Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (Q12001)

Identification
NameDolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Synonyms
  • Asparagine-linked glycosylation protein 6
  • Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
  • Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
Gene NameALG6
Enzyme ClassNot Available
Biological Properties
General Functionprotein N-linked glycosylation
Specific FunctionAdds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
Cellular LocationNot Available
SMPDB Pathways
N-Glycan biosynthesisPW002501 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
N-Glycan biosynthesisec00510 Map00510
SMPDB Reactions
(Mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol + Dolichyl b-D-glucosyl phosphate → Glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol + Dolichol phosphate + hydron
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00241Dolichyl b-D-glucosyl phosphateShow
YMDB00862hydronShow
YMDB00864Dolichol phosphateShow
YMDB16234Glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolicholShow
GO Classification
Function
integral component of membrane
endoplasmic reticulum membrane
endoplasmic reticulum
aerobic respiration
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
protein glycosylation
transferase activity, transferring hexosyl groups
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1635 bp ATGGCCATTGGCAAAAGGTTACTGGTGAACAAACCAGCAGAAGAATCATTTTATGCTTCT CCAATGTATGATTTTTTGTATCCGTTTAGGCCAGTGGGGAACCAATGGCTGCCAGAATAT ATTATCTTTGTATGTGCTGTAATACTGAGGTGCACAATTGGACTTGGTCCATATTCTGGG AAAGGCAGTCCACCGCTGTACGGCGATTTTGAGGCTCAGAGACATTGGATGGAAATTACG CAACATTTACCGCTTTCTAAGTGGTACTGGTATGATTTGCAATACTGGGGATTGGACTAT CCACCATTAACAGCATTTCATTCGTACCTTCTGGGCCTAATTGGATCTTTTTTCAATCCA TCTTGGTTTGCACTAGAAAAGTCACGTGGCTTTGAATCCCCCGATAATGGCCTGAAAACA TATATGCGTTCTACTGTCATCATTAGCGACATATTGTTTTACTTTCCTGCAGTAATATAC TTTACTAAGTGGCTTGGTAGATATCGAAACCAGTCGCCCATAGGACAATCTATTGCGGCA TCAGCGATTTTGTTCCAACCTTCATTAATGCTCATTGACCATGGGCACTTTCAATATAAT TCAGTCATGCTTGGCCTTACTGCTTATGCCATAAATAACTTATTAGATGAGTATTATGCT ATGGCGGCCGTTTGTTTTGTCCTATCCATTTGTTTTAAACAAATGGCATTGTATTATGCA CCGATTTTTTTTGCTTATCTATTAAGTCGATCATTGCTGTTCCCCAAATTTAACATAGCT AGATTGACGGTTATTGCGTTTGCAACACTCGCAACTTTTGCTATAATATTTGCGCCATTA TATTTCTTGGGAGGAGGATTAAAGAATATTCACCAATGTATTCACAGGATATTCCCTTTT GCCAGGGGCATCTTCGAAGACAAGGTTGCTAACTTCTGGTGCGTTACGAACGTGTTTGTA AAATACAAGGAAAGATTCACTATACAACAACTCCAGCTATATTCATTGATTGCCACCGTG ATTGGTTTCTTACCAGCCATGATAATGACATTACTTCATCCCAAAAAGCATCTTCTCCCA TACGTGTTAATCGCATGTTCGATGTCCTTTTTTCTTTTTAGCTTTCAAGTACATGAGAAA ACTATCCTCATCCCACTTTTGCCTATTACACTACTCTACTCCTCTACTGATTGGAATGTT CTATCTCTTGTAAGTTGGATAAACAATGTGGCTTTGTTTACGCTATGGCCTTTGTTGAAA AAGGACGGTCTTCATTTACAGTATGCCGTATCTTTCTTACTAAGCAATTGGCTGATTGGA AATTTCAGTTTTATTACACCAAGGTTCTTGCCAAAATCTTTAACTCCTGGCCCTTCTATC AGCAGCATCAATAGCGACTATAGAAGAAGAAGCTTACTGCCATATAATGTGGTTTGGAAA AGTTTTATCATAGGAACGTATATTGCTATGGGCTTTTATCATTTCTTAGATCAATTTGTA GCACCTCCATCGAAATATCCAGACTTGTGGGTGTTGTTGAACTGTGCTGTTGGGTTCATT TGCTTTAGCATATTTTGGCTATGGTCTTATTACAAGATATTCACTTCCGGTAGCAAATCC ATGAAGGACTTGTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues544
Protein Molecular Weight62782.275
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane Regions
  • 36-56
  • 105-125
  • 146-166
  • 172-192
  • 224-244
  • 264-284
  • 333-353
  • 357-377
  • 399-419
  • 426-446
  • 482-502
  • 509-529
Protein Sequence>Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase MAIGKRLLVNKPAEESFYASPMYDFLYPFRPVGNQWLPEYIIFVCAVILRCTIGLGPYSG KGSPPLYGDFEAQRHWMEITQHLPLSKWYWYDLQYWGLDYPPLTAFHSYLLGLIGSFFNP SWFALEKSRGFESPDNGLKTYMRSTVIISDILFYFPAVIYFTKWLGRYRNQSPIGQSIAA SAILFQPSLMLIDHGHFQYNSVMLGLTAYAINNLLDEYYAMAAVCFVLSICFKQMALYYA PIFFAYLLSRSLLFPKFNIARLTVIAFATLATFAIIFAPLYFLGGGLKNIHQCIHRIFPF ARGIFEDKVANFWCVTNVFVKYKERFTIQQLQLYSLIATVIGFLPAMIMTLLHPKKHLLP YVLIACSMSFFLFSFQVHEKTILIPLLPITLLYSSTDWNVLSLVSWINNVALFTLWPLLK KDGLHLQYAVSFLLSNWLIGNFSFITPRFLPKSLTPGPSISSINSDYRRRSLLPYNVVWK SFIIGTYIAMGFYHFLDQFVAPPSKYPDLWVLLNCAVGFICFSIFWLWSYYKIFTSGSKS MKDL
References
External Links
ResourceLink
Saccharomyces Genome Database ALG6
Uniprot IDQ12001
Uniprot NameALG6
General ReferenceNot Available