{"ymdb_id":"YMDB00011","created_at":"2011-05-29T15:48:14.000Z","updated_at":"2016-10-18T17:11:14.000Z","name":"D-Fructose 2,6-bisphosphate","cas":null,"state":"Solid","melting_point":"","description":"D-Fructose 2,6-bisphosphate is a regulatory molecule controlling the activity of the phosphofructokinase-1 (PFK1) which is the key regulatory enzyme of glycolysis.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Shulman, Hagit; Makarov, Carina; Ogawa, Anthony K.; Romesberg, Floyd; Keinan, Ehud. Chemically Reactive Immunogens Lead to Functional Convergence of the Immune Response. Journal of the American Chemical Society (2000), 122(44), 10743-10753.","chebi_id":"28602","hmdb_id":"HMDB01047","kegg_id":"C00665","pubchem_id":"105021","cs_id":"24534245","foodb_id":null,"wikipedia_link":"Fructose_2,6-bisphosphate","biocyc_id":"CPD-535","iupac":"{[(2R,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)-5-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"fructose-2,6-diphosphate","logp":"-3.0051313806666666","pka":"1.3703815262407373","alogps_solubility":"1.58e+01 g/l","alogps_logp":"-1.50","alogps_logs":"-1.33","acceptor_count":"10","donor_count":"7","rotatable_bond_count":"6","polar_surface_area":"203.43999999999997","refractivity":"58.1066","polarizability":"25.243417387291053","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"-3.4678657648404636","pka_strongest_acidic":"0.6839676218192321","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2,6-Di-O-phosphono-b-D-fructofuranose","2,6-Di-O-phosphono-beta-D-fructofuranose","2,6-Di-O-phosphono-β-D-fructofuranose","b-D-fructose 2,6-bisphosphate","beta-D-fructose 2,6-bisphosphate","D-Fructose 2,6-bisphosphate","D-Fructose 2,6-bisphosphic acid","D-Fructose 2,6-bisphosphoric acid","Fru 2,6-P2, Fructose 2,6-diphosphate","Fructose 2,6-biphosphate","fructose 2,6-bisphosphate","Fructose 2,6-diphosphate","Phosphofructokinase activation factor","Phosphofructokinase activator"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"growth_conditions":[{"growth_media":"Synthetic medium with 2% glucose","concentration":"1200.0","concentration_units":"\u0026#181;M","error":"200.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"360.0","concentration_units":"\u0026#181;M","error":"1.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"510.0","concentration_units":"\u0026#181;M","error":"20.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"1700.0","concentration_units":"\u0026#181;M","error":"200.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":2831055,"citation":"Francois, J., Van Schaftigen, E., Hers, H. G. (1988). \"Characterization of phosphofructokinase 2 and of enzymes involved in the degradation of fructose 2,6-bisphosphate in yeast.\" Eur J Biochem 171:599-608."},{"pubmed_id":2825652,"citation":"Kretschmer, M., Schellenberger, W., Otto, A., Kessler, R., Hofmann, E. (1987). \"Fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase are separable in yeast.\" Biochem J 246:755-759."},{"pubmed_id":9746941,"citation":"Goncalves, P., Planta, R. J. (1998). \"Starting up yeast glycolysis.\" Trends Microbiol 6:314-319."},{"pubmed_id":7878741,"citation":"Thevelein, J. M., Hohmann, S. (1995). \"Trehalose synthase: guard to the gate of glycolysis in yeast?\" Trends Biochem Sci 20:3-10."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."}],"proteins":[{"created_at":"2011-05-24T19:56:05.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Fructose-2,6-bisphosphatase","uniprot_id":"P32604","uniprot_name":"F26_YEAST","enzyme":true,"transporter":false,"gene_name":"FBP26","num_residues":452,"molecular_weight":"52594.5","theoretical_pi":"6.8","general_function":"Involved in catalytic activity","specific_function":"This is predominantly if not solely a fructose-2,6- bisphosphatase","reactions":[{"id":1550,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2283,"direction":"\u003e","locations":"Cytoplasm","altext":"Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006337","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"S42124","genbank_protein_id":"253335","gene_card_id":"FBP26","chromosome_location":"chromosome 10","locus":"YJL155C","synonyms":[],"enzyme_classes":["3.1.3.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" 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metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGGTACAGTACTATTTCCAACGATAATGATATCAAAGTATGTGTGATAATGGTTGGCCTACCAGCTAGAGGAAAGTCTTTTATTTCCCAAAAAATTATCAGGTACTTATCGTGGTTATCCATAAAAGCCAAGTGTTTTAATGTGGGAAATTACAGAAGAGACGTGAGTGGAAATGTCCCAATGGATGCTGAGTTTTTTAACTTCGAAAATACAGATAATTTTAAACTCAGAGAATTGGCTGCCCAAAATGCCATAAAAGATATTGTTAATTTTTTTACTAAAGAAGACGGATCTGTGGCAGTTTTCGATGCTACTAATAGTACACGTAAAAGAAGGAAATGGCTTAAAGATATATGTGAAAAGAATAATATTCAACCGATGTTTTTAGAGAGCTGGAGTAACGATCATGAACTGATTATAAATAACGCTAAGGATATCGGTAGCACATCTCCTGATTATGAAAACTCTGAACCTCATGTGGCGGAAGCTGATTTTTTGGAAAGAATTAGACAATATGAAAGATTTTATGAACCTTTGGACCCCCAAAAAGATAAGGATATGACGTTCATTAAGTTGGTCAATATTATTGAACAAGTAGTAATTAATAAGATCAGAACATATTTGGAAAGTAGGATTGTATTTTATGTTATGAATATTCGTCCTAAACCAAAATATATCTGGCTCTCCCGTCACGGCGAATCGATCTATAACGTAGAGAAAAAAATTGGCGGGGATTCATCACTGTCTGAAAGAGGCTTTCAGTACGCTAAAAAATTGGAGCAGTTAGTGAAAGAGAGCGCAGGAGAAATAAATTTGACCGTGTGGACTTCCACCTTAAAAAGAACACAACAAACGGCAAATTATCTTCCCTATAAGAAACTGCAATGGAAAGCACTTGATGAATTAGACGCTGGCGTTTGTGACGGAATGACGTATGAGGAAATTGAAAAAGAATATCCTGAAGATTTTAAAGCACGTGATAATGACAAATACGAGTACAGATATCGTGGTGGAGAATCATACAGAGATGTAGTGATTCGTTTAGAGCCCGTCATTATGGAATTGGAGCGCCAAGAAAATGAACTCATTATAACTCATCAAGCCGTACTTCGGTGTATATATGCATATTTTATGAACGTTCCACAGGAGGAATCCCCTTGGATGTCAATCCCACTACACACATTGATCAAGCTGGAGCCTAGGGCCTATGGCACAAAGGTCACCAAAATTAAAGCAAACATCCCTGCAGTGAGTACATATAAAGAGAAGGGTACAAGCCAAGTAGGTGAGCTTTCTCAAAGCTCAACTAAACTTCATCAACTGCTCAATGACTCTCCTTTCCAAGACAAATTTTAA","protein_sequence":"MGYSTISNDNDIKVCVIMVGLPARGKSFISQKIIRYLSWLSIKAKCFNVGNYRRDVSGNVPMDAEFFNFENTDNFKLRELAAQNAIKDIVNFFTKEDGSVAVFDATNSTRKRRKWLKDICEKNNIQPMFLESWSNDHELIINNAKDIGSTSPDYENSEPHVAEADFLERIRQYERFYEPLDPQKDKDMTFIKLVNIIEEVVINKIRTYLESRIVFYVMNIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESAGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIKANIPAVSTYKEKGTSQVGELSQSSTKLHQLLNDSPLEDKF"},{"created_at":"2011-05-24T19:56:36.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"6-phosphofructo-2-kinase 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Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGTGGTTCTTCCGATTCAGACTCTCACGATGGATATTTGACTTCCGAATATAATTCCTCGAATTCTCTTTTTTCACTTAACACCGGTAACAGCTATTCAAGCGCATCTCTCGACAGAGCCACTTTAGATTGTCAAGATTCTGTTTTTTTCGATAATCACAAAAGTTCACTGCTGTCTACAGAGGTCCCAAGGTTTATTTCTAACGACCCGTTACACTTACCCATTACACTGAATTACAAAAGAGATAATGCAGACCCTACGTATACAAATGGAAAAGTTAACAAGTTTATGATTGTTTTGATTGGGCTACCAGCTACTGGGAAGTCTACCATTTCTTCTCATTTAATTCAATGTTTGAAGAACAATCCACTAACTAATTCATTACGCTGTAAAGTTTTTAATGCTGGTAAGATAAGAAGGCAAATCAGTTGTGCTACCATTTCAAAGCCTTTGCTTTTGTCGAATACATCTTCGGAAGACTTATTTAATCCGAAAAATAACGATAAAAAGGAAACGTATGCCAGGATCACTTTGCAAAAGTTGTTTCACGAAATCAACAACGATGAATGTGACGTGGGAATCTTCGACGCCACAAATTCGACCATCGAAAGAAGAAGATTTATATTTGAGGAGGTTTGTTCGTTCAATACAGATGAGCTTTCTAGTTTCAATTTGGTGCCCATAATCTTACAGGTGTCATGTTTTAACAGAAGCTTTATCAAATACAATATCCACAATAAATCGTTTAATGAAGACTACTTAGACAAACCTTATGAACTTGCCATCAAAGATTTTGCAAAGAGATTAAAACATTACTATTCGCAGTTTACACCTTTCTCCCTTGATGAGTTCAATCAAATCCATCGATATATCAGCCAACATGAAGAAATCGATACGAGCTTATTTTTCTTCAATGTTATCAATGCGGGCGTCGTTGAGCCACATTCTTTAAATCAAAGTCATTACCCTTCGACCTGTGGCAAGCAAATTAGGGACACCATTATGGTTATTGAAAATTTCATCAATCACTATTCTCAGATGTTTGGTTTTGAATACATCGAAGCTGTTAAATTGTTTTTTGAAAGTTTTGGAAATAGCTCAGAGGAAACTTTAACTACACTAGACTCTGTTGTTAATGATAAATTTTTTGATGATTTGCAGAGCCTAATTGAAAGCAACGGATTTGCTTGA","protein_sequence":"MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCLKNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQKLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSFIKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDTSLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLFFESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA"},{"created_at":"2011-05-24T19:57:09.000Z","updated_at":"2011-05-24T19:57:09.000Z","name":"Putative 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W","uniprot_id":"Q06137","uniprot_name":"YL345_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":509,"molecular_weight":"58385.19922","theoretical_pi":"6.4","general_function":"Involved in catalytic activity","specific_function":"Synthesis and degradation of fructose 2,6-bisphosphate","reactions":[{"id":2283,"direction":"\u003e","locations":"Cytoplasm","altext":"Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19028","genbank_protein_id":"609382","gene_card_id":null,"chromosome_location":null,"locus":"YLR345W","synonyms":["6-phosphofructo-2-kinase","Fructose-2,6-bisphosphatase"],"enzyme_classes":["2.7.1.105","3.1.3.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"},{"name":"PGAM","identifier":"PF00300"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"}],"gene_sequence":"ATGCCAAATGTGCTTTCTGATGATGAAGAGCTCCTTAATGGACTAGGAAGTGAGATTATGAAACCCTCTAGACAAGGTAACCATATGGCAAGGACCGTCAAAAGGTGGGTAAATAAAGAACGTGCTACCACAGCCGATCTGAAAAATGTTAATATTGATGGAGTTCATGGACCGGTAAATACCGAAAGTTATATATCACCAGGACAGCTTTACTCCACTGACTCGGGCAATTTATTTCATGCTGGAAGAATCCTTGTCGTTCTAGTCGGTCTTCCAGCAACATCAAAGACACTATTGTCAGTAGCGATTACAAGATATACAAGATGGTTAGGAGTTAGGACGAAATCGTTCCATTTTTCAGAATATAAAGAATCAGCTAAAAATATACCCTCAGACTATTTTTGCGTAGTGCCAACGTCAAAAGAAGGTGTAGCGTTTGTTGAAAAGCTTCGCATGCAGATGTTGAATGATATACTGGCATTTTTCAACGACTTGTCAGGTCAGCTGGCCATTTATGATGCCCTAAACATCCGTAAAATTGACAGAAAGAATTTGGAGACAACGTTTTCTGAAATTGGAGTTAAAGTACTCTTCATAGAATCAATCGTGTCTGATCAAGAAATCATGAATAGAAACATAGCTCTTGCACTGGAGTCGAACGATTACAAGGGACTTTCAACTGATGAAGCCATTGACGAATATATGAGACGTTTATCAGTGAACGAACCATACTATGAAATGATGACACATGACGAAGAATTATCGTACATTAAATATATAAATTTGGGAAAGCAGATAATTGTGAAAGATAACATACATGGTTATTTGGTCAACAAAATAGTATTTTTCTTAATGAATTTGAGGCAGAAAAAGGGGTGTGTATATTTTGCTCGCTGTGGCACCAGCGATAAAGACAACTACATACATGATGAGGAACTAAACGAGGAGGGAATCCATTACTCTCAAGTTCTCAAGGATTTTGTCCTCCAACGAATTAAACAGAAGAGACAGGCCAAAAAAAATTCGGATTCCTTAGTCGAAGTAATAGATGGAAGTCATGATGAAGATTTGAAGACTTCCTTGATAGTTTGGACAGGTCCCAGGAAAAGAACCCACGATACTGCACTCTTTTTTTCAAAAGAAGGTATTAAAGTTCAGCAACGGTCAGAGTTGAGACAGTTGAACCCAGGAAGTATTGCTGATCTTACTGATCAACAGATAATGGACAAATTTCCATCAGAATATAAAGAATCATTAAAAGACCCATATCATTTTCGATTCCCTAGGGCGGAATCTTACCATGACTTAGCCGTTCGTATGGAACCTTTACTATTAGAAATGGAGCATACGAGCAAGGACATTCTCATCATTGCACATGAGTCAACATTAAGAGTATTATATGGCTATTTAATGGCTTGCACCTGCGTAGAGTTACCAAATCTAAATTTCACAAGAGACAAATTAGTTGAAATTTCATTCAGCCCTTTCTGTAATACTGTAGAGTTACTGAACATTCCTTTAACTAGCTAA","protein_sequence":"MPNVLSDDEELLNGLGSEIMKPSRQGNHMARTVKRWVNKERATTADLKNVNIDGVHGPVNTESYISPGQLYSTDSGNLFHAGRILVVLVGLPATSKTLLSVAITRYTRWLGVRTKSFHFSEYKESAKNIPSDYFCVVPTSKEGVAFVEKLRMQMLNDILAFFNDLSGQLAIYDALNIRKIDRKNLETTFSEIGVKVLFIESIVSDQEIMNRNIALALESNDYKGLSTDEAIDEYMRRLSVNEPYYEMMTHDEELSYIKYINLGKQIIVKDNIHGYLVNKIVFFLMNLRQKKGCVYFARCGTSDKDNYIHDEELNEEGIHYSQVLKDFVLQRIKQKRQAKKNSDSLVEVIDGSHDEDLKTSLIVWTGPRKRTHDTALFFSKEGIKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHTSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCNTVELLNIPLTS"},{"created_at":"2011-05-24T19:57:42.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"6-phosphofructo-2-kinase 1","uniprot_id":"P40433","uniprot_name":"6P21_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK26","num_residues":827,"molecular_weight":"93416.20313","theoretical_pi":"9.02","general_function":"Involved in catalytic activity","specific_function":"Synthesis of fructose 2,6-bisphosphate","reactions":[{"id":1223,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006336","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692819","genbank_protein_id":"51013089","gene_card_id":"PFK26","chromosome_location":"chromosome 9","locus":"YIL107C","synonyms":["6PF-2-K 1","Phosphofructokinase 2 I"],"enzyme_classes":["2.7.1.105"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"},{"name":"PGAM","identifier":"PF00300"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTCAAACCAGTAGACTTCTCTGAAACATCTCCTGTGCCGCCTGATATTGATCTTGCTCCTACACAATCTCCACACCATGTGGCACCTAGTCAAGACTCCAGTTATGATCTTTTATCCCGGAGTTCCGATGATAAAATTGATGCTGAAAAGGGTCCGCATGATGAATTATCTAAGCACTTACCACTTTTTCAGAAAAGACCTTTGAGCGATACTCCTATATCGAGCAATTGGAACTCTCCTGGAATCACTGAAGAAAATACACCTTCTGACTCTCCTGAAAATAGCGCTACTAATTTGAAATCGCTACATCGATTGCATATTAACGACGAAACGCAACTAAAAAATGCTAAAATTCCCACAAACGATACTACTGACTACATGCCTCCTTCAGATGGAGCAAATGAGGTAACTCGGATTGATTTGAAAGACATTAAATCACCTACGAGACACCATAAAAGAAGACCTACCACCATCGATGTTCCTGGTTTAACAAAGTCTAAAACATCTCCAGATGGTCTCATATCAAAGGAAGATAGTGGATCAAAGTTAGTGATTGTCATGGTCGGACTGCCAGCTACGGGAAAGTCATTTATTACAAATAAATTATCCAGATTTTTAAATTATTCTTTATACTATTGTAAAGTGTTTAATGTCGGTAACACTAGAAGGAAGTTTGCTAAGGAGCATGGCCTAAAGGACCAGGATTCAAAGTTTTTCGAGCCGAAAAACGCCGACTCTACTAGGTTGAGAGACAAATGGGCCATGGATACTCTGGATGAATTGCTAGATTATTTATTAGAAGGTTCAGGATCTGTGGGAATTTTTGATGCTACAAATACCTCTCGTGAAAGAAGAAAAAACGTTCTGGCTAGAATCAGAAAGAGAAGTCCTCATTTGAAGGTTTTATTTTTAGAATCTGTTTGTTCGGATCATGCACTGGTACAGAAAAATATTAGACTCAAATTATTTGGTCCAGATTACAAAGGTAAAGATCCTGAAAGCTCTTTAAAAGATTTTAAAAGTCGCCTGGCAAACTACTTGAAAGCCTATGAACCAATTGAGGATGACGAAAATTTGCAGTACATCAAAATGATAGATGTGGGAAAGAAAGTCATCGCATACAATATTCAAGGGTTTTTAGCTTCGCAGACGGTATATTATTTATTAAATTTCAATTTGGCTGACAGACAAATTTGGATAACGAGAAGTGGCGAGAGCGAAGATAATGTTAGTGGCCGTATAGGCGGAAATTCCCATTTGACTCCTCGTGGTCTAAGATTTGCTAAAAGTCTACCAAAATTCATTGCCAGACAGAGAGAAATATTTTATCAAAATCTCATGCAACAAAAAAAGAATAATGAAAATACAGATGGGAACATTTATAATGACTTTTTCGTTTGGACCAGCATGCGTGCTAGGACTATAGGGACTGCTCAATATTTCAACGAAGATGATTATCCTATCAAACAAATGAAAATGTTAGATGAGTTAAGTGCAGGTGATTATGATGGTATGACATATCCAGAAATTAAAAACAACTTTCCTGAAGAATTCGAAAAAAGACAGAAAGATAAGTTGAGATACAGATACCCTGGTATTGGCGGTGAATCGTATATGGACGTTATTAATAGACTCAGACCTGTTATCACAGAACTAGAAAGAATCGAGGATAACGTTCTTATTATTACACACCGGGTGGTGGCAAGAGCCTTATTGGGTTATTTTATGAACTTGAGTATGGGTATTATTGCCAATTTGGATGTCCCATTACATTGTGTATATTGCCTAGAACCAAAACCATATGGAATCACTTGGTCATTATGGGAGTATGATGAAGCATCGGATTCATTTTCTAAGGTCCCACAAACGGACTTGAATACCACCAGAGTAAAGGAGGTTGGCCTTGTTTATAATGAAAGAAGATATTCTGTTATACCAACAGCTCCGCCAAGTGCAAGAAGCAGCTTTGCAAGTGACTTTTTGTCAAGAAAAAGATCTAATCCTACTTCTGCATCTTCATCCCAGAGTGAATTATCAGAACAACCCAAGAATAGCGTTAGTGCTCAAACTGGCAGCAATAATACCACTCTCATTGGGAGCAACTTTAACATCAAGAATGAAAATGGTGATTCGAGAATACCATTATCTGCACCACTTATGGCCACTAATACTTCTAATAACATCTTAGATGGTGGAGGTACCTCAATTTCGATACATCGTCCCAGGGTTGTTCCAAATCAAAACAACGTGAATCCCCTTTTGGCTAACAACAATAAAGCGGCTTCTAATGTACCTAATGTAAAGAAGTCAGCGGCTACACCAAGGCAAATTTTTGAAATAGATAAAGTGGACGAAAAGTTATCCATGTTGAAAAATAAAAGTTTTCTATTACATGGAAAGGATTATCCTAATAATGCTGATAATAATGACAACGAAGATATAAGGGCAAAAACCATGAATCGCAGCCAAAGTCACGTTTAA","protein_sequence":"MFKPVDFSETSPVPPDIDLAPTQSPHHVAPSQDSSYDLLSRSSDDKIDAEKGPHDELSKHLPLFQKRPLSDTPISSNWNSPGITEENTPSDSPENSATNLKSLHRLHINDETQLKNAKIPTNDTTDYMPPSDGANEVTRIDLKDIKSPTRHHKRRPTTIDVPGLTKSKTSPDGLISKEDSGSKLVIVMVGLPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFAKEHGLKDQDSKFFEPKNADSTRLRDKWAMDTLDELLDYLLEGSGSVGIFDATNTSRERRKNVLARIRKRSPHLKVLFLESVCSDHALVQKNIRLKLFGPDYKGKDPESSLKDFKSRLANYLKAYEPIEDDENLQYIKMIDVGKKVIAYNIQGFLASQTVYYLLNFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFYQNLMQQKKNNENTDGNIYNDFFVWTSMRARTIGTAQYFNEDDYPIKQMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGIGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEVGLVYNERRYSVIPTAPPSARSSFASDFLSRKRSNPTSASSSQSELSEQPKNSVSAQTGSNNTTLIGSNFNIKNENGDSRIPLSAPLMATNTSNNILDGGGTSISIHRPRVVPNQNNVNPLLANNNKAASNVPNVKKSAATPRQIFEIDKVDEKLSMLKNKSFLLHGKDYPNNADNNDNEDIRAKTMNRSQSHV"},{"created_at":"2011-05-26T23:22:21.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Repressible alkaline phosphatase","uniprot_id":"P11491","uniprot_name":"PPB_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO8","num_residues":566,"molecular_weight":"63003.60156","theoretical_pi":"5.33","general_function":"Involved in catalytic activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1309,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2613,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"(2E,6E)-farnesyl diphosphate + H(2)O = (2E,6E)-farnesol + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2614,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"34-59","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass membrane protein (Potential).","genbank_gene_id":"M21134","genbank_protein_id":"172164","gene_card_id":"PHO8","chromosome_location":"chromosome 4","locus":"YDR481C","synonyms":[],"enzyme_classes":["3.1.3.1","3.1.7.6","3.1.3.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Alk_phosphatase","identifier":"PF00245"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGATGACTCACAGATTACCAAGCGAACAGACACGTCTTGTTCCTGGATCTGACTCGAGCTCTCGTCCTAAAAAGAGACGGATCTCGAAGAGATCGAAGATAATAGTATCCACTGTGGTCTGTATTGGTTTGTTGCTGGTTTTAGTGCAACTGGCATTTCCAACCAGTTTTGCTATACGTTCTGCATCACACAAGAAGAAGAATGTCATATTCTTCGTGACGGATGGAATGGGACCTGCGTCTTTGTCCATGGCAAGATCATTCAACCAGCACGTTAATGATCTACCTATAGACGACATCCTGACACTTGACGAGCATTTTATCGGGTCTTCGAGAACAAGGTCCTCGGACTCACTAGTCACTGACTCAGCTGCGGGCGCCACCGCATTTGCATCTGCATTAAAGAGCTATAATGGGGCCATCGGCGTTGATCCGCATCACAGACCTTGTGGTACAGTGCTCGAGGCGGCTAAGTTAGCAGGTTATCTCACTGGGCTTGTTGTTACGACAAGAATCACAGATGCCACTCCGGCTTCATTCAGTTCACATGTTGATTACAGATGGCAGGAAGATCTTATTGCTACGCACCAGTTAGGCGAATATCCTCTGGGGAGAGTAGTAGACTTACTCATGGGTGGCGGCAGGAGCCATTTCTACCCTCAAGGCGAAAAGGCTTCTCCATATGGTCACCACGGTGCTAGAAAAGATGGAAGAGATTTAATCGATGAGGCTCAATCTAATGGCTGGCAGTACGTGGGTGACCGTAAAAATTTTGATTCTTTGTTGAAAAGCCACGGTGAAAACGTTACTTTTCCTTTCTTGGGTCTCTTTGCAGATAACGACATTCCTTTTGAAATTGACAGAGATGAAAAGGAGTATCCTTCTCTTAAGGAACAAGTCAAGGTGGCTTTGGGTGCCTTGGAAAAAGCTTCCAATGAGGACAAAGATTCTAATGGGTTTTTCTTAATGGTGGAAGGCTCCAGAATTGACCACGCTGGTCACCAAAACGATCCAGCTTCACAGGTAAGGGAGGTGTTGGCTTTCGATGAAGCATTCCAATACGTTTTGGAGTTTGCTGAAAATTCCGATACGGAGACTGTTTTGGTCTCTACGTCGGATCATGAAACGGGTGGTTTAGTCACTTCAAGACAAGTCACTGCTAGCTATCCTCAGTATGTCTGGTATCCACAGGTGCTTGCCAACGCCACCCATTCAGGTGAGTTTTTGAAAAGAAAACTAGTAGATTTTGTTCATGAACATAAGGGCGCAAGCAGCAAAATAGAAAATTTCATCAAACATGAGATCCTGGAAAAGGATTTGGGCATTTACGATTACACGGAAAGTGATTTAGAAACATTAATTCATTTGGATGACAACGCAAATGCTATCCAAGACAAACTGAATGACATGGTATCATTTAGGGCCCAAATTGGCTGGACCACGCATGGTCACAGCGCAGTCGACGTCAACATATATGCATACGCCAATAAGAAAGCTACATGGTCATATGTCTTGAACAATTTACAAGGCAATCACGAAAATACGGAAGTTGGCCAGTTCTTAGAAAACTTTTTAGAATTGAACCTGAACGAAGTCACTGATTTGATTAGGGACACCAAACACACATCAGATTTTGATGCTACAGAAATAGCTAGTGAAGTACAACATTATGACGAATACTACCATGAGTTGACCAACTGA","protein_sequence":"MMTHTLPSEQTRLVPGSDSSSRPKKRRISKRSKIIVSTVVCIGLLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDEHFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRWQEDLIATHQLGEYPLGRVVDLLMGGGRSHFYPQGEKASPYGHHGARKDGRDLIDEAQSNGWQYVGDRKNFDSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKIENFIKHEILEKDLGIYDYTDSDLETLIHLDDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEVGQFLENFLELNLNEVTDLIRDTKHTSDFDATEIASEVQHYDEYYHELTN"}]}