Putative mitochondrial carnitine O-acetyltransferase (P80235)

Identification

Name

Putative mitochondrial carnitine O-acetyltransferase

Synonyms

Not Available

Gene Name

YAT1

Enzyme Class

2.3.1.7

Biological Properties

General Function

Involved in acyltransferase activity

Specific Function

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol

Cellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side

SMPDB Pathways

Not Available

KEGG Pathways

Not Available

SMPDB Reactions

Not Available

KEGG Reactions

(R)-Carnitine + Acetyl-CoA ↔ O-acetylcarnitinium + Coenzyme A

Metabolites

YMDB ID	Name	View
YMDB00045	Coenzyme A	Show
YMDB00188	L-Carnitine	Show
YMDB00312	Acetyl-CoA	Show
YMDB00351	L-Acetylcarnitine	Show
YMDB00438	S-Adenosyl-L-methionine	Show
YMDB00616	(R)-Carnitine	Show
YMDB00617	O-acetylcarnitinium	Show

GO Classification

Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
acyltransferase activity
Process
Not Available

Gene Properties

Chromosome Location

chromosome 1

Locus

YAR035W

Gene Sequence

>2064 bp ATGCCAAACTTAAAGAGACTACCCATCCCGCCACTGCAGGACACGCTCAACCGCTACCTG GCACGCGTGGAACCCCTGCAGGACGAGCGCCAAAACCGCCGTACGCGCCGCACTGTGCTC TCCGCAGAAAACCTGGACGCATTGAACACGCTGCACGAGCGGCTGCTAGAATACGACGCA CGGCTCGCGGAAAGCAACCCAGAGTCCTCATACATCGAGCAGTTCTGGTATGACGCGTAC TTGCTATATGATGCAACTGTCGTTCTCAACGTCAACCCGTACTTCCAACTGCAGGACGAC CCAACCATCAAAGACACACCAGAGACGGCGGCACAGGGCCCCTATGGCGCACACACGGTG CAGGTTCGTCGTGCCGCACGACTCACCACCTCTATTCTCAAGTTCATCCGCCAGATTCGC CACGGCACACTCCGCACAGACACTGTGCGCGGCAAAACGCCGCTGTCGATGGACCAGTAT GAGCGGCTATTCGGCTCCAGTAGAATCCCTCCGGGTCCCGGCGAGCCCTCTTGCCACTTG CAAACAGACGCCACGTCGCATCACGTGGTGGCGATGTATCGTGGCCAGTTCTACTGGTTC GACGTGCTGGACACACGCAACGAGCCCATCTTCGCCACCCCAGAACAACTGGAGTGGAAC CTCTACTCGATCATCATGGACGCGGAATCCGCCGGAAGCGGATCCGCGCCCTTTGGCGTG TTCACCACAGAGTCGCGCCGGGTGTGGTCCAACATCAGGGACTATCTGTTCCATGCGGAC GACTGCACCAACTGGCGCAATCTCAAGCTGATCGACTCCGCGCTGTTCGTGGTCTGTCTC GACGACGTGGCGTTTGCCGCCGATCAGCAGGACGAGCTCACGCGTTCGATGCTGTGCGGG ACTTCTACCATCAATCTCGACCCGCACCAACACCAGCCGCCATTGAACGTGCAGACAGGC ACCTGTCTCAACCGCTGGTACGACAAGTTACAACTGATCGTGACCAAGAACGGTAAGGCG GGCATCAACTTCGAACACACCGGTGTGGACGGCCACACTGTGCTGCGGCTCGCCACAGAC ATCTACACAGACTCGATCCTGAGCTTCGCACGCGGTGTCACCAAGAACGTCGTCGACATC TTTAGCGACGACGATGGAAAACCATCGTCGTCGTCGTTGGCCTCGGCGGCTCACTCCGCC AACTTGATCACCATCCCTCGTAAACTGGAATGGCGCACTGACAATTTCCTGCAATCGTCG CTGCACTTTGCCGAGACGCGCATCTCGGACTTGATCTCGCAATACGAGTTTGTTAATCTT GACTTCTCCAACTACGGCGCGTCCCATATCAAGACAGTGTTCAAGTGCTCGCCAGACGCC TTCGTGCAGCAGGTGTTCCAGGTCGCATACTTCGCGTTGTACGGTCGCTTCGAGACCGTG TACGAGCCTGCCATGACCAAGGCGTTCCAAAACGGCCGCACAGAGGCCATCCGCTCCGTC ACGGGCCAATCGAAGCTCTTTGTCAAGTCACTACTGGACCAGGATGCCTCGGACGCCACC AAAATTCAGCTCTTGCACGACGCCTGTACGGCGCACTCGCAAATCACAAGGGAATGCTCC CAGGGGCTCGGCCAGGACCGTCACTTGTATGCGCTCTACTGCCTCTGGAACCAATGGTAC AAGGACAAGTTGGAGCTCCCACCCATCTTCCGCGACAAGTCCTGGACTACCATGCAGAAC AACGTCTTGAGCACCTCCAACTGCGGTAACCCCTGCCTCAAGAGCTTCGGGTTCGGGCCT GTCACCGCCAACGGCTTCGGCATCGGCTACATCATCAGAGACCACTCCGTCTCTGTGGTG GTGTCCTCAAGGCATCGCCAGACTGCTCGGTTTGCGTCGCTCATGGAAAAGTCGCTGCTG GAGATCGACCGCATCTTCAAACGGCAGCAAGCTCGCGCAGCAAAACCCGCTGCCAGGACC ACTGCTAGCGCCAACACCAAATCAGAAGACATGAAATACCTGTTGTCCGGCTACGATTAC TTCGACGTGAGCGTGTCCGGTTGA

Protein Properties

Pfam Domain Function

Carn_acyltransf (PF00755 )

Protein Residues

687

Protein Molecular Weight

77764.79688

Protein Theoretical pI

6.92

Signalling Regions

None

Transmembrane Regions

None

Protein Sequence

>Putative mitochondrial carnitine O-acetyltransferase MPNLKRLPIPPLQDTLNRYLARVEPLQDERQNRRTRRTVLSAENLDALNTLHERLLEYDA RLAESNPESSYIEQFWYDAYLLYDATVVLNVNPYFQLQDDPTIKDTPETAAQGPYGAHTV QVRRAARLTTSILKFIRQIRHGTLRTDTVRGKTPLSMDQYERLFGSSRIPPGPGEPSCHL QTDATSHHVVAMYRGQFYWFDVLDTRNEPIFATPEQLEWNLYSIIMDAESAGSGSAPFGV FTTESRRVWSNIRDYLFHADDCTNWRNLKLIDSALFVVCLDDVAFAADQQDELTRSMLCG TSTINLDPHQHQPPLNVQTGTCLNRWYDKLQLIVTKNGKAGINFEHTGVDGHTVLRLATD IYTDSILSFARGVTKNVVDIFSDDDGKPSSSSLASAAHSANLITIPRKLEWRTDNFLQSS LHFAETRISDLISQYEFVNLDFSNYGASHIKTVFKCSPDAFVQQVFQVAYFALYGRFETV YEPAMTKAFQNGRTEAIRSVTGQSKLFVKSLLDQDASDATKIQLLHDACTAHSQITRECS QGLGQDRHLYALYCLWNQWYKDKLELPPIFRDKSWTTMQNNVLSTSNCGNPCLKSFGFGP VTANGFGIGYIIRDHSVSVVVSSRHRQTARFASLMEKSLLEIDRIFKRQQARAAKPAART TASANTKSEDMKYLLSGYDYFDVSVSG

References

External Links

Resource	Link
Saccharomyces Genome Database	YAT1
Uniprot ID	P80235
Uniprot Name	CACM_YEAST
GenBank Gene ID	L28920
Genebank Protein ID	456138

General Reference

Schmalix, W., Bandlow, W. (1993). "The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase." J Biol Chem 268:27428-27439.8262985
Bussey, H., Kaback, D. B., Zhong, W., Vo, D. T., Clark, M. W., Fortin, N., Hall, J., Ouellette, B. F., Keng, T., Barton, A. B., et, a. l. .. (1995). "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A 92:3809-3813.7731988
Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666