{"ymdb_id":"YMDB00702","created_at":"2011-05-29T18:44:46.000Z","updated_at":"2016-09-08T18:35:48.000Z","name":"L-histidinol","cas":"4836-52-6","state":"Solid","melting_point":"","description":"L-Histidinol is a structural analogue of the essential amino acid L-histidine. It is the final intermediate in the production of histidine via Histidinol dehydrogenase.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Beltra, A. P.; Bonete, P.; Gonzalez-Garcia, J.; Garcia-Garcia, V.; Montiel, V. Electrochemical synthesis of L-histidinol using solvated electrons. Journal of the Electrochemical Society (2005), 152(4), D65-D68.","chebi_id":"16255","hmdb_id":"HMDB03431","kegg_id":"C00860","pubchem_id":"165271","cs_id":"144886","foodb_id":null,"wikipedia_link":null,"biocyc_id":"L-HISTIDINOL-P","iupac":"(2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol","traditional_iupac":"HSO","logp":"-1.6698298503333333","pka":"15.128179925243142","alogps_solubility":"1.40e+02 g/l","alogps_logp":"-1.10","alogps_logs":"-0.00","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"74.93","refractivity":"38.1916","polarizability":"14.739769318197347","formal_charge":"0","physiological_charge":"2","pka_strongest_basic":"9.405190517544417","pka_strongest_acidic":"13.445305409985384","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(S)-beta-Amino-1H-imidazole-4-propanol","HSO"],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9778369,"citation":"Raju, R. V., Datla, R. S., Warrington, R. C., Sharma, R. K. (1998). \"Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity.\" Biochemistry 37:14928-14936."},{"pubmed_id":12669100,"citation":"Vallen, E. (2002). \"Analysis of protein localization and secretory pathway function using the yeast Saccharomyces cerevisiae.\" Cell Biol Educ 1:173-192."}],"proteins":[{"created_at":"2011-05-27T01:43:05.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"Histidine biosynthesis trifunctional protein","uniprot_id":"P00815","uniprot_name":"HIS2_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS4","num_residues":799,"molecular_weight":"87720.5","theoretical_pi":"4.94","general_function":"Involved in oxidoreductase activity","specific_function":"1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide","reactions":[{"id":1630,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1882,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1883,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2637,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2638,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2639,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":4155,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006452","source":"Smpdb"},{"id":4156,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006453","source":"Smpdb"},{"id":4157,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006455","source":"Smpdb"},{"id":4158,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006461","source":"Smpdb"},{"id":4159,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006462","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"V01310","genbank_protein_id":"3785","gene_card_id":"HIS4","chromosome_location":"chromosome 3","locus":"YCL030C","synonyms":["Phosphoribosyl-AMP cyclohydrolase","Phosphoribosyl-ATP pyrophosphohydrolase","Histidinol dehydrogenase","HDH"],"enzyme_classes":["3.5.4.19","3.6.1.31","1.1.1.23"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" phosphoribosyl-ATP diphosphatase activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" phosphoribosyl-AMP cyclohydrolase activity"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" histidinol dehydrogenase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Histidinol_dh","identifier":"PF00815"},{"name":"PRA-CH","identifier":"PF01502"},{"name":"PRA-PH","identifier":"PF01503"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGTTTTGCCGATTCTACCGTTAATTGATGATCTGGCCTCATGGAATAGTAAGAAGGAATACGTTTCACTTGTTGGTCAGGTACTTTTGGATGGCTCGAGCCTGAGTAATGAAGAGATTCTCCAGTTCTCCAAAGAGGAAGAAGTTCCATTGGTGCGTTTGTCCTTGCCAAGTGGTAAATTCAGCGATGATGAAATCATTGCCTTCTTGAACAACGGAGTTTCTTCTCTGTTCATTGCTAGCCAAGATGCTAAAACAGCCGAACACTTGGTTGAACAATTGAATGTACCAAAGGAGCGTGTTGTTGTGGAAGAGAACGGTGTTTTCTCCAATCAATTCATGGTAAAACAAAAATTCTCGCAAGATAAAATTGTGTCCATAAAGAAATTAAGCAAGGATATGTTGACCAAAGAAGTGCTTGGTGAAGTACGTACAGACCGTCCTGACGGTTTATATACCACCCTAGTTGTCGACCAATATGAGCGTTGTCTAGGGTTGGTGTATTCTTCGAAGAAATCTATAGCAAAGGCCATCGATTTGGGTCGTGGCGTTTATTATTCTCGTTCTAGGAATGAAATCTGGATCAAGGGTGAAACTTCTGGCAATGGCCAAAAGCTTTTACAAATCTCTACTGACTGTGATTCGGATGCCTTAAAGTTTATCGTTGAACAAGAAAACGTTGGATTTTGCCACTTGGAGACCATGTCTTGCTTTGGTGAATTCAAGCATGGTTTGGTGGGGCTAGAATCTTTACTAAAACAAAGGCTACAGGACGCTCCAGAGGAATCTTATACTAGAAGACTATTCAACGACTCTGCATTGTTAGATGCCAAGATCAAGGAAGAAGCTGAAGAACTGACTGAGGCAAAGGGTAAGAAGGAGCTTTCTTGGGAGGCTGCCGATTTGTTCTACTTTGCACTGGCCAAATTAGTGGCCAACGATGTTTCATTGAAGGACGTCGAGAATAATCTGAATATGAAGCATCTGAAGGTTACAAGACGGAAAGGTGATGCTAAGCCAAAGTTTGTTGGACAACCAAAGGCTGAAGAAGAAAAACTGACCGGTCCAATTCACTTGGACGTGGTGAAGGCTTCCGACAAAGTTGGTGTGCAGAAGGCTTTGAGCAGACCAATCCAAAAGACTTCTGAAATTATGTATTTAGTCAATCCGATCATCGAAAATGTTAGAGACAAAGGTAACTCTGTTTTTTTGGAGTACACAGAAAAGTTTGATGGTGTAAAATTATCCAATCCTGTTCTTAATGCTCCATTCCCAGAAGAATACTTTGAAGGTTTAACCGAGGAAATGAAGGAAGCTTTGAACCTTTCAATTGAAAACGTCCGCAAATTCCATGCTGCTCAATTGCCAACAGAGACTCTTGAAGTTGAAACCCAACCTGGTGTCTTGTGTTCCAGATTCCCTCGTCCTATTGAAAAAGTTGGTTTGTATATCCCTGGTGGCACTGCCATTTTACCAAGTACTGCATTAATGCTTGGTGTTCCAGCACAAGTTGCCCAATGTAAGGAGATTGTGTTTGCATCTCCACCAAGAAAATCTGATGGTAAAGTTTCACCCGAAGTTGTTTATGTCGCAGAAAAAGTTGGCGCTTCCAAGATTGTTCTAGCTGGTGGTGCCCAAGCCGTTGCTGCTATGGCTTACGGGACAGAAACTATTCCTAAAGTGGATAAGATCTTGGGTCCAGGTAATCAATTTGTGACTGCCGCCAAAATGTATGTTCAAAATGACACTCAAGCTCTATGTTCCATTGATATGCCAGCTGGCCCAAGTGAAGTTTTGGTTATTGCCGATGAAGATGCCGATGTGGATTTTGTTGCAAGTGATTTGCTATCGCAAGCTGAACACGGTATTGACTCCCAAGTTATCCTTGTTGGTGTTAACTTGAGCGAAAAGAAAATTCAAGAGATTCAAGATGCTGTTCACAATCAAGCTTTACAACTGCCACGTGTGGATATTGTTCGTAAATGTATTGCTCACAGTACGATCGTTCTTTGTGACGGTTACGAAGAAGCCCTTGAAATGTCCAACCAATATGCACCAGAACATTTGATTCTACAAATCGCCAATGCTAACGATTATGTTAAATTGGTTGACAATGCAGGGTCCGTATTTGTGGGTGCTTACACTCCAGAATCGTGCGGTGACTATTCAAGTGGTACTAACCATACATTACCAACCTATGGTTACGCTAGGCAGTACAGTGGTGCCAACACTGCAACCTTCCAAAAGTTTATCACTGCCCAAAACATTACCCCTGAAGGTTTAGAAAACATCGGTAGAGCTGTTATGTGCGTTGCCAAGAAGGAGGGTCTAGACGGTCACAGAAACGCTGTGAAAATCAGAATGAGTAAGCTTGGGTTGTTCCCAAAGGATTTCCAGTAG","protein_sequence":"MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGKFSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFSQDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDLGRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAADLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLDVVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVGLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRKCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHRNAVKIRMSKLGLIPKDFQ"},{"created_at":"2011-05-27T02:14:11.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Histidinol-phosphatase","uniprot_id":"P38635","uniprot_name":"HIS9_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS2","num_residues":335,"molecular_weight":"38581.5","theoretical_pi":"5.81","general_function":"Involved in histidinol-phosphatase activity","specific_function":"L-histidinol phosphate + H(2)O = L-histidinol + phosphate","reactions":[{"id":1631,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2664,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-histidinol phosphate + H(2)O = L-histidinol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4164,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006460","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"D50617","genbank_protein_id":"836780","gene_card_id":"HIS2","chromosome_location":"chromosome 6","locus":"YFR025C","synonyms":["HolPase"],"enzyme_classes":["3.1.3.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" histidinol-phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PHP","identifier":"PF02811"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGCACTCACACCATTCACACTCCGGTGACTATAGTGCCCACGGTACGGACCCTTTGGATTCCGTGGTCGATCAAGTGGTCAACCTCAACTTTCACACGTACTGTTTGACAGAGCACATACCAAGAATTGAGGCCAAGTTTATATACCCCGAAGAGCAGTCATTGGGCAAGAATCCTGAGGAAGTCATAACCAAGCTAGAAACATCGTTCAAGAATTTCATGAGTCATGCGCAAGAAATCAAGACTCGTTATGCTGATAGACCCGATGTGCGGACTAAATTCATTATAGGAATGGAGATCGAAAGTTGTGACATGGCTCATATCGAATATGCAAAGCGACTCATGAAGGAGAATAATGATATTTTGAAGTTTTGTGTGGGTTCGGTCCATCACGTCAACGGGATCCCTATTGATTTCGACCAACAACAATGGTACAATTCATTGCATTCCTTCAATGATAATTTGAAACATTTTCTCCTGTCTTACTTCCAATCACAGTACGAAATGCTGATCAATATTAAACCGTTGGTCGTGGGTCACTTCGACCTTTACAAATTATTTTTGCCCAATGACATGCTAGTAAACCAGAAATCGGGCAACTGCAACGAAGAAACCGGAGTTCCTGTAGCTTCACTGGACGTCATCAGTGAATGGCCAGAAATATACGATGCAGTTGTAAGAAATTTACAATTTATAGACTCCTATGGCGGCGCAATTGAAATCAATACGTCCGCATTAAGAAAGCGCCTCGAGGAGCCGTACCCCAGCAAAACCTTATGTAATCTGGTCAAGAAGCACTGTGGATCCAGATTTGTTCTAAGTGATGACGCACACGGCGTGGCGCAAGTGGGTGTGTGCTATGACAAGGTAAAGAAATACATAGTAGACGTGCTACAATTAGAGTATATTTGCTACCTTGAGGAAAGCCAATCACCAGAGAATCTGTTAACTGTAAAGAGATTACCCATTTCGCAATTCGTTAATGATCCCTTTTGGGCCAATATATAA","protein_sequence":"MHSHHSHSGDYSAHGTDPLDSVVDQVVNLNFHTYCLTEHIPRIEAKFIYPEEQSLGKNPEEVITKLETSFKNFMSHAQEIKTRYADRPDVRTKFIIGMEIESCDMAHIEYAKRLMKENNDILKFCVGSVHHVNGIPIDFDQQQWYNSLHSFNDNLKHFLLSYFQSQYEMLINIKPLVVGHFDLYKLFLPNDMLVNQKSGNCNEETGVPVASLDVISEWPEIYDAVVRNLQFIDSYGGAIEINTSALRKRLEEPYPSKTLCNLVKKHCGSRFVLSDDAHGVAQVGVCYDKVKKYIVDVLQLEYICYLEESQSPENLLTVKRLPISQFVNDPFWANI"}]}