGCACACAGATGTTATGCCATGACATGTATCACTGCTTTAAATGCTCAAACTCCAGTTAAAGTCTACAGCATAAATAACACACCAAAAGAAGTGGTTTTCCAAACTTTGGAATCCAATTTAAAGGATATGAAATGTAATGTTATCAAAACCGGTATGCTTACCGCAGCTGCTATCGAAGTCTTGCACGAAAAACTGCTGCAACTCGGCGAAAATAGACCTAAGTTGGTTGTTGATCCAGTTCTTGTCGCTACTTCTGGTTCTTCTTTAGCTGGAAAGGATATAGTTAGTTTGATTACGGAGAAGGTTGCACCTTTTGCTGATATTTTGACTCCTAACATCCCAGAGTGTTACAAATTGTTAGGTGAGGAAAGAAAGGTTAACGGATTACAGGATATTTTCCAAATCGCAAAAGACCTTGCTAAAATAACCAAGTGTTCGAATATACTAGTGAAGGGTGGCCATATTCCATGGAATGATGAAAAGGAAAAGTACATTACCGACGTTCTTTTCTTGGGTGCTGAACAAAAATTCATTATCTTTAAAGGCAATTTCGTTAACACCACGCATACACATGGTACTGGGTGCACACTAGCTTCTGCCATTGCATCAAACTTGGCTCGTGGTTATTCTCTTCCTCAGTCTGTTTATGGTGGTATTGAATACGTCCAAAATGCCGTGGCAATTGGTTGTGATGTCACAAAAGAAACTGTCAAGGATAATGGACCAATTAATCATGTTTACGCCGTGGAAATTCCATTGGAGAAAATGCTCAGTGATGAATGTTTTACTGCATCAGATGTTATACCTAAAAAGCCGCTCAAAGGTGCTGCTGACAAAATCCCAGGCGGTAATTTCTATGAATACCTGATCAATCACCCTAAAGTTAAGCCACACTGGGATTCCTATATTAACCATGAGTTTGTTAAAAAGGTTGCGGACGGTACATTAGAACGTAAGAAGTTTCAGTTCTTTATTGAACAAGATTATGCATACTTGGTTGATTATGCTAGAGTTCATTGTATCGCGGGTAGTAAAGCTCCATGCCTAGAAGATATGGAAAAGGAGCTAGTCATTGTTGGAGGTGTTCGTACTGAAATGGGTCAACATGAAAAGAGATTAAAAGAAGTATTTGGTGTTAAAGATCCTGATTACTTTCAAAAGATTAAGAGAGGACCTGCATTAAGAGCTTACTCTCGTTACTTTAACGATGTTTCCAGAAGAGGTAACTGGCAAGAATTGGTTGCATCCCTTACTCCTTGTTTGATGGGTTATGGTGAAGCTTTAACTAAAATGAAGGGTAAAGTCACCGCACCTGAAGGGTCCGTTTACCACGAATGGTGTGAAACTTACGCATCTTCATGGTATCGTGAAGCCATGGATGAAGGTGAAAAACTTTTGAACCACATCTTAGAAACATACCCTCCAGAGCAACTTGACACTTTAGTAACAATCTACGCTGAAGTTTGTGAATTAGAAACAAATTTTTGGACCGCTGCGCTAGAATACGAGTAG","protein_sequence":"MTYSTVSINTPPPYLTLACNEKLPTVLSIAGTDPSGGAGIEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVFQTLESNLKDMKCNVIKTGMLTAAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIVSLITEKVAPFADILTPNIPECYKLLGEERKVNGLQDIFQIAKDLAKITKCSNILVKGGHIPWNDEKEKYITDVLFLGAEQKFIIFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAVEIPLEKMLSDECFTASDVIPKKPLKSAADKIPGGNFYEYLINHPKVKPHWDSYINHEFVKKVADGTLERKKFQFFIEQDYAYLVDYARVHCIAGSKAPCLEDMEKELVIVGGVRTEMGQHEKRLKEVFGVKDPDYFQKIKRGPALRAYSRYFNDVSRRGNWQELVASLTPCLMGYGEALTKMKGKVTAPEGSVYHEWCETYASSWYREAMDEGEKLLNHILETYPPEQLDTLVTIYAEVCELETNFWTAALEYE"},{"created_at":"2011-05-27T00:33:49.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Thiamine biosynthetic bifunctional enzyme","uniprot_id":"P41835","uniprot_name":"THI6_YEAST","enzyme":true,"transporter":false,"gene_name":"THI6","num_residues":540,"molecular_weight":"58058.19922","theoretical_pi":"5.74","general_function":"Involved in catalytic activity","specific_function":"Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole","reactions":[{"id":1646,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2003,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2621,"direction":"\u003e","locations":null,"altext":"2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2622,"direction":"\u003e","locations":null,"altext":"ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.","export":false,"pw_reaction_id":null,"source":null},{"id":14440,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006953","source":"Smpdb"},{"id":14441,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006954","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D31908","genbank_protein_id":"633125","gene_card_id":"THI6","chromosome_location":"chromosome 16","locus":"YPL214C","synonyms":["Thiamine-phosphate pyrophosphorylase","TMP pyrophosphorylase","TMP-PPASE","Hydroxyethylthiazole kinase","4-methyl-5-beta-hydroxyethylthiazole kinase","TH kinase","THZ kinase"],"enzyme_classes":["2.5.1.3","2.7.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" thiamin-phosphate diphosphorylase activity"},{"category":"Function","description":" hydroxyethylthiazole kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" thiamin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"}],"pfams":[{"name":"HK","identifier":"PF02110"},{"name":"TMP-TENI","identifier":"PF02581"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTATTTACTAAGGAAGAAGTTGATTACTCATTATATCTGGTTACAGATTCTACCATGCTTCCACCGGGAACTACTTTATGTTCTCAGGTTGAAGCTGGGTTGAAAAATGGTGTAACGCTAGTTCAAATCCGTGAAAAGGATATTGAAACAAAAAATTTCGTTGCAGAGGCTTTAGAAGTTCAAAAAATATGTAAGAAGTACAATGTTCCACTTATTATCAATGACCGTATAGACGTCGCTATGGCAATTGACGCCGATGGGGTTCATGTGGGCCAGGACGATATGCCAATCCCAATGGTAAGAAAACTTTTGGGCCCTTCTAAAATTCTTGGATGGAGTGTTGGTAAACCTTCGGAGGTAGAGACATTGGCTAAATGGGGGCCAGATATGGTAGATTATATTGGTGTTGGTACTCTTTTCCCTACATCAACAAAGAAAAATCCTAAGAAATCACCCATGGGTCCTCAAGGCGCCATTGCCATTTTGGATGCTTTGGAGGAATTTAAAGCTACATGGTGTAGAACCGTTGGTATTGGTGGTCTTCATCCTGACAATATTCAACGTGTGCTTTGTCAATGTGTTGCTTCAAATGGAAAGAGATCGTTGGATGGTATCTCTCTAGTCAGCGATATTATGGCCGCTCCAGATGCATGTGCAGCAACCAAGAGGTTGAGAGGCTTGTTAGATGCTACCAGATACCAATTTGTTGAGTGCGAGTTAAATAATACATTTCCGACCACAACTTCAATTCAAAACGTTATATCTCAAGTATCAAACAATCGTCCATTAGTGCAACATATCACCAATAAGGTTCATCAAAATTTTGGTGCCAATGTCACTCTAGCTTTAGGCTCATCTCCTATCATGTCTGAAATTGAAAGTGAAGTATCTGAACTAGCAAGAATCCCAAATGCTTCTTTACTGTTAAATACCGGATCAGTGGCACCTATTGAAATGCTAAAAGCCGCAATTAATGCTTATAATGAAGTAAATAGACCCATCACCTTTGACCCGGTCGGGTACAGCGCCACTGAAACAAGGCTCTGTCTAAACAACACTTTGCTCACTTACGGCCAATTTGCTTGTATAAAGGGCAATTGCAGTGAAATACTGTCTCTAGCCAAGTTAAATAACCATAAAATGAAGGGCGTCGACTCTAGCAGCGGCAAAACGAACATCGACACACTTGTGCGCGCTACACAAATTGTGGCATTCCAATACAGGACTGTTGCTGTTTGCACGGGTGAGTTTGATTGCGTTGCTGATGGTACTTTTGGAGGCGAATACAAACTTTCATCAGGAACAGAAGGAATAACCGCTGAAGATCTTCCATGTGTAATAATTGAAGATGGCCCAATTCCTATCATGGGTGACATCACTGCAAGTGGATGTTCACTTGGTTCTACAATTGCTTCCTTTATCGGTGGGTTAGATTCCACTGGAAAACTGTTTGATGCTGTGGTTGGTGCTGTCCTATTATACAAATCAGCTGGTAAGTTGGCTTCCACCCGTTGTCAAGGAAGTGGTTCATTCCATGTCGAATTGATTGACGCATTATATCAATTATTCCATGAAAATAAACCAGAAAAGTGGTCCGCTTCTTTGAAGAAATTCAAATAA","protein_sequence":"MVFTKEEVDYSLYLVTDSTMLPPGTTLCSQVEAGLKNGVTLVQIREKDIETKNFVAEALEVQKICKKYNVPLIINDRIDVAMAIDADGVHVGQDDMPIPMVRKLLGPSKILGWSVGKPSEVETLAKWGPDMVDYIGVGTLFPTSTKKNPKKSPMGPQGAIAILDALEEFKATWCRTVGIGGLHPDNIQRVLCQCVASNGKRSLDGISLVSDIMAAPDACAATKRLRGLLDATRYQFVECELNNTFPTTTSIQNVISQVSNNRPLVQHITNKVHQNFGANVTLALGSSPIMSEIESEVSELARIPNASLLLNTGSVAPIEMLKAAINAYNEVNRPITFDPVGYSATETRLCLNNTLLTYGQFACIKGNCSEILSLAKLNNHKMKGVDSSSGKTNIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFGGEYKLSSGTEGITAEDLPCVIIEDGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDAVVGAVLLYKSAGKLASTRCQGSGSFHVELIDALYQLFHENKPEKWSASLKKFK"},{"created_at":"2011-05-27T02:10:54.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Thiamine biosynthesis protein THI22","uniprot_id":"Q06490","uniprot_name":"THI22_YEAST","enzyme":true,"transporter":false,"gene_name":"THI22","num_residues":572,"molecular_weight":"63306.39844","theoretical_pi":"5.81","general_function":"Coenzyme transport and metabolism","specific_function":"Essential for thiamine biosynthesis","reactions":[{"id":1650,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1877,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"1-19","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Secreted (Potential)","genbank_gene_id":"U40828","genbank_protein_id":"1066472","gene_card_id":"THI22","chromosome_location":"chromosome 16","locus":"YPR121W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Phos_pyr_kin","identifier":"PF08543"},{"name":"TENA_THI-4","identifier":"PF03070"}],"pathways":[],"gene_sequence":"ATGGTTATCATCCTCCTAGGTCTTTGCACATTAGGTTTTCCAAGAACAGCATTCTGTCCCTCCATAATGACAAATTCTACAGTGAGTATTAACACGCCTCCACCATATCTTACTCTAGCTTGTAATGAAAAATTACCAACAGTTATGTCAATTGCTGGATCAGACTCAAGTGGTGGAGCCGGTGTTGAAGCTGATATTAAGACTATCACCGCACACAGATGTTATGCCATGACATGCGTCACTACTTTGACTGCTCAAACTCCAGTGAAGGTGTACGGCGCTCATAATATACCAAAGAAAATGGTATCTCAAATATTAGACGCCAATTTACAGGACATGAAATGTAATGTTATTAAGACTGGCATGCTTACGGTGGATGCAATCGAAGTCTTGCACGAAAAACTTTTGCAACTTGGTGAAAATAGACCCAAGTTAGTAATTGATCCAGTTCTTTGCGCCGCTTCTGACTCTTCTCCAACTGGAAAGGATGTGGTTAGCTTAATCATAGAAAAAATTTCTCCTTTTGCCGACATTTTAACTCCTAACATTTCAGACTGTTTCATGTTACTGGGCGAGAACAGAGAAGTTAGCAAACTACAAGACGTTCTTGAAATCGCGAAAGACCTTTCTAGAATCACCAATTGCTCCAATATTTTAGTGAAGGGAGGCCACATTCCATGTGACGATGGAAAAGAAAAGCATATTACTGACGTTCTTTACTTAGGTGCTGAACAAAAATTCATCACTTTTAAGGGCCAATTCGTTAATACTACACGCACTCATGGCGCTGGATGCACACTGGCTTCTGCTATAGCATCTAACTTGGCTCGCGGTTATTCTCTTTCCCAATCTGTTTATGGTGGTATTGAGTATGTACAGAATGCCATCGCAATTGGCTGTGACGTTACCAAGAAAGCTGTGAAGGTTGGACCAATTAATCACGTTTACGCCGTAGAGATTCCATTAGAAAAAATGCTCACCGACGAATGCTTTACAGCATCTGATGCTGTACCTAAGAAGCCAATCGAAGGTTCTCTTGACAAAATCCCTGGGGGTAGCTTCTTTAATTATCTGATAAATCATCCTAAAGTCAAGCCGCATTGGGATGCCTACGTGAATCACGAATTTGTTAAAAGAGTGGCAGACGGCACATTGGAACGCAAAAAGTTCCAGTTTTTTATTGAACAAGATTATTTATACTTAATTGATTATGTGAGAGTTTGCTGCGTCACAGGTAGTAAATCTCCAACTCTAGAAGATCTAGAAAAGGACCTTGTTATTGCTGATTGCGCCCGTAATGAACTAAATGAACATGAAAGAAGATTAAGAGAAGAATTTGGAGTTAAGGACCCAGATTACTTACAAAAAATTAAGAGAGGTCCCGCATTAAGGGCCTACTGTCGTTACCTAATTGACATTTCCAGAAGAGGAAACTGGCAAGAAATAGTTGTAGCCCTCAACCCTTGTCTAATGGGTTATGTTTATGCTGTAGACAAAGTTAAGGATAAGATAACAGCAGCAGAGGGTTCTATTTATAGTGAATGGTGTGATACTTGCGCGTCTTCATTTTGCTACCAAGCTGTGCTTGAAGGTGAAAGGCTCATGAATCACATCTTGGAAACATATCCTCCAGATCAACTTGATTCTTTGGTGACGATCTTTGCAAGAGGTTGTGAATTAGAAACTAATTTCTGGACCGCCGCCATGGAATACGAATGA","protein_sequence":"MVIILLGLCTLGFPRTAFCPSIMTNSTVSINTPPPYLTLACNEKLPTVMSIAGSDSSGGAGVEADIKTITAHRCYAMTCVTTLTAQTPVKVYGAHNIPKKMVSQILDANLQDMKCNVIKTGMLTVDAIEVLHEKLLQLGENRPKLVIDPVLCAASDSSPTGKDVVSLIIEKISPFADILTPNISDCFMLLGENREVSKLQDVLEIAKDLSRITNCSNILVKGGHIPCDDGKEKHITDVLYLGAEQKFITFKGQFVNTTRTHGAGCTLASAIASNLARGYSLSQSVYGGIEYVQNAIAIGCDVTKKAVKVGPINHVYAVEIPLEKMLTDECFTASDAVPKKPIEGSLDKIPGGSFFNYLINHPKVKPHWDAYVNHEFVKRVADGTLERKKFQFFIEQDYLYLIDYVRVCCVTGSKSPTLEDLEKDLVIADCARNELNEHERRLREEFGVKDPDYLQKIKRGPALRAYCRYLIDISRRGNWQEIVVALNPCLMGYVYAVDKVKDKITAAEGSIYSEWCDTCASSFCYQAVLEGERLMNHILETYPPDQLDSLVTIFARGCELETNFWTAAMEYE"}]}