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1-phosphatidylinositol-3-phosphate 5-kinase FAB1 (P34756)
Identification | ||||||||||||||||||||||||||||||||
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Name | 1-phosphatidylinositol-3-phosphate 5-kinase FAB1 | |||||||||||||||||||||||||||||||
Synonyms |
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Gene Name | FAB1 | |||||||||||||||||||||||||||||||
Enzyme Class | ||||||||||||||||||||||||||||||||
Biological Properties | ||||||||||||||||||||||||||||||||
General Function | Involved in ATP binding | |||||||||||||||||||||||||||||||
Specific Function | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4 | |||||||||||||||||||||||||||||||
Cellular Location | Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. | |||||||||||||||||||||||||||||||
SMPDB Pathways |
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KEGG Pathways |
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SMPDB Reactions |
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KEGG Reactions |
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Metabolites |
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GO Classification |
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Gene Properties | ||||||||||||||||||||||||||||||||
Chromosome Location | chromosome 6 | |||||||||||||||||||||||||||||||
Locus | YFR019W | |||||||||||||||||||||||||||||||
Gene Sequence | >6837 bp ATGTCATCGGAAGAACCCCATGCATCTATATCCTTTCCAGATGGCTCACATGTCCGGTCG TCCTCCACTGGTACTTCATCTGTGAACACAATCGATGCTACCTTATCCAGACCGAACTAT ATTAAGAAACCGTCCCTGCACATTATGTCGACATCTACGACGTCGACTACGACGGATCTA GTGACAAACCCAATTCTGAGCAATATCTCCGTGCCAAAAATAAGCCCCCCCACATCATCC TCGATAGCAACAGCGACATCAACAAGTCACGTGACCGGCACTGCGTCGCATTCGAACATT AAAGCTAATGCTAACACTAGTACCAGCGTGAATAAGAAAAATTTGCCGCCAACAACTAGT GGGAGGATACCCTCTAGCACCATCAAGAGATATCCGAGTCGCTATAAGCCTTCTCACTCG CTGCAGCTGCCCATTAAGAACGACTCCAACTTTAAACGATCTAGCATATATGCCTCCAAA TCCACTGTTACTGCTATCCCCATTAGGAACAATCGGCCAATTTCCATGCAGAATTCCTAT GCGCGCACTCCTGACAGCGATCATGACGACGTTGGCGATGAAGTGTCTTCGATAAAGAGT GCCTCTTCTTCGTTGACCGCATCCCTGTCCAAGAGTTTCCTGTTCGCATTTTATAACAAC CGCAAGAAGGACAAGACCAGTAACAATGGTGTCCTCTCAAAGGAATATTGGATGAAGGAC GAGAGTTCTAAAGAATGTTTCAGTTGTGGTAAAACGTTTAACACTTTCAGAAGGAAACAC CACTGCAGGATATGCGGCCAAATTTTTTGCAGCAGTTGCACTCTCTTGATAGATGGTGAT CGATTCGGCTGTCATGCCAAGATGCGAGTATGTTACAATTGTTATGAGCATGCAGACACA TACGAGGACTCCAGTGATGAAGAGAATGATTCTACAATGCAATTGAATGAGCCAAGGTCT CGCTCTCGCTCTCGTTCTTCCAATACCAATCCATATTCTCATTCACATTCGCATTTGCAT CTCATTTCACAGGACAACCATAACGGTACCGATCTCCATGATCCAGTAGCAGCAACGGAT AACCCTCAACAGCAGAATGAGGTCTACCTATTAAATGACGATGACGTACAAAGTATAATG ACCTCAGGTGAAGATTCTAAATTGTTCATTTCTACACCCCCACCACCACCGAAGATGGCC ATCCCAGCAACAAAGCAAGGCGGATCGCTGGAAATCTCATTCGATTCGGAAAACGATAGG GCTTTGCATTATCAAGATGACAACCCCGGTCGCCATCATCACCTCGATTCCGTGCCCACA AGGTACACTATCAGAGATATGGACAATATATCACATTACGATACCAACTCTAATTCCACT TTGAGGCCACATTATAACACCAATAACAGCACTATTACCATCAACAACCTCAACAACACT ACTTCCAACAACAGCAACTATAACAATACCAATAGCAACAGCAACATCAATAATCCTGCG CATTCCTTAAGAAGGTCTATTTTCCATTATGTAAGCAGCAATAGTGTTAACAAGGACAGT AACAATAGCTCTGCAACACCCGCTTCGTCTGCACAGTCTTCTTCCATACTGGATCCTGCC AATCGTATTATCGGGAATTATGCTCATAGAAATTACAAGTTTAAATTCAACTACAATTCC AAAGGTCCTTCGCAACAAAATGACACGGCAAATGGAAATAATGATAATAATAATAATAAT AATAATAATAATAATAATAATAATAATAACAGTGCCAGCGGTATTGCTGACAACAATAAC ATTCCCTCAAACGACAATGGCACGACGTTCACTCTAGATAAGAAGAAAAGAAACCCACTG ACAAAATCTAAATCTACGTCCGCTTACCTAGAATATCCTCTAAACGAGGAAGACTCTTCT GAGGACGAAGGTTCCATGTCCATATATTCTGTATTGAATGATGACCATAAAACTGACAAT CCAATTAGATCAATGAGGAACTCCACAAAATCTTTTCAACGAGCGCAAGCTTCACTACAG CGGATGAGGTTTAGAAGGAAAAGTAAAAGCAAGCATTTTCCCAACAATTCGAAAAGTTCC ATTTATAGAGACTTAAATTTCTTGACCAATAGTACTCCCAATTTACTTTCTGTAGTAAGC GACGATAATCTATACGACGATTCTTCTCCTTTGCAAGACAAGGCCTCTTCATCCGCTGCA AGCAGACTCACTGACAGAAAATTCAGCAATAGCAGTGGCAGCAATAATAATAGCAATAGT AATAGCAATATCAACACCGATCCTTGGAAGAGAATCGCTAGTATATCGGGATTCAAACTG AAAAAGGAAAAAAAGAGAGAATTAAATGAAGTCTCTCTTTTACATATGCATGCCCTATTA AAACAATTATTGAATGATCAAGAAATTTCCAATCTTCAAGAATGGATAACCCTTCTAGAT GGCGCTTTGCGTAAAGTTTTAAGGACCATCCTGAACGCGAGGGATTTGAACACATTAGAT TTTAGACAAACTTACGTTAAGATAAAAAGAATTAGTGGTGGATCTCCTCAAAATTCAGAA TATATCGACGGGGTTGTCTTTTCGAAAGCATTGCCGTCGAAAACAATGCCACGGCATTTG AAAAACCCAAGGATACTATTAATCATGTTTCCACTGGAGTACCAAAAGAACAATAACCAC TTTCTAAGTATAGAGTCCGTCTTTAGGCAAGAGCGCGAATATTTGGATAAACTTGTTTCG AGATTAAAGTCATTACATCCTGATATTATATACGTCGGCGCCAATGTTAGTGGGTACGCG TTAGAACTATTAAATGACTCAGGCATTGTCGTACAGTTTAATATGAAACCACAAGTCATT GAAAGAATTGCCAAGCTAACAGAAGCAGATATTGCCATTTCTGTGGATAAGTTGGCTACG AATATTAAGATGGGTGAATGTGAAACTTTTGAAGTTAAAAGCTACATTTATGGAAACATC AGTAAAACATATACATTTCTTCGGGGCTGTAACCCAGAACTTGGTGGAACAATTTTGTTA AGAGGTGATAGTCTTGAAAACTTGAGAAAAATCAAACAAGTCTCTGAATTTATGGTCTAC GCAATTTTTTCATTGAAGTTGGAAAGTTCATTTTTTAACGATAATTTCATACAACTTTCT ACAGATGTTTATTTGAAGAGAGCTGAATCCAAAAAACTGCAAGTTTTCGAAGGTTATTTT GCAGATTTCTTGATCAAATTCAATAACAGGATTTTGACTGTATCACCAACGGTAGATTTC CCCATTCCCTTTTTATTGGAAAAAGCCAGAGGCTTGGAAAAGAAGCTCATAGAAAGGATC AATCAATATGAAAGCGAATCTGATTTAGATCGGCAAACGCAACTAAATATGCTTCAAGGC TTAGAATCGACTATCACTAAGAAACACTTAGGAAATTTAATAAAATTCCTGCATGAAATG GAAATTGAAAATTTAGAGCTTGAGTTTCAGAAGAGAAGTCGTCAATGGGAGGTTTCATAT TCATCATCACAGAACTTACTTGGTACGGGCTCACACCAGTCTATAACAGTTCTCTACTCA ATGGTTTCAACAAAGACTGCCACACCTTGCGTTGGCCCTCAAATTGTTACTATTGACTAT TTTTGGGACAGTGATATTTCCATTGGTCAGTTTATCGAGAACGTCGTGGGAACTGCCAGG TATCCCTGCCAACAAGGCTGTAATGGTCTGTATTTGGATCATTATAGAAGCTATGTTCAT GGGTCAGGAAAAGTAGACGTTTTAATCGAAAAATTCCAAACTAGATTACCAAAATTAAAA GATATTATCCTCACGTGGAGTTATTGTAAAAAATGTGGGACATCTACTCCGATTTTACAA ATTAGCGAAAAAACCTGGAATCATTCTTTCGGTAAATATTTAGAAGTCATGTTTTGGAGT TACAAAGATAGCGTGACAGGAATTGGGAAATGTCCTCATGATTTCACTAAAGATCATGTC AAATACTTTGGTTACAATGATTTAGTGGTTCGACTAGAATATTCTGATTTAGAAGTTCAT GAATTGATAACCCCACCACGCAAAATAAAATGGAAACCTCATATCGACATCAAACTGAAG GTGGAACTATACTATAAGATTCTGGAAAAGATCAATAATTTCTATGGGAGTGTCCTAAGT CGGTTGGAACGTATTAAATTGGATAGTATGACTAAAGATAAAGTTCTTAGTGGACAAGCT AAAATTATCGAATTGAAGAGCAATGCTACAGAGGAGCAAAAATTAATGTTGCAAGACCTG GATACTTTTTACGCAGATAGTCCTTGCGATCAACATTTACCATTGAACCTGGTTATCAAA TCTCTATACGATAAGGCTGTAAATTGGAACTCTACATTTGCGATATTTGCAAAAAGCTAT TTGCCTTCTGAAACTGATATTAGTCGTATCACGGCCAAGCAGCTGAAAAAACTGTTTTAC GATTCTTCAAGAAAAGACAGCGAAGACAAAAAATCACTTCATGATGAAAAGGCGAAGACG AGGAAACCAGAAAAGAACGAATTACCGTTAGAGGGATTGAAAGATGTCGAAAAGCCGAAA ATTGATAGCAAGAATACGACAGAGAATCGTGACAGAACGAACGAACCACAGAATGCCGTG ACGATAACCACTTTTAAAGACGACACTCCAATTATTCCAACAAGTGGTACTAGTCACTTG ACAGTTACACCTTCTGCATCGTCGGTTTCTTCTTCTTTGACCCCTCAAACCGAAGAACGT CCGCCAATAAGCAGAAGTGGAACAGGTATATCTATGACTCATGATAAAAGCACTAGACCT AACATAAGAAAAATGAGTAGTGATAGTAGTTTATGTGGACTAGCATCACTTGCTAATGAA TATAGTAAAAATAATAAGGTGAGTAAGCTAGCTACATTTTTCGATCAAATGCATTTTGAT GCCCTGTCGAAAGAATTTGAACTGGAACGTGAAAGGGAAAGATTACAACTTAATAAGGAT AAATACCAAGCCATACGATTACAAACATCCACACCAATTGTGGAAATTTATAAAAATGTC AAAGACGCAGTTGATGAACCGCTTCACTCTAGAAGTTCAGGCAATAATTTGTCATCTGCG AATGTTAAGACTTTGGAGGCACCTGTGGGAGAACATTCCCGGGCCAATAATTGTAATCCT CCTAATTTAGATCAAAACTTGGAAACTGAATTAGAAAATTCCATTAGCCAATGGGGAGAA AACATTTTGAACCCCTCTGGAAAGACCACCGCAAGTACTCATTTAAATTCTAAGCCAGTA GTAAAGGAAACTTCAGAAAATCCAAAGTCAATAGTTAGAGAATCAGATAATTCAAAGTCG GAGCCGCTTCCACCTGTAATAACAACAACAACTGTCAATAAGGTAGAATCCACTCCACAA CCTGAAAAATCATTATTGATGAAAACCTTGAGCAACTTTTGGGCAGATCGATCTGCGTAT TTGTGGAAACCCCTTGTTTATCCAACCTGTCCTTCGGAACACATTTTTACTGATAGTGAC GTTATAATCCGCGAAGATGAACCAAGTTCCTTGATCGCATTTTGCTTAAGTACTTCTGAC TATAGAAATAAAATGATGAACTTGAATGTCCAGCAACAACAGCAGCAGCAAACAGCAGAA GCTGCTCCTGCCAAAACAGGAGGAAACAGTGGAGGAACTACGCAAACCGGGGATCCTTCT GTTAACATTTCTCCCTCAGTTTCTACAACTTCTCATAATAAGGGGAGGGACTCAGAAATT TCATCCTTAGTAACCACCAAAGAGGGCTTGTTGAACACCCCTCCCATTGAAGGCGCCCGA GATAGGACCCCACAAGAATCACAAACGCATTCCCAAGCAAATTTAGATACTCTTCAAGAA TTAGAGAAAATTATGACAAAAAAAACAGCCACACACTTGAGATATCAATTTGAGGAGGGT TTAACGGTAATGTCATGTAAAATTTTCTTCACAGAACATTTTGACGTGTTTAGAAAGATT TGTGATTGTCAAGAAAACTTCATTCAAAGTTTGTCAAGATGTGTTAAATGGGATTCCAAT GGGGGGAAAAGTGGGAGCGGGTTTTTAAAGACTTTGGATGATAGATTTATTATAAAGGAG CTGTCACACGCAGAACTGGAAGCCTTCATAAAATTTGCACCAAGTTATTTTGAATACATG GCACAAGCAATGTTCCATGATTTGCCCACGACTTTGGCTAAAGTATTTGGGTTTTATCAA ATTCAAGTAAAAAGCTCTATTTCAAGTTCCAAAAGTTATAAAATGGACGTTATCATTATG GAGAACTTATTTTATGAGAAGAAAACAACAAGAATATTTGATTTGAAGGGTTCCATGAGA AATAGACATGTCGAACAAACAGGTAAAGCTAATGAAGTGTTGTTGGATGAAAATATGGTA GAGTATATTTACGAATCACCTATTCATGTTCGCGAATATGACAAGAAACTTTTAAGAGCT TCTGTTTGGAACGACACATTATTTTTGGCCAAAATGAATGTGATGGATTATTCCTTAGTC ATTGGTATTGACAATGAAGGGTATACTTTGACAGTAGGAATCATTGATTTCATTCGAACG TTTACATGGGACAAAAAACTAGAAAGTTGGGTCAAAGAGAAAGGCCTAGTAGGGGGGGCC AGTGTGATCAAGCAGCCTACCGTTGTTACACCAAGACAATATAAAAAACGTTTTAGGGAA GCAATGGAGAGGTATATTTTGATGGTTCCTGATCCGTGGTATTGGGAAGGAAATTAA | |||||||||||||||||||||||||||||||
Protein Properties | ||||||||||||||||||||||||||||||||
Pfam Domain Function | ||||||||||||||||||||||||||||||||
Protein Residues | 2278 | |||||||||||||||||||||||||||||||
Protein Molecular Weight | 257447.0 | |||||||||||||||||||||||||||||||
Protein Theoretical pI | 8.51 | |||||||||||||||||||||||||||||||
Signalling Regions |
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Transmembrane Regions |
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Protein Sequence | >1-phosphatidylinositol-3-phosphate 5-kinase FAB1 MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDL VTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTS GRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSY ARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKD ESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEHADT YEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLISQDNHNGTDLHDPVAATD NPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPPPPKMAIPATKQGGSLEISFDSENDR ALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNSTLRPHYNTNNSTITINNLNNT TSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSATPASSAQSSSILDPA NRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNNNSASGIADNNN IPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDN PIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVS DDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKL KKEKKRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLD FRQTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNH FLSIESVFRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVI ERIAKLTEADIAISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILL RGDSLENLRKIKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYF ADFLIKFNNRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQG LESTITKKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYS MVSTKTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVH GSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWS YKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIKLK VELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLMLQDL DTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQLKKLFY DSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDRTNEPQNAV TITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGISMTHDKSTRP NIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERERERLQLNKD KYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRANNCNP PNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKSIVRESDNSKS EPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVYPTCPSEHIFTDSD VIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGGTTQTGDPS VNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDTLQE LEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSN GGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQ IQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANEVLLDENMV EYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRT FTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYWEGN | |||||||||||||||||||||||||||||||
References | ||||||||||||||||||||||||||||||||
External Links |
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General Reference |
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