NADPH-dependent diflavin oxidoreductase 1 (Q12181)

Identification
NameNADPH-dependent diflavin oxidoreductase 1
Synonyms
  • NADPH-dependent FMN and FAD-containing oxidoreductase
Gene NameTAH18
Enzyme ClassNot Available
Biological Properties
General Functionsmall molecule metabolic process
Specific FunctionComponent of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death.
Cellular LocationNot Available
SMPDB Pathways
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sulfur metabolismec00920 Map00920
SMPDB Reactions
Sulfite + NADPH + hydron → water + NADP + Hydrogen sulfide
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00114SulfiteShow
YMDB00426NADPHShow
YMDB00427NADPShow
YMDB00653Hydrogen sulfideShow
YMDB00862hydronShow
YMDB00890waterShow
GO Classification
Function
nitric oxide biosynthetic process
oxidation-reduction process
small molecule metabolic process
cytosol
mitochondrion
FMN binding
flavin adenine dinucleotide binding
NADP binding
NADPH-hemoprotein reductase activity
oxidoreductase activity, acting on NAD(P)H
iron-sulfur cluster assembly
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1872 bp ATGTCATCGAGCAAGAAAATCGTCATCCTCTATGGATCGGAGACAGGTAACGCGCATGAT TTTGCTACAATCTTATCCCATCGACTACATCGCTGGCATTTCTCCCATACATTTTGCTCC ATTGGTGATTATGACCCACAGGATATCTTGAAATGCAGGTACCTTTTTATTATATGCTCC ACAACAGGCCAAGGTGAATTACCAAGGAATGTCAATGCATTAAAAGGTGAAAGACCCGTC ACGTTCTGGTCGTTTTTAAAGAGAAAGAATCTTCCGTCGAATTTGCTCAACCATATTCAA ACTGCCATGCTTGGACTTGGTGATTCATCTTATCCTAAGTTTAACTACGGCATTAGAAAG CTACATCAGCGCATTGTCACACAATTGGGTGCTAATGAATTATTCGATAGATTGGAGGCT GACGACCAGGCTATGGCTGGTAGCAATAAGGGTACAGGTCTCGGAATTGAATCAGTATAT TTTGAATATGAAAAGAAAGTCCTAAGCTTTCTTTTAAGTAAGTACCCCAACAGAAAGGTC AATGGCCAAATAATTAAGAGGGAAGAATTGGACCCTGAGGTTTACCTAGAGCCAGCATCC TACCTACAGCTTTCAGACGAACATGCCAATGAAAAGTTCACTAGCACCAAGGTTATATTC GAAGGTGATGAATCGTTAAAGGTTGGCAGAGTTAATATAAACAAAAGGATTACATCTGAA GGTCATTTCCAAGACGTGAGGCAGTTCAAGTTTAGTAATGTGGACAAGATTCAAGAAAAC TATGAACCCGGTGATACAGTAACCATATATCCTTGCAATACAGATGAGGATGTTTCAAGA TTCCTAGCAAATCAAAGCCATTGGTTAGAAATTGCGGACAAACCATTGAATTTCACCAGT GGAGTTCCTAATGATCTTAAGGATGGTGGATTAGTTCGCCCGATGACTTTAAGGAACTTG TTGAAATATCACTGTGATTTCATGAGCATTCCTAGAACAAGTTTTTTCTTGAAGATTTGG ACCTTTGCAACTGATGTAACTAAGATGGAACGTGGCCAAGAACAACTGAATGATCAAAGA GAAAAATTGCGCCAATTTGCTACTGATCAAGATATGCAGGACTTATATGACTACTGTAAT AGACCCAGAAGGTCAATTCTTGAAGTACTGGAAGATTTTATCTCCGTAAAGTTGCCCTGG AAATATGTGCTAGATTACTTGCCCATCATTAAACCAAGGTACTACTCTATATCTAGCGGC CCTGGGGATCCTAATATTGAATTAACAGTTGCGATAGTAAAATATAAAACTATCTTAAGG AAAATTCGAAGAGGAATTTGCACTAACTACATTGCACGATTGCAAGAGGGGGAACAGATA AGGTATAAGTTACAAAATAATCACATAATCAAAAAGGAATTTTTGAATAAACCTATGATT CTTGTCGGACCGGGTGTCGGTCTAGCACCATTATTATCAGTGGTTAAAGCGGAGATATCT AAAGATATCAAACTCCTCTTCGGTTGTAGATATAAAGATAAAGATTATATTTATAAAGAT ATGCTGGAAGATTGGTTCCGTAAGGGCAAAATTGCCTTACATTCATCCTTTTCCAGAGAT GAGGAAAATTCACCAGGTGTTAAATATGTCCAAGACTACTTATGGAGATTAGGTGAGGAA ATAACTAATTTGGTAGTTAATAAAGACGCCGTTTTTTTCTTATGTGGCTCATCAGGTAAA ATGCCTATCCAAGTCAGATTAACATTCATTGAAATGTTAAAAAAATGGGGCAATTTTAGT GATGAAGAAACTGCCAAAAAATACCTGAAAGAAATGGAAAAATCTGATAGATATATCCAG GAAACTTGGTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues623
Protein Molecular Weight72327.29
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>NADPH-dependent diflavin oxidoreductase 1 MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRYLFIICS TTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRK LHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKV NGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSE GHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTS GVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQR EKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSG PGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFLNKPMI LVGPGVGLAPLLSVVKAEISKDIKLLFGCRYKDKDYIYKDMLEDWFRKGKIALHSSFSRD EENSPGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFS DEETAKKYLKEMEKSDRYIQETW
References
External Links
ResourceLink
Saccharomyces Genome Database TAH18
Uniprot IDQ12181
Uniprot NameTAH18
General ReferenceNot Available