{"ymdb_id":"YMDB00393","created_at":"2011-05-29T18:12:20.000Z","updated_at":"2016-09-08T18:35:26.000Z","name":"Phosphohydroxypyruvic acid","cas":"3913-50-6","state":"Solid","melting_point":"","description":"Phosphohydroxypyruvic acid is a product of both enzyme phosphoglycerate dehydrogenase [EC 1.1.1.95] and phosphoserine transaminase [EC 2.6.1.52] in glycine, serine and threonine metabolism pathway. [KEGG]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"30933","hmdb_id":"HMDB01024","kegg_id":"C03232","pubchem_id":"105","cs_id":"103","foodb_id":null,"wikipedia_link":"Phosphohydroxypyruvic_acid","biocyc_id":"3-P-HYDROXYPYRUVATE","iupac":"2-oxo-3-(phosphonooxy)propanoic acid","traditional_iupac":"phosphohydroxypyruvate","logp":"-0.8749401239999998","pka":"2.771821818294329","alogps_solubility":"1.34e+01 g/l","alogps_logp":"-1.75","alogps_logs":"-1.14","acceptor_count":"6","donor_count":"3","rotatable_bond_count":"4","polar_surface_area":"121.13","refractivity":"30.564799999999998","polarizability":"12.689006616785997","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":null,"pka_strongest_acidic":"1.0202501691523165","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-oxo-3-(phosphonooxy)-Propanoate","2-oxo-3-(phosphonooxy)-Propanoic acid","3-Phosphohydroxypyruvate","3-Phosphohydroxypyruvic acid","3-Phosphonooxypyruvate","3-Phosphonooxypyruvic acid","Phosphohydroxypyruvate","phosphohydroxypyruvic acid"],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."},{"pubmed_id":8017107,"citation":"Belhumeur, P., Fortin, N., Clark, M. W. (1994). \"A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase.\" Yeast 10:385-389."},{"pubmed_id":12525494,"citation":"Albers, E., Laize, V., Blomberg, A., Hohmann, S., Gustafsson, L. (2003). \"Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae.\" J Biol Chem 278:10264-10272."}],"proteins":[{"created_at":"2011-05-26T16:51:54.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"D-3-phosphoglycerate dehydrogenase 2","uniprot_id":"P40510","uniprot_name":"SER33_YEAST","enzyme":true,"transporter":false,"gene_name":"SER33","num_residues":469,"molecular_weight":"51187.80078","theoretical_pi":"6.38","general_function":"Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","specific_function":"3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH","reactions":[{"id":1866,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2448,"direction":"\u003e","locations":"","altext":"3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2449,"direction":"\u003e","locations":"","altext":"2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3841,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006364","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z37997","genbank_protein_id":"556873","gene_card_id":"SER33","chromosome_location":"chromosome 9","locus":"YIL074C","synonyms":["3-PGDH 2"],"enzyme_classes":["1.1.1.95"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"2-Hacid_dh","identifier":"PF00389"},{"name":"2-Hacid_dh_C","identifier":"PF02826"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTATTCAGCTGCCGATAATTTACAAGATTCATTCCAACGTGCCATGAACTTTTCTGGCTCTCCTGGTGCAGTCTCAACCTCACCAACTCAGTCATTTATGAACACACTACCTCGTCGTGTAAGCATTACAAAGCAACCAAAGGCTTTAAAACCTTTTTCTACTGGTGACATGAATATTCTACTGTTGGAAAATGTCAATGCAACTGCAATCAAAATCTTCAAGGATCAGGGTTACCAAGTAGAGTTCCACAAGTCTTCTCTACCTGAGGATGAATTGATTGAAAAAATCAAAGACGTACACGCTATCGGTATAAGATCCAAAACTAGATTGACTGAAAAAATACTACAGCATGCCAGGAATCTAGTTTGTATTGGTTGTTTTTGCATAGGTACCAATCAAGTAGACCTAAAATATGCCGCTAGTAAAGGTATTGCTGTTTTCAATTCGCCATTCTCCAATTCAAGATCCGTAGCAGAATTGGTAATTGGTGAGATCATTAGTTTAGCAAGACAATTAGGTGATAGATCCATTGAACTGCATACAGGTACATGGAATAAAGTCGCTGCTAGGTGTTGGGAAGTAAGAGGAAAAACTCTCGGTATTATTGGGTATGGTCACATTGGTTCGCAATTATCAGTTCTTGCAGAAGCTATGGGCCTGCATGTGCTATACTATGATATCGTGACAATTATGGCCTTAGGTACTGCCAGACAAGTTTCTACATTAGATGAATTGTTGAATAAATCTGATTTTGTAACACTACATGTACCAGCTACTCCAGAAACTGAAAAAATGTTATCTGCTCCACAATTCGCTGCTATGAAGGACGGGGCTTATGTTATTAATGCCTCAAGAGGTACTGTCGTGGACATTCCATCTCTGATCCAAGCCGTCAAGGCCAACAAAATTGCAGGTGCTGCTTTAGATGTTTATCCACATGAACCAGCTAAGAACGGTGAAGGTTCATTTAACGATGAACTTAACAGCTGGACTTCTGAGTTGGTTTCATTACCAAATATAATCCTGACACCACATATTGGTGGCTCTACAGAAGAAGCTCAAAGTTCAATCGGTATTGAGGTGGCTACTGCATTGTCCAAATACATCAATGAAGGTAACTCTGTCGGTTCTGTGAACTTCCCAGAAGTCAGTTTGAAGTCTTTGGACTACGATCAAGAGAACACAGTACGTGTCTTGTATATTCATCGTAACGTTCCTGGTGTTTTGAAGACCGTTAATGATATCTTATCCGATCATAATATCGAGAAACAGTTTTCTGATTCTCACGGCGAGATCGCTTATCTAATGGCAGACATCTCTTCTGTTAATCAAAGTGAAATCAAGGATATATATGAAAAGTTGAACCAAACTTCTGCCAAAGTTTCCATCAGGTTATTATACTAA","protein_sequence":"MSYSAADNLQDSFQRAMNFSGSPGAVSTSPTQSFMNTLPRRVSITKQPKALKPFSTGDMNILLLENVNATAIKIFKDQGYQVEFHKSSLPEDELIEKIKDVHAIGIRSKTRLTEKILQHARNLVCIGCFCIGTNQVDLKYAASKGIAVFNSPFSNSRSVAELVIGEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVSLKSLDYDQENTVRVLYIHRNVPGVLKTVNDILSDHNIEKQFSDSHGEIAYLMADISSVNQSEIKDIYEKLNQTSAKVSIRLLY"},{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine","reactions":[{"id":1800,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1894,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2474,"direction":"\u003e","locations":null,"altext":"O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2475,"direction":"\u003e","locations":null,"altext":"4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3842,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006365","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L20917","genbank_protein_id":"311153","gene_card_id":"SER1","chromosome_location":"chromosome 15","locus":"YOR184W","synonyms":["PSAT","Phosphohydroxythreonine aminotransferase"],"enzyme_classes":["2.6.1.52"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTTGGAAAGAGAGGAACCACAACATTTCGGAGCAGGGCCAGCTCAAATGCCTACACCAGTTTTGCAACAAGCTGCTAAAGACTTAATCAATTTCAATGACATAGGTTTGGGTATCGGTGAAATTTCTCACCGTTCGAAGGATGCCACCAAAGTGATTGAAGACTCTAAGAAGCACTTAATCGAACTGCTAAATATTCCTGACACTCATGAAGTGTTCTACTTGCAAGGTGGTGGCACTACTGGTTTTTCTTCCGTTGCTACTAATTTGGCAGCTGCATATGTGGGTAAGCATGGGAAGATTGCACCTGCCGGTTATTTAGTCACCGGTAGTTGGTCTCAGAAATCTTTTGAAGAGGCAAAGAGATTGCACGTTCCTGCTGAAGTTATCTTCAACGCTAAAGATTATAACAATGGCAAATTTGGTAAAATTCCGGATGAATCCCTTTGGGAAGATAAAATCAAAGGTAAGGCTTTCTCATACGTGTACCTATGTGAGAATGAAACTGTTCATGGTGTTGAATGGCCAGAATTACCAAAATGTTTAGTAAACGACCCCAACATCGAAATTGTTGCTGACTTATCCAGCGACATTTTGTCTCGTAAGATTGACGTTTCTCAATACGGTGTCATCATGGCAGGCGCCCAAAAAAACATTGGTTTAGCAGGCTTAACCCTATACATTATCAAGAAATCCATCCTTAAGAATATTTCTGGCGCTTCTGATGAAACATTACATGAATTGGGAGTACCAATCACCCCTATTGCATTCGACTATCCAACGGTGGTGAAGAACAACTCAGCCTATAATACAATTCCAATTTTCACTTTACATGTTATGGATCTCGTGTTCCAACATATTTTGAAGAAGGGTGGTGTTGAAGCGCAACAGGCTGAAAATGAAGAAAAGGCCAAGATATTATATGAGGCATTGGATGCAAATTCAGATTTTTACAACGTTCCAGTGGATCCAAAGTGTAGATCAAAAATGAATGTCGTTTTCACCCTTAAAAAGGACGGCCTTGATGACCAGTTTCTAAAAGAGGCAGCTGCTCGTCATTTAACCGGTTTGAAAGGACATCGTTCAGTTGGTGGGTTCAGAGCCTCCATCTATAACGCGCTTTCAGTGAAAGCTGTACAAAACTTGGTAGATTTTATCAAGGAATTTGCTGAGAAAAACGCTTAA","protein_sequence":"MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA"},{"created_at":"2011-05-27T17:20:48.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"D-3-phosphoglycerate dehydrogenase 1","uniprot_id":"P40054","uniprot_name":"SERA_YEAST","enzyme":true,"transporter":false,"gene_name":"SER3","num_residues":469,"molecular_weight":"51192.80078","theoretical_pi":"5.28","general_function":"Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","specific_function":"3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH","reactions":[{"id":1866,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2448,"direction":"\u003e","locations":"","altext":"3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2449,"direction":"\u003e","locations":"","altext":"2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3841,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006364","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"SER3","chromosome_location":"chromosome 5","locus":"YER081W","synonyms":["3-PGDH 1"],"enzyme_classes":["1.1.1.95"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"2-Hacid_dh","identifier":"PF00389"},{"name":"2-Hacid_dh_C","identifier":"PF02826"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACAAGCATTGACATTAACAACTTACAAAATACCTTTCAACAAGCTATGAATATGAGCGGCTCCCCAGGCGCTGTTTGTACTTCACCTACGCAATCTTTCATGAATACCGTTCCACAGCGCTTGAATGCTGTAAAGCACCCAAAAATTTTGAAGCCTTTCTCAACGGGTGATATGAAGATTTTACTATTAGAAAACGTTAATCAAACTGCTATTACAATCTTCGAAGAGCAAGGTTACCAAGTCGAATTCTATAAATCTTCATTGCCCGAGGAAGAGTTGATCGAAAAGATCAAGGACGTTCATGCTATTGGTATCAGATCAAAGACTAGATTAACTTCAAATGTCTTACAACATGCGAAGAATCTGGTTTGTATTGGTTGTTTCTGTATCGGTACCAACCAAGTTGACTTAGACTACGCTACCAGCAGAGGTATTGCTGTTTTCAACTCGCCTTTCTCCAACTCAAGATCAGTAGCAGAATTGGTCATCGCTGAAATCATTAGTTTAGCAAGACAACTAGGTGATAGATCTATCGAATTACATACCGGTACATGGAATAAGGTTGCTGCTAGATGTTGGGAGGTAAGAGGAAAAACTCTTGGTATTATTGGGTACGGTCACATTGGTTCCCAATTATCAGTTCTTGCAGAAGCTATGGGTTTGCATGTGTTGTACTACGATATTGTAACTATCATGGCCTTGGGTACTGCCAGACAAGTTTCTACATTAGATGAATTGTTGAATAAATCTGATTTTGTGACACTACATGTACCAGCTACTCCTGAAACTGAAAAAATGTTATCTGCCCCACAATTTGCTGCTATGAAGGATGGCGCTTATGTTATTAATGCTTCAAGAGGTACTGTCGTGGACATTCCATCTTTGATCCAAGCCGTGAAAGCCAACAAAATTGCAGGTGCTGCTTTGGATGTTTATCCACATGAACCAGCTAAGAACGGTGAAGGTTCATTTAACGATGAGCTAAATAGCTGGACTTCTGAATTAGTTTCATTACCAAATATCATCTTGACACCACACATTGGTGGCTCTACCGAAGAAGCCCAAAGCTCAATCGGTATTGAAGTGGCTACCGCATTGTCCAAATACATCAATGAAGGTAACTCTGTCGGTTCAGTCAACTTCCCAGAAGTGGCATTGAAATCATTGTCTTACGACCAAGAGAACACTGTGCGTGTGTTATACATTCACCAAAATGTACCAGGTGTTTTGAAGACCGTCAATGATATTTTATCGAACCATAACATCGAAAAGCAATTTTCCGATTCAAATGGTGAAATTGCTTATTTAATGGCTGATATCTCTTCTGTTGACCAAAGCGATATTAAAGATATTTATGAACAACTAAATCAAACCTCTGCTAAGATCTCAATTAGATTGCTATATTAA","protein_sequence":"MTSIDINNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAVKHPKILKPFSTGDMKILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVLQHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDILSNHNIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY"}]}