{"ymdb_id":"YMDB00369","created_at":"2011-05-29T18:10:21.000Z","updated_at":"2016-10-18T17:11:28.000Z","name":"L-Histidine","cas":"71-00-1","state":"Solid","melting_point":"287 oC","description":"Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic nature of the imidazole side chain. L-Histidine is a positively charged (pKa 6.5) aromatic amino acid. Histidine residues are often found in enzyme active sites, where the chemistry of the imidazole ring of histidine makes it a nucleophile and a good acid/base catalyzer.  Histidine is special in that its biosynthesis is inherently linked to the pathways of nucleotide formation. In the first step of histidine synthesis, PRPP (5-phosphoribosyl-alpha-pyrophosphate) condenses with ATP to form a purine, N1-5'-phosphoribosyl ATP, in a reaction that is driven by the subsequent hydrolysis of the pyrophosphate that condenses out. Glutamine plays a role as an amino group donor resulting in the formation of 5-aminoamidazole-4-carboximide ribonucleotide (ACAIR), which is an intermediate in purine biosynthesis. Hisitidne is catabolized by the enzyme histidine ammonia-lyase which converts histidine into ammonia and urocanic acid.","experimental_water_solubility":"45.6 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.32 [CHMELIK,J ET AL. (1991)]","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":"Aurelio Luigi; Brownlee Robert T C; Hughes Andrew B  A novel synthesis of N-methyl asparagine, arginine, histidine, and tryptophan.    Organic letters  (2002),  4(21),  3767-9.","chebi_id":"15971","hmdb_id":"HMDB00177","kegg_id":"C00135","pubchem_id":"6274","cs_id":"6038","foodb_id":null,"wikipedia_link":"Histidine","biocyc_id":"HIS","iupac":"(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid","traditional_iupac":"L-histidine","logp":"-3.6160224799542067","pka":"12.941172308417478","alogps_solubility":"7.13e+01 g/l","alogps_logp":"-2.67","alogps_logs":"-0.34","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"92.0","refractivity":"38.059","polarizability":"14.670259477862192","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.437137464922305","pka_strongest_acidic":"1.8499726767043656","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(S)-1H-Imidazole-4-alanine","(S)-2-Amino-3-(4-imidazolyl)propionsaeure","(S)-4-(2-Amino-2-carboxyethyl)imidazole","(S)-a-Amino-1H-imidazole-4-propanoate","(S)-a-Amino-1H-imidazole-4-propanoic acid","(S)-alpha-Amino-1H-imidazole-4-propanoate","(S)-alpha-Amino-1H-imidazole-4-propanoic acid","(S)-alpha-Amino-1H-imidazole-4-propionate","(S)-alpha-Amino-1H-imidazole-4-propionic acid","(S)-Histidine","(S)1H-Imidazole-4-alanine","3-(1H-imidazol-4-yl)-L-Alanine","amino-1H-imidazole-4-propanoate","amino-1H-imidazole-4-propanoic acid","amino-4-imidazoleproprionate","amino-4-imidazoleproprionic acid","Glyoxaline-5-alanine","His","Histidine","L-(-)-Histidine"],"pathways":[{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"8990.29744","concentration_units":"\u0026#181;M","error":"179.94872"},{"growth_media":"YPG media","concentration":"8923.96923","concentration_units":"\u0026#181;M","error":"178.46154"},{"growth_media":"SD media","concentration":"4098.36923","concentration_units":"\u0026#181;M","error":"82.09231"},{"growth_media":"SG media","concentration":"4098.36923","concentration_units":"\u0026#181;M","error":"82.09231"},{"growth_media":"M (molasses)","concentration":"5883.28205","concentration_units":"\u0026#181;M","error":"117.78462"},{"growth_media":"MA (molasses)","concentration":"6280.06154","concentration_units":"\u0026#181;M","error":"125.51795"},{"growth_media":"MB (molasses)","concentration":"4693.53846","concentration_units":"\u0026#181;M","error":"93.98974"},{"growth_media":"MAB (molasses)","concentration":"4957.95897","concentration_units":"\u0026#181;M","error":"99.04615"},{"growth_media":"hops, malted barley","concentration":"367.0","concentration_units":"\u0026#181;M","error":"19.0"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"767.0","concentration_units":"\u0026#181;M","error":"38.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"1970.0","concentration_units":"\u0026#181;M","error":"152.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"6.0","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."},{"pubmed_id":16448171,"citation":"Almeida, C., Duarte, I. F., Barros, A., Rodrigues, J., Spraul, M., Gil, A. M. (2006). \"Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production.\" J Agric Food Chem 54:700-706."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":15572352,"citation":"Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y., Kakinuma, Y. (2005). \"A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae.\" J Biol Chem 280:4851-4857."},{"pubmed_id":8647869,"citation":"Gary, J. D., Lin, W. J., Yang, M. C., Herschman, H. R., Clarke, S. (1996). \"The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae.\" J Biol Chem 271:12585-12594."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T21:03:55.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine/tyrosine/tryptophan amino-acid permease 1","uniprot_id":"P38085","uniprot_name":"TAT1_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT1","num_residues":619,"molecular_weight":"68756.89844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High-affinity transport of valine and tyrosine. Low- affinity transport of tryptophan. Can also transport L-cysteine","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;123-143;173-193;205-225;234-254;282-302;321-341;369-389;423-443;447-467;500-520;530-550","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U10503","genbank_protein_id":"558077","gene_card_id":"TAT1","chromosome_location":"chromosome 2","locus":"YBR069C","synonyms":["Tyrosine and tryptophan amino acid transporter 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGACGATAGTGTCAGTTTCATTGCCAAAGAGGCCAGTCCAGCACAATATTCGCACAGTTTGCATGAAAGAACACACAGTGAAAAACAAAAGAGAGACTTTACAATAACAGAAAAACAAGATGAGGTATCTGGACAAACAGCGGAGCCTCGAAGGACGGACAGCAAATCCATATTACAGAGGAAATGCAAAGAATTCTTCGACTCTTTTAAAAGGCAGCTGCCACCAGACCGTAATTCCGAACTAGAGTCCCAAGAAAAAAACAACCTGACAAAGTCGATCAAATCTCGTCACTTAGTCATGATCAGTCTCGGTACCGGTATAGGTACTGGTTTACTGGTCGGTAATGGTCAGGTGCTGGGAACAGCTGGTCCTGCCGGGTTAGTCCTTGGTTACGGAATAGCATCGATCATGCTTTACTGTATCATCCAAGCGGCAGGCGAGTTAGGTCTCTGTTATGCAGGACTAACCGGCAATTACACCAGATATCCTTCTATTTTAGTCGACCCTTCGTTGGGTTTTGCAGTTTCTGTGGTTTACACCATTCAATGGCTAACTGTTCTGCCCTTACAATTGGTCACTGCGGCAATGACAGTTAAGTACTGGACGAGTGTAAATGCAGACATCTTTGTTGCCGTGGTTTTCGTTTTTGTAATTATCATTAATCTATTTGGGTCCAGAGGCTATGCTGAAGCCGAGTTCATTTTCAATTCCTGTAAGATATTGATGGTAATCGGATTCGTCATTCTGGCGATTATCATCAATTGTGGGGGTGCAGGTGACAGAAGATACATCGGTGCTGAGTACTGGCACAATCCTGGTCCATTTGCCCACGGTTTCAAAGGTGTATGTACGGTTTTCTGTTATGCTGCATTCAGCTACGGTGGAATTGAAGTTCTACTTCTATCTGCCGCTGAGCAGGAAAACCCAACAAAATCTATTCCCAATGCCTGCAAAAAAGTGGTATACCGTATTCTGCTGATTTACATGCTCACCACCATTTTGGTTTGCTTTCTTGTTCCATACAACAGTGACGAATTATTAGGGTCTAGTGACTCCTCTGGATCCCATGCCTCCCCATTTGTCATTGCTGTTGCATCACATGGTGTCAAAGTTGTGCCTCACTTTATAAATGCTGTTATTTTGATTTCTGTCATTTCTGTTGCAAACTCTTCGTTATATTCTGGGCCAAGATTGTTATTATCATTGGCAGAACAAGGCGTCTTACCTAAATGCTTAGCATATGTTGATAGAAACGGCAGGCCTTTACTTTGTTTTTTTGTTTCCCTTGTCTTTGGATGCATTGGGTTTGTAGCCACTAGTGACGCTGAAGAACAGGTTTTCACCTGGTTATTGGCAATTTCTAGTCTTTCGCAATTATTTATCTGGATGTCAATGTCCTTGTCACATATAAGATTTAGAGATGCCATGGCAAAGCAAGGTCGTTCGATGAACGAAGTTGGATACAAAGCACAAACTGGCTATTGGGGTTCATGGCTTGCAGTTTTAATTGCAATCTTCTTCCTTGTGTGCCAGTTCTGGGTAGCCATCGCACCTGTTAATGAACATGGAAAACTTAACGTCAAAGTGTTTTTCCAAAATTATTTGGCAATGCCCATCGTTTTGTTTGCCTATTTTGGTCACAAGATATACTTCAAATCATGGAGCTTTTGGATTCCAGCCGAAAAAATTGATTTGGACTCACATAGAAACATATTTGTGTCTCCATCGCTTACAGAGATCGACAAAGTTGACGATAACGATGATCTTAAAGAGTATGAAAATTCAGAATCGTCGGAAAATCCAAACAGTTCGCGTTCAAGAAAGTTTTTTAAGAGGATGACCAATTTCTGGTGCTAA","protein_sequence":"MDDSVSFIAKEASPAQYSHSLHERTHSEKQKRDFTITEKQDEVSGQTAEPRRTDSKSILQRKCKEFFDSFKRQLPPDRNSELESQEKNNLTKSIKSRHLVMISLGTGIGTGLLVGNGQVLGTAGPAGLVLGYGIASIMLYCIIQAAGELGLCYAGLTGNYTRYPSILVDPSLGFAVSVVYTIQWLTVLPLQLVTAAMTVKYWTSVNADIFVAVVFVFVIIINLFGSRGYAEAEFIFNSCKILMVIGFVILAIIINCGGAGDRRYIGAEYWHNPGPFAHGFKGVCTVFCYAAFSYGGIEVLLLSAAEQENPTKSIPNACKKVVYRILLIYMLTTILVCFLVPYNSDELLGSSDSSGSHASPFVIAVASHGVKVVPHFINAVILISVISVANSSLYSGPRLLLSLAEQGVLPKCLAYVDRNGRPLLCFFVSLVFGCIGFVATSDAEEQVFTWLLAISSLSQLFIWMSMSLSHIRFRDAMAKQGRSMNEVGYKAQTGYWGSWLAVLIAIFFLVCQFWVAIAPVNEHGKLNVKVFFQNYLAMPIVLFAYFGHKIYFKSWSFWIPAEKIDLDSHRNIFVSPSLTEIDKVDDNDDLKEYENSESSENPNSSRSRKFFKRMTNFWC"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T18:51:32.000Z","updated_at":"2011-05-27T15:01:05.000Z","name":"Histidyl-tRNA synthetase, mitochondrial","uniprot_id":"P07263","uniprot_name":"SYH_YEAST","enzyme":true,"transporter":false,"gene_name":"HTS1","num_residues":546,"molecular_weight":"59952.0","theoretical_pi":"7.87","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)","reactions":[{"id":1633,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2553,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm","altext":"ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"AY692751","genbank_protein_id":"51012953","gene_card_id":"HTS1","chromosome_location":"chromosome 16","locus":"YPR033C","synonyms":["Histidine--tRNA ligase","HisRS"],"enzyme_classes":["6.1.1.21"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" histidine-tRNA ligase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"},{"category":"Process","description":" histidyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"}],"pfams":[{"name":"HGTP_anticodon","identifier":"PF03129"},{"name":"tRNA-synt_2b","identifier":"PF00587"}],"pathways":[],"gene_sequence":"ATGCTTAGTAGATCACTAAATAAAGTAGTCACATCTATAAAGTCGTCTTCGATAATCAGGATGTCATCCGCTACCGCTGCTGCTACTTCTGCTCCTACTGCTAATGCTGCTAATGCTCTAAAAGCTTCAAAGGCTCCAAAGAAAGGTAAACTACAAGTGTCTTTGAAAACACCTAAGGGTACGAAGGATTGGGCTGATAGTGATATGGTTATCAGAGAAGCCATTTTTAGCACTTTATCTGGCCTATTCAAGAAGCATGGTGGTGTCACTATCGACACACCTGTTTTCGAGTTAAGAGAAATTTTAGCAGGCAAGTATGGTGAGGACTCCAAACTGATCTACAACTTGGAGGACCAGGGTGGTGAATTATGTTCTTTACGTTACGATTTGACCGTTCCTTTTGCCAGGTACGTTGCCATGAACAATATTCAGAGTATCAAGAGGTATCACATTGCAAAAGTCTACAGAAGAGACCAACCAGCCATGACTAAGGGTCGTATGAGAGAATTTTACCAGTGTGATTTTGACGTTGCAGGCACATTCGAATCTATGGTTCCTGATTCCGAATGTTTGTCCATTTTAGTGGAAGGTTTGACCAGTTTGGGAATCAAAGATTTCAAAATCAAATTGAATCACAGGAAGATTCTTGATGGGATCTTCCAAATCGCTGGTGTTAAAGATGAGGATGTGAGGAAAATCTCTTCTGCTGTCGATAAGTTGGACAAATCTCCATGGGAAGCAGTCAAGAAGGAAATGACCGAAGAAAAAGGTCAATCCGAAGAAACTGCTGATAAAATCGGTGAGTATGTTAAATTAAATGGTTCTTTGAAGGAAATTCACGCTGTTCTATCCGCAGATGCCAACATTACTTCAAACGAAAAGGCTAAACAAGGTTTGGATGATATTGCTACTTTGATGAAGTATACCGAAGCATTTGACATTGACTCATTCATCTCTTTTGATCTTTCTCTTGCAAGAGGTTTGGATTACTATACAGGTTTGATCTATGAAGTTGTTACTTCTGCATCTGCTCCACCAGAGAATGCTTCAGAATTGAAGAAGAAGGCCAAATCTGCAGAAGACGCGTCAGAATTCGTTGGTGTCGGCTCTATTGCAGCCGGTGGTCGATATGATAATTTGGTCAACATGTTCTCTGAAGCTTCCGGCAAAAAATCTACTCAAATTCCATGTGTTGGTATTTCATTTGGTGTTGAAAGAATATTTTCTTTGATCAAACAAAGAATTAATTCCTCTACAACTATAAAGCCAACGGCTACACAGGTGTTCGTTATGGCTTTTGGTGGTGGTAAGGACTGGACTGGTTATTTACCCGAAAGAATGAAGGTTACTAAGCAATTATGGGATGCTGGCATTGAAGCTGAATATGTCTATAAGGCCAAGGCTAATCCTAGGAAGCAATTCGATGCTGCTGAAAAAGCGGGTTGTCACATTGCCGTAATCCTCGGTAAGGAGGAGTACTTAGAAGGTAAATTACGTGTCAAAAGATTGGGCCAAGAATTTGCCGATGATGATGGTGAATTGGTTAGTGCGGCTGACATTGTTCCTATTGTTCAAGAAAAGTTATCACAAATTCATGAAGATGGTCTAAATGAGGTCACTCGTTTAATTAAAGGATTATAA","protein_sequence":"MLSRSLNKVVTSIKSSSIIRMSSATAAATSAPTANAANALKASKAPKKGKLQVSLKTPKGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDSKLIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKISSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNEKAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYEVVTSASAPPENASELKKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQRINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQFDAAEKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAADIVPIVQEKLSQIHEDGLNEVTRLIKGL"},{"created_at":"2011-05-27T01:43:05.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"Histidine biosynthesis trifunctional protein","uniprot_id":"P00815","uniprot_name":"HIS2_YEAST","enzyme":true,"transporter":false,"gene_name":"HIS4","num_residues":799,"molecular_weight":"87720.5","theoretical_pi":"4.94","general_function":"Involved in oxidoreductase activity","specific_function":"1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide","reactions":[{"id":1630,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1882,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1883,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2637,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2638,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2639,"direction":"\u003e","locations":"Cytoplasmic","altext":"L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":4155,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006452","source":"Smpdb"},{"id":4156,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006453","source":"Smpdb"},{"id":4157,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006455","source":"Smpdb"},{"id":4158,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006461","source":"Smpdb"},{"id":4159,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006462","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"V01310","genbank_protein_id":"3785","gene_card_id":"HIS4","chromosome_location":"chromosome 3","locus":"YCL030C","synonyms":["Phosphoribosyl-AMP cyclohydrolase","Phosphoribosyl-ATP pyrophosphohydrolase","Histidinol dehydrogenase","HDH"],"enzyme_classes":["3.5.4.19","3.6.1.31","1.1.1.23"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" phosphoribosyl-ATP diphosphatase activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" phosphoribosyl-AMP cyclohydrolase activity"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" histidinol dehydrogenase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" histidine family amino acid metabolic process"},{"category":"Process","description":" histidine metabolic process"},{"category":"Process","description":" histidine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"Histidinol_dh","identifier":"PF00815"},{"name":"PRA-CH","identifier":"PF01502"},{"name":"PRA-PH","identifier":"PF01503"}],"pathways":[{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Histidine Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGTTTTGCCGATTCTACCGTTAATTGATGATCTGGCCTCATGGAATAGTAAGAAGGAATACGTTTCACTTGTTGGTCAGGTACTTTTGGATGGCTCGAGCCTGAGTAATGAAGAGATTCTCCAGTTCTCCAAAGAGGAAGAAGTTCCATTGGTGCGTTTGTCCTTGCCAAGTGGTAAATTCAGCGATGATGAAATCATTGCCTTCTTGAACAACGGAGTTTCTTCTCTGTTCATTGCTAGCCAAGATGCTAAAACAGCCGAACACTTGGTTGAACAATTGAATGTACCAAAGGAGCGTGTTGTTGTGGAAGAGAACGGTGTTTTCTCCAATCAATTCATGGTAAAACAAAAATTCTCGCAAGATAAAATTGTGTCCATAAAGAAATTAAGCAAGGATATGTTGACCAAAGAAGTGCTTGGTGAAGTACGTACAGACCGTCCTGACGGTTTATATACCACCCTAGTTGTCGACCAATATGAGCGTTGTCTAGGGTTGGTGTATTCTTCGAAGAAATCTATAGCAAAGGCCATCGATTTGGGTCGTGGCGTTTATTATTCTCGTTCTAGGAATGAAATCTGGATCAAGGGTGAAACTTCTGGCAATGGCCAAAAGCTTTTACAAATCTCTACTGACTGTGATTCGGATGCCTTAAAGTTTATCGTTGAACAAGAAAACGTTGGATTTTGCCACTTGGAGACCATGTCTTGCTTTGGTGAATTCAAGCATGGTTTGGTGGGGCTAGAATCTTTACTAAAACAAAGGCTACAGGACGCTCCAGAGGAATCTTATACTAGAAGACTATTCAACGACTCTGCATTGTTAGATGCCAAGATCAAGGAAGAAGCTGAAGAACTGACTGAGGCAAAGGGTAAGAAGGAGCTTTCTTGGGAGGCTGCCGATTTGTTCTACTTTGCACTGGCCAAATTAGTGGCCAACGATGTTTCATTGAAGGACGTCGAGAATAATCTGAATATGAAGCATCTGAAGGTTACAAGACGGAAAGGTGATGCTAAGCCAAAGTTTGTTGGACAACCAAAGGCTGAAGAAGAAAAACTGACCGGTCCAATTCACTTGGACGTGGTGAAGGCTTCCGACAAAGTTGGTGTGCAGAAGGCTTTGAGCAGACCAATCCAAAAGACTTCTGAAATTATGTATTTAGTCAATCCGATCATCGAAAATGTTAGAGACAAAGGTAACTCTGTTTTTTTGGAGTACACAGAAAAGTTTGATGGTGTAAAATTATCCAATCCTGTTCTTAATGCTCCATTCCCAGAAGAATACTTTGAAGGTTTAACCGAGGAAATGAAGGAAGCTTTGAACCTTTCAATTGAAAACGTCCGCAAATTCCATGCTGCTCAATTGCCAACAGAGACTCTTGAAGTTGAAACCCAACCTGGTGTCTTGTGTTCCAGATTCCCTCGTCCTATTGAAAAAGTTGGTTTGTATATCCCTGGTGGCACTGCCATTTTACCAAGTACTGCATTAATGCTTGGTGTTCCAGCACAAGTTGCCCAATGTAAGGAGATTGTGTTTGCATCTCCACCAAGAAAATCTGATGGTAAAGTTTCACCCGAAGTTGTTTATGTCGCAGAAAAAGTTGGCGCTTCCAAGATTGTTCTAGCTGGTGGTGCCCAAGCCGTTGCTGCTATGGCTTACGGGACAGAAACTATTCCTAAAGTGGATAAGATCTTGGGTCCAGGTAATCAATTTGTGACTGCCGCCAAAATGTATGTTCAAAATGACACTCAAGCTCTATGTTCCATTGATATGCCAGCTGGCCCAAGTGAAGTTTTGGTTATTGCCGATGAAGATGCCGATGTGGATTTTGTTGCAAGTGATTTGCTATCGCAAGCTGAACACGGTATTGACTCCCAAGTTATCCTTGTTGGTGTTAACTTGAGCGAAAAGAAAATTCAAGAGATTCAAGATGCTGTTCACAATCAAGCTTTACAACTGCCACGTGTGGATATTGTTCGTAAATGTATTGCTCACAGTACGATCGTTCTTTGTGACGGTTACGAAGAAGCCCTTGAAATGTCCAACCAATATGCACCAGAACATTTGATTCTACAAATCGCCAATGCTAACGATTATGTTAAATTGGTTGACAATGCAGGGTCCGTATTTGTGGGTGCTTACACTCCAGAATCGTGCGGTGACTATTCAAGTGGTACTAACCATACATTACCAACCTATGGTTACGCTAGGCAGTACAGTGGTGCCAACACTGCAACCTTCCAAAAGTTTATCACTGCCCAAAACATTACCCCTGAAGGTTTAGAAAACATCGGTAGAGCTGTTATGTGCGTTGCCAAGAAGGAGGGTCTAGACGGTCACAGAAACGCTGTGAAAATCAGAATGAGTAAGCTTGGGTTGTTCCCAAAGGATTTCCAGTAG","protein_sequence":"MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGKFSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFSQDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDLGRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAADLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLDVVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVGLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRKCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHRNAVKIRMSKLGLIPKDFQ"},{"created_at":"2011-05-27T03:36:30.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"HNRNP arginine N-methyltransferase","uniprot_id":"P38074","uniprot_name":"HMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"HMT1","num_residues":348,"molecular_weight":"39785.80078","theoretical_pi":"5.15","general_function":"Involved in protein methyltransferase activity","specific_function":"Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation","reactions":[{"id":1634,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1G6Q","cellular_location":null,"genbank_gene_id":"AY557869","genbank_protein_id":"45269629","gene_card_id":"HMT1","chromosome_location":"chromosome 2","locus":"YBR034C","synonyms":["Protein ODP1"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" post-translational protein modification"},{"category":"Process","description":" protein amino acid alkylation"},{"category":"Process","description":" protein amino acid methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"}],"pfams":[{"name":"PrmA","identifier":"PF06325"}],"pathways":[],"gene_sequence":"ATGAGCAAGACAGCCGTGAAAGATTCTGCTACAGAAAAAACCAAGCTAAGTGAAAGCGAACAGCACTACTTCAATTCGTACGATCACTATGGTATTCACGAAGAGATGCTTCAAGATACTGTTCGTACCTTATCTTACAGAAACGCAATTATCCAAAATAAGGATCTTTTTAAGGACAAGATTGTTTTAGACGTCGGTTGCGGTACCGGTATTTTATCCATGTTTGCCGCTAAACACGGTGCGAAGCATGTTATCGGTGTTGATATGTCAAGCATTATTGAGATGGCGAAGGAATTGGTAGAGTTGAACGGATTCAGCGACAAGATCACCTTGCTAAGAGGCAAGTTGGAGGACGTTCATTTACCCTTTCCTAAAGTTGACATCATAATTTCTGAATGGATGGGTTACTTTCTACTATACGAGTCCATGATGGACACCGTTCTTTACGCTAGAGACCACTATTTGGTAGAAGGCGGTCTGATCTTTCCCGACAAGTGCTCCATTCATTTGGCCGGTTTGGAAGACTCTCAGTATAAAGACGAGAAGTTGAACTACTGGCAAGACGTTTACGGGTTTGATTATTCGCCATTTGTTCCGTTGGTCTTACACGAGCCCATCGTCGACACCGTGGAAAGAAACAATGTCAACACCACCTCAGACAAATTGATCGAATTTGATTTAAATACAGTAAAAATATCAGATCTAGCGTTTAAGAGTAACTTTAAATTGACGGCCAAGAGACAAGATATGATTAATGGTATAGTCACCTGGTTCGACATTGTTTTCCCTGCACCAAAGGGTAAGAGACCTGTTGAGTTCTCCACTGGTCCTCATGCTCCATACACTCACTGGAAGCAAACAATATTTTATTTCCCTGATGATCTAGATGCTGAAACTGGTGACACCATTGAAGGTGAATTGGTTTGCTCTCCAAACGAGAAGAATAACAGAGATCTAAATATCAAAATTTCTTACAAGTTCGAATCGAATGGCATCGACGGTAATTCAAGAAGCAGAAAAAACGAAGGTTCTTATTTAATGCATTAA","protein_sequence":"MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH"},{"created_at":"2011-05-27T06:50:44.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar basic amino acid transporter 1","uniprot_id":"Q04301","uniprot_name":"VBA1_YEAST","enzyme":false,"transporter":true,"gene_name":"VBA1","num_residues":562,"molecular_weight":"62638.80078","theoretical_pi":"9.02","general_function":"Involved in transmembrane transport","specific_function":"Transporter required for vacuolar uptake of at least histidine and lysine","reactions":[],"signal_regions":"None","transmembrane_regions":"31-51;101-121;132-152;167-187;191-211;233-253;256-276;293-313;332-352;366-386;420-440;449-469;529-549","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z49259","genbank_protein_id":"807971","gene_card_id":"VBA1","chromosome_location":"chromosome 13","locus":"YMR088C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGCAAACACTAGACGAGACTTCAAATCTACTCCCTCCACCTGAGGAAGCTGAAGCCCCTCCCTTGGAACAAAAATTTCATGAATATAATTTGGCCTTACCTAAGTTTCCCATTTTGTTTTCGCTATGGTTGGGTAGTTTTTTGAGTTCCTTGGATAGCACTATTGTCGCAAATATAATGAATAGAGTTGCTGAGGAATTCTCTGAATCAAGTAAAAAGCAATGGATTGCGACGAGTTTTCTTTTGACAAATACGGCTTTCCAACCACTATATGGGAAGCTTTCTGATATAACAGGGCGGAAGTCAGCATTATTAACCGCTCAATTTTTTTTTGGCCTTGGGTGCTTATTAACATGTTTTGCCAGAAACGTCACGGAATTCTCAATAGCAAGAGCCATATGTGGTATTGGTGCAGGAGGATTGAATGCTATTAGTAGCATTGCTGTTAGTGACATATGTACAGCAAGAGAAAGGGGCGTTTACCAGGGATATGCGAATATTGTTTTCGGGTTTGGTCAATTACTAGGTGCTCCGTTGGGTGGTGTATTTATAGAAACCATTGGATGGAGGGCTCTTTTTGGTATCCAAGTACCCGTGATAATGTTGTGCTCGGTATTAGCAATCAAAAACATTAATATTAAGCTATTCCATGTTCCTCCTATGAAAGAAAGATATACCTTAAAGAATCTGTCACGGATAGATATATTTGGCTCATTAAGCCTGGTGGCGACCATTAGTGGAGTTTTATTTTTGTGCTCTAGCCAGTTGAACAAGTTGTATTTAGCATTGTTTACCATTGGTAGCTTTATTGTTTTTATCCTGGTTGAACGTTATTACGCGACTGAGAAAATTTTACCATTCGAACTATTGACTCGCTCATTCTGTTTGAGCTCAGCGGTAACGGTTATATCTTCATTTGTTGTATTTGGTGAAATCTTTAGGTCACCAATCTATTTACAATTGCTTCAAAATATTAGTGTAACAAAGACTGGCCTCTTTTTGATTTTCCCCTCTATATCAGTTGCAGTCGGATCATTGGTAACAGGATGGGTATTGCGGAATACGAAAATTAACCTAGCACACTGTGCATATCAAATCATTTTTGGTGGTATGATAATGCAGCTATTGGGTTTGGGATTGGGCTATTTCCTACTTTCACACTTGAATCCTGACTACACCATATATGATATGCTTGAGTCTATTACATTCAGATCTAACTCAATATGGTGGAAATTGATATATGTGTTTGCATCAGTCCTTGTGTCCTTTGGTTACGCTTGTCTATTAGTGGCCACGTTAGTAAGCATCGTATTCACCGTCGAAAAATCACAGCAAGGAACCATGACTGGTGTTTTCTATTTGTGGAGATCCATTGGTAACGTTCTTGGTGCCTCTTTAACTTTAGTGTCCTATGAGAATAGCCTGTCGTCCATGTTATGGAATTATATGTTCAAAACCAAGCGTGATGACGAATATCACTTCACCAAAAAGCAGTACTACTCCCTTATCAATGATTCGAGTTACTTGAGAGGGCCCAATTTTCCAACGGATATATTTGTTCGCATTCTTGATGTCTACAAAAAGGCATTCCTGATTTCCTATATTCCAAATATAGCCCTGGCAGCAGTGGGAATTGTTTTATCGTTATATCTGGTGAAACATACTTACAAACGTAGTTCAAGTTCTTGA","protein_sequence":"MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTAQFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFGSLSLVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILPFELLTRSFCLSSAVTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLAHCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDYTIYDMLESITFRSNSIWWKLIYVFASVLVSFGYACLLVATLVSIVFTVEKSQQGTMTGVFYLWRSIGNVLGASLTLVSYENSLSSMLWNYMFKTKRDDEYHFTKKQYYSLINDSSYLRGPNFPTDIFVRILDVYKKAFLISYIPNIALAAVGIVLSLYLVKHTYKRSSSS"},{"created_at":"2011-05-27T06:51:35.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar basic amino acid transporter 3","uniprot_id":"P25594","uniprot_name":"VBA3_YEAST","enzyme":false,"transporter":true,"gene_name":"VBA3","num_residues":458,"molecular_weight":"50224.89844","theoretical_pi":"9.52","general_function":"Involved in transmembrane transport","specific_function":"Transporter required for vacuolar uptake of histidine and lysine","reactions":[],"signal_regions":"None","transmembrane_regions":"10-30;37-57;68-88;133-153;164-184;206-226;249-269;278-298;307-327;416-436","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"X59720","genbank_protein_id":"5290","gene_card_id":"VBA3","chromosome_location":"chromosome 3","locus":"YCL069W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Sugar_tr","identifier":"PF00083"},{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGAATATGCTCATTGTCGGTAGAGTTGTTGCTAGTGTTGGGGGAAGCGGACTTCAAACGCTTTGCTTTGTTATTGGTTGTACGATGGTTGGTGAAAGGTCACGTCCATTGGTGATTTCCATCCTAAGTTGTGCATTTGCTGTAGCTGCTATCGTTGGTCCTATAATCGGAGGTGCCTTTACAACCCATGTTACCTGGAGGTGGTGCTTCTATATCAATCTTCCTATCGGTGGTCTTGCCATTATTATGTTTTTACTCACATATAAGGCCGAGAATAAGGGTATACTTCAACAAATTAAAGATGCTATAGGAACAATCTCGAGCTTTACTTTTAGTAAGTTCAGACACCAAGTTAATTTTAAAAGACTTATGAATGGCATAATCTTCAAGTTTGACTTCTTTGGTTTTGCCCTCTGCTCTGCAGGGCTGGTCCTTTTCCTACTGGGGCTAACCTTTGGTGGTAATAAATATAGTTGGAACTCTGGCCAAGTCATCGCATATTTGGTTTTGGGTGTCTTACTTTTTATTTTTTCATTGGTGTACGATTTCTTCTTATTCGATAAATTCAACCCGGAACCTGATAATATATCCTACAGGCCTCTCCTTCTAAGAAGATTGGTAGCAAAACCAGCCATAATAATAATAAACATGGTAACATTTCTATTATGTACCGGTTACAATGGGCAAATGATATACTCTGTCCAGTTTTTCCAACTTATATTTGCGTCGAGTGCATGGAAAGCCGGTCTTCACTTGATACCAATCGTTATTACCAACGTTATTGCGGCCATTGCAAGTGGTGTGATTACCAAAAAGCTCGGTTTAGTTAAACCACTCTTAATATTTGGAGGCGTTCTTGGGGTAATTGGAGCAGGGCTTATGACACTTATGACAAATACGTCCACGAAGTCAACTCAAATTGGTGTTTTGCTATTACCGGGGTTTTCCCTTGGATTTGCTCTACAAGCATCGCTCATGAGTGCACAGCTTCAAATTACCAAAGATCGTCCAGAAGCTGCTATGGACTTTATTGAAGTAACAGCTTTCAATACATTCATGAAGTCATTAGGTACAACTCTTGGTGGTGTGCTTTCAACCACTGTTTTTTCCGCCTCCTTTCACAACAAAGTATCACGAGCTCATCTAGAGCCTTACGAAGGAAAAACGGTTGATGACATGATTTTGTATCGTCTTCAAAACTACGACGGTTCTCATTCGACTATTGGAAACATTTTAAGCGACTCCATTAAGAACGTATTTTGGATGGATCTAGGGTTTTATGCCTTAGGATTTTTGTTTTGTAGTTTTTCATCCAATAAGAAATTAATCATACCAAAAAAGGACGAGACACCAGAAGATAATTTAGAAGACAAGTAG","protein_sequence":"MNMLIVGRVVASVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIINMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDETPEDNLEDK"},{"created_at":"2011-05-27T06:52:17.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Vacuolar basic amino acid transporter 2","uniprot_id":"P38358","uniprot_name":"VBA2_YEAST","enzyme":false,"transporter":true,"gene_name":"VBA2","num_residues":474,"molecular_weight":"51676.39844","theoretical_pi":"10.15","general_function":"Involved in transmembrane transport","specific_function":"Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine","reactions":[],"signal_regions":"None","transmembrane_regions":"34-54;63-85;98-118;122-142;168-188;197-217;239-259;274-294;304-324;332-352;376-396;448-468","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"AY692630","genbank_protein_id":"51012711","gene_card_id":"VBA2","chromosome_location":"chromosome 2","locus":"YBR293W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGAGTATTTCAAATTGGATCACCACTGCGTATTTAATTACATCAACATCTTTTCAACCTCTTTATGGGTCATTTTCTGATGCACTTGGTCGAAGAAACTGCCTTTTCTTTGCTAATGGGGCTTTTACCATTGGATGTCTAGCCTGTGGTTTCTCGAAAAACATCTACATGCTTAGTTTTATGAGAGCATTGACAGGCATAGGAGGTGGTGGCTTGATCACACTTTCTACAATCGTAAATTCAGACGTTATTCCAAGTTCGAAAAGAGGAATTTTTCAAGCGTTTCAGAATTTACTTTTGGGATTTGGTGCCATATGTGGAGCGTCTTTCGGTGGCACAATAGCGTCGAGCATTGGTTGGAGGTGGTGTTTTCTCATCCAAGTACCCATATCTGTGATTAGTTCCATATTAATGAATTATTATGTACCTAATCAGAAAGAATATAATCGTCAAAATTCTAGCATATTCCAAAATCCCGGAAAAATACTCAGGGACATAGATGTTATGGGCTCAATTCTTATTATAACTGGTCTCACACTACAGCTTCTTTACCTGAGCCTGGGGTGTTCTACTTCTAAATTATCATGGACCAGCCCTTCTGTGCTACTGCTATTAGTTGGGAGTGTAATAATCCTCTTACTGTTCATATTGCACGAAAGGAAAACAAGTGCTAGAGCGATTATTCCTATGGAGCTGGTCAATTCCTCCTACAGTGTCGTTGTACTTTCGATAAGTATACTTGTTGGTTTTGCCAGCTACGCGTATCTTTTTACTTTACCATTATTCTTTCAGATTGTACTTGGAGATTCCACTGCAAAAGCAGGATTACGTCTTACGATTCCTTCCCTATTTACTCCGGTAGGCAGTCTCATAACAGGATTTTCCATGAGCAAGTACAACTGTCTAAGATTATTACTCTACATTGGTATTTCTTTGATGTTTTTGGGTAACTTTTTATTCCTGTTTATTGAAAAAACTTCTCCGAACTGGTTGATTGGTCTATTTTTGATACCTGCAAATCTAGGACAAGGTATCACTTTTCCTACGACCTTGTTTACTTTCATATTTATGTTCTCTAAGAGTGACCAAGCTACTGCGACATCAACTTTATATTTATTCCGTAGTATTGGATCTGTATGGGGTGTTGCAATTTCAGCTGGCGTCATTCAATTATCTTTCGCAGGTTTATTGCGTAGTAATTTGAAAGGTCTACTGGATGAAAACAAGATAAAGAAACTTATTGTTCAGCTTAGTGCAAACTCCTCATATATTGGATCTTTACATGGCGAAGTTAAAAACACAGTCATAAAGAGTTTTGATGAGGCAACAAAGAGGGCTCATCTAATGTCTACATTACTCTCTTCATTGGCCCTGATACTCTGCATCCTTAAAGACAATCTGGCGAAACCTAAAACAAGAAGATAA","protein_sequence":"MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGWRWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTLQLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVVVLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYNCLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSKSDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSANSSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR"},{"created_at":"2011-05-27T07:06:56.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Histidine permease","uniprot_id":"P06775","uniprot_name":"HIP1_YEAST","enzyme":false,"transporter":true,"gene_name":"HIP1","num_residues":603,"molecular_weight":"66005.60156","theoretical_pi":"7.44","general_function":"Involved in transport","specific_function":"High-affinity permease for histidine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;204-223;237-255;280-297;322-342;377-396;424-442;452-472;492-510;531-549","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"M11980","genbank_protein_id":"553131","gene_card_id":"HIP1","chromosome_location":"chromosome 7","locus":"YGR191W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCCTAGAAACCCATTGAAAAAGGAATATTGGGCAGATGTAGTTGACGGATTCAAGCCGGCTACTTCTCCAGCCTTCGAGAATGAAAAAGAATCTACTACATTTGTTACCGAACTAACTTCCAAAACCGATTCTGCATTTCCATTAAGTAGCAAGGATTCACCTGGCATAAACCAAACCACAAACGATATTACCTCTTCAGATCGCTTCCGTCGTAATGAAGACACAGAGCAGGAAGACATCAACAACACCAACCTGAGTAAAGATCTATCCGTGAGACATCTTTTAACTCTAGCTGTCGGGGGTGCAATAGGTACTGGTTTATATGTGAATACGGGTGCTGCTTTATCTACAGGTGGTCCGGCCAGTTTAGTTATTGATTGGGTTATTATCAGTACATGTCTTTTTACTGTGATTAACTCTCTTGGTGAGCTGTCCGCTGCTTTTCCCGTTGTTGGTGGGTTCAATGTTTACAGTATGCGTTTTATTGAGCCTTCATTTGCATTCGCAGTGAACTTAAACTATTTAGCACAATGGCTAGTTCTTCTACCCTTGGAATTAGTGGCCGCATCTATTACTATAAAATACTGGAATGATAAAATTAATTCCGACGCCTGGGTTGCTATCTTTTATGCCACCATTGCACTGGCTAATATGTTGGATGTTAAGTCATTTGGTGAGACCGAATTTGTATTGTCCATGATTAAAATCCTCTCCATCATTGGCTTTACTATCTTAGGTATTGTTTTGTCCTGTGGTGGTGGGCCTCACGGCGGTTACATTGGTGGTAAATACTGGCATGACCCAGGCGCTTTTGTAGGGCACAGCTCGGGAACTCAGTTTAAAGGTTTATGTTCAGTTTTTGTTACCGCTGCCTTTTCTTATTCCGGTATTGAAATGACTGCTGTCTCCGCTGCTGAAAGTAAAAATCCAAGAGAAACCATTCCCAAGGCAGCAAAGAGAACTTTTTGGCTGATTACCGCCTCTTATGTGACTATATTGACTTTGATTGGTTGCTTGGTTCCATCCAATGACCCTAGGTTACTAAACGGTTCAAGTTCAGTGGACGCTGCCTCATCTCCTCTGGTTATCGCAATTGAAAACGGGGGTATTAAAGGTCTACCATCATTAATGAACGCCATTATTTTGATTGCTGTTGTTTCCGTGGCTAACAGTGCTGTTTATGCATGTTCAAGGTGTATGGTCGCCATGGCTCATATTGGTAATTTACCAAAATTTTTGAACCGTGTTGACAAAAGGGGTAGACCAATGAATGCTATCTTGTTAACTTTGTTTTTTGGTTTGCTTTCCTTTGTGGCAGCAAGTGATAAGCAAGCTGAAGTCTTTACATGGTTGAGTGCCTTATCTGGTTTATCGACAATTTTCTGCTGGATGGCCATTAATCTTTCCCATATTAGATTTCGCCAAGCCATGAAAGTTCAAGAAAGGTCTTTAGACGAATTACCCTTCATTTCTCAAACTGGCGTCAAGGGATCCTGGTATGGTTTTATCGTTTTATTTCTGGTTCTTATAGCATCGTTTTGGACTTCTCTGTTCCCATTAGGCGGTTCAGGAGCCAGCGCAGAATCATTCTTTGAAGGATACTTATCCTTTCCAATTTTGATTGTCTGTTACGTTGGACATAAACTGTATACTAGAAATTGGACTTTGATGGTGAAACTAGAAGATATGGATCTTGATACCGGCAGAAAACAAGTAGATTTGACTCTTCGTAGGGAAGAAATGAGGATTGAGCGAGAAACATTAGCAAAAAGATCCTTCGTAACAAGATTTTTACATTTCTGGTGTTGA","protein_sequence":"MPRNPLKKEYWADVVDGFKPATSPAFENEKESTTFVTELTSKTDSAFPLSSKDSPGINQTTNDITSSDRFRRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTGAALSTGGPASLVIDWVIISTCLFTVINSLGELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASITIKYWNDKINSDAWVAIFYATIALANMLDVKSFGETEFVLSMIKILSIIGFTILGIVLSCGGGPHGGYIGGKYWHDPGAFVGHSSGTQFKGLCSVFVTAAFSYSGIEMTAVSAAESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASSPLVIAIENGGIKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKRGRPMNAILLTLFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINLSHIRFRQAMKVQERSLDELPFISQTGVKGSWYGFIVLFLVLIASFWTSLFPLGGSGASAESFFEGYLSFPILIVCYVGHKLYTRNWTLMVKLEDMDLDTGRKQVDLTLRREEMRIERETLAKRSFVTRFLHFWC"}]}