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Identification |
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Name | Citrate synthase 3 |
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Synonyms | Not Available |
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Gene Name | CIT3 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer |
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Specific Function | Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA |
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Cellular Location | Not Available |
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SMPDB Pathways | |
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KEGG Pathways | Citrate cycle (TCA cycle) | ec00020 | | Glyoxylate and dicarboxylate metabolism | ec00630 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00045 | Coenzyme A | Show | YMDB00086 | Citric acid | Show | YMDB00235 | Oxalacetic acid | Show | YMDB00312 | Acetyl-CoA | Show | YMDB00446 | propionyl-CoA | Show | YMDB00862 | hydron | Show | YMDB00890 | water | Show | YMDB00978 | (2S,3S)-2-Methylcitric acid | Show |
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GO Classification | Component |
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Not Available | Function |
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transferase activity, transferring acyl groups | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | catalytic activity | transferase activity | Process |
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coenzyme metabolic process | acetyl-CoA metabolic process | acetyl-CoA catabolic process | tricarboxylic acid cycle | cellular carbohydrate metabolic process | metabolic process | cellular metabolic process | primary metabolic process | carbohydrate metabolic process | cofactor metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 16 |
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Locus | YPR001W |
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Gene Sequence | >1461 bp
ATGGTACAAAGGCTTCTACCGGGCGCACATATATGCAGAAGGTCCTTCAATTCGTCTGCA
ATTATAAAGTCTTCTGCATTGACTCTCAAGGAAGCATTAGAAAACGTGATACCTAAGAAA
AGAGATGCTGTGAAGAAATTGAAGGCCTGTTATGGCAGCACGTTTGTCGGACCGATTACC
ATTTCATCAGTTCTAGGTGGGATGAGAGGTAATCAGTCAATGTTTTGGCAAGGAACATCA
TTAGATCCCGAACATGGCATTAAATTTCAAGGTTTAACGATTGAAGAATGTCAAAATAGA
TTACCTAATACAGGTATTGATGGCGATAATTTCCTGCCAGAATCAATGTTATGGCTGTTG
ATGACAGGTGGTGTGCCAACTTTCCAGCAAGCTGCTTCTTTCAGGAAAGAATTGGCTATT
CGTGGAAGGAAATTGCCACATTATACAGAGAAAGTTTTGTCAAGTTTACCCAAAGATATG
CACCCTATGACCCAACTTGCAATTGGTTTAGCATCAATGAACAAAGGATCCCTCTTTGCT
ACAAACTACCAAAAGGGCCTCATAGGAAAGATGGAATTTTGGAAAGATACTCTTGAAGAT
TCGCTAAATTTAATTGCTTCACTCCCGCTGCTGACTGGGAGAATTTATTCGAACATTACA
AATGAGGGACACCCATTAGGTCAATATAGTGAGGAGGTGGATTGGTGTACAAACATATGT
TCCCTGCTCGGCATGACAAATGGAACGAACTCTTCTAATACATGCAACCTTACTTCCCAG
CAATCCCTGGACTTCATAAACTTGATGCGGTTATATACCGGTATACATGTAGACCATGAA
GGTGGTAATGTTTCTGCTCACACCACCCACTTGGTTGGAAGTGCGTTGAGTGACCCGTAT
CTCAGCTATTCATCTGGAATAATGGGATTAGCGGGTCCTTTGCATGGGTTAGCAGCACAA
GAAGTAGTAAGGTTTCTCATAGAGATGAACTCTAATATTTCCAGCATTGCACGAGAACAA
GAAATCAAAGATTATCTTTGGAAAATTTTGAATTCAAACCGTGTGATCCCCGGTTATGGG
CACGCAGTTTTGCGTAAACCGGATCCTCGATTTACAGCAATGCTTGAATTTGCGCAAAAG
AGGCCTATTGAATTTGAGAACGACAAGAACGTTTTGTTGATGCAAAAATTGGCAGAAATA
GCGCCTAAGGTTTTGTTGGAACACGGAAAGAGTAAGAATCCATTTCCCAATGTTGACTCT
GCATCGGGGATTTTGTTTTATCATTATGGAATCAGGGAATTATTATTCTTTACCGTCATT
TTTGGGTGTTCAAGGGCCATGGGACCCTTGACACAACTTGTTTGGGATCGCATTCTAGGT
TTACCAATTGAAAGGCCCAAGAGTTTGAACTTGGAGGGTCTGGAAGCACTTACCAAAGCA
AGCAATGTTAACAAGTTGTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 486 |
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Protein Molecular Weight | 53810.69922 |
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Protein Theoretical pI | 8.79 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Citrate synthase 3
MVQRLLPGAHICRRSFNSSAIIKSSALTLKEALENVIPKKRDAVKKLKACYGSTFVGPIT
ISSVLGGMRGNQSMFWQGTSLDPEHGIKFQGLTIEECQNRLPNTGIDGDNFLPESMLWLL
MTGGVPTFQQAASFRKELAIRGRKLPHYTEKVLSSLPKDMHPMTQLAIGLASMNKGSLFA
TNYQKGLIGKMEFWKDTLEDSLNLIASLPLLTGRIYSNITNEGHPLGQYSEEVDWCTNIC
SLLGMTNGTNSSNTCNLTSQQSLDFINLMRLYTGIHVDHEGGNVSAHTTHLVGSALSDPY
LSYSSGIMGLAGPLHGLAAQEVVRFLIEMNSNISSIAREQEIKDYLWKILNSNRVIPGYG
HAVLRKPDPRFTAMLEFAQKRPIEFENDKNVLLMQKLAEIAPKVLLEHGKSKNPFPNVDS
ASGILFYHYGIRELLFFTVIFGCSRAMGPLTQLVWDRILGLPIERPKSLNLEGLEALTKA
SNVNKL |
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References |
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External Links | |
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General Reference | - Graybill, E. R., Rouhier, M. F., Kirby, C. E., Hawes, J. W. (2007). "Functional comparison of citrate synthase isoforms from S. cerevisiae." Arch Biochem Biophys 465:26-37.17570335
- Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
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