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Identification |
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Name | 6-phosphofructo-2-kinase 2 |
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Synonyms | - 6PF-2-K 2
- Phosphofructokinase 2 II
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Gene Name | PFK27 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in catalytic activity |
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Specific Function | Synthesis of fructose 2,6-bisphosphate |
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Cellular Location | Not Available |
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SMPDB Pathways | |
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KEGG Pathways | Fructose and mannose metabolism | ec00051 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00011 | D-Fructose 2,6-bisphosphate | Show | YMDB00078 | Fructose 6-phosphate | Show | YMDB00109 | Adenosine triphosphate | Show | YMDB00862 | hydron | Show | YMDB00914 | ADP | Show | YMDB16262 | β-D-fructofuranose 6-phosphate | Show |
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GO Classification | Component |
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Not Available | Function |
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catalytic activity | phosphofructokinase activity | transferase activity | 6-phosphofructo-2-kinase activity | transferase activity, transferring phosphorus-containing groups | binding | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | adenyl ribonucleotide binding | ATP binding | phosphotransferase activity, alcohol group as acceptor | Process |
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hexose metabolic process | metabolic process | fructose metabolic process | fructose 2,6-bisphosphate metabolic process | small molecule metabolic process | alcohol metabolic process | monosaccharide metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 15 |
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Locus | YOL136C |
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Gene Sequence | >1194 bp
ATGGGTGGTTCTTCCGATTCAGACTCTCACGATGGATATTTGACTTCCGAATATAATTCC
TCGAATTCTCTTTTTTCACTTAACACCGGTAACAGCTATTCAAGCGCATCTCTCGACAGA
GCCACTTTAGATTGTCAAGATTCTGTTTTTTTCGATAATCACAAAAGTTCACTGCTGTCT
ACAGAGGTCCCAAGGTTTATTTCTAACGACCCGTTACACTTACCCATTACACTGAATTAC
AAAAGAGATAATGCAGACCCTACGTATACAAATGGAAAAGTTAACAAGTTTATGATTGTT
TTGATTGGGCTACCAGCTACTGGGAAGTCTACCATTTCTTCTCATTTAATTCAATGTTTG
AAGAACAATCCACTAACTAATTCATTACGCTGTAAAGTTTTTAATGCTGGTAAGATAAGA
AGGCAAATCAGTTGTGCTACCATTTCAAAGCCTTTGCTTTTGTCGAATACATCTTCGGAA
GACTTATTTAATCCGAAAAATAACGATAAAAAGGAAACGTATGCCAGGATCACTTTGCAA
AAGTTGTTTCACGAAATCAACAACGATGAATGTGACGTGGGAATCTTCGACGCCACAAAT
TCGACCATCGAAAGAAGAAGATTTATATTTGAGGAGGTTTGTTCGTTCAATACAGATGAG
CTTTCTAGTTTCAATTTGGTGCCCATAATCTTACAGGTGTCATGTTTTAACAGAAGCTTT
ATCAAATACAATATCCACAATAAATCGTTTAATGAAGACTACTTAGACAAACCTTATGAA
CTTGCCATCAAAGATTTTGCAAAGAGATTAAAACATTACTATTCGCAGTTTACACCTTTC
TCCCTTGATGAGTTCAATCAAATCCATCGATATATCAGCCAACATGAAGAAATCGATACG
AGCTTATTTTTCTTCAATGTTATCAATGCGGGCGTCGTTGAGCCACATTCTTTAAATCAA
AGTCATTACCCTTCGACCTGTGGCAAGCAAATTAGGGACACCATTATGGTTATTGAAAAT
TTCATCAATCACTATTCTCAGATGTTTGGTTTTGAATACATCGAAGCTGTTAAATTGTTT
TTTGAAAGTTTTGGAAATAGCTCAGAGGAAACTTTAACTACACTAGACTCTGTTGTTAAT
GATAAATTTTTTGATGATTTGCAGAGCCTAATTGAAAGCAACGGATTTGCTTGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 397 |
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Protein Molecular Weight | 45317.10156 |
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Protein Theoretical pI | 5.4 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >6-phosphofructo-2-kinase 2
MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLS
TEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCL
KNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQ
KLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSF
IKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDT
SLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLF
FESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA |
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References |
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External Links | |
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General Reference | - Boles, E., Gohlmann, H. W., Zimmermann, F. K. (1996). "Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate." Mol Microbiol 20:65-76.8861205
- Aldea, M., Piedrafita, L., Casas, C., Casamayor, A., Khalid, H., Balcells, L., Arino, J., Herrero, E. (1996). "Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames." Yeast 12:1053-1058.8896270
- Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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