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Identification |
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Name | Histidine biosynthesis trifunctional protein |
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Synonyms | - Phosphoribosyl-AMP cyclohydrolase
- Phosphoribosyl-ATP pyrophosphohydrolase
- Histidinol dehydrogenase
- HDH
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Gene Name | HIS4 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in oxidoreductase activity |
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Specific Function | 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide |
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Cellular Location | Cytoplasmic |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00110 | NAD | Show | YMDB00143 | NADH | Show | YMDB00165 | Phosphoribosyl-ATP | Show | YMDB00219 | Pyrophosphate | Show | YMDB00317 | Phosphoribosyl-AMP | Show | YMDB00369 | L-Histidine | Show | YMDB00412 | NAD(+) | Show | YMDB00417 | 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide | Show | YMDB00702 | L-histidinol | Show | YMDB00862 | hydron | Show | YMDB00868 | 1-(5-phosphoribosyl)-5'-AMP | Show | YMDB00890 | water | Show | YMDB16235 | Histidinal | Show | YMDB16238 | PhosphoribosylformiminoAICAR-phosphate | Show | YMDB16274 | 1-(5-phosphoribosyl)-ATP | Show |
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GO Classification | Component |
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Not Available | Function |
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zinc ion binding | hydrolase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | oxidoreductase activity, acting on CH-OH group of donors | hydrolase activity, acting on acid anhydrides | binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | nucleotide binding | NAD or NADH binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | cyclohydrolase activity | ion binding | pyrophosphatase activity | cation binding | phosphoribosyl-ATP diphosphatase activity | metal ion binding | phosphoribosyl-AMP cyclohydrolase activity | transition metal ion binding | histidinol dehydrogenase activity | oxidoreductase activity | catalytic activity | Process |
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metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid metabolic process | histidine family amino acid metabolic process | histidine metabolic process | histidine biosynthetic process | oxidation reduction |
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Gene Properties |
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Chromosome Location | chromosome 3 |
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Locus | YCL030C |
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Gene Sequence | >2400 bp
ATGGTTTTGCCGATTCTACCGTTAATTGATGATCTGGCCTCATGGAATAGTAAGAAGGAA
TACGTTTCACTTGTTGGTCAGGTACTTTTGGATGGCTCGAGCCTGAGTAATGAAGAGATT
CTCCAGTTCTCCAAAGAGGAAGAAGTTCCATTGGTGCGTTTGTCCTTGCCAAGTGGTAAA
TTCAGCGATGATGAAATCATTGCCTTCTTGAACAACGGAGTTTCTTCTCTGTTCATTGCT
AGCCAAGATGCTAAAACAGCCGAACACTTGGTTGAACAATTGAATGTACCAAAGGAGCGT
GTTGTTGTGGAAGAGAACGGTGTTTTCTCCAATCAATTCATGGTAAAACAAAAATTCTCG
CAAGATAAAATTGTGTCCATAAAGAAATTAAGCAAGGATATGTTGACCAAAGAAGTGCTT
GGTGAAGTACGTACAGACCGTCCTGACGGTTTATATACCACCCTAGTTGTCGACCAATAT
GAGCGTTGTCTAGGGTTGGTGTATTCTTCGAAGAAATCTATAGCAAAGGCCATCGATTTG
GGTCGTGGCGTTTATTATTCTCGTTCTAGGAATGAAATCTGGATCAAGGGTGAAACTTCT
GGCAATGGCCAAAAGCTTTTACAAATCTCTACTGACTGTGATTCGGATGCCTTAAAGTTT
ATCGTTGAACAAGAAAACGTTGGATTTTGCCACTTGGAGACCATGTCTTGCTTTGGTGAA
TTCAAGCATGGTTTGGTGGGGCTAGAATCTTTACTAAAACAAAGGCTACAGGACGCTCCA
GAGGAATCTTATACTAGAAGACTATTCAACGACTCTGCATTGTTAGATGCCAAGATCAAG
GAAGAAGCTGAAGAACTGACTGAGGCAAAGGGTAAGAAGGAGCTTTCTTGGGAGGCTGCC
GATTTGTTCTACTTTGCACTGGCCAAATTAGTGGCCAACGATGTTTCATTGAAGGACGTC
GAGAATAATCTGAATATGAAGCATCTGAAGGTTACAAGACGGAAAGGTGATGCTAAGCCA
AAGTTTGTTGGACAACCAAAGGCTGAAGAAGAAAAACTGACCGGTCCAATTCACTTGGAC
GTGGTGAAGGCTTCCGACAAAGTTGGTGTGCAGAAGGCTTTGAGCAGACCAATCCAAAAG
ACTTCTGAAATTATGTATTTAGTCAATCCGATCATCGAAAATGTTAGAGACAAAGGTAAC
TCTGTTTTTTTGGAGTACACAGAAAAGTTTGATGGTGTAAAATTATCCAATCCTGTTCTT
AATGCTCCATTCCCAGAAGAATACTTTGAAGGTTTAACCGAGGAAATGAAGGAAGCTTTG
AACCTTTCAATTGAAAACGTCCGCAAATTCCATGCTGCTCAATTGCCAACAGAGACTCTT
GAAGTTGAAACCCAACCTGGTGTCTTGTGTTCCAGATTCCCTCGTCCTATTGAAAAAGTT
GGTTTGTATATCCCTGGTGGCACTGCCATTTTACCAAGTACTGCATTAATGCTTGGTGTT
CCAGCACAAGTTGCCCAATGTAAGGAGATTGTGTTTGCATCTCCACCAAGAAAATCTGAT
GGTAAAGTTTCACCCGAAGTTGTTTATGTCGCAGAAAAAGTTGGCGCTTCCAAGATTGTT
CTAGCTGGTGGTGCCCAAGCCGTTGCTGCTATGGCTTACGGGACAGAAACTATTCCTAAA
GTGGATAAGATCTTGGGTCCAGGTAATCAATTTGTGACTGCCGCCAAAATGTATGTTCAA
AATGACACTCAAGCTCTATGTTCCATTGATATGCCAGCTGGCCCAAGTGAAGTTTTGGTT
ATTGCCGATGAAGATGCCGATGTGGATTTTGTTGCAAGTGATTTGCTATCGCAAGCTGAA
CACGGTATTGACTCCCAAGTTATCCTTGTTGGTGTTAACTTGAGCGAAAAGAAAATTCAA
GAGATTCAAGATGCTGTTCACAATCAAGCTTTACAACTGCCACGTGTGGATATTGTTCGT
AAATGTATTGCTCACAGTACGATCGTTCTTTGTGACGGTTACGAAGAAGCCCTTGAAATG
TCCAACCAATATGCACCAGAACATTTGATTCTACAAATCGCCAATGCTAACGATTATGTT
AAATTGGTTGACAATGCAGGGTCCGTATTTGTGGGTGCTTACACTCCAGAATCGTGCGGT
GACTATTCAAGTGGTACTAACCATACATTACCAACCTATGGTTACGCTAGGCAGTACAGT
GGTGCCAACACTGCAACCTTCCAAAAGTTTATCACTGCCCAAAACATTACCCCTGAAGGT
TTAGAAAACATCGGTAGAGCTGTTATGTGCGTTGCCAAGAAGGAGGGTCTAGACGGTCAC
AGAAACGCTGTGAAAATCAGAATGAGTAAGCTTGGGTTGTTCCCAAAGGATTTCCAGTAG
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 799 |
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Protein Molecular Weight | 87720.5 |
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Protein Theoretical pI | 4.94 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Histidine biosynthesis trifunctional protein
MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGK
FSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFS
QDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDL
GRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGE
FKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAA
DLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLD
VVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVL
NAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKV
GLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIV
LAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLV
IADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVR
KCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCG
DYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGH
RNAVKIRMSKLGLIPKDFQ |
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References |
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External Links | |
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General Reference | - Donahue, T. F., Farabaugh, P. J., Fink, G. R. (1982). "The nucleotide sequence of the HIS4 region of yeast." Gene 18:47-59.7049842
- Rad, M. R., Lutzenkirchen, K., Xu, G., Kleinhans, U., Hollenberg, C. P. (1991). "The complete sequence of a 11,953 bp fragment from C1G on chromosome III encompasses four new open reading frames." Yeast 7:533-538.1897318
- Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
- Farabaugh, P. J., Fink, G. R. (1980). "Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication." Nature 286:352-356.6250062
- Roeder, G. S., Rose, A. B., Pearlman, R. E. (1985). "Transposable element sequences involved in the enhancement of yeast gene expression." Proc Natl Acad Sci U S A 82:5428-5432.2991923
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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