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Thioredoxin-2 (P22803)

Identification
NameThioredoxin-2
Synonyms
  • Thioredoxin II
  • TR-II
  • Thioredoxin-1
Gene NameTRX2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in electron carrier activity
Specific FunctionParticipates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress
Cellular LocationCytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
Adenosine triphosphate + thioredoxin dithiol → dATP + thioredoxin disulfide + water
thioredoxin dithiol + Cytidine triphosphate → thioredoxin disulfide + water + dCTP
GTP + thioredoxin dithiol → thioredoxin disulfide + water + dGTP
Uridine triphosphate + thioredoxin dithiol → thioredoxin disulfide + Deoxyuridine triphosphate + water
Metabolites
YMDB IDNameView
YMDB00109Adenosine triphosphateShow
YMDB00201Deoxyuridine triphosphateShow
YMDB00279Cytidine triphosphateShow
YMDB00326Uridine triphosphateShow
YMDB00426NADPHShow
YMDB00427NADPShow
YMDB00558GTPShow
YMDB00658dCTPShow
YMDB00700dATPShow
YMDB00744dGTPShow
YMDB00862hydronShow
YMDB00888Hydrogen peroxideShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
catalytic activity
oxidoreductase activity
electron carrier activity
oxidoreductase activity, acting on a sulfur group of donors
disulfide oxidoreductase activity
protein disulfide oxidoreductase activity
Process
metabolic process
small molecule metabolic process
cellular process
cellular homeostasis
cell redox homeostasis
organic ether metabolic process
glycerol ether metabolic process
Gene Properties
Chromosome Locationchromosome 7
LocusYGR209C
Gene Sequence>315 bp ATGGTCACTCAATTAAAATCCGCTTCTGAATACGACAGTGCTTTAGCATCTGGCGACAAG TTAGTCGTTGTTGACTTTTTTGCCACATGGTGTGGGCCATGTAAAATGATTGCACCAATG ATTGAAAAGTTTGCAGAACAATATTCTGACGCTGCTTTTTACAAGTTGGATGTTGATGAA GTCTCAGATGTTGCTCAAAAAGCTGAAGTTTCTTCCATGCCTACCCTAATCTTCTACAAG GGCGGTAAGGAGGTTACCAGAGTCGTCGGTGCCAACCCAGCTGCTATCAAGCAAGCTATT GCTTCCAACGTATAG
Protein Properties
Pfam Domain Function
Protein Residues104
Protein Molecular Weight11203.7998
Protein Theoretical pI4.54
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Thioredoxin-2 MVTQLKSASEYDSALASGDKLVVVDFFATWCGPCKMIAPMIEKFAEQYSDAAFYKLDVDE VSDVAQKAEVSSMPTLIFYKGGKEVTRVVGANPAAIKQAIASNV
References
External Links
ResourceLink
Saccharomyces Genome Database TRX2
Uniprot IDP22803
Uniprot NameTRX2_YEAST
GenBank Gene IDAY557817
Genebank Protein ID45269525
General Reference
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  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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