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Identification |
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Name | Catabolic L-serine/threonine dehydratase |
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Synonyms | - L-serine dehydratase
- L-serine deaminase
- L-threonine dehydratase
- L-threonine deaminase
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Gene Name | CHA1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in catalytic activity |
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Specific Function | L-serine = pyruvate + NH(3) |
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Cellular Location | Mitochondrion |
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SMPDB Pathways | |
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KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | | Valine, leucine and isoleucine biosynthesis | ec00290 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00071 | 2-Ketobutyric acid | Show | YMDB00091 | Ammonia | Show | YMDB00112 | L-Serine | Show | YMDB00175 | Pyruvic acid | Show | YMDB00214 | L-Threonine | Show | YMDB00423 | Ammonium | Show | YMDB00862 | hydron | Show | YMDB00890 | water | Show | YMDB16258 | 2-aminoprop-2-enoate | Show |
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GO Classification | Component |
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Not Available | Function |
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binding | cofactor binding | pyridoxal phosphate binding | catalytic activity | Process |
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cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process | metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 3 |
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Locus | YCL064C |
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Gene Sequence | >1083 bp
ATGTCGATAGTCTACAATAAAACACCATTATTACGTCAATTCTTCCCCGGAAAGGCTTCT
GCACAATTTTTCTTGAAATATGAATGCCTTCAACCAAGTGCCTCCTTCAAAAGTAGAGGA
ATCGGTAATCTCATCATGAAAAGTGCCATTCGAATTCAAAAGGACGGTAAAAGATCTCCT
CAGGTTTTCGCTAGTTCTGGCGGTAATGCCGGTTTTGCTGCTGCAACAGCATGTCAAAGA
CTGTCTCTACCATGTACAGTCGTGGTTCCTACAGCGACAAAGAAGAGAATGGTAGATAAA
ATCAGGAACACCGGTGCCCAGGTTATCGTGAGTGGTGCCTACTGGAAAGAAGCAGATACT
TTTTTAAAAACAAATGTCATGAATAAAATAGACTCTCAGGTCATTGAGCCCATTTATGTT
CATCCCTTCGATAATCCGGATATTTGGGAAGGACATTCATCTATGATAGATGAAATAGTA
CAAGATTTGAAATCGCAACATATTTCCGTAAATAAGGTTAAAGGCATAGTATGCAGCGTT
GGTGGAGGTGGTTTATACAATGGTATTATTCAAGGTTTGGAAAGGTATGGTTTAGCTGAT
AGGATCCCTATTGTGGGGGTGGAAACGAATGGATGTCATGTTTTCAATACTTCTTTGAAA
ATAGGCCAACCAGTTCAATTCAAGAAGATAACAAGTATTGCTACTTCTCTAGGAACGGCC
GTGATCTCTAATCAAACTTTCGAATACGCTCGCAAATACAACACCAGATCCGTTGTAATA
GAGGACAAAGATGTGATTGAACCCTGTCTTAAATATACACATCAATTCAATATGGTGATT
GAACCGGCATGTGGCGCCGCATTGCATTTGGGTTACAACACTAAGATCCTAGAAAATGCA
CTGGGCTCAAAATTAGCTGCGGATGACATTGTGATAATTATTGCTTGTGCGAGCTCCTCT
AATACTATAAAGGACTTGGAAGAAGCGTTGGATAGCATGAGAAAAAAAGACACTCCTGTA
ATAGAAGTCGCTGACAATTTCATATTTCCAGAAAAAAATATTGTGAATTTAAAAAGTGCT
TGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 360 |
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Protein Molecular Weight | 39301.0 |
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Protein Theoretical pI | 9.01 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Catabolic L-serine/threonine dehydratase
MSIVYNKTPLLRQFFPGKASAQFFLKYECLQPSGSFKSRGIGNLIMKSAIRIQKDGKRSP
QVFASSGGNAGFAAATACQRLSLPCTVVVPTATKKRMVDKIRNTGAQVIVSGAYWKEADT
FLKTNVMNKIDSQVIEPIYVHPFDNPDIWEGHSSMIDEIVQDLKSQHISVNKVKGIVCSV
GGGGLYNGIIQGLERYGLADRIPIVGVETNGCHVFNTSLKIGQPVQFKKITSIATSLGTA
VISNQTFEYARKYNTRSVVIEDKDVIETCLKYTHQFNMVIEPACGAALHLGYNTKILENA
LGSKLAADDIVIIIACGGSSNTIKDLEEALDSMRKKDTPVIEVADNFIFPEKNIVNLKSA
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References |
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External Links | |
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General Reference | - Bornaes, C., Petersen, J. G., Holmberg, S. (1992). "Serine and threonine catabolism in Saccharomyces cerevisiae: the CHA1 polypeptide is homologous with other serine and threonine dehydratases." Genetics 131:531-539.1628804
- Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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