{"ymdb_id":"YMDB16251","created_at":"2016-09-12T18:28:48.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"1-phosphatidyl-1D-myo-inositol 4,5-biphosphate","cas":null,"state":null,"melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"[(4-{[(2-{[2-(formyloxy)acetyl]oxy}ethoxy)(hydroxy)phosphoryl]oxy}-2,3,5,6-tetrahydroxycyclohexyl)oxy]phosphonic acid","traditional_iupac":"{4-[(2-{[2-(formyloxy)acetyl]oxy}ethoxy(hydroxy)phosphoryl)oxy]-2,3,5,6-tetrahydroxycyclohexyl}oxyphosphonic acid","logp":"-4.324978937333333","pka":"1.920146292498484","alogps_solubility":"1.62e+01 g/l","alogps_logp":"-1.06","alogps_logs":"-1.46","acceptor_count":"11","donor_count":"7","rotatable_bond_count":"12","polar_surface_area":"256.03999999999996","refractivity":"83.81009999999999","polarizability":"37.83922618016847","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-3.667896896112227","pka_strongest_acidic":"1.0789804154535299","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-27T00:42:41.000Z","updated_at":"2011-07-22T17:53:40.000Z","name":"1-phosphatidylinositol-3-phosphate 5-kinase FAB1","uniprot_id":"P34756","uniprot_name":"FAB1_YEAST","enzyme":true,"transporter":false,"gene_name":"FAB1","num_residues":2278,"molecular_weight":"257447.0","theoretical_pi":"8.51","general_function":"Involved in ATP binding","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4","reactions":[{"id":1133,"direction":"\u003c\u003e","locations":"vacuole","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1134,"direction":"\u003e","locations":"cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2625,"direction":"\u003e","locations":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","altext":"ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.","genbank_gene_id":"D50617","genbank_protein_id":"836774","gene_card_id":"FAB1","chromosome_location":"chromosome 6","locus":"YFR019W","synonyms":["Phosphatidylinositol-3-phosphate 5-kinase","Type III PIP kinase","PIPkin-III"],"enzyme_classes":["2.7.1.150"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" lipid kinase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" phosphatidylinositol phosphate kinase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphatidylinositol metabolic process"},{"category":"Process","description":" cellular protein metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" protein metabolic process"}],"pfams":[{"name":"Cpn60_TCP1","identifier":"PF00118"},{"name":"FYVE","identifier":"PF01363"},{"name":"PIP5K","identifier":"PF01504"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCATCGGAAGAACCCCATGCATCTATATCCTTTCCAGATGGCTCACATGTCCGGTCGTCCTCCACTGGTACTTCATCTGTGAACACAATCGATGCTACCTTATCCAGACCGAACTATATTAAGAAACCGTCCCTGCACATTATGTCGACATCTACGACGTCGACTACGACGGATCTAGTGACAAACCCAATTCTGAGCAATATCTCCGTGCCAAAAATAAGCCCCCCCACATCATCCTCGATAGCAACAGCGACATCAACAAGTCACGTGACCGGCACTGCGTCGCATTCGAACATTAAAGCTAATGCTAACACTAGTACCAGCGTGAATAAGAAAAATTTGCCGCCAACAACTAGTGGGAGGATACCCTCTAGCACCATCAAGAGATATCCGAGTCGCTATAAGCCTTCTCACTCGCTGCAGCTGCCCATTAAGAACGACTCCAACTTTAAACGATCTAGCATATATGCCTCCAAATCCACTGTTACTGCTATCCCCATTAGGAACAATCGGCCAATTTCCATGCAGAATTCCTATGCGCGCACTCCTGACAGCGATCATGACGACGTTGGCGATGAAGTGTCTTCGATAAAGAGTGCCTCTTCTTCGTTGACCGCATCCCTGTCCAAGAGTTTCCTGTTCGCATTTTATAACAACCGCAAGAAGGACAAGACCAGTAACAATGGTGTCCTCTCAAAGGAATATTGGATGAAGGACGAGAGTTCTAAAGAATGTTTCAGTTGTGGTAAAACGTTTAACACTTTCAGAAGGAAACACCACTGCAGGATATGCGGCCAAATTTTTTGCAGCAGTTGCACTCTCTTGATAGATGGTGATCGATTCGGCTGTCATGCCAAGATGCGAGTATGTTACAATTGTTATGAGCATGCAGACACATACGAGGACTCCAGTGATGAAGAGAATGATTCTACAATGCAATTGAATGAGCCAAGGTCTCGCTCTCGCTCTCGTTCTTCCAATACCAATCCATATTCTCATTCACATTCGCATTTGCATCTCATTTCACAGGACAACCATAACGGTACCGATCTCCATGATCCAGTAGCAGCAACGGATAACCCTCAACAGCAGAATGAGGTCTACCTATTAAATGACGATGACGTACAAAGTATAATGACCTCAGGTGAAGATTCTAAATTGTTCATTTCTACACCCCCACCACCACCGAAGATGGCCATCCCAGCAACAAAGCAAGGCGGATCGCTGGAAATCTCATTCGATTCGGAAAACGATAGGGCTTTGCATTATCAAGATGACAACCCCGGTCGCCATCATCACCTCGATTCCGTGCCCACAAGGTACACTATCAGAGATATGGACAATATATCACATTACGATACCAACTCTAATTCCACTTTGAGGCCACATTATAACACCAATAACAGCACTATTACCATCAACAACCTCAACAACACTACTTCCAACAACAGCAACTATAACAATACCAATAGCAACAGCAACATCAATAATCCTGCGCATTCCTTAAGAAGGTCTATTTTCCATTATGTAAGCAGCAATAGTGTTAACAAGGACAGTAACAATAGCTCTGCAACACCCGCTTCGTCTGCACAGTCTTCTTCCATACTGGATCCTGCCAATCGTATTATCGGGAATTATGCTCATAGAAATTACAAGTTTAAATTCAACTACAATTCCAAAGGTCCTTCGCAACAAAATGACACGGCAAATGGAAATAATGATAATAATAATAATAATAATAATAATAATAATAATAATAATAATAACAGTGCCAGCGGTATTGCTGACAACAATAACATTCCCTCAAACGACAATGGCACGACGTTCACTCTAGATAAGAAGAAAAGAAACCCACTGACAAAATCTAAATCTACGTCCGCTTACCTAGAATATCCTCTAAACGAGGAAGACTCTTCTGAGGACGAAGGTTCCATGTCCATATATTCTGTATTGAATGATGACCATAAAACTGACAATCCAATTAGATCAATGAGGAACTCCACAAAATCTTTTCAACGAGCGCAAGCTTCACTACAGCGGATGAGGTTTAGAAGGAAAAGTAAAAGCAAGCATTTTCCCAACAATTCGAAAAGTTCCATTTATAGAGACTTAAATTTCTTGACCAATAGTACTCCCAATTTACTTTCTGTAGTAAGCGACGATAATCTATACGACGATTCTTCTCCTTTGCAAGACAAGGCCTCTTCATCCGCTGCAAGCAGACTCACTGACAGAAAATTCAGCAATAGCAGTGGCAGCAATAATAATAGCAATAGTAATAGCAATATCAACACCGATCCTTGGAAGAGAATCGCTAGTATATCGGGATTCAAACTGAAAAAGGAAAAAAAGAGAGAATTAAATGAAGTCTCTCTTTTACATATGCATGCCCTATTAAAACAATTATTGAATGATCAAGAAATTTCCAATCTTCAAGAATGGATAACCCTTCTAGATGGCGCTTTGCGTAAAGTTTTAAGGACCATCCTGAACGCGAGGGATTTGAACACATTAGATTTTAGACAAACTTACGTTAAGATAAAAAGAATTAGTGGTGGATCTCCTCAAAATTCAGAATATATCGACGGGGTTGTCTTTTCGAAAGCATTGCCGTCGAAAACAATGCCACGGCATTTGAAAAACCCAAGGATACTATTAATCATGTTTCCACTGGAGTACCAAAAGAACAATAACCACTTTCTAAGTATAGAGTCCGTCTTTAGGCAAGAGCGCGAATATTTGGATAAACTTGTTTCGAGATTAAAGTCATTACATCCTGATATTATATACGTCGGCGCCAATGTTAGTGGGTACGCGTTAGAACTATTAAATGACTCAGGCATTGTCGTACAGTTTAATATGAAACCACAAGTCATTGAAAGAATTGCCAAGCTAACAGAAGCAGATATTGCCATTTCTGTGGATAAGTTGGCTACGAATATTAAGATGGGTGAATGTGAAACTTTTGAAGTTAAAAGCTACATTTATGGAAACATCAGTAAAACATATACATTTCTTCGGGGCTGTAACCCAGAACTTGGTGGAACAATTTTGTTAAGAGGTGATAGTCTTGAAAACTTGAGAAAAATCAAACAAGTCTCTGAATTTATGGTCTACGCAATTTTTTCATTGAAGTTGGAAAGTTCATTTTTTAACGATAATTTCATACAACTTTCTACAGATGTTTATTTGAAGAGAGCTGAATCCAAAAAACTGCAAGTTTTCGAAGGTTATTTTGCAGATTTCTTGATCAAATTCAATAACAGGATTTTGACTGTATCACCAACGGTAGATTTCCCCATTCCCTTTTTATTGGAAAAAGCCAGAGGCTTGGAAAAGAAGCTCATAGAAAGGATCAATCAATATGAAAGCGAATCTGATTTAGATCGGCAAACGCAACTAAATATGCTTCAAGGCTTAGAATCGACTATCACTAAGAAACACTTAGGAAATTTAATAAAATTCCTGCATGAAATGGAAATTGAAAATTTAGAGCTTGAGTTTCAGAAGAGAAGTCGTCAATGGGAGGTTTCATATTCATCATCACAGAACTTACTTGGTACGGGCTCACACCAGTCTATAACAGTTCTCTACTCAATGGTTTCAACAAAGACTGCCACACCTTGCGTTGGCCCTCAAATTGTTACTATTGACTATTTTTGGGACAGTGATATTTCCATTGGTCAGTTTATCGAGAACGTCGTGGGAACTGCCAGGTATCCCTGCCAACAAGGCTGTAATGGTCTGTATTTGGATCATTATAGAAGCTATGTTCATGGGTCAGGAAAAGTAGACGTTTTAATCGAAAAATTCCAAACTAGATTACCAAAATTAAAAGATATTATCCTCACGTGGAGTTATTGTAAAAAATGTGGGACATCTACTCCGATTTTACAAATTAGCGAAAAAACCTGGAATCATTCTTTCGGTAAATATTTAGAAGTCATGTTTTGGAGTTACAAAGATAGCGTGACAGGAATTGGGAAATGTCCTCATGATTTCACTAAAGATCATGTCAAATACTTTGGTTACAATGATTTAGTGGTTCGACTAGAATATTCTGATTTAGAAGTTCATGAATTGATAACCCCACCACGCAAAATAAAATGGAAACCTCATATCGACATCAAACTGAAGGTGGAACTATACTATAAGATTCTGGAAAAGATCAATAATTTCTATGGGAGTGTCCTAAGTCGGTTGGAACGTATTAAATTGGATAGTATGACTAAAGATAAAGTTCTTAGTGGACAAGCTAAAATTATCGAATTGAAGAGCAATGCTACAGAGGAGCAAAAATTAATGTTGCAAGACCTGGATACTTTTTACGCAGATAGTCCTTGCGATCAACATTTACCATTGAACCTGGTTATCAAATCTCTATACGATAAGGCTGTAAATTGGAACTCTACATTTGCGATATTTGCAAAAAGCTATTTGCCTTCTGAAACTGATATTAGTCGTATCACGGCCAAGCAGCTGAAAAAACTGTTTTACGATTCTTCAAGAAAAGACAGCGAAGACAAAAAATCACTTCATGATGAAAAGGCGAAGACGAGGAAACCAGAAAAGAACGAATTACCGTTAGAGGGATTGAAAGATGTCGAAAAGCCGAAAATTGATAGCAAGAATACGACAGAGAATCGTGACAGAACGAACGAACCACAGAATGCCGTGACGATAACCACTTTTAAAGACGACACTCCAATTATTCCAACAAGTGGTACTAGTCACTTGACAGTTACACCTTCTGCATCGTCGGTTTCTTCTTCTTTGACCCCTCAAACCGAAGAACGTCCGCCAATAAGCAGAAGTGGAACAGGTATATCTATGACTCATGATAAAAGCACTAGACCTAACATAAGAAAAATGAGTAGTGATAGTAGTTTATGTGGACTAGCATCACTTGCTAATGAATATAGTAAAAATAATAAGGTGAGTAAGCTAGCTACATTTTTCGATCAAATGCATTTTGATGCCCTGTCGAAAGAATTTGAACTGGAACGTGAAAGGGAAAGATTACAACTTAATAAGGATAAATACCAAGCCATACGATTACAAACATCCACACCAATTGTGGAAATTTATAAAAATGTCAAAGACGCAGTTGATGAACCGCTTCACTCTAGAAGTTCAGGCAATAATTTGTCATCTGCGAATGTTAAGACTTTGGAGGCACCTGTGGGAGAACATTCCCGGGCCAATAATTGTAATCCTCCTAATTTAGATCAAAACTTGGAAACTGAATTAGAAAATTCCATTAGCCAATGGGGAGAAAACATTTTGAACCCCTCTGGAAAGACCACCGCAAGTACTCATTTAAATTCTAAGCCAGTAGTAAAGGAAACTTCAGAAAATCCAAAGTCAATAGTTAGAGAATCAGATAATTCAAAGTCGGAGCCGCTTCCACCTGTAATAACAACAACAACTGTCAATAAGGTAGAATCCACTCCACAACCTGAAAAATCATTATTGATGAAAACCTTGAGCAACTTTTGGGCAGATCGATCTGCGTATTTGTGGAAACCCCTTGTTTATCCAACCTGTCCTTCGGAACACATTTTTACTGATAGTGACGTTATAATCCGCGAAGATGAACCAAGTTCCTTGATCGCATTTTGCTTAAGTACTTCTGACTATAGAAATAAAATGATGAACTTGAATGTCCAGCAACAACAGCAGCAGCAAACAGCAGAAGCTGCTCCTGCCAAAACAGGAGGAAACAGTGGAGGAACTACGCAAACCGGGGATCCTTCTGTTAACATTTCTCCCTCAGTTTCTACAACTTCTCATAATAAGGGGAGGGACTCAGAAATTTCATCCTTAGTAACCACCAAAGAGGGCTTGTTGAACACCCCTCCCATTGAAGGCGCCCGAGATAGGACCCCACAAGAATCACAAACGCATTCCCAAGCAAATTTAGATACTCTTCAAGAATTAGAGAAAATTATGACAAAAAAAACAGCCACACACTTGAGATATCAATTTGAGGAGGGTTTAACGGTAATGTCATGTAAAATTTTCTTCACAGAACATTTTGACGTGTTTAGAAAGATTTGTGATTGTCAAGAAAACTTCATTCAAAGTTTGTCAAGATGTGTTAAATGGGATTCCAATGGGGGGAAAAGTGGGAGCGGGTTTTTAAAGACTTTGGATGATAGATTTATTATAAAGGAGCTGTCACACGCAGAACTGGAAGCCTTCATAAAATTTGCACCAAGTTATTTTGAATACATGGCACAAGCAATGTTCCATGATTTGCCCACGACTTTGGCTAAAGTATTTGGGTTTTATCAAATTCAAGTAAAAAGCTCTATTTCAAGTTCCAAAAGTTATAAAATGGACGTTATCATTATGGAGAACTTATTTTATGAGAAGAAAACAACAAGAATATTTGATTTGAAGGGTTCCATGAGAAATAGACATGTCGAACAAACAGGTAAAGCTAATGAAGTGTTGTTGGATGAAAATATGGTAGAGTATATTTACGAATCACCTATTCATGTTCGCGAATATGACAAGAAACTTTTAAGAGCTTCTGTTTGGAACGACACATTATTTTTGGCCAAAATGAATGTGATGGATTATTCCTTAGTCATTGGTATTGACAATGAAGGGTATACTTTGACAGTAGGAATCATTGATTTCATTCGAACGTTTACATGGGACAAAAAACTAGAAAGTTGGGTCAAAGAGAAAGGCCTAGTAGGGGGGGCCAGTGTGATCAAGCAGCCTACCGTTGTTACACCAAGACAATATAAAAAACGTTTTAGGGAAGCAATGGAGAGGTATATTTTGATGGTTCCTGATCCGTGGTATTGGGAAGGAAATTAA","protein_sequence":"MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDLVTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTSGRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPPPPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNSTLRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSATPASSAQSSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNNNSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDNPIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVSDDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEKKRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLDFRQTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESVFRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIAISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRKIKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYFADFLIKFNNRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQGLESTITKKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYSMVSTKTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVHGSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWSYKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIKLKVELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLMLQDLDTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQLKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDRTNEPQNAVTITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGISMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERERERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRANNCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKSIVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVYPTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGGTTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDTLQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSNGGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYWEGN"},{"created_at":"2011-05-27T00:43:23.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Phosphatidylinositol 4-kinase PIK1","uniprot_id":"P39104","uniprot_name":"PIK1_YEAST","enzyme":true,"transporter":false,"gene_name":"PIK1","num_residues":1066,"molecular_weight":"119922.0","theoretical_pi":"6.46","general_function":"Involved in binding","specific_function":"Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton","reactions":[{"id":1849,"direction":"\u003c\u003e","locations":"vacuole;Golgi;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1850,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2590,"direction":"\u003e","locations":" Peripheral membrane protein.; Cytoplasmic side.; Peripheral membrane protein;Cell membrane; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein. Vacuole membrane;Nucleus","altext":"ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14858,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007046","source":"Smpdb"},{"id":14859,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007047","source":"Smpdb"},{"id":14860,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007048","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"L20220","genbank_protein_id":"432496","gene_card_id":"PIK1","chromosome_location":"chromosome 14","locus":"YNL267W","synonyms":["PI4-kinase","PtdIns-4-kinase"],"enzyme_classes":["2.7.1.67"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" organophosphate metabolic process"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" intracellular signal transduction"},{"category":"Process","description":" second-messenger-mediated signaling"},{"category":"Process","description":" phosphoinositide-mediated signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycerophospholipid metabolic process"},{"category":"Process","description":" phosphoinositide metabolic process"},{"category":"Process","description":" phosphoinositide phosphorylation"}],"pfams":[{"name":"PI3_PI4_kinase","identifier":"PF00454"},{"name":"PI3Ka","identifier":"PF00613"},{"name":"Pik1","identifier":"PF11522"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCATAAAGCATCCAGTTCAAAGAAAAGCTTTGATGATACTATTGAACTAAAAAAAAATGAACAATTACTGAAACTGATCAACTCTAGTGAATTCACCCTTCACAATTGTGTGGAGTTACTGTGCAAACACTCCGAAAATATTGGTATACATTACTATTTATGTCAGAAATTGGCCACATTTCCTCACAGCGAACTACAGTTCTATATTCCCCAACTAGTACAGGTCCTCGTCACCATGGAGACAGAATCAATGGCTTTAGAAGATTTACTATTAAGGTTGAGGGCGGAAAACCCTCATTTTGCACTACTGACGTTTTGGCAGTTACAAGCGTTACTAACGGATTTATCTACTGACCCCGCTTCTTATGGCTTCCAAGTGGCTAGAAGAGTCTTAAACAACTTACAAACCAATCTCTTTAACACAAGTTCAGGTAGCGATAAAAATGTTAAAATACATGAAAACGTTGCACCGGCCTTAGTTCTTTCCTCTATGATAATGTCGGCTATAGCATTCCCCCAATTAAGCGAAGTGACCAAACCATTAGTGGAATCTCAAGGTAGAAGACAAAAAGCTTTCGTTTTTAAGTTGGCTAGAAGTGCAATGAAAGATTTTACCAAGAACATGACCTTGAAAAATACCCTACTAAACAAGAAAACTTCCAGATCCAAAAGAGTTAGCTCAAATCGCAGTTCAACTCCGACTTCTCCAATAGATTTAATAGATCCAATAAAAACTAAAGAAGATGCATCCTTCAGGAAATCCAGACATAGTGAGGTAAAATTGGATTTCGACATTGTGGATGATATAGGTAACCAGGTCTTTGAAGAAAGAATCTCATCTTCAATCAAACTCCCAAAACGTAAACCTAAGTATTTGGATAATTCATACGTTCATAGGACATATGATGGCAAAAATATAAACAGGGACGGAAGCATTTCAAATACCGCAAAGGCTCTCGATGGAAATAAAGGTGATTATATTTCTCCAAAGGGACGTAATGATGAAAATAATGAGATTGGTAACAATGAAGATGAAACTGGTGGTGAAACGGAGGAGGACGCGGACGCTTTAAACTCTGATCACTTCACCAGTTCTATGCCAGATCTGCATAATATTCAACCAAGGACTTCTTCTGCTTCATCTGCTTCTTTAGAAGGGACACCTAAGTTAAACAGGACCAATTCCCAACCCCTTTCGCGCCAGGCATTCAAAAACAGTAAAAAAGCGAATTCTTCTTTGAGTCAAGAAATTGACTTGTCGCAATTATCGACCACTTCAAAAATAAAAATGTTAAAAGCAAATTATTTTCGTTGCGAGACACAATTTGCCATTGCGCTAGAAACAATATCTCAAAGGCTAGCTCGAGTACCGACAGAAGCTAGATTGAGTGCCTTACGAGCCGAGTTGTTTCTATTAAACAGGGACCTACCAGCGGAAGTAGATATCCCCACTTTATTGCCTCCAAATAAAAAAGGAAAGTTACATAAATTAGTGACCATTACTGCTAATGAGGCACAAGTTTTGAACTCTGCAGAAAAAGTTCCATATTTACTCCTGATAGAATACTTGAGAGACGAATTTGATTTTGACCCAACAAGTGAAACCAATGAAAGATTATTAAAGAAGATCAGTGGTAATCAGGGAGGCTTGATATTTGATTTAAATTACATGAATAGAAAAGAAAACAACGAAAATAGAAATGAAAGTACTCTTACTAGCAACAACACTCGATCTTCGGTATATGATAGTAACTCGTTCAACAACGGGGCCTCCCGCAATGAAGGTCTATCCAGTACCTCAAGAAGTGATTCAGCGTCCACAGCTCATGTTAGGACTGAAGTCAATAAAGAGGAAGATTTAGGTGATATGTCAATGGTAAAAGTCAGGAACAGAACGGATGACGAAGCGTATAGAAATGCTTTAGTAATACAGAGTGCCGCAAATGTTCCAATTTTACCTGATGATAGTCAAGACAGAAGCCCAGAGTTGAACTTTGGCTCAAACTTGGACGAAGTACTCATCGAGAATGGAATTAATAGCAAAAATATACATAGCCAAACTGACGCTTTAGCAGACCAGATGAGAGTTTCAGCTGTTATGTTAGCACAATTGGATAAGTCGCCACAACAGTTATCAGAAAGTACCAAACAAATCCGCGCTCAAATTATTTCATCAATGAAGGAGGTGCAGGATAAATTTGGTTACCATGATTTGGAAGCCCTTCATGGAATGGCAGGTGAGAGAAAATTGGAAAACGATTTAATGACGGGTGGTATTGACACTTCATATCTAGGTGAAGATTGGGCTACCAAGAAAGAGAGGATACGTAAAACTTCGGAATATGGCCATTTCGAAAACTGGGATTTATGTTCTGTAATCGCCAAGACGGGTGATGATTTGAGACAGGAGGCGTTTGCATACCAGATGATTCAAGCGATGGCCAATATTTGGGTTAAAGAAAAAGTTGACGTTTGGGTTAAAAGAATGAAAATTTTAATTACTAGTGCGAATACGGGACTTGTGGAGACCATCACAAATGCTATGTCTGTGCATAGTATTAAAAAGGCTTTAACCAAAAAAATGATTGAAGATGCAGAACTAGATGACAAGGGTGGTATTGCCTCTTTGAATGATCACTTCCTTAGAGCTTTTGGTAATCCTAATGGATTTAAGTATAGAAGAGCACAAGACAACTTTGCTTCTTCGTTAGCCGCATATTCTGTCATTTGCTATCTCTTGCAGGTTAAAGATAGACACAACGGTAACATTATGATCGATAACGAAGGCCATGTAAGTCACATCGATTTTGGATTTATGCTATCAAATTCACCCGGCTCAGTGGGCTTTGAGGCCGCACCATTCAAATTAACTTACGAATATATTGAACTGCTAGGCGGAGTAGAGGGAGAAGCGTTTAAAAAGTTTGTTGAACTAACTAAAAGTTCGTTCAAGGCTCTGAGAAAGTATGCTGATCAAATCGTATCAATGTGTGAGATTATGCAAAAGGACAATATGCAGCCTTGTTTCGATGCTGGCGAACAAACAAGTGTACAACTACGACAAAGGTTCCAATTGGACTTATCAGAAAAAGAAGTTGATGACTTCGTAGAAAATTTCTTGATAGGTAAATCTTTGGGTAGTATTTACACCAGAATATACGACCAATTTCAACTTATTACACAGGGTATATATAGCTGA","protein_sequence":"MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS"},{"created_at":"2011-05-27T06:28:05.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1","uniprot_id":"P32383","uniprot_name":"PLC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PLC1","num_residues":869,"molecular_weight":"100547.0","theoretical_pi":"9.55","general_function":"Involved in protein binding","specific_function":"The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1","reactions":[{"id":1872,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2787,"direction":"\u003e","locations":"Cytoplasmic","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.","export":false,"pw_reaction_id":null,"source":null},{"id":14855,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007043","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"D12738","genbank_protein_id":"287612","gene_card_id":"PLC1","chromosome_location":"chromosome 16","locus":"YPL268W","synonyms":["Phosphoinositide phospholipase C","Phospholipase C-1","PLC-1"],"enzyme_classes":["3.1.4.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" phospholipase C activity"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" phosphoinositide phospholipase C activity"},{"category":"Function","description":" calcium ion binding"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" lipase activity"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" phospholipase activity"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" signaling"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" intracellular signaling pathway"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" primary metabolic process"}],"pfams":[{"name":"PI-PLC-X","identifier":"PF00388"},{"name":"PI-PLC-Y","identifier":"PF00387"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGAAAGTGCTATAGATGACCAAAGGTTTAATCTTACAAAGGAGTTACAACGACACTCATGCAGAGATCAAGGGAAAATAACACAAAAGGATGATGCTTTAGATTTTATAAGTTACAGTTCTTTTCAATCCTCTTTTAATACTGACCAAAAAAGCGCGAACAATGGAAGTACTGTGAGAAGAAGCATAAGGTCGATTTTTAGAAGAGCAGCCGAATTGCCTAGAGTCCATATGGGGCCTCTTACTTATTCACATGGGATAAATGAGCTTGTTAACAAGAAATTAAGAAAAGACTGTGATCTCAGCACGCTATGTCGCGTATTGCAAAGAGGAATCAGGATGATTAGGATGACAAGAAGAAGAAGGAAGTTCTATGAATTTAAATTAATCAATAACAACGGGCAAATAATATGGAAAGATGGTTCGAAGTATCTGGAATTAGACTCCGTTAAAGACATCAGAATCGGTGATACGGCGAGTACTTATCAAGAGGAAGTAGATCCGAAAAGATTGAGATCGGACAGTAAACTTTGGATTGCTATTATTTATAAGGTTTCCAACAAATTGAAAGCGTTACACGTAGTTGCTTTGAATGAATTGGACTTTAACACATTCTTAAGCTGCATTTGCGGTTTAGTGAAGTTAAGGAGGGAATTAATGGAAAGCATACTTTTGCCTGATAATTCGCAATTCGCTAGGATACATTGGCAAATTACTGTTTCTGAAAAAGAGGAAGATGAGAAAAAGGACACATTGAGCTTTGCAGATGTGAAGAAACTATGTGATAAATTTCATATTTATGTGTCAACTGGTCAATTGTTAGAGTTTTTCCAATTAGCAGACATCAATCATAACGGACTATTAAATTATTTTGAATTTGAAAAGTTCATTAAAATCTTAAAGAATAGGAAAGAGGTAAATATGATTTGGTCTAAATTTACAAAACCTCCACACTCCCACTTATCATTTGAAAATTTTTTTCAATTTTTAATTACAGAGCAGCATGAGCAAGTGGATCGTCAAACTGCATGGTCATATTTTATTAAGTACAGAGAACCGACTCAGCTGACGATGGGGCAAGATGGTTTTACCAAGTTCTTGAAGGAGCAACCATATTTGGTGGAGGTTAAAGAGGAGTTATATTCAAAGCCATTAAACCATTATTTTATTGCATCTTCACATAATACTTATTTATTGGGGAAACAAATTGCAGAAACTCCATCTGTGGAGGGATATATTCAAGTCCTACAACAAGGTTGTAGGTGCGTAGAAATTGATATATGGGATGGTGAAAATGGGCCAGTGGTATGCCATGGATTTTTAACGTCAGCTATTCCCTTAAAAACAGTTATACGCGTGATAAAGAAGTACGCTTTTATAACGTCTCCGTATCCTTTGATTATTTCACTGGAAATAAACTGTAACAAGGATAATCAAAAATTGGCAAGCCTGATAATGAGAGAGGTTTTAGCAGAACAGCTGTACTTTGTTGGCACAAGAACTGATAAACTGCCATCACCAAGGGAATTAAAACATAAAATACTGTTGAAATCCAAGAAGACGAGTGAAGCAACTAGAGGTCTTAGCGTTAATGAGCCATTTCCATCTTCTTTTAGTTCTTCTTACGAATCAGCTAATGAACAGGAATTAAGAATGAAAGATGACTCCACGAACAGTAGTAGCGCAACAAATTCTTCTAGTATGCAACGCATCAAAAGAATTGGATTAAAAAAGCACGCTGATATAATTAATGATGTTTCTAACATTTCTGGAATACATGGCATCAAGTTCAGGAATTTCTCTTTACCAGAGTCCAAAACGATAGCGCATTGTTTTTCACTGAATGAGCGCAAAGTAGAATACATGATAAAAGACAAACACTTAAAATTATCGTTGGATAAACATAATAGAAGATATTTGATGAGAGTCTATCCTCACGTTTTACGATACAAATCATCAAATTTTAACCCAATACCTTTTTGGAAGGCCGGTGTACAAATGGTGGCTACGAATTGGCAAACTAATGATATTGGACAGCAACTTAATCTGGCAATGTTTCAAATATTAGATCACCAACCTGATGGAAGTTTTAAATCAGGATACGTGCTAAAACCAAAAAAGTTGCTACCTGTAGTAACAAAGGCGAAAATGATTCCATTAATTTACGAACATTTTGAAAATGGTAGTGATCCTGTTACTGTTAAAATTCGAATTTTATCTACACAGTTATTGCCCAGATTGAATGATACATCGCCAAGCAGAAATAACACCAATTCCTTTGTTAAAGTGGAGTTTCATACCGATGACGAGCCGACAATGCCCATCTCAATCGATAAGGGTACAAGGATTTCTGCCACTGAAGCATCCACTAAGAGTTCTCAAGGGAATGGATTCAACCCAATATGGGATGCTGAAGTTTCTATCACATTGAAAGATACAGACCTCACATTTATAAAATTCATGGTTATCTCTGAAGAGACCCAGATTGCATCTGTTTGCCTTAAGCTGAACTATTTGAGGATGGGATATCGTCACATTCCGTTGTTTAACATGGAGGGGGAACAATACATATTTTGCACTTTATTTATTCATACACAAATTTTATAG","protein_sequence":"MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQSSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDLSTLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNSSSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQIL"},{"created_at":"2011-05-27T06:30:19.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Inositol-1,4,5-trisphosphate 5-phosphatase 2","uniprot_id":"P50942","uniprot_name":"INP52_YEAST","enzyme":true,"transporter":false,"gene_name":"INP52","num_residues":1183,"molecular_weight":"133330.0","theoretical_pi":"8.89","general_function":"Involved in inositol or phosphatidylinositol phosphatase activity","specific_function":"Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization","reactions":[{"id":1845,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;vacuole;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1846,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1847,"direction":"\u003c\u003e","locations":"endoplasmic reticulum;cytoplasm;cell envelope","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1848,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1851,"direction":"\u003c\u003e","locations":"mitochondrion;endoplasmic reticulum;cell envelope;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1904,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2788,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch; Cytoplasmic side;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2789,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,4,5-trisphosphate + H2O = D-myo-inositol 1,4-bisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":2790,"direction":"\u003e","locations":"Cytoplasm.;Cytoplasm, cytoskeleton, actin patch","altext":"D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,3,4-trisphosphate + phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytoskeleton, actin patch","genbank_gene_id":"Z71382","genbank_protein_id":"1302022","gene_card_id":"INP52","chromosome_location":"chromosome 14","locus":"YNL106C","synonyms":["Synaptojanin-like protein 2"],"enzyme_classes":["3.1.3.36","3.1.3.56"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" inositol or phosphatidylinositol phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Exo_endo_phos","identifier":"PF03372"},{"name":"Syja_N","identifier":"PF02383"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"},{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAAATACTCCTATCGAAACAGCAAACTAGAAAGATAGCAATAGTTTCAGAAACACATGGACTGGTATTTAGGCCAATAAACAGTAAGAACTCTCGCAGATCTACATGTGCCGTGGAATTGGTTCCGAAAGCTGAATTAAATGGTAATGGTTTCAGAAGACTATCTAACCATGAAATATACGGTTTTATTGGTCTCATAGAAATTGAAGGCCTTATGTTCATAGCAACCATAACAGGTAAATCTAAGGTGGCCCAGCCGATCCCAAACAAAACGGTTAACAAAATATATGCTGTGGATTTTTTTTGCTTAAATAATTCTAAATGGGATTTCATGGACATCGATTCATCCGGTTATCCGATTGTTACTAATGATGGAGATTTTGCAATAAGCTCGCCTCCTAGTATTTCCACACATTCTTCTAGATCATCGCTACGTTCTTCTTCCTCTAGGAGTTTGAATGCTCAAGAACAAGCTCCCAAGCATCCATGTCATGAACTAAGAAAGCTATTATCAAATGGATCTTTTTATTACAGCACCGATTTTGATTTAACTTGTACATTGCAGAAACGTGGATTCACGGAACACTCTTTGAGTTTTGATGATTTTGACCGGGAGTTTATGTGGAACTCGTTTCTTATGGACGAAATCATCACATACAGAGACAGACTAGATGTAACGGCCAAAGAACTATTGGATCAACGAGGATTCCTCACGACCGTAATCCGAGGGTTTGCTGAAACAATTTTTAGCTATATTAATAGGTTGAAAGTAGGACTTACCATTATTTCCAGGCAAAGTTGGAAAAGAGCAGGCACAAGGTTTAATGCACGTGGTATAGATGATGATGGCCATGTCGCAAATTTTGTTGAAACAGAAATGATTATGTACTCTTCTCAGTATTGTTATGCTTTCACGCAGATAAGAGGAAGCCTTCCAATTTTTTGGGAGCAGGATACATCTTTGATTAGTCCAAAGATTCAAATTACCAGATCTGTTGAAGCAACACAGCCCACGTTTGATGAACATTTTATAAGACTATTTAAGAAGTATGGGCCAGTTCATATAATCAACCTGCTGTCTACTAAATCTTCAGAAATTCAATTATCGAGGCGATACAAGGAACAGTTGAAAAATTCTGAGAAAATGAAAATCGGTAGAGATGTGTTCCTAACAAGCTTTGATTTCCATAGAGAAACTTCGCAAGATGGGTTTGCAGCTGCAAGTAGGATTATCCCTAAAATAAGAAACACAATTTTGGACGCCGGTTACTTTTCATACGATGTAAAAGAAGGGCGATTAATATCCGAACAAGACGGTGTCTTTAGAACCAATTGCTTGGATTGTTTAGATAGAACAAATTTGATCCAACAGACGATTTCACTGGCCGTTTTCAAACTATTTTTGGAAGACTTCCGATTGGTAAAACCCAGTAGTTTCATCGACGATAATGAATTTGTGCAAAAGGTGAATGCTTTATGGGCCGACAACGGAGATCAGATATCACAAATTTACACTGGGACAAATGCTCTGAAATCGTCCTATTCAAGGAAAGGTAAAATGTCTTTTTCTGGCGCCCTTTCTGATGCGACGAAGTCCGTTAGTAGAATGTACATCAACAATTTTGTAGATAAAGGAAAACAGCAAAATATTGACACACTTTTGGGCAAACTACCGCACCAGCAAGTTGTTGAACTTTATGATCCAATCTGCGAATACGTCAATGAAAGGCTGTTAGAGTCAGAGGAAAAATTCACCACTCATTCTAACATAAATTTGTTTGTCGGTACATTCAATGTTAACGGAAACTCTCGAAGAGCAGATTTGTCAAAATGGTTATTTCCAATCGGCGATAAATTCAAACCTGATGTCGTTGTGTTAGGGTTGCAGGAAGTTATAGAGTTGACCGCAGGGTCTATCTTGAATGCAGATTATACGAAAAGTTCTTTTTGGGAAACTATGGTTACTGACTGTTTGAATCAATACGAAGAAAAATATCTTTTACTTAGAGTGGAACAGATGTCCTCTCTTTTGATACTATTTTTTGCAAGATCAGATAGAGCCTATAACATAAAAGAGGTAGGTGGGTCTACCAAAAAGACTGGGTTTGGTGGTATTACTGGAAACAAAGGTGCAGTAGCCATTAGATTCGATTATGGGGCAACTTCATTCTGTTTCGTTAATACACATTTATCAGCAGGTGCGAGTAACATTGACGAACGTCGCAATGACTACAACAATATCTACAGGAACATAACCTTTCCAAGATCAAAGACAATTCCACACCATGATTCGTTGTTTTGGTTGGGTGACCTTAACTACAGGATAACTTTGACAAATGATGAAGTTAGAAGAGAATTAAGGGCTCAAAAGGATGGCTATATTGATAGATTGCTTCAATATGATCAGTTGACTCAAGAAATAAATGAAGGAGTGGTATTTCAGGGCTTTAAAGAACCGACCCTCCAATTCCGTCCGACCTATAAATATGATTATGGCACAGATAATTATGATACTTCTGAAAAGGCGAGAACTCCGTCTTGGACTGATAGAATCATATATAAAGGTGAAAACCTGCATCCATTGGCATATTCGGACGCACCTTTAAAAATAAGCGATCATAAACCAGTTTATGCTGCATATAGGGCAAATGTGAAATTTGTTGACGAAAAAGAGAAGCTTAACCTAGTTGAGAAGCTGTATGCAGAATATAAGAATACGCATCCCGAAGCACTAACTACAGGTCCTGACGAACTTTCTCATGCAAGAATGGAAAAACAAAAGGAAAGTATACCCTTAGATGCAACCGTTCAATCAGCGGGCATAAAACTAATTGACCTAGATGATACTTCCTCGTGCGTTTCGCCTCTACTTTCTGGTCCCAGTCCCCAACCGTCTGTTGTTGGCCCTGGAGGACTCAGTAACGTATCACCCGATAAAAGTAAGCTCAATGTGCTTCCTCCGCCTCCTCCTACCTCGAGGCACAATAAGGAACCATCTTCTAAACTTCTTTCCCCTACCAAAGAGATTTCCATTGTCAGCGTATCGCCGCGTAAAGGTGAGAGCAATCTTCCTGCCTTAGAGAGACACAGTACACCCAAACCACTGCCGCCAGTGCCCGCTTTATCTTTATCTAAGCCAGTCTCTTTACAGAAAAGTTCTTCAGAATTACAGCATGCTAAAGAGACCATAGATAATGGGAAAATTGTTCCTCGACCTTGTCCTCCTATTAGAAGGAAGAGCAGTACTGCCCCGGACGAAATCTCTACATCTACCAAAAATTCAGGTGTGTCCACTACAGAAGATCCTGAGCCAGCAAAGGCCTCCACAAAACCTGAGAAGCCACCAGTTGTCAAAAAACCGCATTATTTAAGTGTTGCTGCTAACAAGCTTAACACCTCTCAAGAACACTCAATAAAAGTTTCCCCGTCGAATTCAAAATCTGAAGAGGAACTCCCTTGCAAGAAAAAGTCTAAACCAAAAGTTCCTGCGAAGAACCCTGAACTAGAGAAGCTAAGCGTTCATCCATTGAAGCCTTGCGACCCCAATTAA","protein_sequence":"MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN"},{"created_at":"2016-09-09T22:50:12.000Z","updated_at":"2016-09-09T22:50:13.000Z","name":"Vacuole morphology and inheritance protein 14","uniprot_id":"Q06708","uniprot_name":"VAC14","enzyme":false,"transporter":false,"gene_name":"VAC14","num_residues":880,"molecular_weight":"99771.325","theoretical_pi":null,"general_function":"regulation of lipid kinase activity","specific_function":"The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity.","reactions":[{"id":14856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007044","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Swollen vacuole phenotype 2 protein"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"positive regulation of kinase activity"},{"category":"Function","description":"protein transport"},{"category":"Function","description":"regulation of lipid kinase activity"},{"category":"Function","description":"identical protein binding"},{"category":"Function","description":"fungal-type vacuole membrane"},{"category":"Function","description":"phosphatidylinositol biosynthetic process"},{"category":"Function","description":"extrinsic component of vacuolar membrane"},{"category":"Function","description":"PAS complex"},{"category":"Function","description":"protein binding, bridging"}],"pfams":[],"pathways":[{"name":"Inositol Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAAAAATCGATTGCCAAAGGTTTAAGCGACAAACTATACGAAAAACGGAAGGCTGCCGCCTTGGAGTTGGAAAAGTTGGTCAAACAATGCGTTCTAGAAGGGGACTATGATCGTATTGACAAGATAATAGACGAACTATGCAGAGACTATGCATACGCTTTGCATCAGCCCATGGCTAGAAATGCAGGATTAATGGGCTTGGCTGCCACAGCAATTGCTTTAGGAATAAACGATGTTGGCCGTTACTTGAGGAATATTCTTCCTCCAGTTCTCGCATGTTTTGGCGACCAGAATGACCAAGTAAGATTTTATGCGTGTGAGAGTTTGTACAATATTGCAAAGATTGCGAAGGGTGAAATACTGGTCTATTTCAATGAAATATTTGACGTACTCTGTAAAATTAGTGCTGATACAGAAAACTCGGTCCGAGGAGCAGCTGAACTATTAGATCGGTTGATAAAAGATATTGTTGCTGAAAGAGCATCCAATTACATAAGCATTGTAAATAATGGATCGCATGGTTTGCTTCCAGCCATAAAAACGGATCCAATCAGCGGGGATGTCTACCAAGAAGAATATGAGCAAGATAATCAATTGGCGTTCTCTTTACCAAAATTTATTCCTTTATTAACAGAGAGAATTTACGCCATTAACCCTGATACGCGTGTTTTTTTAGTTGACTGGCTTAAAGTCTTGCTCAATACCCCAGGACTAGAGCTCATATCGTATCTACCATCATTTCTTGGCGGGTTATTCACGTTCTTGGGCGATTCTCATAAAGATGTCAGAACAGTTACACACACCCTTATGGACTCACTACTTCACGAAGTCGACCGCATTTCAAAATTACAAACTGAAATTAAAATGAAGAGACTGGAAAGACTGAAAATGCTGGAAGATAAATACAATAACAGTTCTACTCCAACGAAAAAGGCCGATGGTGCACTTATTGCTGAAAAGAAGAAAACTTTAATGACTGCATTAGGTGGGTTATCCAAACCTCTGAGTATGGAGACTGATGATACCAAATTATCTAATACTAATGAGACAGATGATGAAAGACACTTGACAAGCCAGGAGCAGCTGCTAGATAGCGAGGCAACTAGCCAAGAACCTCTTCGCGATGGCGAAGAATATATACCTGGTCAAGATATCAACCTCAATTTCCCAGAGGTTATTACCGTTCTTGTGAACAATTTGGCATCATCTGAGGCAGAGATTCAATTGATTGCATTACACTGGATTCAGGTTATTTTATCCATTTCTCCAAATGTGTTTATCCCCTTCCTTTCAAAAATTCTTTCTGTGCTTTTAAAGCTATTGAGCGATTCGGATCCGCATATTACTGAAATTGCTCAGCTGGTGAACGGTCAATTACTCTCATTGTGCAGCTCATATGTGGGAAAAGAGACAGACGGGAAAATTGCATACGGGCCAATCGTTAATAGCTTAACTCTACAGTTTTTCGATAGTAGGATTGATGCCAAGATTGCCTGCTTGGATTGGCTCATCTTAATTTATCACAAGGCTCCAAACCAAATCTTGAAACATAACGACAGCATGTTCCTAACTTTGTTGAAGTCATTATCAAATAGAGACTCGGTGCTAATCGAGAAAGCTTTAAGTCTCTTACAGAGTTTATGTTCTGACTCAAATGATAATTATTTACGTCAGTTTCTTCAAGATTTATTAACTTTATTCAAGAGAGATACCAAATTGGTGAAAACTAGAGCAAACTTTATCATGAGACAGATATCTTCCCGTTTATCACCAGAACGTGTTTATAAAGTAATTTCTTCGATATTGGACAATTATAACGACACAACGTTTGTGAAAATGATGATTCAGATTTTAAGTACAAACTTAATAACTTCACCGGAGATGTCGTCGTTAAGAAACAAACTTAGAACTTGTGAAGACGGTATGTTTTTCAATAGTTTATTCAAATCTTGGTGTCCCAACCCCGTGTCCGTGATATCCTTATGTTTTGTAGCAGAAAATTATGAGTTAGCTTACACAGTGTTACAAACTTACGCGAACTACGAGTTGAAGTTAAATGATCTAGTGCAGTTGGATATTTTGATTCAGTTGTTCGAATCACCCGTTTTCACAAGGATGCGGTTGCAACTTTTAGAACAACAGAAACATCCGTTTCTGCATAAGTGTCTATTTGGTATACTGATGATTATACCACAGTCAAAGGCATTTGAAACATTGAACCGCAGATTGAATAGTTTGAACATATGGACATCCCAATCTTATGTCATGAACAACTATATAAGACAAAGGGAGAATAGTAACTTTTGTGATTCCAATTCTGATATCTCGCAAAGGTCCGTTAGCCAAAGTAAACTACATTTCCAGGAACTAATTAATCATTTTAAGGCCGTTTCAGAAGAAGATGAATATTCATCAGATATGATAAGGCTTGACCATGGTGCTAACAATAAATCACTTCTGCTTGGAAGTTTTTTGGACGGTATTGACGAAGATAAACAAGAAATTGTCACACCAATCTCGCCCATGAATGAAGCTATTAACGAGGAGATGGAATCTCCCAACGATAATAGTTCTGTCATATTAAAAGATAGTGGCAGTCTGCCATTCAACCGCAATGTATCCGATAAATTAAAAAAATAA","protein_sequence":"MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMARNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGEILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAIKTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLELISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLEDKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQEQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVILSISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGPIVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEKALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVISSILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVISLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFLHKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRSVSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPISPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK"}]}