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Identification |
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Name | Malate dehydrogenase, mitochondrial |
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Synonyms | Not Available |
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Gene Name | MDH1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
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Specific Function | (S)-malate + NAD(+) = oxaloacetate + NADH |
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Cellular Location | Mitochondrion matrix |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00110 | NAD | Show | YMDB00143 | NADH | Show | YMDB00235 | Oxalacetic acid | Show | YMDB00280 | (S)-Malic acid | Show | YMDB00412 | NAD(+) | Show | YMDB00862 | hydron | Show |
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GO Classification | Component |
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Not Available | Function |
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binding | oxidoreductase activity | oxidoreductase activity, acting on CH-OH group of donors | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | L-malate dehydrogenase activity | malate dehydrogenase activity | Process |
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malate metabolic process | cellular metabolic process | primary metabolic process | carbohydrate metabolic process | oxidation reduction | organic acid metabolic process | oxoacid metabolic process | carboxylic acid metabolic process | cellular carbohydrate metabolic process | dicarboxylic acid metabolic process | metabolic process |
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Gene Properties |
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Chromosome Location | Not Available |
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Locus | |
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Gene Sequence | >1005 bp
ATGTTGTCAAGAGTAGCTAAACGTGCGTTTTCCTCTACAGTTGCCAACCCTTATAAAGTG
ACTGTTTTGGGTGCAGGCGGTGGTATTGGACAACCATTGTCTTTGCTTCTAAAGCTTAAC
CATAAAGTCACGGACTTAAGACTGTACGACCTAAAGGGCGCAAAAGGTGTTGCCACCGAT
TTGTCTCATATTCCAACAAACTCCGTGGTCAAGGGGTTTACTCCAGAAGAGCCAGACGGA
TTGAACAACGCTTTAAAGGACACAGACATGGTTTTAATTCCTGCTGGTGTGCCCAGAAAG
CCTGGTATGACACGTGATGACTTGTTCGCCATCAACGCAAGCATCGTTCGCGATTTGGCA
GCAGCAACCGCCGAATCCGCTCCCAATGCTGCCATTCTGGTCATTTCCAACCCAGTCAAT
TCTACCGTTCCAATTGTCGCCCAAGTCTTGAAAAACAAGGGTGTTTACAACCCAAAGAAA
TTGTTCGGTGTGACTACCTTGGACTCTATTAGAGCCGCCAGATTCATCTCAGAAGTCGAG
AACACCGATCCAACTCAGGAAAGGGTTAACGTCATCGGTGGACATTCTGGTATTACCATC
ATCCCATTGATTTCGCAAACAAACCATAAGTTGATGTCTGATGACAAGAGACACGAATTG
ATTCACAGAATACAGTTTGGTGGTGACGAAGTCGTCAAAGCAAAGAATGGTGCTGGCTCT
GCTACGTTGTCAATGGCCCATGCTGGTGCTAAATTCGCTAACGCTGTTTTGTCCGGTTTC
AAAGGCGAAAGAGACGTCATCGAGCCTTCCTTCGTGGACTCTCCCTTGTTCAAATCCGAA
GGCATCGAATTCTTTGCATCTCCGGTCACTTTGGGCCCAGATGGTATTGAAAAGATCCAT
CCAATAGGTGAGTTATCTTCAGAAGAAGAAGAAATGCTACAAAAATGTAAAGAAACCTTG
AAGAAGAATATCGAAAAGGGTGTCAACTTTGTTGCTAGTAAATAG |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 334 |
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Protein Molecular Weight | 35649.60156 |
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Protein Theoretical pI | 8.96 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Malate dehydrogenase, mitochondrial
MLSRVAKRAFSSTVANPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATD
LSHIPTNSVVKGFTPEEPDGLNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLA
AATAESAPNAAILVISNPVNSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFISEVE
NTDPTQERVNVIGGHSGITIIPLISQTNHKLMSDDKRHELIHRIQFGGDEVVKAKNGAGS
ATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIEFFASPVTLGPDGIEKIH
PIGELSSEEEEMLQKCKETLKKNIEKGVNFVASK |
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References |
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External Links | |
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General Reference | - Thompson, L. M., Sutherland, P., Steffan, J. S., McAlister-Henn, L. (1988). "Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae." Biochemistry 27:8393-8400.3072021
- Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
- Kopetzki, E., Entian, K. D., Lottspeich, F., Mecke, D. (1987). "Purification procedure and N-terminal amino acid sequence of yeast malate dehydrogenase isoenzymes." Biochim Biophys Acta 912:398-403.3552052
- Grandier-Vazeille, X., Bathany, K., Chaignepain, S., Camougrand, N., Manon, S., Schmitter, J. M. (2001). "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex." Biochemistry 40:9758-9769.11502169
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666
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