{"ymdb_id":"YMDB00114","created_at":"2011-05-29T15:58:20.000Z","updated_at":"2016-09-08T18:35:03.000Z","name":"Sulfite","cas":"14265-45-3","state":"Solid","melting_point":null,"description":"A sulfite (SO32-) is a salt of sulfurous acid (H2SO3). Sulfite is an intermediate in the sulfate reduction (assimilatory) pathway which reduces sulfate to hydrogen sulfide, the required form for sulfur assimilation into biosynthetic pathways. Sulfites occur naturally in a number of foods and beverages and in all wines to some extent. Sulfites are commonly introduced to arrest fermentation at a desired time, and may also be added to wine as preservatives to prevent spoilage and oxidation at several stages of the winemaking. [Biocyc SO4ASSIM-PWY]","experimental_water_solubility":"558.5 mg/mL [sodium salt, HMP experimental]","experimental_logp_hydrophobicity":null,"location":"extracellular;cytoplasm","synthesis_reference":"Dorain, P. B.; Von Raben, K. U.; Chang, R. K.; Laube, B. L.  Catalytic formation of sulfite and sulfate ions from sulfur dioxide on silver observed by surface-enhanced Raman scattering.    Chemical Physics Letters  (1981),  84(2),  405-9.","chebi_id":"17359","hmdb_id":"HMDB00240","kegg_id":"C00094","pubchem_id":"1099","cs_id":"1068","foodb_id":null,"wikipedia_link":"Sulfite","biocyc_id":"SO3","iupac":"sulfurous acid","traditional_iupac":"sulfurous acid","logp":"-1.1546872626666664","pka":"7.30102999566398","alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"3","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"57.53","refractivity":"12.3279","polarizability":"5.756159735620625","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":null,"pka_strongest_acidic":"1.6989700043360187","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Bisulfite","Sulfite dianion","Sulfite ion","Sulfite ions","Sulfonate","Sulfur trioxide","Sulfuric anhydride","Sulphite","trioxosulfate(2-)","trioxosulfate(IV)"],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":357149,"citation":"Lederer, F. (1978). \"Sulfite binding to a flavodehydrogenase, cytochrome b2 from baker's yeast.\" Eur J Biochem 88:425-431."},{"pubmed_id":2203779,"citation":"Thomas, D., Barbey, R., Surdin-Kerjan, Y. (1990). \"Gene-enzyme relationship in the sulfate assimilation pathway of Saccharomyces cerevisiae. Study of the 3'-phosphoadenylylsulfate reductase structural gene.\" J Biol Chem 265:15518-15524."},{"pubmed_id":9003798,"citation":"Hansen, J., Muldbjerg, M., Cherest, H., Surdin-Kerjan, Y. (1997). \"Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes.\" FEBS Lett 401:20-24."},{"pubmed_id":10482536,"citation":"Hogan, D. A., Auchtung, T. A., Hausinger, R. P. (1999). \"Cloning and characterization of a sulfonate/alpha-ketoglutarate dioxygenase from Saccharomyces cerevisiae.\" J Bacteriol 181:5876-5879."}],"proteins":[{"created_at":"2011-05-26T17:18:06.000Z","updated_at":"2011-05-26T17:18:06.000Z","name":"Putative thiosulfate sulfurtransferase","uniprot_id":"Q08686","uniprot_name":"THTR_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":304,"molecular_weight":"34218.60156","theoretical_pi":"5.93","general_function":"Involved in thiosulfate sulfurtransferase activity","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null},{"id":14422,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006935","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"AY692732","genbank_protein_id":"51012915","gene_card_id":null,"chromosome_location":null,"locus":"YOR251C","synonyms":[],"enzyme_classes":["2.8.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" thiosulfate sulfurtransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" ion transport"},{"category":"Process","description":" anion transport"},{"category":"Process","description":" inorganic anion transport"},{"category":"Process","description":" sulfate transport"}],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATTATTTGATCTTATTTCTCCAAAAGCGTTTGTTAAGTTAGTGGCCAGTGAGAAGGTTCATAGAATCGTTCCAGTTGATGCAACATGGTACCTACCCAGTTGGAAGCTTGATAATAAAGTGGATTTCTTGACCAAACCACGTATACCAAACTCCATTTTCTTTGATATTGATGCAATCAGTGACAAAAAATCGCCCTATCCACATATGTTCCCTACAAAGAAGGTTTTTGACGACGCTATGAGTAATTTAGGAGTTCAAAAAGATGATATATTAGTGGTTTACGATCGTGTTGGTAACTTTAGCTCCCCTAGATGTGCTTGGACATTAGGAGTGATGGGACATCCTAAGGTGTACTTACTAAATAATTTCAACCAGTACAGAGAGTTTAAGTACCCTCTAGATTCCTCTAAGGTGGCAGCGTTTTCACCCTATCCAAAGAGTCATTATGAGTCCTCAGAAAGTTTCCAAGACAAGGAGATTGTAGACTATGAGGAAATGTTCCAATTGGTAAAGAGTGGGGAACTGGCTAAGAAATTCAATGCTTTCGATGCAAGGTCGCTCGGTAGATTCGAAGGTACAGAACCAGAGCCTCGTTCCGACATTCCATCGGGGCATATTCCAGGTACCCAACCATTACCATATGGAAGTTTACTTGATCCGGAGACCAAAACGTACCCAGAAGCTGGGGAGGCGATACACGCTACTTTGGAAAAGGCATTGAAAGACTTTCATTGCACTTTGGACCCAAGTAAACCAACTATTTGCTCTTGTGGAACTGGCGTTTCAGGAGTCATTATCAAGACAGCATTGGAGCTAGCAGGAGTTCCCAATGTTAGATTATATGATGGATCCTGGACCGAGTGGGTCTTGAAATCCGGGCCCGAGTGGATTGCTGAAAACAGAGATTAA","protein_sequence":"MPLFDLISPKAFVKLVASEKVHRIVPVDATWYLPSWKLDNKVDFLTKPRIPNSIFFDIDAISDKKSPYPHMFPTKKVFDDAMSNLGVQKDDILVVYDRVGNFSSPRCAWTLGVMGHPKVYLLNNFNQYREFKYPLDSSKVAAFSPYPKSHYESSESFQDKEIVDYEEMFQLVKSGELAKKFNAFDARSLGRFEGTEPEPRSDIPSGHIPGTQPLPYGSLLDPETKTYPEAGEAIHATLEKALKDFHCTLDPSKPTICSCGTGVSGVIIKTALELAGVPNVRLYDGSWTEWVLKSGPEWIAENRD"},{"created_at":"2011-05-26T17:18:32.000Z","updated_at":"2011-05-26T17:18:32.000Z","name":"Putative thiosulfate sulfurtransferase FMP31, mitochondrial","uniprot_id":"Q08742","uniprot_name":"FMP31_YEAST","enzyme":true,"transporter":false,"gene_name":"FMP31","num_residues":149,"molecular_weight":"16697.19922","theoretical_pi":"10.26","general_function":"Inorganic ion transport and metabolism","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY692684","genbank_protein_id":"51012819","gene_card_id":"FMP31","chromosome_location":null,"locus":"YOR286W","synonyms":["Found in mitochondrial proteome protein 31"],"enzyme_classes":["2.8.1.1"],"go_classes":[],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[],"gene_sequence":"ATGTTCAAGCATAGTACAGGTATTCTCTCGAGGACAGTTTCTGCAAGATCGCCTACATTGGTCCTGAGAACATTTACAACGAAGGCTCCAAAGATCTATACTTTTGACCAGGTCAGGAACCTAGTCGAACACCCCAATGATAAAAAACTATTGGTAGATGTAAGGGAACCCAAGGAAGTAAAGGATTACAAGATGCCAACTACAATAAATATTCCGGTGAATAGTGCCCCTGGCGCTCTTGGATTGCCCGAAAAGGAGTTTCACAAAGTTTTCCAATTTGCTAAACCACCTCACGATAAAGAATTGATTTTTCTTTGTGCGAAAGGAGTAAGAGCCAAAACTGCCGAAGAGTTGGCTCGATCTTATGGGTACGAAAACACTGGTATCTATCCTGGTTCTATTACTGAGTGGTTAGCTAAAGGTGGTGCTGACGTTAAGCCCAAAAAATAA","protein_sequence":"MFKHSTGILSRTVSARSPTLVLRTFTTKAPKIYTFDQVRNLVEHPNDKKLLVDVREPKEVKDYKMPTTINIPVNSAPGALGLPEKEFHKVFQFAKPPHDKELIFLCAKGVRAKTAEELARSYGYENTGIYPGSITEWLAKGGADVKPKK"},{"created_at":"2011-05-26T17:18:56.000Z","updated_at":"2011-05-26T17:18:56.000Z","name":"Putative thiosulfate sulfurtransferase YOR285W","uniprot_id":"Q12305","uniprot_name":"YO285_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":139,"molecular_weight":"15413.2002","theoretical_pi":"6.35","general_function":"Inorganic ion transport and metabolism","specific_function":"Thiosulfate + cyanide = sulfite + thiocyanate","reactions":[{"id":2471,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm;Mitochondrion","altext":"Thiosulfate + cyanide = sulfite + thiocyanate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X89633","genbank_protein_id":"1279709","gene_card_id":null,"chromosome_location":null,"locus":"YOR285W","synonyms":[],"enzyme_classes":["2.8.1.1"],"go_classes":[],"pfams":[{"name":"Rhodanese","identifier":"PF00581"}],"pathways":[],"gene_sequence":"ATGTGGAAGGCCGTGATGAATGCTTGGAATGGAACCGAGAGTCAAAGTAAGAATGTTTCAAATATTCAATCTTACAGTTTTGAAGACATGAAAAGAATCGTTGGAAAGCATGATCCTAATGTGGTTTTGGTAGATGTTAGAGAACCATCTGAGTACTCGATTGTTCATATTCCTGCTTCCATCAATGTGCCATATAGATCGCACCCTGACGCATTTGCCTTAGATCCTTTAGAATTTGAGAAACAGATTGGCATCCCAAAACCTGACAGTGCCAAGGAGCTAATATTTTATTGTGCTTCTGGCAAACGCGGGGGAGAAGCTCAAAAAGTCGCCTCCTCACATGGATATTCAAACACCTCACTATATCCTGGCTCTATGAATGATTGGGTTTCTCATGGGGGTGATAAACTTGACTTATAG","protein_sequence":"MWKAVMNAWNGTESQSKNVSNIQSYSFEDMKRIVGKHDPNVVLVDVREPSEYSIVHIPASINVPYRSHPDAFALDPLEFEKQIGIPKPDSAKELIFYCASGKRGGEAQKVASSHGYSNTSLYPGSMNDWVSHGGDKLDL"},{"created_at":"2011-05-27T02:02:51.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Sulfite efflux pump SSU1","uniprot_id":"P41930","uniprot_name":"SSU1_YEAST","enzyme":false,"transporter":true,"gene_name":"SSU1","num_residues":458,"molecular_weight":"52544.69922","theoretical_pi":"8.6","general_function":"Involved in transmembrane transport","specific_function":"Involved in efflux of free sulfite. Mutations in the SSU1 gene cause sensitivity to sulfite","reactions":[],"signal_regions":"None","transmembrane_regions":"12-32;49-69;90-110;136-156;177-197;221-241;253-275;310-330;351-371;388-408","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"AB002531","genbank_protein_id":"1944122","gene_card_id":"SSU1","chromosome_location":"chromosome 16","locus":"YPL092W","synonyms":["Sulfite sensitivity protein SSU1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"C4dic_mal_tran","identifier":"PF03595"}],"pathways":[],"gene_sequence":"ATGGTTGCCAATTGGGTACTTGCTCTTACGAGGCAGTTTGACCCCTTCATGTTTGTGATGGTCATGGGTGTCGGCATTTCATCGAATATTCTATATAGCTTCCCATATCCTGCAAGGTGGCTAAGAATATGCTCCTACATCATGTTTGCTATCACTTGCCTTATTTTCATTGCTGTGCAGGCACTACAAATATTACATTTGATTGTCTATATTAAGGAGAAAAGCTTCAGAGAATATTTTAATGACTTTTTCAGAAATATGAAGCACAGTTTATTTTGGGGTACTTATCCCATGGGGTTAGTTACAATTATAAATTTCTTAGGAGCACTCTCGAAAGCGAACACGACGAAGAGCCCCACTAATGCCAGAAATTTGATGATATTTGTTTACGTCTTGTGGTGGTATGATCTCGCAGTCTGTCTAGTAATAGCGTGGGGTATCTCGTTTCTCATCTGGCATGACTATTACTCTTTGGAAGGGATTGGGAATTATCCTTCATATAATATCAAAATGGCATCCGAAAACATGAAAAGTGTATTGCTACTGGATATCATTCCGCTGGTTGTCGTCGCTTCAAGTTGTGGAACATTCACAATGTCAGAAATATTCTTCCATGCGTTTAATAGAAACATTCAACTGATAACGTTGGTCATATGTGCCTTAACGTGGCTGCATGCCATTATCTTCGTCTTCATACTGATTGCGATATACTTCTGGAGTCTTTATATTAATAAGATACCACCAATGACACAGGTTTTCACCTTATTCCTGCTTTTGGGCCCGATGGGCCAAGGAAGTTTTGGAGTCTTATTGCTTACAGATAATATAAAAAAATATGCGGGCAAATATTACCCAACAGATAACATTACAAGAGAACAAGAGATATTGACTATTGCAGTTCCATGGTGTTTCAAAATTCTAGGCATGGTTTCTGCTATGGCATTGCTCGCTATGGGCTATTTTTTCACCGTGATTTCTGTCGTTTCAATCCTGTCGTACTACAATAAAAAAGAGATTGAAAACGAGACAGGAAAAGTGAAGAGAGTTTATACCTTCCACAAAGGTTTTTGGGGGATGACTTTCCCGATGGGTACTATGTCTTTAGGAAACGAAGAGTTATATGTGCAGTATAACCAGTACGTTCCCTTATATGCATTTAGAGTCCTAGGAACCATATACGGCGGTGTTTGCGTTTGTTGGTCAATTCTATGCCTTTTATGCACATTGCATGAGTATTCTAAAAAGATGCTGCATGCTGCCCGTAAATCTTCATTATTTTCAGAGTCAGGTACGGAAAAGACGACAGTTTCTCCGTATAACAGCATTGAAAGCGTGGAAGAATCAAACTCGGCTCTAGATTTTACGCGTTTAGCATAA","protein_sequence":"MVANWVLALTRQFDPFMFMMVMGVGISSNILYSFPYPARWLRICSYIMFAIACLIFIAVQALQILHLIVYIKEKSFREYFNDFFRNMKHNLFWGTYPMGLVTIINFLGALSKANTTKSPTNARNLMIFVYVLWWYDLAVCLVIAWGISFLIWHDYYPLEGIGNYPSYNIKMASENMKSVLLLDIIPLVVVASSCGTFTMSEIFFHAFNRNIQLITLVICALTWLHAIIFVFILIAIYFWSLYINKIPPMTQVFTLFLLLGPMGQGSFGVLLLTDNIKKYAGKYYPTDNITREQEILTIAVPWCFKILGMVSAMALLAMGYFFTVISVVSILSYYNKKEIENETGKVKRVYTFHKGFWGMTFPMGTMSLGNEELYVQYNQYVPLYAFRVLGTIYGGVCVCWSILCLLCTLHEYSKKMLHAARKSSLFSESGTEKTTVSPYNSIESVEESNSALDFTRLA"},{"created_at":"2011-05-27T02:03:15.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Alpha-ketoglutarate-dependent sulfonate dioxygenase","uniprot_id":"Q12358","uniprot_name":"JLP1_YEAST","enzyme":true,"transporter":false,"gene_name":"JLP1","num_residues":412,"molecular_weight":"46982.30078","theoretical_pi":"6.65","general_function":"Involved in oxidoreductase activity","specific_function":"Acts as a alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate","reactions":[{"id":1994,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14420,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006933","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692737","genbank_protein_id":"51012925","gene_card_id":"JLP1","chromosome_location":"chromosome 12","locus":"YLL057C","synonyms":[],"enzyme_classes":["1.14.11.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"TauD","identifier":"PF02668"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCTCCTGCAGCAGCTCAAACAGCAATCCCTCTTCCATCTACCGATTTACCAGTCAAAATCATTACAAATGGGTTGAAAAACCTGAATTATACCTCCAAGCAAGGTTACGGGAATTTTGATACCCATTTTTATGATGGCCAAGATGAGGTCTCTCCATCTGGTTTATTGAAAATCCGTAAATCTTATAGAGAGAAATCGAAGTATCCAGATTATTTGCCTACATGGGATCCTACTGAAAAGTATGGCCCGCTGGAATTTCACGAATACCATGATCCTGCTTTGAGAGCTGACGGTAACTTTTCAAACCTTTTTGCAAAAGAAAACGTTGGTCAACTAAAGGTGAAGAAGATCACCCCGAAATTAGGTCTCGAGATCAATGGGATCCAGCTAACTGATCTTTCTGATGCTGCAAAAGATGAACTCGCTTTGCTTGTCGCCCAAAAGGGAGTAGTTGTCTTTAGAAATCAGAATTTTGCTGACGAGGGACCCGATTATGTGACTGAATACGGAAGACATTTTGGCAAGTTGCACATTCATCAAACTAGTGGCCACCCTCAAAACAATCCTGAGCTGCATATCACTTTCCGAAGACCTGATGCGGAAGAATTTGCAAGAGTTTTTGATGACTCGACATCATCTGGTGGCTGGCACACAGACGTCTCTTACGAGTTACAGCCACCTTCTTATACTTTCTTTAGTGTTGTTGAAGGTCCTGATGGTGGTGGAGATACGTTATTTGCGGATACGATCGAGGCTTTCGACAGGTTGTCGAAGCCTTTGCAAGATTTCTTGAGCACGCTTCATGTCATCCATAGCTCAAAGGAACAGGCAGAGAATTCACAGCGCCAGGGCGGCATAAAAAGAAGAGCACCTGTCACGCATATTCATCCACTGGTCAGAGTTCATCCTGTCTTGAAAAAGAAATGCTTGTATGTCAATCGTGCATTTTCTAGGAAAATAGTCGAATTGAAAAGACAAGAATCTGAATCACTTTTGAATTTCTTGTACAATCTAGTGGAGAGCAGCCATGATTTACAGTTAAGAGCCAAATGGGAACCTCATTCCGTCGTCATTTGGGATAACCGCAGAGTTCAACATTCAGCAGTGATTGATTGGGAAGAACCAATTCACAGACATGCGTTCAGGATTACTCCACAAGCGGAAAGGCCCGTGGAAGATCTAAAGTTTTTGAATGATGAAAATTATTATCCTTCTTCATTAACTTTGGATATTTGA","protein_sequence":"MSPAAAQTAIPLPSTDLPVKIITNGLKNLNYTSKQGYGNFDTHFYDGQDEVSPSGLLKIRKSYREKSKYPDYLPTWDPTEKYGPLEFHEYHDPALRADGNFSNLFAKENVGQLKVKKITPKLGLEINGIQLTDLSDAAKDELALLVAQKGVVVFRNQNFADEGPDYVTEYGRHFGKLHIHQTSGHPQNNPELHITFRRPDAEEFARVFDDSTSSGGWHTDVSYELQPPSYTFFSVVEGPDGGGDTLFADTIEAFDRLSKPLQDFLSTLHVIHSSKEQAENSQRQGGIKRRAPVTHIHPLVRVHPVLKKKCLYVNRAFSRKIVELKRQESESLLNFLYNLVESSHDLQLRAKWEPHSVVIWDNRRVQHSAVIDWEEPIHRHAFRITPQAERPVEDLKFLNDENYYPSSLTLDI"},{"created_at":"2011-05-27T02:03:54.000Z","updated_at":"2011-05-27T02:03:54.000Z","name":"Sulfite reductase [NADPH] subunit beta","uniprot_id":"P47169","uniprot_name":"ECM17_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM17","num_residues":1442,"molecular_weight":"161218.0","theoretical_pi":"5.15","general_function":"Involved in iron ion binding","specific_function":"Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate","reactions":[{"id":1992,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2657,"direction":"\u003e","locations":"Cytoplasm","altext":"H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14423,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006936","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49637","genbank_protein_id":"1015876","gene_card_id":"ECM17","chromosome_location":null,"locus":"YJR137C","synonyms":["Extracellular mutant protein 17"],"enzyme_classes":["1.8.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Flavodoxin_1","identifier":"PF00258"},{"name":"NIR_SIR","identifier":"PF01077"},{"name":"NIR_SIR_ferr","identifier":"PF03460"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTGCTTCTGACCTCTTGACGCTCCCACAATTGTTGGCGCAATATTCCTCTAGTGCTCCCCAAAATAAAGTGTTCTACACTACTAGCACAAAAAATAGTCATTCATCCTTCAAAGGGCTAGAATCTGTTGCCACAGATGCTACTCATCTATTGAACAATCAAGATCCATTGAATACCATCAAAGATCAACTCTCTAAGGACATTTTAACTACCGTTTTTACAGATGAAACTACTTTGGTCAAATCCATCCACCATCTATATTCTCTTCCTAATAAACTTCCATTGGTGATTACAGTGGATTTGAATTTGCAAGATTATTCCGCAATTCCTGCGTTAAAGGATCTTTCTTTCCCCATCTTAATATCTTCTGATTTGCAAACTGCAATTTCAAACGCGGACTCTTCTTATAAGATTGCTACAAGTTCTCTGACCCCAGTTTTCCATTTTCTTAACTTGGAGAAAATTGGCACGAGTACAGCTATTGAACAAGACATCGACTTTCCTACCTTGGAGATTGCTAACGAAGAGACTAAAGTAGCATTATCAGAAGCTACTGATTCATTGACAAATTTTGAACTGGTTAAAGGTAAAGAGTCAATTACCACTGTCATTGTTAACCTGTCACCATATGACGCGGAATTCAGTAGCGTATTGCCTTCAAACGTAGGATTGATCAAGATTAGAGTATACAGACCATGGAATTTTTCCAAGTTCTTGGAAATACTGCCATCTTCTGTTACCAAAATCGCCGTTTTACAGGGTGTCTCTAAGAAATCGCAATCAAACGAATTTCAACCATTTCTTTTGGACTTCTTTGGCAATTTTAATGAATTAGTTTCTAGGAACATCGAGCAGGTAGTGTTGACTAATATTGGTAATGTGAATGATTATGGCAACGTTATCAACACCGTCATATCGAATATTAACAAGAAGGAACCAGATAATAACTTATTTTTAGGTGAATCCAATGAAAAGGCTGAGGAACAAGCTGAAGTTACTCAACTTATTTCTTCTGTCAAAAAAGTTGTGAACTTAGAAGACGCCTATATCAAAGTGCTAAAACAGTTATTTTCATCAAATCTACAAATTTTGAATCAATTTTCCAGTGAGACAATTGAACCAAGTAATCCAGAATTTGGTTTTGGACGCTTTTTAAAACAAGAAGCCCAGCGTGAAGAATTGATCAGCTTAGCAAAAACCTCTCTTGATCCAAGTCTTTACTTGTCCGAGGATGCAAATAAAATTGTTCAACTATTATCTAAATGGTTGTCATTCAATGGACGCGATCTTGACGAAGCTCAATTACAAGAGGCCAATGCGACAGGTTTGGAAATATTTCAGTTATTACAATCTAATCAAGATTCCTCTACTGTCTTAAAATTCTTAAAGATAGCTCCAACAAGCGATTCTTTTATTTTCAAATCAAGCTGGCTAATTGGCTCCGATGCCTGGTCTTATGATTTGGGTCACTCAGGTATTCAACAGGTTTTATCCTCCCGTAAAAACATTAATGTTTTATTGATTGATTCAGAGCCATATGACCATAGAAAGCAAAACCAGGATAGAAAGAAAGATGTTGGTTTGTACGCCATGAATTATTACAGTGCCTATGTTGCCTCTGTAGCAGTATATGCTTCTTACACCCAACTATTGACTGCAATAATAGAGGCATCTAAATACAATGGTCCTTCTATTGTCTTGGCTTATTTGCCGTATAATTCCGAAAATGATACTCCATTAGAAGTCTTAAAGGAAACCAAAAACGCCGTTGAATCTGGTTACTGGCCATTGTATAGGTTTAATCCTGTTTATGACGATCCATCAACAGATAAGGAGGCATTTAGCTTGGATTCTTCGGTTATCAGAAAACAATTACAGGACTTCTTAGACCGTGAGAATAAGCTTACCCTATTAACCAGAAAAGATCCATCTTTGTCAAGAAATCTAAAGCAATCTGCTGGTGATGCGTTGACAAGGAAACAAGAAAAAAGAAGCAAGGCTGCCTTCGATCAGTTATTGGAGGGTTTGTCCGGCCCACCGCTACACGTCTATTATGCTTCTGACGGTGGTAATGCTGCAAACTTGGCAAAGAGACTAGCAGCAAGGGCATCTGCAAGAGGTTTAAAGGCTACTGTTCTGTCCATGGATGACATTATTTTGGAAGAATTACCTGGTGAAGAGAATGTAGTTTTCATTACTTCCACGGCTGGGCAAGGTGAATTCCCCCAAGACGGTAAGTCTTTCTGGGAAGCTCTGAAAAATGACACCGACTTGGATTTAGCTAGTTTGAATGTTGCTGTTTTTGGTCTCGGTGATTCTGAGTATTGGCCACGTAAAGAAGATAAACATTATTTTAACAAGCCTTCACAGGATTTATTTAAGCGCTTGGAATTATTGAGTGCCAAAGCCCTAATTCCCTTGGGACTGGGTGATGATCAAGATGCTGATGGTTTCCAAACTGCTTATTCTGAGTGGGAACCTAAATTATGGGAAGCTCTTGGTGTTTCCGGCGCTGCTGTTGATGATGAGCCAAAACCTGTTACAAACGAGGATATTAAGAGAGAATCTAATTTCTTGAGAGGTACTATCAGTGAGAACTTAAAGGATACTTCTTCAGGTGGTGTTACTCACGCTAATGAACAATTAATGAAATTTCACGGTATTTACACCCAAGACGATCGTGACATTAGAGAAATACGTAAGTCACAAGGCTTAGAGCCATACTATATGTTTATGGCAAGAGCTCGTTTACCAGGTGGTAAGACCACTCCACAACAATGGCTTGCTCTGGATCACTTATCTGATACTTCAGGCAATGGTACCCTGAAATTAACAACAAGGGCAACCTTCCAGATTCATGGTGTGCTAAAGAAGAACTTGAAACACACATTGAGAGGAATGAATGCAGTTCTTATGGATACATTAGCTGCTGCAGGTGACGTGAACAGAAATGTCATGGTTTCTGCTCTACCAACCAATGCCAAGGTTCACCAACAAATCGCTGATATGGGAAAATTGATTTCTGATCATTTCTTACCAAAGACTACGGCCTACCACGAAGTTTGGCTGGAGGGCCCAGAAGAACAGGACGATGATCCATCCTGGCCATCTATTTTTGAAAACAGAAAAGATGGTCCAAGAAAAAAGAAGACTCTAGTTAGCGGTAACGCTTTGGTCGATATTGAACCAATTTACGGTCCAACTTATCTGCCAAGAAAGTTTAAATTCAACATCGCCGTTCCTCCATATAACGATGTGGATGTATTATCTATCGATGTCGGTTTAGTTGCTATAGTTAACCCAGAAACTCAAATCGTGGAGGGTTATAATGTTTTTGTTGGTGGTGGTATGGGTACCACTCATAACAACAAGAAAACTTACCCAAGATTAGGGTCATGCTTAGGTTTTGTTAAAACTGAAGACATTATTCCACCACTTGAAGGTATCGTTATTGTCCAAAGAGATCACGGTGACCGTAAAGACCGTAAGCATGCTCGTTTAAAGTATACTGTAGATGATATGGGTGTCGAAGGCTTCAAGCAAAAAGTGGAGGAATACTGGGGTAAGAAATTCGAGCCTGAGAGACCATTTGAGTTTAAATCTAATATTGATTACTTTGGATGGATTAAAGATGAAACTGGGTTAAACCACTTTACCGCATTTATTGAAAATGGTAGGGTTGAAGATACACCAGATTTGCCTCAAAAGACAGGTATTAGAAAGGTTGCTGAATACATGCTTAAGACTAATTCTGGTCATTTCAGATTGACTGGTAATCAACATTTGGTTATCTCTAATATTACAGATGAACATGTTGCTGGAATAAAATCTATTTTAAAGACCTATAAATTGGATAACACCGATTTCAGCGGTTTGAGATTATCTTCATCTTCCTGTGTTGGTTTGCCAACATGTGGTTTAGCGTTTGCCGAATCTGAACGTTTCCTACCTGACATTATTACTCAGTTGGAAGATTGTTTAGAAGAGTATGGTTTACGCCATGATTCCATTATTATGAGAATGACTGGTTGCCCTAACGGTTGTTCTCGTCCATGGCTAGGTGAATTAGCTCTTGTTGGTAAAGCTCCACATACTTATAACTTGATGCTTGGTGGTGGTTACCTCGGCCAAAGGCTAAACAAATTGTATAAGGCCAATGTGAAGGATGAGGAAATTGTCGACTACATCAAACCATTGTTTAAAAGGTATGCTTTAGAAAGAGAAGAAGGGGAACACTTTGGTGATTTCTGTATAAGAGTAGGTATCATTAAACCAACCACCGAGGGTAAATACTTCCATGAAGATGTGTCTGAAGATGCCTATTAA","protein_sequence":"MTASDLLTLPQLLAQYSSSAPQNKVFYTTSTKNSHSSFKGLESVATDATHLLNNQDPLNTIKDQLSKDILTTVFTDETTLVKSIHHLYSLPNKLPLVITVDLNLQDYSAIPALKDLSFPILISSDLQTAISNADSSYKIATSSLTPVFHFLNLEKIGTSTAIEQDIDFPTLEIANEETKVALSEATDSLTNFELVKGKESITTVIVNLSPYDAEFSSVLPSNVGLIKIRVYRPWNFSKFLEILPSSVTKIAVLQGVSKKSQSNEFQPFLLDFFGNFNELVSRNIEQVVLTNIGNVNDYGNVINTVISNINKKEPDNNLFLGESNEKAEEQAEVTQLISSVKKVVNLEDAYIKVLKQLFSSNLQILNQFSSETIEPSNPEFGFGRFLKQEAQREELISLAKTSLDPSLYLSEDANKIVQLLSKWLSFNGRDLDEAQLQEANATGLEIFQLLQSNQDSSTVLKFLKIAPTSDSFIFKSSWLIGSDAWSYDLGHSGIQQVLSSRKNINVLLIDSEPYDHRKQNQDRKKDVGLYAMNYYSAYVASVAVYASYTQLLTAIIEASKYNGPSIVLAYLPYNSENDTPLEVLKETKNAVESGYWPLYRFNPVYDDPSTDKEAFSLDSSVIRKQLQDFLDRENKLTLLTRKDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPLHVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENVVFITSTAGQGEFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLELLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEALGVSGAAVDDEPKPVTNEDIKRESNFLRGTISENLKDTSSGGVTHANEQLMKFHGIYTQDDRDIREIRKSQGLEPYYMFMARARLPGGKTTPQQWLALDHLSDTSGNGTLKLTTRATFQIHGVLKKNLKHTLRGMNAVLMDTLAAAGDVNRNVMVSALPTNAKVHQQIADMGKLISDHFLPKTTAYHEVWLEGPEEQDDDPSWPSIFENRKDGPRKKKTLVSGNALVDIEPIYGPTYLPRKFKFNIAVPPYNDVDVLSIDVGLVAIVNPETQIVEGYNVFVGGGMGTTHNNKKTYPRLGSCLGFVKTEDIIPPLEGIVIVQRDHGDRKDRKHARLKYTVDDMGVEGFKQKVEEYWGKKFEPERPFEFKSNIDYFGWIKDETGLNHFTAFIENGRVEDTPDLPQKTGIRKVAEYMLKTNSGHFRLTGNQHLVISNITDEHVAGIKSILKTYKLDNTDFSGLRLSSSSCVGLPTCGLAFAESERFLPDIITQLEDCLEEYGLRHDSIIMRMTGCPNGCSRPWLGELALVGKAPHTYNLMLGGGYLGQRLNKLYKANVKDEEIVDYIKPLFKRYALEREEGEHFGDFCIRVGIIKPTTEGKYFHEDVSEDAY"},{"created_at":"2011-05-27T02:04:30.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Phosphoadenosine phosphosulfate reductase","uniprot_id":"P18408","uniprot_name":"MET16_YEAST","enzyme":true,"transporter":false,"gene_name":"MET16","num_residues":261,"molecular_weight":"30380.09961","theoretical_pi":"5.8","general_function":"Involved in phosphoadenylyl-sulfate reductase (thioredoxin) activity","specific_function":"The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier","reactions":[{"id":2658,"direction":"\u003e","locations":null,"altext":"Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":14419,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006932","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693236","genbank_protein_id":"51013923","gene_card_id":"MET16","chromosome_location":"chromosome 16","locus":"YPR167C","synonyms":["3'-phosphoadenylylsulfate reductase","PAPS reductase, thioredoxin dependent","PAdoPS reductase"],"enzyme_classes":["1.8.4.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" phosphoadenylyl-sulfate reductase (thioredoxin) activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" cysteine biosynthetic process"},{"category":"Process","description":" sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" sulfur metabolic process"},{"category":"Process","description":" sulfate assimilation"},{"category":"Process","description":" sulfur amino acid metabolic process"}],"pfams":[{"name":"PAPS_reduct","identifier":"PF01507"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGAAGACCTATCATTTGAATAATGATATAATTGTCACACAAGAACAGTTGGATCATTGGAATGAACAACTAATCAAGCTGGAAACGCCACAGGAGATTATTGCATGGTCTATCGTAACGTTTCCTCACCTTTTCCAAACCACTGCATTTGGTTTGACTGGCTTGGTTACTATCGATATGTTGTCAAAGCTATCTGAAAAATACTACATGCCAGAACTATTATTTATAGACACTTTGCACCATTTCCCACAAACTTTAACACTAAAAAACGAGATTGAGAAAAAATACTACCAGCCTAAAAATCAAACCATTCACGTATATAAGCCGGATGGATGTGAATCGGAGGCAGATTTTGCCTCGAAATACGGGGATTTCTTATGGGAGAAAGATGATGACAAGTACGATTATCTGGCCAAAGTGGAACCTGCACATCGTGCCTACAAAGAGCTACATATAAGTGCTGTGTTTACTGGTAGAAGAAAATCACAAGGTTCTGCCCGCTCCCAACTGTCGATTATTGAAATAGACGAACTTAATGGAATCTTAAAAATAAATCCATTGATCAATTGGACGTTCGAGCAGGTTAAACAGTATATAGATGCAAACAATGTACCATACAACGAACTTTTGGACCTTGGATATAGATCCATTGGTGATTACCATTCCACACAACCCGTCAAGGAAGGTGAAGATGAGAGAGCAGGAAGATGGAAGGGCAAGGCCAAGACCGAGTGTGGAATTCATGAAGCCAGCCGATTCGCGCAATTTTTAAAGCAAGATGCCTAG","protein_sequence":"MKTYHLNNDIIVTQEQLDHWNEQLIKLETPQEIIAWSIVTFPHLFQTTAFGLTGLVTIDMLSKLSEKYYMPELLFIDTLHHFPQTLTLKNEIEKKYYQPKNQTIHVYKPDGCESEADFASKYGDFLWEKDDDKYDYLAKVEPAHRAYKELHISAVFTGRRKSQGSARSQLSIIEIDELNGILKINPLINWTFEQVKQYIDANNVPYNELLDLGYRSIGDYHSTQPVKEGEDERAGRWKGKAKTECGIHEASRFAQFLKQDA"},{"created_at":"2011-05-27T02:05:04.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Sulfite reductase [NADPH] flavoprotein component","uniprot_id":"P39692","uniprot_name":"MET10_YEAST","enzyme":true,"transporter":false,"gene_name":"MET10","num_residues":1035,"molecular_weight":"114827.0","theoretical_pi":"4.91","general_function":"Involved in oxidoreductase activity","specific_function":"This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate","reactions":[{"id":1992,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2657,"direction":"\u003e","locations":"Cytoplasm","altext":"H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D44610","genbank_protein_id":"624931","gene_card_id":"MET10","chromosome_location":"chromosome 6","locus":"YFR030W","synonyms":[],"enzyme_classes":["1.8.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"FAD_binding_1","identifier":"PF00667"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCAGTTGAGTTTGCTACCAATCCTTTTGGCGAGGCCAAAAATGCAACTTCACTGCCAAAATATGGTACACCCGTAACTGCCATTTCATCTGTGCTGTTCAATAACGTGGACTCCATTTTTGCTTACAAGTCCTTTTCTCAACCCGATTTGCTACACCAAGATCTAAAAAAATGGTCTGAAAAGCGTGGTAACGAATCACGTGGGAAGCCATTTTTCCAAGAGCTGGATATCAGATCTGGCGCTGGTTTGGCTCCTTTAGGGTTTTCTCATGGATTGAAGAACACTACAGCAATTGTTGCTCCAGGGTTTTCGCTGCCATACTTCATTAACTCTTTGAAAACCGTCTCTCATGATGGTAAGTTTCTTTTGAATGTTGGTGCTTTAAACTACGACAATGCTACCGGCTCTGTCACCAACGATTATGTAACCGCATTGGATGCTGCTTCCAAGCTGAAGTATGGTGTCGTGACTCCGATTTCCGCTAACGAGGTACAAAGTGTCGCCTTACTGACATTGGCGATTGCCACTTTCAGTAATAACTCCGGAGCTATCAATTTATTTGACGGATTAAACTACTCGAAAACCGTCTTGCCGTTGGTCGAATCTGTTCCTGAGGCATCTATTTTGGCAAAACTATCCAAAGTTATTGCACCAGATGCTGCCTTTGATGATGTCTTGGATAAGTTTAATGAATTGACTGGATTGAGACTACATAATTTCCAATACTTTGGTGCTCAGGATGCTGAAACTGTGTTTATCACTTATGGGTCTTTAGAATCCGAATTGTTCAACTCTGCGATTAGTGGTAATAATTCCAAAATCGGGTTAATCAACGTCAGAGTACCATTACCTTTTAACGTTGCTAAGTTTGTCACTCACGTTCCATCCACTACCAAACAAATTGTTGTTATAGGCCAAACTTTGGATGGTTCTTCGCCTTCTTTCTTGAGATCTCAAGTTTCAGCCGCCTTATTTTACCACGGCCGCACCTCAATTAGCGTTTCTGAGTACATCTATCAACCAGATTTCATTTGGTCCCCAAAAGCTGTCAAATCAATTGTATCGTCATTCATCCCTGAATTCACTTACAATGCCGATTCATCTTTCGGCGAAGGATTCATTTATTGGGCCTCTGATAAGAGTATCAATATTGATGTTGCCTCCAAACTTGTGAAAGCTCTGTCTTTGGAAGATGGGAAATTTGTGTCTTTGAGAACGAAATTTGATAACTTGGCTAATGCTGGTACCTTCCAAGCTCAATTTGTGACCTCGAAAGAACAGATACCTGTTTCAAACATCGATTCTACGAAATTATCAGTCGTTGAAGATGTCAGTTTATTGAAGCATTTAGACGTAGCTGCTACCGTCGCAGAACAAGGTTCAATTGCGTTGGTTTCCCAAAAGGCAGTTAAAGATTTGGATTTAAATTCTGTAGAAAGTTACGTCAAGAATTTGGGAATTCCTGAATCATTCCTAATATCTATTGCGAAGAAAAACATCAAATTGTTTATCATCGATGGTGAGACCACTAACGACGAGTCCAAATTGTCCTTGTTTATCCAAGCCGTTTTCTGGAAATTGGCCTTCGGTCTAGATGTCGCAGAATGTACCAACCGTATCTGGAAAAGCATTGATTCAGGTGCAGACATTTCAGCAGCCTCGATTTCTGAATTTCTCACTGGTGCATTCAAAAACTTCCTCAGTGAGGTTCCGCTAGCGCTGTACACTAAATTTTCTGAAATAAACATTGAAAAGAAAGAGGATGAGGAAGAGCCTGCAGCTTTACCAATTTTCGTTAATGAAACATCTTTCCTCCCAAATAACAGTACCATTGAAGAAATACCATTACCTGAGACCTCTGAGATCTCTGATATTGCCAAGAAGTTGTCCTTCAAAGAGGCATATGAAGTTGAGAATAAACTAAGACCCGATTTACCCGTCAAGAACTTCGTCGTGAAAGTTAAAGAAAATAGACGTGTTACGCCTGCTGATTATGATAGATATATTTTCCATATTGAATTCGATATTTCTGGTACTGGAATGACTTATGACATCGGTGAAGCCCTCGGTATTCATGCCAGAAACAATGAATCTTTGGTCAAAGAATTCTTAACCTTCTATGGTCTAAATGAATCCGATGTTGTCTTAGTCCCCAACAAGGACAACCACCATTTGTTAGAAACAAGAACCGTCTTACAAGCATTTGTGGAAAATTTGGATATTTTCGGTAAACCACCAAAAAGATTTTACGAATCATTGATTCCATATGCCTCTAACGAAGAGGAGAAGAAAAAATTAGAGGATTTGGTTACTCCTGCCGGTGCAGTAGATTTGAAGAGATTTCAAGATGTGGAGTATTATACATATGCTGACATTTTTGAATTGTTCCCATCTGTTCGCCCATCTCTTGAGGAACTTGTTACTATCATTGAACCATTGAAGAGAAGAGAATACTCAATTGCCTCCTCTCAGAAAGTTCATCCAAATGAAGTTCATTTATTGATCGTTGTTGTTGATTGGGTGGATAATAAAGGAAGAAAAAGGTACGGTCAAGCTTCTAAGTATATCTCAGACCTTGCTGTCGGTTCAGAATTGGTCGTTAGCGTTAAACCATCTGTTATGAAATTACCACCATCTCCAAAGCAACCAGTTATTATGAGTGGTTTAGGTACTGGTTTGGCACCATTCAAGGCCATTGTTGAAGAGAAATTATGGCAAAAGCAGCAAGGTTATGAGATTGGTGAAGTCTTCCTATATCTAGGTTCAAGACACAAAAGAGAAGAATATTTATATGGTGAGTTATGGGAGGCTTACAAAGATGCAGGTATTATCACACACATCGGCGCTGCTTTCTCAAGAGACCAACCTCAAAAAATTTACATTCAAGATCGTATCAAAGAGAATTTGGATGAATTAAAAACTGCAATGATTGATAATAAAGGTTCATTTTACTTGTGTGGCCCTACTTGGCCAGTTCCAGATATTACTCAAGCTTTGCAAGACATTCTGGCTAAAGACGCCGAGGAAAGAGGCATCAAAGTCGACTTGGATGCCGCAATTGAAGAATTAAAGGAAGCATCAAGATACATTTTAGAAGTCTACTAA","protein_sequence":"MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYKSFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAPGFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPISANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIAPDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIGLINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSISVSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLVKALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKHLDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDGETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKNFLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEISDIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY"},{"created_at":"2016-09-09T22:50:41.000Z","updated_at":"2016-09-09T22:50:41.000Z","name":"NADPH-dependent diflavin oxidoreductase 1","uniprot_id":"Q12181","uniprot_name":"TAH18","enzyme":false,"transporter":false,"gene_name":"TAH18","num_residues":623,"molecular_weight":"72327.29","theoretical_pi":null,"general_function":"small molecule metabolic process","specific_function":"Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death.","reactions":[{"id":14423,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006936","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["NADPH-dependent FMN and FAD-containing oxidoreductase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"cytosol"},{"category":"Function","description":"mitochondrion"},{"category":"Function","description":"FMN binding"},{"category":"Function","description":"flavin adenine dinucleotide binding"},{"category":"Function","description":"NADP binding"},{"category":"Function","description":"NADPH-hemoprotein reductase activity"},{"category":"Function","description":"oxidoreductase activity, acting on NAD(P)H"},{"category":"Function","description":"iron-sulfur cluster assembly"},{"category":"Function","description":"nitric oxide biosynthetic process"},{"category":"Function","description":"oxidation-reduction process"},{"category":"Function","description":"small molecule metabolic process"}],"pfams":[],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCATCGAGCAAGAAAATCGTCATCCTCTATGGATCGGAGACAGGTAACGCGCATGATTTTGCTACAATCTTATCCCATCGACTACATCGCTGGCATTTCTCCCATACATTTTGCTCCATTGGTGATTATGACCCACAGGATATCTTGAAATGCAGGTACCTTTTTATTATATGCTCCACAACAGGCCAAGGTGAATTACCAAGGAATGTCAATGCATTAAAAGGTGAAAGACCCGTCACGTTCTGGTCGTTTTTAAAGAGAAAGAATCTTCCGTCGAATTTGCTCAACCATATTCAAACTGCCATGCTTGGACTTGGTGATTCATCTTATCCTAAGTTTAACTACGGCATTAGAAAGCTACATCAGCGCATTGTCACACAATTGGGTGCTAATGAATTATTCGATAGATTGGAGGCTGACGACCAGGCTATGGCTGGTAGCAATAAGGGTACAGGTCTCGGAATTGAATCAGTATATTTTGAATATGAAAAGAAAGTCCTAAGCTTTCTTTTAAGTAAGTACCCCAACAGAAAGGTCAATGGCCAAATAATTAAGAGGGAAGAATTGGACCCTGAGGTTTACCTAGAGCCAGCATCCTACCTACAGCTTTCAGACGAACATGCCAATGAAAAGTTCACTAGCACCAAGGTTATATTCGAAGGTGATGAATCGTTAAAGGTTGGCAGAGTTAATATAAACAAAAGGATTACATCTGAAGGTCATTTCCAAGACGTGAGGCAGTTCAAGTTTAGTAATGTGGACAAGATTCAAGAAAACTATGAACCCGGTGATACAGTAACCATATATCCTTGCAATACAGATGAGGATGTTTCAAGATTCCTAGCAAATCAAAGCCATTGGTTAGAAATTGCGGACAAACCATTGAATTTCACCAGTGGAGTTCCTAATGATCTTAAGGATGGTGGATTAGTTCGCCCGATGACTTTAAGGAACTTGTTGAAATATCACTGTGATTTCATGAGCATTCCTAGAACAAGTTTTTTCTTGAAGATTTGGACCTTTGCAACTGATGTAACTAAGATGGAACGTGGCCAAGAACAACTGAATGATCAAAGAGAAAAATTGCGCCAATTTGCTACTGATCAAGATATGCAGGACTTATATGACTACTGTAATAGACCCAGAAGGTCAATTCTTGAAGTACTGGAAGATTTTATCTCCGTAAAGTTGCCCTGGAAATATGTGCTAGATTACTTGCCCATCATTAAACCAAGGTACTACTCTATATCTAGCGGCCCTGGGGATCCTAATATTGAATTAACAGTTGCGATAGTAAAATATAAAACTATCTTAAGGAAAATTCGAAGAGGAATTTGCACTAACTACATTGCACGATTGCAAGAGGGGGAACAGATAAGGTATAAGTTACAAAATAATCACATAATCAAAAAGGAATTTTTGAATAAACCTATGATTCTTGTCGGACCGGGTGTCGGTCTAGCACCATTATTATCAGTGGTTAAAGCGGAGATATCTAAAGATATCAAACTCCTCTTCGGTTGTAGATATAAAGATAAAGATTATATTTATAAAGATATGCTGGAAGATTGGTTCCGTAAGGGCAAAATTGCCTTACATTCATCCTTTTCCAGAGATGAGGAAAATTCACCAGGTGTTAAATATGTCCAAGACTACTTATGGAGATTAGGTGAGGAAATAACTAATTTGGTAGTTAATAAAGACGCCGTTTTTTTCTTATGTGGCTCATCAGGTAAAATGCCTATCCAAGTCAGATTAACATTCATTGAAATGTTAAAAAAATGGGGCAATTTTAGTGATGAAGAAACTGCCAAAAAATACCTGAAAGAAATGGAAAAATCTGATAGATATATCCAGGAAACTTGGTAG","protein_sequence":"MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFLNKPMILVGPGVGLAPLLSVVKAEISKDIKLLFGCRYKDKDYIYKDMLEDWFRKGKIALHSSFSRDEENSPGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW"}]}