{"ymdb_id":"YMDB16249","created_at":"2016-09-12T18:28:24.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"1-phosphatidyl-1D-myo-inositol 4-phosphate ","cas":null,"state":null,"melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2-{[2-(formyloxy)acetyl]oxy}ethoxy)[(2,3,4,5,6-pentahydroxycyclohexyl)oxy]phosphinic acid","traditional_iupac":"2-{[2-(formyloxy)acetyl]oxy}ethoxy(2,3,4,5,6-pentahydroxycyclohexyl)oxyphosphinic acid","logp":"-4.201412906","pka":"12.360530532250554","alogps_solubility":"2.50e+01 g/l","alogps_logp":"-1.89","alogps_logs":"-1.19","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"10","polar_surface_area":"209.50999999999996","refractivity":"72.9372","polarizability":"33.251093012724226","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-3.6458130204247503","pka_strongest_acidic":"1.8368013046311256","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T00:26:08.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 3-kinase VPS34","uniprot_id":"P22543","uniprot_name":"VPS34_YEAST","enzyme":true,"transporter":false,"gene_name":"VPS34","num_residues":875,"molecular_weight":"100920.0","theoretical_pi":"7.9","general_function":"Involved in binding","specific_function":"Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3- kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity","reactions":[{"id":1897,"direction":"\u003e","locations":"vacuole;vacuolar membrane","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2619,"direction":"\u003e","locations":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14857,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007045","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein","genbank_gene_id":"U20865","genbank_protein_id":"662340","gene_card_id":"VPS34","chromosome_location":"chromosome 12","locus":"YLR240W","synonyms":["PI3-kinase VPS34","PI3K VPS34","PtdIns-3-kinase VPS34","Carboxypeptidase Y-deficient protein 15","Vacuolar protein sorting-associated protein 34","Vacuolar protein-targeting protein 29"],"enzyme_classes":["2.7.1.137"],"go_classes":[{"category":"Component","description":" phosphoinositide 3-kinase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" phosphoinositide 3-kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" 1-phosphatidylinositol-3-kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" kinase activity"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"PI3K_C2","identifier":"PF00792"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCACTGAACAACATAACATTCTGTGTCTCACAGGATCTGGATGTTCCCCTGAAAGTGAAAATCAAGTCATTGGAAGGACATAAGCCACTGTTGAAGCCATCTCAAAAAATCCTGAACCCTGAATTAATGCTGATAGGGTCAAATGTATTCCCTTCTAGTGATCTAATTGTATCCTTACAGGTATTTGATAAAGAGAGAAACAGAAATTTAACTCTTCCGATATACACGCCGTATATTCCTTTCAGAAACTCTAGAACCTGGGATTATTGGTTGACTTTGCCCATACGTATCAAACAGCTTACCTTTAGCAGTCATTTACGCATTATTTTGTGGGAATACAATGGATCCAAGCAAATTCCCTTTTTCAATCTAGAAACGAGCATCTTTAACTTAAAAGACTGTACTTTAAAAAGAGGGTTTGAATCCTTAAAATTTCGTTATGATGTGATTGACCACTGTGAAGTGGTCACTGATAACAAAGATCAAGAAAATTTGAATAAATATTTTCAGGGTGAATTCACGAGACTCCCTTGGCTTGACGAAATCACTATAAGCAAATTAAGGAAACAACGGGAAAATAGGACTTGGCCTCAGGGCACCTTTGTCTTAAACTTAGAATTTCCAATGTTAGAGCTTCCTGTTGTGTTCATCGAAAGGGAAATTATGAATACTCAAATGAATATTCCAACTTTGAAGAACAATCCTGGACTAAGCACAGACTTACGAGAACCGAATAGGAATGATCCTCAAATCAAAATTTCTTTGGGGGACAAATATCACTCCACATTGAAGTTTTACGATCCTGACCAACCAAACAATGATCCAATAGAGGAAAAGTATAGGAGATTGGAAAGAGCATCTAAAAATGCAAACTTGGACAAGCAAGTGAAGCCGGACATTAAAAAGAGGGACTACTTGAATAAAATCATCAACTACCCCCCTGGCACTAAATTAACAGCACATGAAAAGGGTTCAATATGGAAATATAGGTATTATTTGATGAACAATAAAAAAGCTCTTACAAAGTTATTACAGAGTACAAATTTGAGAGAAGAATCGGAAAGAGTAGAGGTTTTAGAACTAATGGACTCATGGGCAGAAATTGATATAGACGACGCATTAGAACTATTAGGCTCAACTTTTAAAAACCTTTCAGTGAGATCGTACGCCGTAAATAGGCTGAAGAAGGCATCAGACAAGGAGCTGGAATTGTACTTATTACAGTTGGTAGAAGCTGTCTGTTTTGAGAACCTGTCCACTTTTTCCGACAAATCTAACAGTGAATTCACTATTGTGGATGCCGTATCTTCGCAAAAGCTTTCGGGTGATTCTATGTTACTATCTACATCGCATGCCAACCAAAAATTATTAAAGTCCATCTCGAGTGAATCGGAAACTTCCGGGACAGAATCGCTACCAATCGTCATTTCTCCCTTGGCTGAGTTTTTGATTAGGAGAGCACTGGTCAACCCAAGGTTAGGAAGTTTTTTCTATTGGTATTTAAAGTCCGAGTCTGAGGACAAGCCATATTTAGACCAGATTTTAAGTTCCTTTTGGAGTAGACTGGATAAAAAATCTCGGAATATACTGAACGATCAAGTCAGGCTAATAAATGTGCTCAGGGAATGTTGTGAAACAATTAAGAGGCTGAAAGATACTACAGCCAAAAAGATGGAATTACTAGTGCATTTATTGGAGACGAAAGTCAGGCCTCTTGTCAAAGTACGACCAATTGCTTTACCACTAGACCCTGATGTGTTGATATGCGACGTTTGTCCTGAAACTTCGAAGGTATTTAAAAGCTCTTTATCGCCACTAAAAATAACATTCAAAACGACCTTAAACCAACCATATCACTTAATGTTTAAGGTTGGCGATGATTTGAGACAAGATCAACTGGTAGTACAGATCATAAGTTTAATGAATGAGTTATTAAAAAATGAAAACGTGGACTTGAAATTGACACCATACAAAATTTTGGCAACAGGACCACAAGAAGGTGCCATTGAATTTATCCCTAATGACACATTAGCTAGCATACTAAGCAAATATCACGGTATTCTTGGCTACCTTAAACTCCACTATCCTGATGAGAACGCGACATTAGGCGTACAAGGCTGGGTTTTAGATAATTTTGTCAAATCTTGTGCTGGCTATTGTGTTATTACATACATCTTAGGTGTCGGCGATAGGCATTTAGACAACTTACTAGTCACGCCAGATGGGCACTTTTTTCACGCAGACTTTGGTTATATCTTGGGTCAGGACCCCAAACCTTTTCCGCCATTAATGAAATTGCCCCCTCAAATTATAGAGGCGTTTGGGGGTGCAGAATCATCAAATTATGATAAATTTCGCAGCTACTGTTTTGTGGCATATTCGATTTTAAGAAGGAATGCAGGCTTAATCTTAAACCTGTTTGAATTAATGAAGACTTCGAACATACCTGATATCAGAATAGATCCCAATGGTGCTATATTACGTGTAAGAGAGAGATTTAATTTGAATATGTCCGAAGAAGATGCCACAGTGCATTTTCAGAATCTAATCAATGATAGTGTAAATGCTTTGCTGCCTATCGTGATTGATCATTTACATAATCTGGCACAATACTGGCGGACCTGA","protein_sequence":"MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT"},{"created_at":"2011-05-27T00:42:41.000Z","updated_at":"2011-07-22T17:53:40.000Z","name":"1-phosphatidylinositol-3-phosphate 5-kinase FAB1","uniprot_id":"P34756","uniprot_name":"FAB1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAB1","num_residues":2278,"molecular_weight":"257447.0","theoretical_pi":"8.51","general_function":"Involved in ATP binding","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4","reactions":[{"id":1133,"direction":"\u003c\u003e","locations":"vacuole","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1134,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2625,"direction":"\u003e","locations":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","altext":"ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","genbank_gene_id":"D50617","genbank_protein_id":"836774","gene_card_id":"FAB1","chromosome_location":"chromosome 6","locus":"YFR019W","synonyms":["Phosphatidylinositol-3-phosphate 5-kinase","Type III PIP kinase","PIPkin-III"],"enzyme_classes":["2.7.1.150"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" phosphatidylinositol phosphate kinase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphatidylinositol metabolic process"},{"category":"Process","description":" cellular protein metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" protein metabolic process"}],"pfams":[{"name":"Cpn60_TCP1","identifier":"PF00118"},{"name":"FYVE","identifier":"PF01363"},{"name":"PIP5K","identifier":"PF01504"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCATCGGAAGAACCCCATGCATCTATATCCTTTCCAGATGGCTCACATGTCCGGTCGTCCTCCACTGGTACTTCATCTGTGAACACAATCGATGCTACCTTATCCAGACCGAACTATATTAAGAAACCGTCCCTGCACATTATGTCGACATCTACGACGTCGACTACGACGGATCTAGTGACAAACCCAATTCTGAGCAATATCTCCGTGCCAAAAATAAGCCCCCCCACATCATCCTCGATAGCAACAGCGACATCAACAAGTCACGTGACCGGCACTGCGTCGCATTCGAACATTAAAGCTAATGCTAACACTAGTACCAGCGTGAATAAGAAAAATTTGCCGCCAACAACTAGTGGGAGGATACCCTCTAGCACCATCAAGAGATATCCGAGTCGCTATAAGCCTTCTCACTCGCTGCAGCTGCCCATTAAGAACGACTCCAACTTTAAACGATCTAGCATATATGCCTCCAAATCCACTGTTACTGCTATCCCCATTAGGAACAATCGGCCAATTTCCATGCAGAATTCCTATGCGCGCACTCCTGACAGCGATCATGACGACGTTGGCGATGAAGTGTCTTCGATAAAGAGTGCCTCTTCTTCGTTGACCGCATCCCTGTCCAAGAGTTTCCTGTTCGCATTTTATAACAACCGCAAGAAGGACAAGACCAGTAACAATGGTGTCCTCTCAAAGGAATATTGGATGAAGGACGAGAGTTCTAAAGAATGTTTCAGTTGTGGTAAAACGTTTAACACTTTCAGAAGGAAACACCACTGCAGGATATGCGGCCAAATTTTTTGCAGCAGTTGCACTCTCTTGATAGATGGTGATCGATTCGGCTGTCATGCCAAGATGCGAGTATGTTACAATTGTTATGAGCATGCAGACACATACGAGGACTCCAGTGATGAAGAGAATGATTCTACAATGCAATTGAATGAGCCAAGGTCTCGCTCTCGCTCTCGTTCTTCCAATACCAATCCATATTCTCATTCACATTCGCATTTGCATCTCATTTCACAGGACAACCATAACGGTACCGATCTCCATGATCCAGTAGCAGCAACGGATAACCCTCAACAGCAGAATGAGGTCTACCTATTAAATGACGATGACGTACAAAGTATAATGACCTCAGGTGAAGATTCTAAATTGTTCATTTCTACACCCCCACCACCACCGAAGATGGCCATCCCAGCAACAAAGCAAGGCGGATCGCTGGAAATCTCATTCGATTCGGAAAACGATAGGGCTTTGCATTATCAAGATGACAACCCCGGTCGCCATCATCACCTCGATTCCGTGCCCACAAGGTACACTATCAGAGATATGGACAATATATCACATTACGATACCAACTCTAATTCCACTTTGAGGCCACATTATAACACCAATAACAGCACTATTACCATCAACAACCTCAACAACACTACTTCCAACAACAGCAACTATAACAATACCAATAGCAACAGCAACATCAATAATCCTGCGCATTCCTTAAGAAGGTCTATTTTCCATTATGTAAGCAGCAATAGTGTTAACAAGGACAGTAACAATAGCTCTGCAACACCCGCTTCGTCTGCACAGTCTTCTTCCATACTGGATCCTGCCAATCGTATTATCGGGAATTATGCTCATAGAAATTACAAGTTTAAATTCAACTACAATTCCAAAGGTCCTTCGCAACAAAATGACACGGCAAATGGAAATAATGATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAACAGTGCCAGCGGTATTGCTGACAACAATAACATTCCCTCAAACGACAATGGCACGACGTTCACTCTAGATAAGAAGAAAAGAAACCCACTGACAAAATCTAAATCTACGTCCGCTTACCTAGAATATCCTCTAAACGAGGAAGACTCTTCTGAGGACGAAGGTTCCATGTCCATATATTCTGTATTGAATGATGACCATAAAACTGACAATCCAATTAGATCAATGAGGAACTCCACAAAATCTTTTCAACGAGCGCAAGCTTCACTACAGCGGATGAGGTTTAGAAGGAAAAGTAAAAGCAAGCATTTTCCCAACAATTCGAAAAGTTCCATTTATAGAGACTTAAATTTCTTGACCAATAGTACTCCCAATTTACTTTCTGTAGTAAGCGACGATAATCTATACGACGATTCTTCTCCTTTGCAAGACAAGGCCTCTTCATCCGCTGCAAGCAGACTCACTGACAGAAAATTCAGCAATAGCAGTGGCAGCAATAATAATAGCAATAGTAATAGCAATATCAACACCGATCCTTGGAAGAGAATCGCTAGTATATCGGGATTCAAACTGAAAAAGGAAAAAAAGAGAGAATTAAATGAAGTCTCTCTTTTACATATGCATGCCCTATTAAAACAATTATTGAATGATCAAGAAATTTCCAATCTTCAAGAATGGATAACCCTTCTAGATGGCGCTTTGCGTAAAGTTTTAAGGACCATCCTGAACGCGAGGGATTTGAACACATTAGATTTTAGACAAACTTACGTTAAGATAAAAAGAATTAGTGGTGGATCTCCTCAAAATTCAGAATATATCGACGGGGTTGTCTTTTCGAAAGCATTGCCGTCGAAAACAATGCCACGGCATTTGAAAAACCCAAGGATACTATTAATCATGTTTCCACTGGAGTACCAAAAGAACAATAACCACTTTCTAAGTATAGAGTCCGTCTTTAGGCAAGAGCGCGAATATTTGGATAAACTTGTTTCGAGATTAAAGTCATTACATCCTGATATTATATACGTCGGCGCCAATGTTAGTGGGTACGCGTTAGAACTATTAAATGACTCAGGCATTGTCGTACAGTTTAATATGAAACCACAAGTCATTGAAAGAATTGCCAAGCTAACAGAAGCAGATATTGCCATTTCTGTGGATAAGTTGGCTACGAATATTAAGATGGGTGAATGTGAAACTTTTGAAGTTAAAAGCTACATTTATGGAAACATCAGTAAAACATATACATTTCTTCGGGGCTGTAACCCAGAACTTGGTGGAACAATTTTGTTAAGAGGTGATAGTCTTGAAAACTTGAGAAAAATCAAACAAGTCTCTGAATTTATGGTCTACGCAATTTTTTCATTGAAGTTGGAAAGTTCATTTTTTAACGATAATTTCATACAACTTTCTACAGATGTTTATTTGAAGAGAGCTGAATCCAAAAAACTGCAAGTTTTCGAAGGTTATTTTGCAGATTTCTTGATCAAATTCAATAACAGGATTTTGACTGTATCACCAACGGTAGATTTCCCCATTCCCTTTTTATTGGAAAAAGCCAGAGGCTTGGAAAAGAAGCTCATAGAAAGGATCAATCAATATGAAAGCGAATCTGATTTAGATCGGCAAACGCAACTAAATATGCTTCAAGGCTTAGAATCGACTATCACTAAGAAACACTTAGGAAATTTAATAAAATTCCTGCATGAAATGGAAATTGAAAATTTAGAGCTTGAGTTTCAGAAGAGAAGTCGTCAATGGGAGGTTTCATATTCATCATCACAGAACTTACTTGGTACGGGCTCACACCAGTCTATAACAGTTCTCTACTCAATGGTTTCAACAAAGACTGCCACACCTTGCGTTGGCCCTCAAATTGTTACTATTGACTATTTTTGGGACAGTGATATTTCCATTGGTCAGTTTATCGAGAACGTCGTGGGAACTGCCAGGTATCCCTGCCAACAAGGCTGTAATGGTCTGTATTTGGATCATTATAGAAGCTATGTTCATGGGTCAGGAAAAGTAGACGTTTTAATCGAAAAATTCCAAACTAGATTACCAAAATTAAAAGATATTATCCTCACGTGGAGTTATTGTAAAAAATGTGGGACATCTACTCCGATTTTACAAATTAGCGAAAAAACCTGGAATCATTCTTTCGGTAAATATTTAGAAGTCATGTTTTGGAGTTACAAAGATAGCGTGACAGGAATTGGGAAATGTCCTCATGATTTCACTAAAGATCATGTCAAATACTTTGGTTACAATGATTTAGTGGTTCGACTAGAATATTCTGATTTAGAAGTTCATGAATTGATAACCCCACCACGCAAAATAAAATGGAAACCTCATATCGACATCAAACTGAAGGTGGAACTATACTATAAGATTCTGGAAAAGATCAATAATTTCTATGGGAGTGTCCTAAGTCGGTTGGAACGTATTAAATTGGATAGTATGACTAAAGATAAAGTTCTTAGTGGACAAGCTAAAATTATCGAATTGAAGAGCAATGCTACAGAGGAGCAAAAATTAATGTTGCAAGACCTGGATACTTTTTACGCAGATAGTCCTTGCGATCAACATTTACCATTGAACCTGGTTATCAAATCTCTATACGATAAGGCTGTAAATTGGAACTCTACATTTGCGATATTTGCAAAAAGCTATTTGCCTTCTGAAACTGATATTAGTCGTATCACGGCCAAGCAGCTGAAAAAACTGTTTTACGATTCTTCAAGAAAAGACAGCGAAGACAAAAAATCACTTCATGATGAAAAGGCGAAGACGAGGAAACCAGAAAAGAACGAATTACCGTTAGAGGGATTGAAAGATGTCGAAAAGCCGAAAATTGATAGCAAGAATACGACAGAGAATCGTGACAGAACGAACGAACCACAGAATGCCGTGACGATAACCACTTTTAAAGACGACACTCCAATTATTCCAACAAGTGGTACTAGTCACTTGACAGTTACACCTTCTGCATCGTCGGTTTCTTCTTCTTTGACCCCTCAAACCGAAGAACGTCCGCCAATAAGCAGAAGTGGAACAGGTATATCTATGACTCATGATAAAAGCACTAGACCTAACATAAGAAAAATGAGTAGTGATAGTAGTTTATGTGGACTAGCATCACTTGCTAATGAATATAGTAAAAATAATAAGGTGAGTAAGCTAGCTACATTTTTCGATCAAATGCATTTTGATGCCCTGTCGAAAGAATTTGAACTGGAACGTGAAAGGGAAAGATTACAACTTAATAAGGATAAATACCAAGCCATACGATTACAAACATCCACACCAATTGTGGAAATTTATAAAAATGTCAAAGACGCAGTTGATGAACCGCTTCACTCTAGAAGTTCAGGCAATAATTTGTCATCTGCGAATGTTAAGACTTTGGAGGCACCTGTGGGAGAACATTCCCGGGCCAATAATTGTAATCCTCCTAATTTAGATCAAAACTTGGAAACTGAATTAGAAAATTCCATTAGCCAATGGGGAGAAAACATTTTGAACCCCTCTGGAAAGACCACCGCAAGTACTCATTTAAATTCTAAGCCAGTAGTAAAGGAAACTTCAGAAAATCCAAAGTCAATAGTTAGAGAATCAGATAATTCAAAGTCGGAGCCGCTTCCACCTGTAATAACAACAACAACTGTCAATAAGGTAGAATCCACTCCACAACCTGAAAAATCATTATTGATGAAAACCTTGAGCAACTTTTGGGCAGATCGATCTGCGTATTTGTGGAAACCCCTTGTTTATCCAACCTGTCCTTCGGAACACATTTTTACTGATAGTGACGTTATAATCCGCGAAGATGAACCAAGTTCCTTGATCGCATTTTGCTTAAGTACTTCTGACTATAGAAATAAAATGATGAACTTGAATGTCCAGCAACAACAGCAGCAGCAAACAGCAGAAGCTGCTCCTGCCAAAACAGGAGGAAACAGTGGAGGAACTACGCAAACCGGGGATCCTTCTGTTAACATTTCTCCCTCAGTTTCTACAACTTCTCATAATAAGGGGAGGGACTCAGAAATTTCATCCTTAGTAACCACCAAAGAGGGCTTGTTGAACACCCCTCCCATTGAAGGCGCCCGAGATAGGACCCCACAAGAATCACAAACGCATTCCCAAGCAAATTTAGATACTCTTCAAGAATTAGAGAAAATTATGACAAAAAAAACAGCCACACACTTGAGATATCAATTTGAGGAGGGTTTAACGGTAATGTCATGTAAAATTTTCTTCACAGAACATTTTGACGTGTTTAGAAAGATTTGTGATTGTCAAGAAAACTTCATTCAAAGTTTGTCAAGATGTGTTAAATGGGATTCCAATGGGGGGAAAAGTGGGAGCGGGTTTTTAAAGACTTTGGATGATAGATTTATTATAAAGGAGCTGTCACACGCAGAACTGGAAGCCTTCATAAAATTTGCACCAAGTTATTTTGAATACATGGCACAAGCAATGTTCCATGATTTGCCCACGACTTTGGCTAAAGTATTTGGGTTTTATCAAATTCAAGTAAAAAGCTCTATTTCAAGTTCCAAAAGTTATAAAATGGACGTTATCATTATGGAGAACTTATTTTATGAGAAGAAAACAACAAGAATATTTGATTTGAAGGGTTCCATGAGAAATAGACATGTCGAACAAACAGGTAAAGCTAATGAAGTGTTGTTGGATGAAAATATGGTAGAGTATATTTACGAATCACCTATTCATGTTCGCGAATATGACAAGAAACTTTTAAGAGCTTCTGTTTGGAACGACACATTATTTTTGGCCAAAATGAATGTGATGGATTATTCCTTAGTCATTGGTATTGACAATGAAGGGTATACTTTGACAGTAGGAATCATTGATTTCATTCGAACGTTTACATGGGACAAAAAACTAGAAAGTTGGGTCAAAGAGAAAGGCCTAGTAGGGGGGGCCAGTGTGATCAAGCAGCCTACCGTTGTTACACCAAGACAATATAAAAAACGTTTTAGGGAAGCAATGGAGAGGTATATTTTGATGGTTCCTGATCCGTGGTATTGGGAAGGAAATTAA","protein_sequence":"MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDLVTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTSGRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPPPPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNSTLRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSATPASSAQSSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNNNSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDNPIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVSDDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEKKRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLDFRQTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESVFRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIAISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRKIKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYFADFLIKFNNRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQGLESTITKKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYSMVSTKTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVHGSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWSYKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIKLKVELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLMLQDLDTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQLKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDRTNEPQNAVTITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGISMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERERERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRANNCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKSIVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVYPTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGGTTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDTLQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSNGGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYWEGN"},{"created_at":"2011-05-27T06:30:19.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 2","uniprot_id":"P50942","uniprot_name":"INP52_YEAST","enzyme":true,"transporter":false,"gene_name":"INP52","num_residues":1183,"molecular_weight":"133330.0","theoretical_pi":"8.89","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1904,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2789,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,4,5-trisphosphate + H2O = D-myo-inositol 1,4-bisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":2790,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,3,4-trisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z71382","genbank_protein_id":"1302022","gene_card_id":"INP52","chromosome_location":"chromosome 14","locus":"YNL106C","synonyms":["Synaptojanin-like protein 2"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAAATACTCCTATCGAAACAGCAAACTAGAAAGATAGCAATAGTTTCAGAAACACATGGACTGGTATTTAGGCCAATAAACAGTAAGAACTCTCGCAGATCTACATGTGCCGTGGAATTGGTTCCGAAAGCTGAATTAAATGGTAATGGTTTCAGAAGACTATCTAACCATGAAATATACGGTTTTATTGGTCTCATAGAAATTGAAGGCCTTATGTTCATAGCAACCATAACAGGTAAATCTAAGGTGGCCCAGCCGATCCCAAACAAAACGGTTAACAAAATATATGCTGTGGATTTTTTTTGCTTAAATAATTCTAAATGGGATTTCATGGACATCGATTCATCCGGTTATCCGATTGTTACTAATGATGGAGATTTTGCAATAAGCTCGCCTCCTAGTATTTCCACACATTCTTCTAGATCATCGCTACGTTCTTCTTCCTCTAGGAGTTTGAATGCTCAAGAACAAGCTCCCAAGCATCCATGTCATGAACTAAGAAAGCTATTATCAAATGGATCTTTTTATTACAGCACCGATTTTGATTTAACTTGTACATTGCAGAAACGTGGATTCACGGAACACTCTTTGAGTTTTGATGATTTTGACCGGGAGTTTATGTGGAACTCGTTTCTTATGGACGAAATCATCACATACAGAGACAGACTAGATGTAACGGCCAAAGAACTATTGGATCAACGAGGATTCCTCACGACCGTAATCCGAGGGTTTGCTGAAACAATTTTTAGCTATATTAATAGGTTGAAAGTAGGACTTACCATTATTTCCAGGCAAAGTTGGAAAAGAGCAGGCACAAGGTTTAATGCACGTGGTATAGATGATGATGGCCATGTCGCAAATTTTGTTGAAACAGAAATGATTATGTACTCTTCTCAGTATTGTTATGCTTTCACGCAGATAAGAGGAAGCCTTCCAATTTTTTGGGAGCAGGATACATCTTTGATTAGTCCAAAGATTCAAATTACCAGATCTGTTGAAGCAACACAGCCCACGTTTGATGAACATTTTATAAGACTATTTAAGAAGTATGGGCCAGTTCATATAATCAACCTGCTGTCTACTAAATCTTCAGAAATTCAATTATCGAGGCGATACAAGGAACAGTTGAAAAATTCTGAGAAAATGAAAATCGGTAGAGATGTGTTCCTAACAAGCTTTGATTTCCATAGAGAAACTTCGCAAGATGGGTTTGCAGCTGCAAGTAGGATTATCCCTAAAATAAGAAACACAATTTTGGACGCCGGTTACTTTTCATACGATGTAAAAGAAGGGCGATTAATATCCGAACAAGACGGTGTCTTTAGAACCAATTGCTTGGATTGTTTAGATAGAACAAATTTGATCCAACAGACGATTTCACTGGCCGTTTTCAAACTATTTTTGGAAGACTTCCGATTGGTAAAACCCAGTAGTTTCATCGACGATAATGAATTTGTGCAAAAGGTGAATGCTTTATGGGCCGACAACGGAGATCAGATATCACAAATTTACACTGGGACAAATGCTCTGAAATCGTCCTATTCAAGGAAAGGTAAAATGTCTTTTTCTGGCGCCCTTTCTGATGCGACGAAGTCCGTTAGTAGAATGTACATCAACAATTTTGTAGATAAAGGAAAACAGCAAAATATTGACACACTTTTGGGCAAACTACCGCACCAGCAAGTTGTTGAACTTTATGATCCAATCTGCGAATACGTCAATGAAAGGCTGTTAGAGTCAGAGGAAAAATTCACCACTCATTCTAACATAAATTTGTTTGTCGGTACATTCAATGTTAACGGAAACTCTCGAAGAGCAGATTTGTCAAAATGGTTATTTCCAATCGGCGATAAATTCAAACCTGATGTCGTTGTGTTAGGGTTGCAGGAAGTTATAGAGTTGACCGCAGGGTCTATCTTGAATGCAGATTATACGAAAAGTTCTTTTTGGGAAACTATGGTTACTGACTGTTTGAATCAATACGAAGAAAAATATCTTTTACTTAGAGTGGAACAGATGTCCTCTCTTTTGATACTATTTTTTGCAAGATCAGATAGAGCCTATAACATAAAAGAGGTAGGTGGGTCTACCAAAAAGACTGGGTTTGGTGGTATTACTGGAAACAAAGGTGCAGTAGCCATTAGATTCGATTATGGGGCAACTTCATTCTGTTTCGTTAATACACATTTATCAGCAGGTGCGAGTAACATTGACGAACGTCGCAATGACTACAACAATATCTACAGGAACATAACCTTTCCAAGATCAAAGACAATTCCACACCATGATTCGTTGTTTTGGTTGGGTGACCTTAACTACAGGATAACTTTGACAAATGATGAAGTTAGAAGAGAATTAAGGGCTCAAAAGGATGGCTATATTGATAGATTGCTTCAATATGATCAGTTGACTCAAGAAATAAATGAAGGAGTGGTATTTCAGGGCTTTAAAGAACCGACCCTCCAATTCCGTCCGACCTATAAATATGATTATGGCACAGATAATTATGATACTTCTGAAAAGGCGAGAACTCCGTCTTGGACTGATAGAATCATATATAAAGGTGAAAACCTGCATCCATTGGCATATTCGGACGCACCTTTAAAAATAAGCGATCATAAACCAGTTTATGCTGCATATAGGGCAAATGTGAAATTTGTTGACGAAAAAGAGAAGCTTAACCTAGTTGAGAAGCTGTATGCAGAATATAAGAATACGCATCCCGAAGCACTAACTACAGGTCCTGACGAACTTTCTCATGCAAGAATGGAAAAACAAAAGGAAAGTATACCCTTAGATGCAACCGTTCAATCAGCGGGCATAAAACTAATTGACCTAGATGATACTTCCTCGTGCGTTTCGCCTCTACTTTCTGGTCCCAGTCCCCAACCGTCTGTTGTTGGCCCTGGAGGACTCAGTAACGTATCACCCGATAAAAGTAAGCTCAATGTGCTTCCTCCGCCTCCTCCTACCTCGAGGCACAATAAGGAACCATCTTCTAAACTTCTTTCCCCTACCAAAGAGATTTCCATTGTCAGCGTATCGCCGCGTAAAGGTGAGAGCAATCTTCCTGCCTTAGAGAGACACAGTACACCCAAACCACTGCCGCCAGTGCCCGCTTTATCTTTATCTAAGCCAGTCTCTTTACAGAAAAGTTCTTCAGAATTACAGCATGCTAAAGAGACCATAGATAATGGGAAAATTGTTCCTCGACCTTGTCCTCCTATTAGAAGGAAGAGCAGTACTGCCCCGGACGAAATCTCTACATCTACCAAAAATTCAGGTGTGTCCACTACAGAAGATCCTGAGCCAGCAAAGGCCTCCACAAAACCTGAGAAGCCACCAGTTGTCAAAAAACCGCATTATTTAAGTGTTGCTGCTAACAAGCTTAACACCTCTCAAGAACACTCAATAAAAGTTTCCCCGTCGAATTCAAAATCTGAAGAGGAACTCCCTTGCAAGAAAAAGTCTAAACCAAAAGTTCCTGCGAAGAACCCTGAACTAGAGAAGCTAAGCGTTCATCCATTGAAGCCTTGCGACCCCAATTAA","protein_sequence":"MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN"},{"created_at":"2016-09-09T22:50:12.000Z","updated_at":"2016-09-09T22:50:13.000Z","name":"Vacuole morphology and inheritance protein 14","uniprot_id":"Q06708","uniprot_name":"VAC14","enzyme":false,"transporter":false,"gene_name":"VAC14","num_residues":880,"molecular_weight":"99771.325","theoretical_pi":null,"general_function":"regulation of lipid kinase activity","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity.","reactions":[{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Swollen vacuole phenotype 2 protein"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"positive regulation of kinase activity"},{"category":"Function","description":"protein transport"},{"category":"Function","description":"regulation of lipid kinase activity"},{"category":"Function","description":"identical protein binding"},{"category":"Function","description":"fungal-type vacuole membrane"},{"category":"Function","description":"phosphatidylinositol biosynthetic process"},{"category":"Function","description":"extrinsic component of vacuolar membrane"},{"category":"Function","description":"PAS complex"},{"category":"Function","description":"protein binding, bridging"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAAAAATCGATTGCCAAAGGTTTAAGCGACAAACTATACGAAAAACGGAAGGCTGCCGCCTTGGAGTTGGAAAAGTTGGTCAAACAATGCGTTCTAGAAGGGGACTATGATCGTATTGACAAGATAATAGACGAACTATGCAGAGACTATGCATACGCTTTGCATCAGCCCATGGCTAGAAATGCAGGATTAATGGGCTTGGCTGCCACAGCAATTGCTTTAGGAATAAACGATGTTGGCCGTTACTTGAGGAATATTCTTCCTCCAGTTCTCGCATGTTTTGGCGACCAGAATGACCAAGTAAGATTTTATGCGTGTGAGAGTTTGTACAATATTGCAAAGATTGCGAAGGGTGAAATACTGGTCTATTTCAATGAAATATTTGACGTACTCTGTAAAATTAGTGCTGATACAGAAAACTCGGTCCGAGGAGCAGCTGAACTATTAGATCGGTTGATAAAAGATATTGTTGCTGAAAGAGCATCCAATTACATAAGCATTGTAAATAATGGATCGCATGGTTTGCTTCCAGCCATAAAAACGGATCCAATCAGCGGGGATGTCTACCAAGAAGAATATGAGCAAGATAATCAATTGGCGTTCTCTTTACCAAAATTTATTCCTTTATTAACAGAGAGAATTTACGCCATTAACCCTGATACGCGTGTTTTTTTAGTTGACTGGCTTAAAGTCTTGCTCAATACCCCAGGACTAGAGCTCATATCGTATCTACCATCATTTCTTGGCGGGTTATTCACGTTCTTGGGCGATTCTCATAAAGATGTCAGAACAGTTACACACACCCTTATGGACTCACTACTTCACGAAGTCGACCGCATTTCAAAATTACAAACTGAAATTAAAATGAAGAGACTGGAAAGACTGAAAATGCTGGAAGATAAATACAATAACAGTTCTACTCCAACGAAAAAGGCCGATGGTGCACTTATTGCTGAAAAGAAGAAAACTTTAATGACTGCATTAGGTGGGTTATCCAAACCTCTGAGTATGGAGACTGATGATACCAAATTATCTAATACTAATGAGACAGATGATGAAAGACACTTGACAAGCCAGGAGCAGCTGCTAGATAGCGAGGCAACTAGCCAAGAACCTCTTCGCGATGGCGAAGAATATATACCTGGTCAAGATATCAACCTCAATTTCCCAGAGGTTATTACCGTTCTTGTGAACAATTTGGCATCATCTGAGGCAGAGATTCAATTGATTGCATTACACTGGATTCAGGTTATTTTATCCATTTCTCCAAATGTGTTTATCCCCTTCCTTTCAAAAATTCTTTCTGTGCTTTTAAAGCTATTGAGCGATTCGGATCCGCATATTACTGAAATTGCTCAGCTGGTGAACGGTCAATTACTCTCATTGTGCAGCTCATATGTGGGAAAAGAGACAGACGGGAAAATTGCATACGGGCCAATCGTTAATAGCTTAACTCTACAGTTTTTCGATAGTAGGATTGATGCCAAGATTGCCTGCTTGGATTGGCTCATCTTAATTTATCACAAGGCTCCAAACCAAATCTTGAAACATAACGACAGCATGTTCCTAACTTTGTTGAAGTCATTATCAAATAGAGACTCGGTGCTAATCGAGAAAGCTTTAAGTCTCTTACAGAGTTTATGTTCTGACTCAAATGATAATTATTTACGTCAGTTTCTTCAAGATTTATTAACTTTATTCAAGAGAGATACCAAATTGGTGAAAACTAGAGCAAACTTTATCATGAGACAGATATCTTCCCGTTTATCACCAGAACGTGTTTATAAAGTAATTTCTTCGATATTGGACAATTATAACGACACAACGTTTGTGAAAATGATGATTCAGATTTTAAGTACAAACTTAATAACTTCACCGGAGATGTCGTCGTTAAGAAACAAACTTAGAACTTGTGAAGACGGTATGTTTTTCAATAGTTTATTCAAATCTTGGTGTCCCAACCCCGTGTCCGTGATATCCTTATGTTTTGTAGCAGAAAATTATGAGTTAGCTTACACAGTGTTACAAACTTACGCGAACTACGAGTTGAAGTTAAATGATCTAGTGCAGTTGGATATTTTGATTCAGTTGTTCGAATCACCCGTTTTCACAAGGATGCGGTTGCAACTTTTAGAACAACAGAAACATCCGTTTCTGCATAAGTGTCTATTTGGTATACTGATGATTATACCACAGTCAAAGGCATTTGAAACATTGAACCGCAGATTGAATAGTTTGAACATATGGACATCCCAATCTTATGTCATGAACAACTATATAAGACAAAGGGAGAATAGTAACTTTTGTGATTCCAATTCTGATATCTCGCAAAGGTCCGTTAGCCAAAGTAAACTACATTTCCAGGAACTAATTAATCATTTTAAGGCCGTTTCAGAAGAAGATGAATATTCATCAGATATGATAAGGCTTGACCATGGTGCTAACAATAAATCACTTCTGCTTGGAAGTTTTTTGGACGGTATTGACGAAGATAAACAAGAAATTGTCACACCAATCTCGCCCATGAATGAAGCTATTAACGAGGAGATGGAATCTCCCAACGATAATAGTTCTGTCATATTAAAAGATAGTGGCAGTCTGCCATTCAACCGCAATGTATCCGATAAATTAAAAAAATAA","protein_sequence":"MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMARNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGEILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAIKTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLELISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLEDKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQEQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVILSISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGPIVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEKALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVISSILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVISLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFLHKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRSVSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPISPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK"}]}