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Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (P40351)

Identification
NameDolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Synonyms
  • Asparagine-linked glycosylation protein 8
  • Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase
  • Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
Gene NameALG8
Enzyme ClassNot Available
Biological Properties
General Functionprotein N-linked glycosylation
Specific FunctionAdds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
Cellular LocationNot Available
SMPDB Pathways
N-Glycan biosynthesisPW002501 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
N-Glycan biosynthesisec00510 Map00510
SMPDB Reactions
Glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol + Dolichyl b-D-glucosyl phosphate → (Glucosyl)2(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol + Dolichol phosphate + hydron
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00241Dolichyl b-D-glucosyl phosphateShow
YMDB00862hydronShow
YMDB00864Dolichol phosphateShow
YMDB16224(Glucosyl)2(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolicholShow
YMDB16234Glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolicholShow
GO Classification
Function
integral component of membrane
endoplasmic reticulum membrane
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1734 bp ATGAAAGGTGATCGTTCGAGGCAAAATATGGCTGTGACAAAGAAGGCAAAGTTAAAAAAA AATGACGAGCCAAAAAAGGTTTTGAAGACTGCCGCGACCGAAAAAGGTGAGGGATCCAAG CGCTACTCCTTATGGAATTTCTGGATAAGCACATTGTTTTTAAAATTACTATTGATTCCT GACTACTTCAGTACAGATTTTGACGTTCATAGAAATTGGCTGGCAATCACCAATAAATTG CCCATCAGCGAATGGTATTATGAGCACACTAGTCAATGGACATTGGATTATCCGCCATTT TTTGCTTATTTTGAATGGTTTTTATCGCAATTTGTTCCTAAATCTGTACGTGATGACGGT TGTTTGGATATAGTGGAGATCGGAAAGTTCGGTTTGCCAACAATCGTTTTCCAACGACTC ACTGTCATCTTCAGCGAAATTCTTCTATTTGTCATCCTTCAAATATACATTAATACTACA AAGCTAAGTGAAAGATCTCAAAGTTTTGTGGTTGCTTCTAGCATTGTACTATCACCCGGG TTTTTAATAATAGATCACATTCACTTCCAATATAATGGTTTTCTTTTTGCGATTCTAATA GGCTCCATTGTCGCCGCCAAGAATAAGAGATACATCTTGTGCGCTGTTCTGTATACTACA GCCATATGTTTCAAGCATATATTTTTATATTTGGCGCCATGTTATTTCGTGTTTTTATTG AGAGCATACGTTCTCAATGTCAACAATTTCAAGTTTAAAAGTTACAAAGATTTTTTGTTC CTGATAAGATGGGCAAATCTTTTGAAGTTGGCTACCGTTGTTGTTGGAATTTTCACTATT TGTTTCCTTCCATTTGCTCATCAAATGCCGCAAGTGTTGAGCAGGTTATTCCCATTCTCA AGAGGACTGACGCATGCATATTGGGCACCAAATTTCTGGGCGTTGTATTCTTTTATGGAT AAAATACTCACTACGGTAATGTTGAAATTACCGTACGTCCACACTTTTGCTACAAAATTT ATTAAACCTCCTCTGATCCCTCAGAATATCAAGGAAATTAATGAAAGGCTCGCGGCAAAC AACAATGGAAGTAAAGGTCTAGTTCAAGACGTATTTTTTGTTATTCTCCCTCAAATTCCT CCAAAATTAACGTTTATTTTGACGATATTTTACCAGGTCTTAGCAGTACTTCCACTTTTG TTTGATCCATCGTTCAAAAGATTTGTTGGCTCGTTGACTCTCTGTGGGTTGGCATCGTTT TTGTTCGGGTGGCATGTGCATGAGAAAGCTATAATGCTAGTCATCATTCCGTTCACATTT CTTGTTGGATTTGATCGTCGTCTTTTGGTACCGTTTATGTTAGTTGCCTCAGCTGGTTAT GTTTCCTTGTATCCTCTTCTGTACAAAGGCCAAGATTTTTTCATTAAAACATTATACACT TATGTTTGGTGTATAATTTATTTTGCCGCTTTTAGAAAAACTACGAAGATTTCTTCAAGT GTAGAAAGAAGAATCTTTTTCTTGGATAGGTTGGCATTAACGTACATCTTTTCATTGTTA CCAATCGTCACCGTATTACAAATATTGGATGAAGTCAAGTGGAGATATTCATTTTTGCAA AAATTTGAATTCTTAGGATTAATGATATATAGTGTCTATTGTTCATTAGGTATAATCAGC TCGTGGTTTGCCTTATCGTGGTTATATAATTTTGACGAATTACTATGGCAGTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues577
Protein Molecular Weight67384.29
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane Regions
  • 43-63
  • 93-113
  • 140-160
  • 169-189
  • 220-240
  • 267-287
  • 308-328
  • 383-403
  • 420-440
  • 448-468
  • 471-491
  • 505-525
  • 544-564
Protein Sequence>Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase MKGDRSRQNMAVTKKAKLKKNDEPKKVLKTAATEKGEGSKRYSLWNFWISTLFLKLLLIP DYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWFLSQFVPKSVRDDG CLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVASSIVLSPG FLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYFVFLL RAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFS RGLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAAN NNGSKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKRFVGSLTLCGLASF LFGWHVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIKTLYT YVWCIIYFAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFLQ KFEFLGLMIYSVYCSLGIISSWFALSWLYNFDELLWQ
References
External Links
ResourceLink
Saccharomyces Genome Database ALG8
Uniprot IDP40351
Uniprot NameALG8
General ReferenceNot Available