{"ymdb_id":"YMDB16224","created_at":"2016-09-12T18:24:52.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"(Glucosyl)2(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-({[(2S,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5R,6R)-4-{[(2R,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-({[(2S,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,5-dihydroxyoxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5R,6R)-4-{[(2R,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"1.5805910950000053","pka":"3.1717817363564187","alogps_solubility":"1.44e-01 g/l","alogps_logp":"3.04","alogps_logs":"-4.38","acceptor_count":"69","donor_count":"42","rotatable_bond_count":"92","polar_surface_area":"1159.9800000000005","refractivity":"848.7749000000009","polarizability":"368.9492237368181","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.9542149685442736","pka_strongest_acidic":"1.7444953207594671","bioavailability":"0","number_of_rings":"13","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T06:18:50.000Z","updated_at":"2011-07-22T17:54:10.000Z","name":"Alpha-1,2 glucosyltransferase ALG10","uniprot_id":"P50076","uniprot_name":"ALG10_YEAST","enzyme":true,"transporter":false,"gene_name":"DIE2","num_residues":525,"molecular_weight":"61807.0","theoretical_pi":"9.75","general_function":"Involved in transferase activity, transferring hexosyl groups","specific_function":"Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol","reactions":[{"id":1316,"direction":"\u003c\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14883,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007074","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"36-56;95-115;128-148;151-171;188-208;214-234;257-277;295-315;334-354;376-396;424-444;448-468;493-513","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"D38049","genbank_protein_id":"902940","gene_card_id":"DIE2","chromosome_location":"chromosome 7","locus":"YGR227W","synonyms":["Alpha-2-glucosyltransferase ALG10","Asparagine-linked glycosylation protein 10","Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10"],"enzyme_classes":["2.4.1.-"],"go_classes":[{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"DIE2_ALG10","identifier":"PF04922"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGATGCAAAGAAAAATACTGGTGAAGCCAATAATGATGTATTGGAAGAGGAAGCAGCGATTCAGTTGATTGCACCAGGTATAGCGAGAAACTTAACACAAGAAGTCATTACCGGTATCTTCTGTAATGTAGTAATATATCCTCTTCTTCTAATATATTTTGTCTTAACTTTCCGTTACATGACTACAAATATTGTACCTTATGAATTTATAGATGAAAAGTTTCACGTTGGCCAAACTTTGACCTATTTAAAAGGTAAATGGACTCAATGGGACCCTAAAATAACAACCCCCCCTGGAATCTATATTTTGGGTTTAATTAATTATTATTGTATAAAGCCCATATTCAAGTCGTGGAGCACACTAACCATACTAAGATTAGTTAATTTACTTGGAGGGATTATCGTTTTCCCCATTTTAGTACTCAGGCCAATATTCCTTTTTAATGCCTTAGGTTTTTGGCCCGTTTCATTAATGAGCTTCCCATTGATGACAACTTATTATTACTTATTTTACACCGATGTGTGGTCTACAATTCTGATATTGCAATCACTCAGCTGCGTGTTAACATTACCGTTTGGCCCCGTGAAGAGTATATGGTTGAGTGCTTTTTTTGCTGGTGTAAGCTGTCTCTTCAGACAAACGAATATCATTTGGACGGGATTTATAATGATTCTTGCTGTTGAACGCCCAGCCATTTTACAAAAACAGTTCAACACGCATACGTTCAATAACTATTTGAAATTATTCATTCATGCTATTGACGATTTCTCCAACCTTGTTCTGCCCTATATGATAAATTTTGTTTTGTTCTTCATTTATCTGATTTGGAACAGATCCATAACACTAGGTGATAAGTCCAGCCACTCAGCAGGCCTGCATATAGTACAAATATTCTATTGTTTCACATTCATCACCGTTTTCAGTTTACCTATATGGATATCTCGTAATTTTATGAAGTTGTACAAATTAAGGATAAAACGGAAGCCAGTACAAACTTTTTTTGAATTTATTGGTATTATGCTAATCATAAGATACTTTACAAAAGTTCACCCATTTTTGTTAGCAGATAATAGACACTACACGTTCTACCTCTTCAGAAGATTGATAGGCAACAAAAGTAGACTAATCAAGTACTTTTTTATGACACCAATCTATCATTTCTCCACTTTCGCATACCTTGAAGTGATGAGACCCAACCAGCTCACCTTTCACCCCATCACTCCACTCCCCATCAAAGAACCTGTACATTTACCCATACAACTGACACATGTATCGTGGACGGCCTTAATAACGTGCACCATGGTAACTATCGTTCCATCACCCTTATTCGAACCTCGTTACTATATATTGCCCTATTTCTTTTGGAGAATATTTATTACCTGCAGCTGCGAACCTTTGATAAAGGATTTAAAACCTGCTAAAGAAGGCGAAAACCCAATTACCATAAGCAGTACGAAAAGACTGTTCATGGAATTTTTATGGTTCATGCTCTTCAATGTCGTTACTTTAGTTATCTTTTCCAAGGTCTCATTTCCTTGGACCACTGAGCCCTATTTGCAAAGAATAATATGGTGA","protein_sequence":"MDAKKNTGEANNDVLEEEAAIQLIAPGIARNLTQEVITGIFCNVVIYPLLLIYFVLTFRYMTTNIVPYEFIDEKFHVGQTLTYLKGKWTQWDPKITTPPGIYILGLINYYCIKPIFKSWSTLTILRLVNLLGGIIVFPILVLRPIFLFNALGFWPVSLMSFPLMTTYYYLFYTDVWSTILILQSLSCVLTLPFGPVKSIWLSAFFAGVSCLFRQTNIIWTGFIMILAVERPAILQKQFNTHTFNNYLKLFIHAIDDFSNLVLPYMKNFVLFFIYLIWNRSITLGDKSSHSAGLHIVQIFYCFTFITVFSLPIWISRNFMKLYKLRIKRKPVQTFFEFIGIMLIIRYFTKVHPFLLADNRHYTFYLFRRLIGNKSRLIKYFFMTPIYHFSTFAYLEVMRPNQLTFHPITPLPIKEPVHLPIQLTHVSWTALITCTMVTIVPSPLFEPRYYILPYFFWRIFITCSCEPLIKDLKPAKEGENPITISSTKRLFMEFLWFMLFNVVTLVIFSKVSFPWTTEPYLQRIIW"},{"created_at":"2016-09-09T22:46:30.000Z","updated_at":"2016-09-09T22:46:31.000Z","name":"Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase","uniprot_id":"P40351","uniprot_name":"ALG8","enzyme":true,"transporter":false,"gene_name":"ALG8","num_residues":577,"molecular_weight":"67384.29","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.","reactions":[{"id":14882,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007073","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"43-63;93-113;140-160;169-189;220-240;267-287;308-328;383-403;420-440;448-468;471-491;505-525;544-564","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 8","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase","Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAAAGGTGATCGTTCGAGGCAAAATATGGCTGTGACAAAGAAGGCAAAGTTAAAAAAAAATGACGAGCCAAAAAAGGTTTTGAAGACTGCCGCGACCGAAAAAGGTGAGGGATCCAAGCGCTACTCCTTATGGAATTTCTGGATAAGCACATTGTTTTTAAAATTACTATTGATTCCTGACTACTTCAGTACAGATTTTGACGTTCATAGAAATTGGCTGGCAATCACCAATAAATTGCCCATCAGCGAATGGTATTATGAGCACACTAGTCAATGGACATTGGATTATCCGCCATTTTTTGCTTATTTTGAATGGTTTTTATCGCAATTTGTTCCTAAATCTGTACGTGATGACGGTTGTTTGGATATAGTGGAGATCGGAAAGTTCGGTTTGCCAACAATCGTTTTCCAACGACTCACTGTCATCTTCAGCGAAATTCTTCTATTTGTCATCCTTCAAATATACATTAATACTACAAAGCTAAGTGAAAGATCTCAAAGTTTTGTGGTTGCTTCTAGCATTGTACTATCACCCGGGTTTTTAATAATAGATCACATTCACTTCCAATATAATGGTTTTCTTTTTGCGATTCTAATAGGCTCCATTGTCGCCGCCAAGAATAAGAGATACATCTTGTGCGCTGTTCTGTATACTACAGCCATATGTTTCAAGCATATATTTTTATATTTGGCGCCATGTTATTTCGTGTTTTTATTGAGAGCATACGTTCTCAATGTCAACAATTTCAAGTTTAAAAGTTACAAAGATTTTTTGTTCCTGATAAGATGGGCAAATCTTTTGAAGTTGGCTACCGTTGTTGTTGGAATTTTCACTATTTGTTTCCTTCCATTTGCTCATCAAATGCCGCAAGTGTTGAGCAGGTTATTCCCATTCTCAAGAGGACTGACGCATGCATATTGGGCACCAAATTTCTGGGCGTTGTATTCTTTTATGGATAAAATACTCACTACGGTAATGTTGAAATTACCGTACGTCCACACTTTTGCTACAAAATTTATTAAACCTCCTCTGATCCCTCAGAATATCAAGGAAATTAATGAAAGGCTCGCGGCAAACAACAATGGAAGTAAAGGTCTAGTTCAAGACGTATTTTTTGTTATTCTCCCTCAAATTCCTCCAAAATTAACGTTTATTTTGACGATATTTTACCAGGTCTTAGCAGTACTTCCACTTTTGTTTGATCCATCGTTCAAAAGATTTGTTGGCTCGTTGACTCTCTGTGGGTTGGCATCGTTTTTGTTCGGGTGGCATGTGCATGAGAAAGCTATAATGCTAGTCATCATTCCGTTCACATTTCTTGTTGGATTTGATCGTCGTCTTTTGGTACCGTTTATGTTAGTTGCCTCAGCTGGTTATGTTTCCTTGTATCCTCTTCTGTACAAAGGCCAAGATTTTTTCATTAAAACATTATACACTTATGTTTGGTGTATAATTTATTTTGCCGCTTTTAGAAAAACTACGAAGATTTCTTCAAGTGTAGAAAGAAGAATCTTTTTCTTGGATAGGTTGGCATTAACGTACATCTTTTCATTGTTACCAATCGTCACCGTATTACAAATATTGGATGAAGTCAAGTGGAGATATTCATTTTTGCAAAAATTTGAATTCTTAGGATTAATGATATATAGTGTCTATTGTTCATTAGGTATAATCAGCTCGTGGTTTGCCTTATCGTGGTTATATAATTTTGACGAATTACTATGGCAGTGA","protein_sequence":"MKGDRSRQNMAVTKKAKLKKNDEPKKVLKTAATEKGEGSKRYSLWNFWISTLFLKLLLIPDYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWFLSQFVPKSVRDDGCLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVASSIVLSPGFLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYFVFLLRAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFSRGLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAANNNGSKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKRFVGSLTLCGLASFLFGWHVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIKTLYTYVWCIIYFAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFLQKFEFLGLMIYSVYCSLGIISSWFALSWLYNFDELLWQ"}]}