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Identification |
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Name | D-3-phosphoglycerate dehydrogenase 1 |
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Synonyms | |
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Gene Name | SER3 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
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Specific Function | 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH |
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Cellular Location | Not Available |
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SMPDB Pathways | |
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KEGG Pathways | Glycine, serine and threonine metabolism | ec00260 | | Methane metabolism | ec00680 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00059 | 2-hydroxyglutaric acid | Show | YMDB00110 | NAD | Show | YMDB00143 | NADH | Show | YMDB00153 | Oxoglutaric acid | Show | YMDB00341 | 3-Phosphoglyceric acid | Show | YMDB00393 | Phosphohydroxypyruvic acid | Show | YMDB00412 | NAD(+) | Show | YMDB00756 | 3-phospho-D-glyceric acid | Show | YMDB00862 | hydron | Show |
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GO Classification | Component |
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Not Available | Function |
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binding | nucleotide binding | oxidoreductase activity | cofactor binding | oxidoreductase activity, acting on CH-OH group of donors | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | NAD or NADH binding | catalytic activity | Process |
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metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 5 |
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Locus | YER081W |
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Gene Sequence | >YER081W Chr 5
ATGACAAGCATTGACATTAACAACTTACAAAATACCTTTCAACAAGCTATGAATATGAGC
GGCTCCCCAGGCGCTGTTTGTACTTCACCTACGCAATCTTTCATGAATACCGTTCCACAG
CGCTTGAATGCTGTAAAGCACCCAAAAATTTTGAAGCCTTTCTCAACGGGTGATATGAAG
ATTTTACTATTAGAAAACGTTAATCAAACTGCTATTACAATCTTCGAAGAGCAAGGTTAC
CAAGTCGAATTCTATAAATCTTCATTGCCCGAGGAAGAGTTGATCGAAAAGATCAAGGAC
GTTCATGCTATTGGTATCAGATCAAAGACTAGATTAACTTCAAATGTCTTACAACATGCG
AAGAATCTGGTTTGTATTGGTTGTTTCTGTATCGGTACCAACCAAGTTGACTTAGACTAC
GCTACCAGCAGAGGTATTGCTGTTTTCAACTCGCCTTTCTCCAACTCAAGATCAGTAGCA
GAATTGGTCATCGCTGAAATCATTAGTTTAGCAAGACAACTAGGTGATAGATCTATCGAA
TTACATACCGGTACATGGAATAAGGTTGCTGCTAGATGTTGGGAGGTAAGAGGAAAAACT
CTTGGTATTATTGGGTACGGTCACATTGGTTCCCAATTATCAGTTCTTGCAGAAGCTATG
GGTTTGCATGTGTTGTACTACGATATTGTAACTATCATGGCCTTGGGTACTGCCAGACAA
GTTTCTACATTAGATGAATTGTTGAATAAATCTGATTTTGTGACACTACATGTACCAGCT
ACTCCTGAAACTGAAAAAATGTTATCTGCCCCACAATTTGCTGCTATGAAGGATGGCGCT
TATGTTATTAATGCTTCAAGAGGTACTGTCGTGGACATTCCATCTTTGATCCAAGCCGTG
AAAGCCAACAAAATTGCAGGTGCTGCTTTGGATGTTTATCCACATGAACCAGCTAAGAAC
GGTGAAGGTTCATTTAACGATGAGCTAAATAGCTGGACTTCTGAATTAGTTTCATTACCA
AATATCATCTTGACACCACACATTGGTGGCTCTACCGAAGAAGCCCAAAGCTCAATCGGT
ATTGAAGTGGCTACCGCATTGTCCAAATACATCAATGAAGGTAACTCTGTCGGTTCAGTC
AACTTCCCAGAAGTGGCATTGAAATCATTGTCTTACGACCAAGAGAACACTGTGCGTGTG
TTATACATTCACCAAAATGTACCAGGTGTTTTGAAGACCGTCAATGATATTTTATCGAAC
CATAACATCGAAAAGCAATTTTCCGATTCAAATGGTGAAATTGCTTATTTAATGGCTGAT
ATCTCTTCTGTTGACCAAAGCGATATTAAAGATATTTATGAACAACTAAATCAAACCTCT
GCTAAGATCTCAATTAGATTGCTATATTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 469 |
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Protein Molecular Weight | 51192.80078 |
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Protein Theoretical pI | 5.28 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >D-3-phosphoglycerate dehydrogenase 1
MTSIDINNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAVKHPKILKPFSTGDMK
ILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVLQHA
KNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDRSIE
LHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQ
VSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAV
KANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIG
IEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDILSN
HNIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY |
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References |
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External Links | |
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General Reference | - Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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