{"ymdb_id":"YMDB00864","created_at":"2011-05-29T18:59:18.000Z","updated_at":"2016-09-08T18:35:59.000Z","name":"Dolichol phosphate","cas":"34457-14-2","state":"Solid","melting_point":"","description":"Dolichol phosphate is involved in reactions such as the C-4 and O-mannosylation of proteins, the formation of glycosylphosphatidylinositol (GPI) anchors and the N-glycosylation of proteins. It is the most prevalent polyisoprenyl-glycosyl carrier found in mammals.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":"HMDB06353","kegg_id":"C00110","pubchem_id":"5280322","cs_id":null,"foodb_id":null,"wikipedia_link":"Dolichol","biocyc_id":null,"iupac":null,"traditional_iupac":null,"logp":null,"pka":null,"alogps_solubility":"4.85e-02 g/l","alogps_logp":"3.40","alogps_logs":"-3.80","acceptor_count":null,"donor_count":null,"rotatable_bond_count":null,"polar_surface_area":null,"refractivity":null,"polarizability":null,"formal_charge":"0","physiological_charge":null,"pka_strongest_basic":null,"pka_strongest_acidic":null,"bioavailability":null,"number_of_rings":null,"rule_of_five":"0","ghose_filter":"0","veber_rule":null,"mddr_like_rule":null,"synonyms":["dolichol monophosphate","Dolichol-P","dolichol-phosphate","Dolichol-PO4","dolichyl-phosphate","Dolychol phosphate"],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":16100113,"citation":"Bickel, T., Lehle, L., Schwarz, M., Aebi, M., Jakob, C. A. (2005). \"Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol.\" J Biol Chem 280:34500-34506."}],"proteins":[{"created_at":"2011-05-24T19:17:52.000Z","updated_at":"2011-05-29T05:06:10.000Z","name":"Dolichyl-phosphate beta-glucosyltransferase","uniprot_id":"P40350","uniprot_name":"ALG5_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG5","num_residues":334,"molecular_weight":"38346.39844","theoretical_pi":"9.03","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate","reactions":[{"id":2243,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type II membrane protein.","altext":"UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14881,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007072","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"13-33","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type II membrane protein.","genbank_gene_id":"X77573","genbank_protein_id":"535141","gene_card_id":"ALG5","chromosome_location":"chromosome 16","locus":"YPL227C","synonyms":["DolP-glucosyltransferase","Asparagine-linked glycosylation protein 5"],"enzyme_classes":["2.4.1.117"],"go_classes":[],"pfams":[{"name":"Glycos_transf_2","identifier":"PF00535"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAGAGCGTTGAGATTCCTGATTGAGAACAGAAACACTGTCTTTTTTACGCTCTTAGTAGCCTTGGTGCTTTCACTGTATTTATTGGTCTATTTATTTTCGCATACACCAAGGCCGCCATATCCAGAGGAGCTCAAATACATAGCTATTGATGAAAAAGGTCATGAAGTTAGTCGTGCCTTACCTAACTTGAATGAACACCAAGATGACGAAGAAATATTTTTATCTGTTGTTATCCCAAGCTATAATGAGACAGGTAGAATTTTACTAATGTTGACAGACGCAATCAGCTTTTTAAAGGAAAAATATGGTTCCAGATGGGAGATTGTCATAGTGGATGATGGTTCCACAGATAATACCACACAATACTGTTTGAAAATTTGTAAAGAACAGTTCAAATTGAACTACGAACAATTCAGAATCATCAAGTTTTCTCAAAACAGAGGCAAAGGTGGCGCAGTGAGACAAGGTTTTTTACATATTAGAGGTAAGTATGGTCTTTTTGCCGATGCTGATGGTGCTAGTAAGTTCAGTGATGTAGAAAAACTAATAGATGCTATTAGCAAAATTGAAACGTCTAGTACAGATCTAAAAACGACTAAACCAGCAGTAGCAATTGGTTCCAGAGCACATATGGTAAATACCGAAGCCGTCATAAAGAGATCAATGATAAGAAACTGCTTGATGTACGGTTTCCATACCTTAGTTTTCATCTTCGGCATCAGGTCTATCAAAGACACACAATGTGGATTCAAATTGTTCAACAGAGCCGCTATATTGAAAATTTTTCCGTATTTGCATACAGAGGGTTGGATCTTTGACGTTGAAATTTTGATCTTAGCCATCAGAAAAAGAATCCAAATTGAGGAGATACCAATTTCCTGGCATGAGGTTGATGGCTCTAAGATGGCTTTAGCTATTGATAGTATCAAAATGGCGAAAGACTTGGTTATTATAAGAATGGCCTATTTATTAGGGATATATAGAGATAATAAGAAATGTTAG","protein_sequence":"MRALRFLIENRNTVFFTLLVALVLSLYLLVYLFSHTPRPPYPEELKYIAIDEKGHEVSRALPNLNEHQDDEEIFLSVVIPSYNETGRILLMLTDAISFLKEKYGSRWEIVIVDDGSTDNTTQYCLKICKEQFKLNYEQFRIIKFSQNRGKGGAVRQGFLHIRGKYGLFADADGASKFSDVEKLIDAISKIETSSTDLKTTKPAVAIGSRAHMVNTEAVIKRSMIRNCLMYGFHTLVFIFGIRSIKDTQCGFKLFNRAAILKIFPYLHTEGWIFDVEILILAIRKRIQIEEIPISWHEVDGSKMALAIDSIKMAKDLVIIRMAYLLGIYRDNKKC"},{"created_at":"2011-05-24T19:18:45.000Z","updated_at":"2011-07-22T17:54:39.000Z","name":"Dolichol kinase","uniprot_id":"P20048","uniprot_name":"SEC59_YEAST","enzyme":true,"transporter":false,"gene_name":"SEC59","num_residues":519,"molecular_weight":"58905.39844","theoretical_pi":"9.22","general_function":"Involved in transferase activity, transferring phosphorus-containing groups","specific_function":"Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism","reactions":[{"id":1471,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2244,"direction":"\u003e","locations":"Endoplasmic reticulum membrane (Probable)","altext":"CTP + dolichol = CDP + dolichyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14868,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007056","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"48-68;89-109;119-139;152-172;182-203;224-244;254-274;295-315;327-347;350-370;395-415;418-438;450-470;473-493","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane (Probable)","genbank_gene_id":"AY692829","genbank_protein_id":"51013109","gene_card_id":"SEC59","chromosome_location":"chromosome 13","locus":"YMR013C","synonyms":[],"enzyme_classes":["2.7.1.108"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"CTP_transf_1","identifier":"PF01148"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGTCGCTATAATACCTCATGCTTCCTTTACCACAATTAAACTAACCCAGAAAACTGAGGGAAGCCAAATGCCAACTGAGGAGATCTGCAAAATCAATATGAGGACTCGTAAATTTGATGTGGGCGGGAATTCTCGAGATTTTGAGTGCTTTTATTCGAATTTTGTTCAAACTGTTATATTGTTGGGCACTTTTTTTTACTGTGTTGAAAGGCTTCAGCCGTGGTCCATTGTTACCGCTGATATATCTTATAAACAAATCTTTGTAAATGTCTTTGTGGTGTGTTTGATAATGGTTGGTCTGATATTCACAAAATATTGGCAACATGGTTACAAAAGCCTACCCAAGTTCGATACCATTTACAGTTTATATTTACCGTTTATGGTTTCGTTGTTGTTCGATACATCATCTACGGTGATAAATACTATTTTGATCCTTTCGGTATTAAATTCATATAGATGGCGAACTCAGTTGGTAGTGATCATTTTACAGCTCTGCCTCATATTTTTTAATTTTGAGGCTGGTGACAGGTTAAAGAATATTATTAGCATAGTAATAAATTCTTTACTGTCGTTAATTTTGAAGTATATTGGGCAATTGAAAAGTTTAGATAATATCGACTCTAATCTTTTTAGTATCCTATTAACCAATATTCTGTACGTTTCAGAGGCTGGCACAGTACATTTTAGAATTTTGAAGGGCATTATCCTTGCTCTCACAACAATAATTTCAATTAACTATGTGCTCAAAAAGGTAATGCACTTTAAACCGTTTATGCTGTCAATATCCTTTGCCATCGGGCTTCCACTTTTTGCCAATACCTTCATTCATTTAGAAGACGGTGAAAATCCGCTACTTTGGCTGGTAAAATATATCTTAGAGTCTACTATTCGTCAAAAGATTTTGTTTGCTTGGTCTTCAATTCTTATACTGTCCATACCAAGTATATTGATCGAGAAGGACAGTCTATCGTTGAACACCTCCCGAAAATTGTGGCATTTCATCATTTTCTTACTCATAATACCGTCATTCCAAATGGATTCAAACTTTGTGAAAATTGCATTGTCCGGAACAATACCAGTCTTCTTATCAATTGAGTACATAAGATTTCAAAACCTACCGCCGTTAGGATCTGCTATTGAATTACAACTAAGAAGGTTTGCTGATGATAGGGACCACAGCGGGCCATTGATCATATCATACCTTTATTTACTCTTCGGAATATCAACACCTTTATTAATGAATAACTCTCCAATGGGTCTAATAGGATTGGGAATTGGTGATTCCTTAGCATCTATTATTGGTAAAAGGTATGGCCGCATTCGTTGGAAAGGTACACAAAAAACTTTAGAGGGAACTCTTGCGTTTATAGTAACGAGTTTTATCGTTTGTTTGGTATTGTTACGTTTTGATAAAGCTGCAATTTTTAACCACCTAACTACTTTACAATTGCTTACCCTTTGTACACTGAGTGGAGTGCTAGAAGGTAATAGTGTGCTTAATGACAATATTTTGATACCTGCATTTATGATGATTTGTGAAAAATTAATTACTCTTTGA","protein_sequence":"MVAIIPHASFTTIKLTQKTEGSQMPTEEICKINMRTRKFDVGGNSRDFECFYSNFVQTVILLGTFFYCVERLQPWSIVTADISYKQIFVNVFVVCLIMVGLIFTKYWQHGYKSLPKFDTIYSLYLPFMVSLLFDTSSTVINTILILSVLNSYRWRTQLVVIILQLCLIFFNFEAGDRLKNIISIVINSLLSLILKYIGQLKSLDNIDSNLFSILLTNILYVSEAGTVHFRILKGIILALTTIISINYVLKKVMHFKPFMLSISFAIGLPLFANTFIHLEDGENPLLWLVKYILESTIRQKILFAWSSILILSIPSILIEKDSLSLNTSRKLWHFIIFLLIIPSFQMDSNFVKIALSGTIPVFLSIEYIRFQNLPPLGSAIELQLRRFADDRDHSGPLIISYLYLLFGISTPLLMNNSPMGLIGLGIGDSLASIIGKRYGRIRWKGTQKTLEGTLAFIVTSFIVCLVLLRFDKAAIFNHLTTLQLLTLCTLSGVLEGNSVLNDNILIPAFMMICEKLITL"},{"created_at":"2011-05-24T19:19:45.000Z","updated_at":"2011-07-22T17:54:39.000Z","name":"Dolichol-phosphate mannosyltransferase","uniprot_id":"P14020","uniprot_name":"DPM1_YEAST","enzyme":true,"transporter":false,"gene_name":"DPM1","num_residues":267,"molecular_weight":"30362.0","theoretical_pi":"8.06","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins","reactions":[{"id":1472,"direction":"\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2246,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","altext":"GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14875,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007066","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"239-259","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","genbank_gene_id":"J04184","genbank_protein_id":"171418","gene_card_id":"DPM1","chromosome_location":"chromosome 16","locus":"YPR183W","synonyms":["Dolichol-phosphate mannose synthase","DPM synthase","Dolichyl-phosphate beta-D-mannosyltransferase","Mannose-P-dolichol synthase","MPD synthase"],"enzyme_classes":["2.4.1.83"],"go_classes":[],"pfams":[{"name":"Glycos_transf_2","identifier":"PF00535"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAGCATCGAATACTCTGTTATCGTTCCCGCTTACCATGAAAAGCTGAACATCAAACCCTTAACAACCAGATTGTTTGCCGGTATGAGCCCTGAAATGGCCAAGAAGACCGAGTTGATCTTTGTCGATGACAACTCACAGGATGGCTCCGTTGAGGAGGTGGACGCCCTAGCTCACCAAGGCTACAACGTCCGCATCATCGTCAGGACAAATGAACGTGGTCTATCCTCCGCCGTGCTTAAGGGTTTCTACGAGGCCAAGGGTCAGTACCTGGTATGCATGGACGCAGACCTACAACACCCTCCAGAGACCGTGCCCAAGTTGTTCGAGTCTTTGCACGATCACGCCTTTACTCTGGGCACCAGATATGCCCCAGGTGTCGGCATTGACAAGGACTGGCCTATGTACAGACGCGTCATTTCCTCCACTGCTAGAATGATGGCCAGACCTTTGACCATCGCCTCCGACCCCATGAGCGGGTTCTTCGGTCTACAAAAGAAGTACCTCGAAAACTGCAACCCTAGGGACATCAACTCGCAAGGTTTCAAGATTGCCCTCGAGCTTCTCGCCAAGCTTCCTCTTCCAAGAGACCCTAGAGTGGCGATCGGCGAAGTGCCATTCACTTTCGGCGTGAGAACGGAAGGTGAATCCAAACTGTCAGGTAAAGTCATTATCCAATACTTGCAACAACTTAAGGAGCTCTACGTCTTCAAGTTTGGCGCCAATAACCTTATCCTTTTCATTACTTTCTGGTCCATTCTGTTCTTCTACGTTTGCTACCAGCTATACCATTTGGTCTTTTAA","protein_sequence":"MSIEYSVIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPPETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSGFFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELYVFKFGANNLILFITFWSILFFYVCYQLYHLVF"},{"created_at":"2011-05-24T19:20:17.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase","uniprot_id":"P07286","uniprot_name":"GPT_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG7","num_residues":448,"molecular_weight":"50367.39844","theoretical_pi":"8.51","general_function":"Involved in phospho-N-acetylmuramoyl-pentapeptide-transferase activity","specific_function":"Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides","reactions":[{"id":2247,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14869,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007060","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"24-44;72-92;129-149;157-177;202-222;231-251;256-276;283-303;309-329;387-407;419-439","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Y00126","genbank_protein_id":"4685","gene_card_id":"ALG7","chromosome_location":"chromosome 2","locus":"YBR243C","synonyms":["GlcNAc-1-P transferase","G1PT","GPT","N-acetylglucosamine-1-phosphate transferase","Tunicamycin resistance protein 1"],"enzyme_classes":["2.7.8.15"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, for other substituted phosphate groups"},{"category":"Function","description":" phospho-N-acetylmuramoyl-pentapeptide-transferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Glycos_transf_4","identifier":"PF00953"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTGCGACTTTTTTCACTGGCACTTATCACATGCTTAATCTACTATTCCAAAAATCAGGGCCCATCTGCTCTTGTTGCGGCCGTGGGATTTGGTATAGCAGGCTATTTAGCTACAGATATGTTGATTCCACGTGTGGGCAAATCCTTCATCAAAATAGGCCTATTCGGTAAGGACTTGAGTAAACCTGGCCGTCCGGTGCTTCCAGAAACAATAGGTGCTATCCCTGCTGCAGTTTATTTATTTGTAATGTTCATTTACATTCCCTTCATTTTCTACAAGTATATGGTCATAACCACTTCAGGTGGGGGCCATCGCGATGTCTCAGTGGTTGAAGATAACGGTATGAATTCTAATATTTTTCCTCATGATAAACTATCTGAATATTTGAGCGCTATCCTATGCTTGGAAAGTACGGTCCTCTTGGGTATCGCTGATGATTTATTTGATTTACGTTGGAGACATAAGTTTTTCTTGCCTGCCATTGCAGCCATCCCACTGCTAATGGTTTATTATGTGGATTTTGGAGTTACGCATGTACTTATTCCCGGATTCATGGAACGCTGGTTGAAAAAGACTAGTGTTGATTTGGGGCTGTGGTATTATGTTTATATGGCATCGATGGCAATTTTTTGCCCCAACTCCATCAACATCCTGGCAGGTGTTAATGGTTTAGAGGTTGGCCAATGTATAGTGTTGGCCATCTTAGCGCTATTGAACGATTTGCTGTACTTCTCGATGGGGCCATTAGCCACAAGAGACTCCCATAGGTTTTCCGCTGTTTTGATTATCCCATTTTTGGGTGTATCCTTGGCGCTATGGAAATGGAATCGTTGGCCCGCCACAGTGTTTGTGGGAGATACATATTGTTATTTCGCTGGAATGGTATTCGCAGTCGTTGGTATACTGGGTCATTTTTCAAAGACGATGCTTTTGCTATTCATTCCTCAAATCGTTAATTTTATTTATTCATGTCCTCAGCTATTCAAATTGGTCCCCTGCCCGAGACATAGGTTACCTAAATTTAATGAAAAAGACGGTTTAATGTATCCATCAAGAGCAAACTTAAAAGAAGAACCGCCAAAGAGCATTTTTAAACCGATCTTGAAGTTACTATACTGTCTCCATTTGATTGACCTGGAATTTGATGAAAATAATGAGATTATTAGCACCTCTAATATGACGTTAATAAACTTGACATTAGTATGGTTTGGCCCTATGAGGGAAGACAAATTGTGCAATACAATCTTGAAGTTGCAATTCTGCATTGGAATTTTGGCTTTACTTGGAAGACACGCTATAGGCGCTATCATCTTTGGCCACGACAACCTATGGACAGTACGTTGA","protein_sequence":"MLRLFSLALITCLIYYSKNQGPSALVAAVGFGIAGYLATDMLIPRVGKSFIKIGLFGKDLSKPGRPVLPETIGAIPAAVYLFVMFIYIPFIFYKYMVITTSGGGHRDVSVVEDNGMNSNIFPHDKLSEYLSAILCLESTVLLGIADDLFDLRWRHKFFLPAIAAIPLLMVYYVDFGVTHVLIPGFMERWLKKTSVDLGLWYYVYMASMAIFCPNSINILAGVNGLEVGQCIVLAILALLNDLLYFSMGPLATRDSHRFSAVLIIPFLGVSLALWKWNRWPATVFVGDTYCYFAGMVFAVVGILGHFSKTMLLLFIPQIVNFIYSCPQLFKLVPCPRHRLPKFNEKDGLMYPSRANLKEEPPKSIFKPILKLLYCLHLIDLEFDENNEIISTSNMTLINLTLVWFGPMREDKLCNTILKLQFCIGILALLGRHAIGAIIFGHDNLWTVR"},{"created_at":"2011-05-26T16:40:26.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"UDP-N-acetylglucosamine transferase subunit ALG13","uniprot_id":"P53178","uniprot_name":"ALG13_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG13","num_residues":202,"molecular_weight":"22660.90039","theoretical_pi":"5.66","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway","reactions":[{"id":2437,"direction":"\u003e","locations":"Endoplasmic reticulum","altext":"UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14870,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007061","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum","genbank_gene_id":"Z72569","genbank_protein_id":"1322537","gene_card_id":"ALG13","chromosome_location":"chromosome 7","locus":"YGL047W","synonyms":["Asparagine-linked glycosylation protein 13"],"enzyme_classes":["2.4.1.141"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carbohydrate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" cellular lipid metabolic process"},{"category":"Process","description":" lipid modification"},{"category":"Process","description":" lipid glycosylation"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Glyco_tran_28_C","identifier":"PF04101"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGGTATTATTGAAGAAAAGGCTCTTTTTGTTACGTGTGGGGCAACGGTGCCATTTCCAAAGCTCGTCTCATGTGTGCTAAGCGACGAATTCTGCCAAGAATTGATTCAATATGGATTCGTACGTCTAATCATTCAGTTTGGGAGAAACTACAGTTCTGAATTTGAGCATTTAGTGCAAGAACGCGGGGGCCAAAGAGAAAGCCAAAAAATTCCAATTGACCAGTTTGGCTGTGGCGACACCGCAAGACAGTATGTCCTGATGAACGGGAAATTAAAGGTGATCGGGTTTGACTTTTCGACCAAGATGCAAAGTATTATACGTGATTATTCAGATTTGGTCATATCACACGCTGGAACGGGCTCTATACTAGATTCTCTACGGTTGAATAAACCGTTGATAGTTTGCGTAAACGATTCTTTGATGGATAACCACCAGCAGCAGATAGCAGACAAGTTTGTAGAGTTGGGCTACGTATGGTCTTGTGCACCCACTGAAACAGGTTTGATAGCTGGTTTACGTGCATCTCAAACAGAGAAACTCAAACCATTCCCAGTTTCTCATAACCCGTCATTTGAGCGATTGCTAGTTGAAACTATATACAGCTAG","protein_sequence":"MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS"},{"created_at":"2011-05-27T06:18:50.000Z","updated_at":"2011-07-22T17:54:10.000Z","name":"Alpha-1,2 glucosyltransferase ALG10","uniprot_id":"P50076","uniprot_name":"ALG10_YEAST","enzyme":true,"transporter":false,"gene_name":"DIE2","num_residues":525,"molecular_weight":"61807.0","theoretical_pi":"9.75","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol","reactions":[{"id":1316,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14883,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007074","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"36-56;95-115;128-148;151-171;188-208;214-234;257-277;295-315;334-354;376-396;424-444;448-468;493-513","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"D38049","genbank_protein_id":"902940","gene_card_id":"DIE2","chromosome_location":"chromosome 7","locus":"YGR227W","synonyms":["Alpha-2-glucosyltransferase ALG10","Asparagine-linked glycosylation protein 10","Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10"],"enzyme_classes":["2.4.1.-"],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"DIE2_ALG10","identifier":"PF04922"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGATGCAAAGAAAAATACTGGTGAAGCCAATAATGATGTATTGGAAGAGGAAGCAGCGATTCAGTTGATTGCACCAGGTATAGCGAGAAACTTAACACAAGAAGTCATTACCGGTATCTTCTGTAATGTAGTAATATATCCTCTTCTTCTAATATATTTTGTCTTAACTTTCCGTTACATGACTACAAATATTGTACCTTATGAATTTATAGATGAAAAGTTTCACGTTGGCCAAACTTTGACCTATTTAAAAGGTAAATGGACTCAATGGGACCCTAAAATAACAACCCCCCCTGGAATCTATATTTTGGGTTTAATTAATTATTATTGTATAAAGCCCATATTCAAGTCGTGGAGCACACTAACCATACTAAGATTAGTTAATTTACTTGGAGGGATTATCGTTTTCCCCATTTTAGTACTCAGGCCAATATTCCTTTTTAATGCCTTAGGTTTTTGGCCCGTTTCATTAATGAGCTTCCCATTGATGACAACTTATTATTACTTATTTTACACCGATGTGTGGTCTACAATTCTGATATTGCAATCACTCAGCTGCGTGTTAACATTACCGTTTGGCCCCGTGAAGAGTATATGGTTGAGTGCTTTTTTTGCTGGTGTAAGCTGTCTCTTCAGACAAACGAATATCATTTGGACGGGATTTATAATGATTCTTGCTGTTGAACGCCCAGCCATTTTACAAAAACAGTTCAACACGCATACGTTCAATAACTATTTGAAATTATTCATTCATGCTATTGACGATTTCTCCAACCTTGTTCTGCCCTATATGATAAATTTTGTTTTGTTCTTCATTTATCTGATTTGGAACAGATCCATAACACTAGGTGATAAGTCCAGCCACTCAGCAGGCCTGCATATAGTACAAATATTCTATTGTTTCACATTCATCACCGTTTTCAGTTTACCTATATGGATATCTCGTAATTTTATGAAGTTGTACAAATTAAGGATAAAACGGAAGCCAGTACAAACTTTTTTTGAATTTATTGGTATTATGCTAATCATAAGATACTTTACAAAAGTTCACCCATTTTTGTTAGCAGATAATAGACACTACACGTTCTACCTCTTCAGAAGATTGATAGGCAACAAAAGTAGACTAATCAAGTACTTTTTTATGACACCAATCTATCATTTCTCCACTTTCGCATACCTTGAAGTGATGAGACCCAACCAGCTCACCTTTCACCCCATCACTCCACTCCCCATCAAAGAACCTGTACATTTACCCATACAACTGACACATGTATCGTGGACGGCCTTAATAACGTGCACCATGGTAACTATCGTTCCATCACCCTTATTCGAACCTCGTTACTATATATTGCCCTATTTCTTTTGGAGAATATTTATTACCTGCAGCTGCGAACCTTTGATAAAGGATTTAAAACCTGCTAAAGAAGGCGAAAACCCAATTACCATAAGCAGTACGAAAAGACTGTTCATGGAATTTTTATGGTTCATGCTCTTCAATGTCGTTACTTTAGTTATCTTTTCCAAGGTCTCATTTCCTTGGACCACTGAGCCCTATTTGCAAAGAATAATATGGTGA","protein_sequence":"MDAKKNTGEANNDVLEEEAAIQLIAPGIARNLTQEVITGIFCNVVIYPLLLIYFVLTFRYMTTNIVPYEFIDEKFHVGQTLTYLKGKWTQWDPKITTPPGIYILGLINYYCIKPIFKSWSTLTILRLVNLLGGIIVFPILVLRPIFLFNALGFWPVSLMSFPLMTTYYYLFYTDVWSTILILQSLSCVLTLPFGPVKSIWLSAFFAGVSCLFRQTNIIWTGFIMILAVERPAILQKQFNTHTFNNYLKLFIHAIDDFSNLVLPYMKNFVLFFIYLIWNRSITLGDKSSHSAGLHIVQIFYCFTFITVFSLPIWISRNFMKLYKLRIKRKPVQTFFEFIGIMLIIRYFTKVHPFLLADNRHYTFYLFRRLIGNKSRLIKYFFMTPIYHFSTFAYLEVMRPNQLTFHPITPLPIKEPVHLPIQLTHVSWTALITCTMVTIVPSPLFEPRYYILPYFFWRIFITCSCEPLIKDLKPAKEGENPITISSTKRLFMEFLWFMLFNVVTLVIFSKVSFPWTTEPYLQRIIW"},{"created_at":"2011-05-27T09:09:38.000Z","updated_at":"2011-07-22T17:54:10.000Z","name":"Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase","uniprot_id":"P38179","uniprot_name":"ALG3_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG3","num_residues":458,"molecular_weight":"52860.39844","theoretical_pi":"9.09","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. Sensitive to H.mrakii HM-1 killer toxin","reactions":[{"id":1317,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14876,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007067","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"42-62;96-116;138-158;172-192;217-237;243-263;303-323;346-366;382-402;416-436","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"X79489","genbank_protein_id":"496697","gene_card_id":"ALG3","chromosome_location":"chromosome 2","locus":"YBL082C","synonyms":["Asparagine-linked glycosylation protein 3","Dol-P-Man-dependent alpha(1-3)-mannosyltransferase","Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase","HM-1 killer toxin resistance protein"],"enzyme_classes":["2.4.1.130"],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" endoplasmic reticulum"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ALG3","identifier":"PF05208"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGAAGGTGAACAGTCTCCGCAAGGTGAAAAGTCTCTGCAAAGGAAGCAATTTGTCAGACCTCCGCTGGATCTGTGGCAGGATCTCAAGGACGGTGTGCGCTACGTGATCTTCGATTGTAGGGCCAATCTTATCGTTATGCCCCTTTTGATTTTGTTCGAAAGCATGCTGTGCAAGATTATCATTAAGAAGGTAGCTTACACAGAGATCGATTACAAGGCGTACATGGAGCAGATCGAGATGATTCAGCTCGATGGCATGCTGGACTACTCTCAGGTGAGTGGTGGAACGGGCCCGCTGGTGTATCCAGCAGGCCACGTCTTGATCTACAAGATGATGTACTGGCTAACAGAGGGAATGGACCACGTTGAGCGCGGGCAAGTGTTTTTCAGATACTTGTATCTCCTTACACTGGCGTTACAAATGGCGTGTTACTACCTTTTACATCTACCACCGTGGTGTGTGGTCTTGGCGTGCCTCTCTAAAAGATTGCACTCTATTTACGTGCTACGGTTATTCAATGATTGCTTCACTACTTTGTTTATGGTCGTCACGGTTTTGGGGGCTATCGTGGCCAGCAGGTGCCATCAGCGCCCCAAATTAAAGAAGTCCCTTGCGCTGGTGATCTCCGCAACATACAGTATGGCTGTGAGCATTAAGATGAATGCGCTGTTGTATTTCCCTGCAATGATGATTTCTCTATTCATCCTTAATGACGCGAACGTAATCCTTACTTTGTTGGATCTCGTTGCGATGATTGCATGGCAAGTCGCAGTTGCAGTGCCCTTCCTGCGCAGCTTTCCGCAACAGTACCTGCATTGCGCTTTTAATTTCGGCAGGAAGTTTATGTACCAATGGAGTATCAATTGGCAAATGATGGATGAAGAGGCTTTCAATGATAAGAGGTTCCACTTGGCCCTTTTAATCAGCCACCTGATAGCGCTCACCACACTGTTCGTCACAAGATACCCTCGCATCCTGCCCGATTTATGGTCTTCCCTGTGCCATCCGCTGAGGAAAAATGCAGTGCTCAATGCCAATCCCGCCAAGACTATTCCATTCGTTCTAATCGCATCCAACTTCATCGGCGTCCTATTTTCAAGGTCCCTCCACTACCAGTTTCTATCCTGGTATCACTGGACTTTGCCTATACTGATCTTTTGGTCGGGAATGCCCTTCTTCGTTGGTCCCATTTGGTACGTCTTGCACGAGTGGTGCTGGAATTCCTATCCACCAAACTCACAAGCAAGCACGCTATTGTTGGCATTGAATACTGTTCTGTTGCTTCTATTGGCCTTGACGCAGCTATCTGGTTCGGTCGCCCTCGCCAAAAGCCATCTTCGTACCACCAGCTCTATGGAAAAAAAGCTCAACTGA","protein_sequence":"MEGEQSPQGEKSLQRKQFVRPPLDLWQDLKDGVRYVIFDCRANLIVMPLLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSGGTGPLVYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIVASRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKFMYQWSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRILPDLWSSLCHPLRKNAVLNANPAKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLHEWCWNSYPPNSQASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSSMEKKLN"},{"created_at":"2016-09-09T22:46:30.000Z","updated_at":"2016-09-09T22:46:31.000Z","name":"Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase","uniprot_id":"P40351","uniprot_name":"ALG8","enzyme":true,"transporter":false,"gene_name":"ALG8","num_residues":577,"molecular_weight":"67384.29","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.","reactions":[{"id":14882,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007073","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"43-63;93-113;140-160;169-189;220-240;267-287;308-328;383-403;420-440;448-468;471-491;505-525;544-564","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 8","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAAAGGTGATCGTTCGAGGCAAAATATGGCTGTGACAAAGAAGGCAAAGTTAAAAAAAAATGACGAGCCAAAAAAGGTTTTGAAGACTGCCGCGACCGAAAAAGGTGAGGGATCCAAGCGCTACTCCTTATGGAATTTCTGGATAAGCACATTGTTTTTAAAATTACTATTGATTCCTGACTACTTCAGTACAGATTTTGACGTTCATAGAAATTGGCTGGCAATCACCAATAAATTGCCCATCAGCGAATGGTATTATGAGCACACTAGTCAATGGACATTGGATTATCCGCCATTTTTTGCTTATTTTGAATGGTTTTTATCGCAATTTGTTCCTAAATCTGTACGTGATGACGGTTGTTTGGATATAGTGGAGATCGGAAAGTTCGGTTTGCCAACAATCGTTTTCCAACGACTCACTGTCATCTTCAGCGAAATTCTTCTATTTGTCATCCTTCAAATATACATTAATACTACAAAGCTAAGTGAAAGATCTCAAAGTTTTGTGGTTGCTTCTAGCATTGTACTATCACCCGGGTTTTTAATAATAGATCACATTCACTTCCAATATAATGGTTTTCTTTTTGCGATTCTAATAGGCTCCATTGTCGCCGCCAAGAATAAGAGATACATCTTGTGCGCTGTTCTGTATACTACAGCCATATGTTTCAAGCATATATTTTTATATTTGGCGCCATGTTATTTCGTGTTTTTATTGAGAGCATACGTTCTCAATGTCAACAATTTCAAGTTTAAAAGTTACAAAGATTTTTTGTTCCTGATAAGATGGGCAAATCTTTTGAAGTTGGCTACCGTTGTTGTTGGAATTTTCACTATTTGTTTCCTTCCATTTGCTCATCAAATGCCGCAAGTGTTGAGCAGGTTATTCCCATTCTCAAGAGGACTGACGCATGCATATTGGGCACCAAATTTCTGGGCGTTGTATTCTTTTATGGATAAAATACTCACTACGGTAATGTTGAAATTACCGTACGTCCACACTTTTGCTACAAAATTTATTAAACCTCCTCTGATCCCTCAGAATATCAAGGAAATTAATGAAAGGCTCGCGGCAAACAACAATGGAAGTAAAGGTCTAGTTCAAGACGTATTTTTTGTTATTCTCCCTCAAATTCCTCCAAAATTAACGTTTATTTTGACGATATTTTACCAGGTCTTAGCAGTACTTCCACTTTTGTTTGATCCATCGTTCAAAAGATTTGTTGGCTCGTTGACTCTCTGTGGGTTGGCATCGTTTTTGTTCGGGTGGCATGTGCATGAGAAAGCTATAATGCTAGTCATCATTCCGTTCACATTTCTTGTTGGATTTGATCGTCGTCTTTTGGTACCGTTTATGTTAGTTGCCTCAGCTGGTTATGTTTCCTTGTATCCTCTTCTGTACAAAGGCCAAGATTTTTTCATTAAAACATTATACACTTATGTTTGGTGTATAATTTATTTTGCCGCTTTTAGAAAAACTACGAAGATTTCTTCAAGTGTAGAAAGAAGAATCTTTTTCTTGGATAGGTTGGCATTAACGTACATCTTTTCATTGTTACCAATCGTCACCGTATTACAAATATTGGATGAAGTCAAGTGGAGATATTCATTTTTGCAAAAATTTGAATTCTTAGGATTAATGATATATAGTGTCTATTGTTCATTAGGTATAATCAGCTCGTGGTTTGCCTTATCGTGGTTATATAATTTTGACGAATTACTATGGCAGTGA","protein_sequence":"MKGDRSRQNMAVTKKAKLKKNDEPKKVLKTAATEKGEGSKRYSLWNFWISTLFLKLLLIPDYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWFLSQFVPKSVRDDGCLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVASSIVLSPGFLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYFVFLLRAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFSRGLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAANNNGSKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKRFVGSLTLCGLASFLFGWHVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIKTLYTYVWCIIYFAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFLQKFEFLGLMIYSVYCSLGIISSWFALSWLYNFDELLWQ"},{"created_at":"2016-09-09T22:47:57.000Z","updated_at":"2016-09-09T22:47:57.000Z","name":"Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase","uniprot_id":"P53730","uniprot_name":"ALG12","enzyme":true,"transporter":false,"gene_name":"ALG12","num_residues":551,"molecular_weight":"62671.87","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.","reactions":[{"id":14879,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007069","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"3-23;62-82;90-110;137-157;179-199;203-223;228-248;276-296;304-324;332-352;366-386;418-438","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 12","Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase","Extracellular mutant protein 39","Mannosyltransferase ALG12"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"},{"category":"Function","description":"alpha-1,6-mannosyltransferase activity"},{"category":"Function","description":"dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"},{"category":"Function","description":"protein glycosylation"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGCGTTGGTCTGTCCTTGATACAGTGCTATTGACCGTGATTTCCTTTCATCTAATCCAAGCTCCATTCACCAAGGTGGAAGAGAGTTTTAATATTCAAGCCATTCATGATATTTTAACCTACAGCGTATTTGATATCTCCCAATATGACCACTTGAAATTTCCTGGAGTAGTCCCTAGAACATTCGTTGGTGCTGTGATTATTGCAATGCTTTCGAGACCTTATCTTTACTTGAGTTCTTTGATCCAAACTTCCAGGCCTACGTCTATAGATGTTCAATTGGTCGTTAGGGGGATTGTTGGCCTCACCAATGGGCTTTCTTTTATCTATTTAAAGAATTGTTTGCAAGATATGTTTGATGAAATCACTGAAAAGAAAAAGGAAGAAAATGAAGACAAGGATATATACATTTACGATAGCGCTGGTACATGGTTTCTTTTATTTTTAATTGGCAGTTTCCACCTCATGTTCTACAGCACTAGGACTCTGCCTAATTTTGTCATGACTCTGCCTCTAACCAACGTCGCATTGGGGTGGGTTTTATTGGGTCGTTATAATGCAGCTATATTCCTATCTGCGCTCGTGGCAATTGTATTTAGACTGGAAGTGTCAGCTCTCAGTGCTGGTATTGCTCTATTTAGCGTCATCTTCAAGAAGATTTCTTTATTCGATGCTATCAAATTCGGTATCTTTGGCTTGGGACTTGGTTCCGCCATCAGTATCACCGTTGATTCATATTTCTGGCAAGAATGGTGTCTACCTGAGGTAGATGGTTTCTTGTTCAACGTGGTTGCGGGTTACGCTTCCAAGTGGGGTGTGGAGCCAGTTACTGCTTATTTCACGCATTACTTGAGAATGATGTTTATGCCACCAACTGTTTTACTATTGAATTACTTCGGCTATAAATTAGCACCTGCAAAATTAAAAATTGTCTCACTAGCATCTCTTTTCCACATTATCGTCTTATCCTTTCAACCTCACAAAGAATGGAGATTCATCATCTACGCTGTTCCATCTATCATGTTGCTAGGTGCCACAGGAGCAGCACATCTATGGGAGAATATGAAAGTAAAAAAGATTACCAATGTTTTATGTTTGGCTATATTGCCCTTATCTATAATGACCTCCTTTTTCATTTCAATGGCGTTCTTGTATATATCAAGAATGAATTATCCAGGCGGCGAGGCTTTAACTTCTTTTAATGACATGATTGTGGAAAAAAATATTACAAACGCTACAGTTCATATCAGCATACCTCCTTGCATGACAGGTGTCACTTTATTTGGTGAATTGAACTACGGTGTGTACGGCATCAATTACGATAAGACTGAAAATACGACTTTACTGCAGGAAATGTGGCCCTCCTTTGATTTCTTGATCACCCACGAGCCAACCGCCTCTCAATTGCCATTCGAGAATAAGACTACCAACCATTGGGAGCTAGTTAACACAACAAAGATGTTTACTGGATTTGACCCAACCTACATTAAGAACTTTGTTTTCCAAGAGAGAGTGAATGTTTTGTCTCTACTCAAACAGATCATTTTCGACAAGACCCCTACCGTTTTTTTGAAAGAATTGACGGCCAATTCGATTGTTAAAAGCGATGTCTTCTTCACCTATAAGAGAATCAAACAAGATGAAAAAACTGATTGA","protein_sequence":"MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATVHISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQLPFENKTTNHWELVNTTKMFTGFDPTYIKNFVFQERVNVLSLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRIKQDEKTD"},{"created_at":"2016-09-09T22:48:16.000Z","updated_at":"2016-09-09T22:48:19.000Z","name":"Alpha-1,2-mannosyltransferase ALG9","uniprot_id":"P53868","uniprot_name":"ALG9","enzyme":true,"transporter":false,"gene_name":"ALG9","num_residues":555,"molecular_weight":"63776.03","theoretical_pi":null,"general_function":"protein glycosylation","specific_function":"Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.","reactions":[{"id":14877,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007068","source":"Smpdb"},{"id":14878,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007070","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"8-28;63-83;87-107;114-134;177-197;214-234;269-289;317-337;350-370","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 9","Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"glycolipid mannosyltransferase activity"},{"category":"Function","description":"mannosyltransferase activity"},{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"endoplasmic reticulum"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAATTGCAAGGCGGTAACCATTAGTTTATTACTGTTGTTATTTTTAACAAGAGTATATATTCAGCCGACATTCTCGTTAATTTCAGATTGCGATGAAACTTTTAATTATTGGGAACCATTAAATTTATTGGTACGTGGATTTGGTAAACAAACCTGGGAATATTCACCCGAGTATTCTATTAGATCATGGGCTTTCTTATTACCTTTTTACTGTATTCTTTATCCAGTAAACAAATTTACTGACCTAGAAAGTCATTGGAACTTTTTCATCACAAGAGCATGCTTAGGCTTTTTTAGTTTTATCATGGAATTTAAACTACATCGTGAAATTGCAGGCAGCTTGGCATTGCAAATCGCAAATATTTGGATTATTTTCCAATTGTTTAATCCGGGCTGGTTCCATGCATCTGTGGAATTATTGCCTTCTGCCGTTGCCATGTTGTTGTATGTAGGTGCCACCAGACACTCTCTACGCTATCTGTCCACTGGGTCTACTTCTAACTTTACGAAAAGTTTAGCGTACAATTTCCTGGCTAGTATACTAGGCTGGCCATTTGTTTTAATTTTAAGCTTGCCATTATGTTTACATTACCTTTTCAACCATAGAATTATTTCTACCATCAGAACCGCATTCGACTGCTGTTTGATATTTTCATTGACTGCATTTGCTGTGATTGTCACTGACAGTATATTTTACGGGAAGCTTGCTCCTGTATCATGGAACATCTTATTTTACAATGTCATTAATGCAAGTGAGGAATCTGGCCCAAATATTTTCGGGGTTGAGCCATGGTACTACTATCCACTAAATTTGTTACTGAATTTCCCACTGCCTGTGCTAGTTTTAGCTATTTTGGGAATTTTCCATTTGAGATTATGGCCATTATGGGCATCATTATTCACATGGATTGCCGTTTTCACTCAACAACCTCACAAAGAGGAAAGATTTCTCTATCCAATTTACGGGTTAATAACTTTGAGTGCAAGTATCGCCTTTTACAAAGTGTTGAATCTATTCAATAGAAAGCCGATTCTTAAAAAAGGTATAAAGTTGTCAGTTTTATTAATTGTTGCAGGCCAGGCAATGTCACGGATAGTGGCTTTGGTGAACAATTACACAGCTCCTATAGCCGTCTACGAGCAATTTTCTTCACTAAATCAAGGTGGTGTGAAGGCACCGGTAGTGAATGTATGTACGGGACGTGAATGGTATCACTTCCCAAGTTCTTTCCTGCTGCCAGATAATCATAGGCTAAAATTTGTTAAATCTGGATTTGATGGTCTTCTTCCAGGTGATTTTCCAGAGAGTGGTTCTATTTTCAAAAAGATTAGAACTTTACCTAAGGGAATGAATAACAAGAATATATATGATACCGGTAAAGAGTGGCCGATCACTAGATGTGATTATTTTATTGACATCGTCGCCCCAATAAATTTAACAAAAGACGTTTTCAACCCTCTACATCTGATGGATAACTGGAATAAGCTGGCATGTGCTGCATTCATCGACGGTGAAAATTCTAAGATTTTGGGTAGAGCATTTTACGTACCGGAGCCAATCAACCGAATCATGCAAATAGTTTTACCAAAACAATGGAATCAAGTGTACGGTGTTCGTTACATTGATTACTGTTTGTTTGAAAAACCAACTGAGACTACTAATTGA","protein_sequence":"MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKGMNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENSKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN"},{"created_at":"2016-09-09T22:50:37.000Z","updated_at":"2016-09-09T22:50:37.000Z","name":"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase","uniprot_id":"Q12001","uniprot_name":"ALG6","enzyme":true,"transporter":false,"gene_name":"ALG6","num_residues":544,"molecular_weight":"62782.275","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.","reactions":[{"id":14880,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007071","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"36-56;105-125;146-166;172-192;224-244;264-284;333-353;357-377;399-419;426-446;482-502;509-529","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 6","Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase","Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"transferase activity, transferring hexosyl groups"},{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"endoplasmic reticulum"},{"category":"Function","description":"aerobic respiration"},{"category":"Function","description":"dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGCCATTGGCAAAAGGTTACTGGTGAACAAACCAGCAGAAGAATCATTTTATGCTTCTCCAATGTATGATTTTTTGTATCCGTTTAGGCCAGTGGGGAACCAATGGCTGCCAGAATATATTATCTTTGTATGTGCTGTAATACTGAGGTGCACAATTGGACTTGGTCCATATTCTGGGAAAGGCAGTCCACCGCTGTACGGCGATTTTGAGGCTCAGAGACATTGGATGGAAATTACGCAACATTTACCGCTTTCTAAGTGGTACTGGTATGATTTGCAATACTGGGGATTGGACTATCCACCATTAACAGCATTTCATTCGTACCTTCTGGGCCTAATTGGATCTTTTTTCAATCCATCTTGGTTTGCACTAGAAAAGTCACGTGGCTTTGAATCCCCCGATAATGGCCTGAAAACATATATGCGTTCTACTGTCATCATTAGCGACATATTGTTTTACTTTCCTGCAGTAATATACTTTACTAAGTGGCTTGGTAGATATCGAAACCAGTCGCCCATAGGACAATCTATTGCGGCATCAGCGATTTTGTTCCAACCTTCATTAATGCTCATTGACCATGGGCACTTTCAATATAATTCAGTCATGCTTGGCCTTACTGCTTATGCCATAAATAACTTATTAGATGAGTATTATGCTATGGCGGCCGTTTGTTTTGTCCTATCCATTTGTTTTAAACAAATGGCATTGTATTATGCACCGATTTTTTTTGCTTATCTATTAAGTCGATCATTGCTGTTCCCCAAATTTAACATAGCTAGATTGACGGTTATTGCGTTTGCAACACTCGCAACTTTTGCTATAATATTTGCGCCATTATATTTCTTGGGAGGAGGATTAAAGAATATTCACCAATGTATTCACAGGATATTCCCTTTTGCCAGGGGCATCTTCGAAGACAAGGTTGCTAACTTCTGGTGCGTTACGAACGTGTTTGTAAAATACAAGGAAAGATTCACTATACAACAACTCCAGCTATATTCATTGATTGCCACCGTGATTGGTTTCTTACCAGCCATGATAATGACATTACTTCATCCCAAAAAGCATCTTCTCCCATACGTGTTAATCGCATGTTCGATGTCCTTTTTTCTTTTTAGCTTTCAAGTACATGAGAAAACTATCCTCATCCCACTTTTGCCTATTACACTACTCTACTCCTCTACTGATTGGAATGTTCTATCTCTTGTAAGTTGGATAAACAATGTGGCTTTGTTTACGCTATGGCCTTTGTTGAAAAAGGACGGTCTTCATTTACAGTATGCCGTATCTTTCTTACTAAGCAATTGGCTGATTGGAAATTTCAGTTTTATTACACCAAGGTTCTTGCCAAAATCTTTAACTCCTGGCCCTTCTATCAGCAGCATCAATAGCGACTATAGAAGAAGAAGCTTACTGCCATATAATGTGGTTTGGAAAAGTTTTATCATAGGAACGTATATTGCTATGGGCTTTTATCATTTCTTAGATCAATTTGTAGCACCTCCATCGAAATATCCAGACTTGTGGGTGTTGTTGAACTGTGCTGTTGGGTTCATTTGCTTTAGCATATTTTGGCTATGGTCTTATTACAAGATATTCACTTCCGGTAGCAAATCCATGAAGGACTTGTAG","protein_sequence":"MAIGKRLLVNKPAEESFYASPMYDFLYPFRPVGNQWLPEYIIFVCAVILRCTIGLGPYSGKGSPPLYGDFEAQRHWMEITQHLPLSKWYWYDLQYWGLDYPPLTAFHSYLLGLIGSFFNPSWFALEKSRGFESPDNGLKTYMRSTVIISDILFYFPAVIYFTKWLGRYRNQSPIGQSIAASAILFQPSLMLIDHGHFQYNSVMLGLTAYAINNLLDEYYAMAAVCFVLSICFKQMALYYAPIFFAYLLSRSLLFPKFNIARLTVIAFATLATFAIIFAPLYFLGGGLKNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKERFTIQQLQLYSLIATVIGFLPAMIMTLLHPKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYSSTDWNVLSLVSWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIGNFSFITPRFLPKSLTPGPSISSINSDYRRRSLLPYNVVWKSFIIGTYIAMGFYHFLDQFVAPPSKYPDLWVLLNCAVGFICFSIFWLWSYYKIFTSGSKSMKDL"}]}