Eukaryotic peptide chain release factor GTP-binding subunit (P05453)

Identification
NameEukaryotic peptide chain release factor GTP-binding subunit
Synonyms
  • ERF-3
  • ERF2
  • G1 to S phase transition protein 1
  • Omnipotent suppressor protein 2
  • PSI no more protein 2
  • Polypeptide release factor 3
  • Translation release factor 3
  • ERF3
Gene NameSUP35
Enzyme ClassNot Available
Biological Properties
General Functiontranslational termination
Specific FunctionInvolved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.
Cellular LocationNot Available
SMPDB Pathways
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sulfur metabolismec00920 Map00920
SMPDB Reactions
Adenosine triphosphate + hydron + Sulfate → Adenosine phosphosulfate + Pyrophosphate
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00005SulfateShow
YMDB00109Adenosine triphosphateShow
YMDB00219PyrophosphateShow
YMDB00256Adenosine phosphosulfateShow
YMDB00862hydronShow
GO Classification
Function
cytosol
cytoplasmic stress granule
translation release factor complex
GTP binding
GTPase activity
translation release factor activity
cytoplasmic translational termination
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
translational termination
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2058 bp ATGTCGGATTCAAACCAAGGCAACAATCAGCAAAACTACCAGCAATACAGCCAGAACGGT AACCAACAACAAGGTAACAACAGATACCAAGGTTATCAAGCTTACAATGCTCAAGCCCAA CCTGCAGGTGGGTACTACCAAAATTACCAAGGTTATTCTGGGTACCAACAAGGTGGCTAT CAACAGTACAATCCCGACGCCGGTTACCAGCAACAGTATAATCCTCAAGGAGGCTATCAA CAGTACAATCCTCAAGGCGGTTATCAGCAGCAATTCAATCCACAAGGTGGCCGTGGAAAT TACAAAAACTTCAACTACAATAACAATTTGCAAGGATATCAAGCTGGTTTCCAACCACAG TCTCAAGGTATGTCTTTGAACGACTTTCAAAAGCAACAAAAGCAGGCCGCTCCCAAACCA AAGAAGACTTTGAAGCTTGTCTCCAGTTCCGGTATCAAGTTGGCCAATGCTACCAAGAAG GTTGGCACAAAACCTGCCGAATCTGATAAGAAAGAGGAAGAGAAGTCTGCTGAAACCAAA GAACCAACTAAAGAGCCAACAAAGGTCGAAGAACCAGTTAAAAAGGAGGAGAAACCAGTC CAGACTGAAGAAAAGACGGAGGAAAAATCGGAACTTCCAAAGGTAGAAGACCTTAAAATC TCTGAATCAACACATAATACCAACAATGCCAATGTTACCAGTGCTGATGCCTTGATCAAG GAACAGGAAGAAGAAGTGGATGACGAAGTTGTTAACGATATGTTTGGTGGTAAAGATCAC GTTTCTTTAATTTTCATGGGTCATGTTGATGCCGGTAAATCTACTATGGGTGGTAATCTA CTATACTTGACTGGCTCTGTGGATAAGAGAACTATTGAGAAATATGAAAGAGAAGCCAAG GATGCAGGCAGACAAGGTTGGTACTTGTCATGGGTCATGGATACCAACAAAGAAGAAAGA AATGATGGTAAGACTATCGAAGTTGGTAAGGCCTACTTTGAAACTGAAAAAAGGCGTTAT ACCATATTGGATGCTCCTGGTCATAAAATGTACGTTTCCGAGATGATCGGTGGTGCTTCT CAAGCTGATGTTGGTGTTTTGGTCATTTCCGCCAGAAAGGGTGAGTACGAAACCGGTTTT GAGAGAGGTGGTCAAACTCGTGAACACGCCCTATTGGCCAAGACCCAAGGTGTTAATAAG ATGGTTGTCGTCGTAAATAAGATGGATGACCCAACCGTTAACTGGTCTAAGGAACGTTAC GACCAATGTGTGAGTAATGTCAGCAATTTCTTGAGAGCAATTGGTTACAACATTAAGACA GACGTTGTATTTATGCCAGTATCCGGCTACAGTGGTGCAAATTTGAAAGATCACGTAGAT CCAAAAGAATGCCCATGGTACACCGGCCCAACTCTGTTAGAATATCTGGATACAATGAAC CACGTCGACCGTCACATCAATGCTCCATTCATGTTGCCTATTGCCGCTAAGATGAAGGAT CTAGGTACCATCGTTGAAGGTAAAATTGAATCCGGTCATATCAAAAAGGGTCAATCCACC CTACTGATGCCTAACAAAACCGCTGTGGAAATTCAAAATATTTACAACGAAACTGAAAAT GAAGTTGATATGGCTATGTGTGGTGAGCAAGTTAAACTAAGAATCAAAGGTGTTGAAGAA GAAGACATTTCACCAGGTTTTGTACTAACATCGCCAAAGAACCCTATCAAGAGTGTTACC AAGTTTGTAGCTCAAATTGCTATTGTAGAATTAAAATCTATCATAGCAGCCGGTTTTTCA TGTGTTATGCATGTTCATACAGCAATTGAAGAGGTACATATTGTTAAGTTATTGCACAAA TTAGAAAAGGGTACCAACCGTAAGTCAAAGAAACCACCTGCTTTTGCTAAGAAGGGTATG AAGGTCATCGCTGTTTTAGAAACTGAAGCTCCAGTTTGTGTGGAAACTTACCAAGATTAC CCTCAATTAGGTAGATTCACTTTGAGAGATCAAGGTACCACAATAGCAATTGGTAAAATT GTTAAAATTGCCGAGTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues685
Protein Molecular Weight76550.76
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Eukaryotic peptide chain release factor GTP-binding subunit MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGY QQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQ SQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVGTKPAESDKKEEEKSAETK EPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIK EQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAK DAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGAS QADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERY DQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMN HVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETEN EVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFS CVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDY PQLGRFTLRDQGTTIAIGKIVKIAE
References
External Links
ResourceLink
Saccharomyces Genome Database SUP35
Uniprot IDP05453
Uniprot NameSUP35
PDB ID
1YJO
General ReferenceNot Available