{"ymdb_id":"YMDB16234","created_at":"2016-09-12T18:26:30.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"Glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-({[(2S,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-({[(2S,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"3.351426740666667","pka":"3.171781736366001","alogps_solubility":"5.63e-02 g/l","alogps_logp":"3.26","alogps_logs":"-4.77","acceptor_count":"64","donor_count":"39","rotatable_bond_count":"89","polar_surface_area":"1080.8300000000006","refractivity":"816.3616000000009","polarizability":"353.9449048225727","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.9477717037497753","pka_strongest_acidic":"1.7444953207598388","bioavailability":"0","number_of_rings":"12","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2016-09-09T22:46:30.000Z","updated_at":"2016-09-09T22:46:31.000Z","name":"Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase","uniprot_id":"P40351","uniprot_name":"ALG8","enzyme":true,"transporter":false,"gene_name":"ALG8","num_residues":577,"molecular_weight":"67384.29","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.","reactions":[{"id":14882,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007073","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"43-63;93-113;140-160;169-189;220-240;267-287;308-328;383-403;420-440;448-468;471-491;505-525;544-564","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 8","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"},{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAAAGGTGATCGTTCGAGGCAAAATATGGCTGTGACAAAGAAGGCAAAGTTAAAAAAAAATGACGAGCCAAAAAAGGTTTTGAAGACTGCCGCGACCGAAAAAGGTGAGGGATCCAAGCGCTACTCCTTATGGAATTTCTGGATAAGCACATTGTTTTTAAAATTACTATTGATTCCTGACTACTTCAGTACAGATTTTGACGTTCATAGAAATTGGCTGGCAATCACCAATAAATTGCCCATCAGCGAATGGTATTATGAGCACACTAGTCAATGGACATTGGATTATCCGCCATTTTTTGCTTATTTTGAATGGTTTTTATCGCAATTTGTTCCTAAATCTGTACGTGATGACGGTTGTTTGGATATAGTGGAGATCGGAAAGTTCGGTTTGCCAACAATCGTTTTCCAACGACTCACTGTCATCTTCAGCGAAATTCTTCTATTTGTCATCCTTCAAATATACATTAATACTACAAAGCTAAGTGAAAGATCTCAAAGTTTTGTGGTTGCTTCTAGCATTGTACTATCACCCGGGTTTTTAATAATAGATCACATTCACTTCCAATATAATGGTTTTCTTTTTGCGATTCTAATAGGCTCCATTGTCGCCGCCAAGAATAAGAGATACATCTTGTGCGCTGTTCTGTATACTACAGCCATATGTTTCAAGCATATATTTTTATATTTGGCGCCATGTTATTTCGTGTTTTTATTGAGAGCATACGTTCTCAATGTCAACAATTTCAAGTTTAAAAGTTACAAAGATTTTTTGTTCCTGATAAGATGGGCAAATCTTTTGAAGTTGGCTACCGTTGTTGTTGGAATTTTCACTATTTGTTTCCTTCCATTTGCTCATCAAATGCCGCAAGTGTTGAGCAGGTTATTCCCATTCTCAAGAGGACTGACGCATGCATATTGGGCACCAAATTTCTGGGCGTTGTATTCTTTTATGGATAAAATACTCACTACGGTAATGTTGAAATTACCGTACGTCCACACTTTTGCTACAAAATTTATTAAACCTCCTCTGATCCCTCAGAATATCAAGGAAATTAATGAAAGGCTCGCGGCAAACAACAATGGAAGTAAAGGTCTAGTTCAAGACGTATTTTTTGTTATTCTCCCTCAAATTCCTCCAAAATTAACGTTTATTTTGACGATATTTTACCAGGTCTTAGCAGTACTTCCACTTTTGTTTGATCCATCGTTCAAAAGATTTGTTGGCTCGTTGACTCTCTGTGGGTTGGCATCGTTTTTGTTCGGGTGGCATGTGCATGAGAAAGCTATAATGCTAGTCATCATTCCGTTCACATTTCTTGTTGGATTTGATCGTCGTCTTTTGGTACCGTTTATGTTAGTTGCCTCAGCTGGTTATGTTTCCTTGTATCCTCTTCTGTACAAAGGCCAAGATTTTTTCATTAAAACATTATACACTTATGTTTGGTGTATAATTTATTTTGCCGCTTTTAGAAAAACTACGAAGATTTCTTCAAGTGTAGAAAGAAGAATCTTTTTCTTGGATAGGTTGGCATTAACGTACATCTTTTCATTGTTACCAATCGTCACCGTATTACAAATATTGGATGAAGTCAAGTGGAGATATTCATTTTTGCAAAAATTTGAATTCTTAGGATTAATGATATATAGTGTCTATTGTTCATTAGGTATAATCAGCTCGTGGTTTGCCTTATCGTGGTTATATAATTTTGACGAATTACTATGGCAGTGA","protein_sequence":"MKGDRSRQNMAVTKKAKLKKNDEPKKVLKTAATEKGEGSKRYSLWNFWISTLFLKLLLIPDYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWFLSQFVPKSVRDDGCLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVASSIVLSPGFLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYFVFLLRAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFSRGLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAANNNGSKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKRFVGSLTLCGLASFLFGWHVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIKTLYTYVWCIIYFAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFLQKFEFLGLMIYSVYCSLGIISSWFALSWLYNFDELLWQ"},{"created_at":"2016-09-09T22:50:37.000Z","updated_at":"2016-09-09T22:50:37.000Z","name":"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase","uniprot_id":"Q12001","uniprot_name":"ALG6","enzyme":true,"transporter":false,"gene_name":"ALG6","num_residues":544,"molecular_weight":"62782.275","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.","reactions":[{"id":14880,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007071","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"36-56;105-125;146-166;172-192;224-244;264-284;333-353;357-377;399-419;426-446;482-502;509-529","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 6","Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase","Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"aerobic respiration"},{"category":"Function","description":"dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"transferase activity, transferring hexosyl groups"},{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"endoplasmic reticulum"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGCCATTGGCAAAAGGTTACTGGTGAACAAACCAGCAGAAGAATCATTTTATGCTTCTCCAATGTATGATTTTTTGTATCCGTTTAGGCCAGTGGGGAACCAATGGCTGCCAGAATATATTATCTTTGTATGTGCTGTAATACTGAGGTGCACAATTGGACTTGGTCCATATTCTGGGAAAGGCAGTCCACCGCTGTACGGCGATTTTGAGGCTCAGAGACATTGGATGGAAATTACGCAACATTTACCGCTTTCTAAGTGGTACTGGTATGATTTGCAATACTGGGGATTGGACTATCCACCATTAACAGCATTTCATTCGTACCTTCTGGGCCTAATTGGATCTTTTTTCAATCCATCTTGGTTTGCACTAGAAAAGTCACGTGGCTTTGAATCCCCCGATAATGGCCTGAAAACATATATGCGTTCTACTGTCATCATTAGCGACATATTGTTTTACTTTCCTGCAGTAATATACTTTACTAAGTGGCTTGGTAGATATCGAAACCAGTCGCCCATAGGACAATCTATTGCGGCATCAGCGATTTTGTTCCAACCTTCATTAATGCTCATTGACCATGGGCACTTTCAATATAATTCAGTCATGCTTGGCCTTACTGCTTATGCCATAAATAACTTATTAGATGAGTATTATGCTATGGCGGCCGTTTGTTTTGTCCTATCCATTTGTTTTAAACAAATGGCATTGTATTATGCACCGATTTTTTTTGCTTATCTATTAAGTCGATCATTGCTGTTCCCCAAATTTAACATAGCTAGATTGACGGTTATTGCGTTTGCAACACTCGCAACTTTTGCTATAATATTTGCGCCATTATATTTCTTGGGAGGAGGATTAAAGAATATTCACCAATGTATTCACAGGATATTCCCTTTTGCCAGGGGCATCTTCGAAGACAAGGTTGCTAACTTCTGGTGCGTTACGAACGTGTTTGTAAAATACAAGGAAAGATTCACTATACAACAACTCCAGCTATATTCATTGATTGCCACCGTGATTGGTTTCTTACCAGCCATGATAATGACATTACTTCATCCCAAAAAGCATCTTCTCCCATACGTGTTAATCGCATGTTCGATGTCCTTTTTTCTTTTTAGCTTTCAAGTACATGAGAAAACTATCCTCATCCCACTTTTGCCTATTACACTACTCTACTCCTCTACTGATTGGAATGTTCTATCTCTTGTAAGTTGGATAAACAATGTGGCTTTGTTTACGCTATGGCCTTTGTTGAAAAAGGACGGTCTTCATTTACAGTATGCCGTATCTTTCTTACTAAGCAATTGGCTGATTGGAAATTTCAGTTTTATTACACCAAGGTTCTTGCCAAAATCTTTAACTCCTGGCCCTTCTATCAGCAGCATCAATAGCGACTATAGAAGAAGAAGCTTACTGCCATATAATGTGGTTTGGAAAAGTTTTATCATAGGAACGTATATTGCTATGGGCTTTTATCATTTCTTAGATCAATTTGTAGCACCTCCATCGAAATATCCAGACTTGTGGGTGTTGTTGAACTGTGCTGTTGGGTTCATTTGCTTTAGCATATTTTGGCTATGGTCTTATTACAAGATATTCACTTCCGGTAGCAAATCCATGAAGGACTTGTAG","protein_sequence":"MAIGKRLLVNKPAEESFYASPMYDFLYPFRPVGNQWLPEYIIFVCAVILRCTIGLGPYSGKGSPPLYGDFEAQRHWMEITQHLPLSKWYWYDLQYWGLDYPPLTAFHSYLLGLIGSFFNPSWFALEKSRGFESPDNGLKTYMRSTVIISDILFYFPAVIYFTKWLGRYRNQSPIGQSIAASAILFQPSLMLIDHGHFQYNSVMLGLTAYAINNLLDEYYAMAAVCFVLSICFKQMALYYAPIFFAYLLSRSLLFPKFNIARLTVIAFATLATFAIIFAPLYFLGGGLKNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKERFTIQQLQLYSLIATVIGFLPAMIMTLLHPKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYSSTDWNVLSLVSWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIGNFSFITPRFLPKSLTPGPSISSINSDYRRRSLLPYNVVWKSFIIGTYIAMGFYHFLDQFVAPPSKYPDLWVLLNCAVGFICFSIFWLWSYYKIFTSGSKSMKDL"}]}