| Identification |
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| Name | Glycyl-tRNA synthetase 2 |
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| Synonyms | - Diadenosine tetraphosphate synthetase
- AP-4-A synthetase
- Glycine--tRNA ligase 2
- GlyRS 2
- GlyRS2
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| Gene Name | GRS2 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in nucleotide binding |
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| Specific Function | Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs |
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| Cellular Location | Cytoplasm |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00016 | Glycine | Show | | YMDB00097 | Adenosine monophosphate | Show | | YMDB00109 | Adenosine triphosphate | Show | | YMDB00219 | Pyrophosphate | Show |
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| GO Classification | | Component |
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| cell part | | intracellular part | | cytoplasm | | Function |
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| nucleoside binding | | purine nucleoside binding | | adenyl nucleotide binding | | glycine-tRNA ligase activity | | adenyl ribonucleotide binding | | ATP binding | | ligase activity, forming carbon-oxygen bonds | | ligase activity, forming aminoacyl-tRNA and related compounds | | catalytic activity | | aminoacyl-tRNA ligase activity | | nucleotide binding | | ligase activity | | binding | | Process |
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| cellular macromolecule biosynthetic process | | translation | | glycyl-tRNA aminoacylation | | metabolic process | | macromolecule metabolic process | | cellular macromolecule metabolic process | | RNA metabolic process | | ncRNA metabolic process | | biosynthetic process | | tRNA metabolic process | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | macromolecule biosynthetic process |
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| Gene Properties |
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| Chromosome Location | chromosome 16 |
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| Locus | YPR081C |
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| Gene Sequence | >1857 bp
ATGCCGTTAATGTCCAATTCGGAAAGAGATAAATTGGAAAGTACATTGAGGAGAAGGTTT
TTCTACACACCCTCGTTTGAGATATATGGTGGTGTGTCAGGTTTATTTGATTTAGGGCCT
CCGGGTTGTCAGTTGCAAAATAACTTGATTCGACTGTGGCGAGAACATTTTATTATGGAA
GAAAACATGCTTCAGGTTGATGGGCCAATGCTAACTCCTTACGATGTGTTGAAGACTTCT
GGGCATGTAGACAAATTTACTGATTGGATGTGCCGAAATCCTAAGACTGGGGAATACTAC
AGAGCAGACCATTTGATTGAACAGACGTTGAAAAAACGGCTGTTGGACAAGGATGTCAAT
CCACAGGATATGAAAAATATGGAGAAAATATTGACCACGATTGACGGGTTTTCGGGTCCT
GAGTTGAATCTCGTCATGCAGGAATATAACATTAATGATCCAGTCACTAACGATGTTTTA
GACGCACTAACTTCCTTTAATTTGATGTTCGAAACTAAAATTGGAGCCTCAGGACAATTG
AAGGCCTTTCTAAGGCCAGAGACTGCACAAGGACAATTTCTCAATTTCAACAAATTATTG
GAAATCAACCAAGGGAAAATTCCGTTTGCTTCAGCTTCCATTGGTAAGTCATTCAGAAAC
GAAATTTCCCCCAGAAGTGGGCTTTTAAGGGTAAGAGAGTTTTTAATGGCAGAAATTGAG
CACTTTGTTGATCCGTTGAATAAGTCACATGCAAAATTCAATGAAGTGTTAAATGAGGAG
ATTCCACTACTATCACGCAGATTACAGGAAAGTGGTGAAGTCCAACTGCCTGTGAAAATG
ACTATAGGAGAGGCAGTGAATTCTGGAATGGTAGAAAATGAAACATTGGGATATTTTATG
GCAAGAGTTCATCAATTTTTGTTGAATATTGGGATCAACAAGGACAAATTCAGATTTCGC
CAGCATTTGAAGAATGAAATGGCACACTATGCCACAGATTGTTGGGACGGTGAAATTTTA
ACATCGTATGGTTGGATTGAATGTGTCGGTTGTGCTGACAGGGCGGCTTTTGATTTAACT
GTACACTCCAAGAAAACGGGAAGAAGTCTGACGGTAAAGCAAAAGCTAGATACACCAAAA
GAAAGAACCGAGTGGGTTGTGGAAGTGAATAAGAAATTTTTCGGATCGAAGTTCAAACAG
AAAGCAAAATTAATCGAATCTGTTTTGTCAAAATTTTCCCAGGATGAATTGATTAGGAGG
CATGAAGAACTGGAAAAGAACGGTGAATTTACCTGTCAAGTAAATGGCCAGATCGTAAAA
CTAGATAGCAGTTTGGTTACTATCAAAATGAAGACAACTTTGCAACATATACGAGAGTAC
ATTCCTAATGTCATTGAGCCCTCGTTCGGTTTAGGTCGTATCATATACTGCATCTTCGAC
CATTGTTTCCAAGTTCGAGTGGATAGTGAGTCAAGAGGCTTCTTCTCTTTTCCATTACAG
ATAGCGCCGATCAAAGTATTTGTTACGACAATATCGAATAACGATGGCTTCCCCGCTATA
CTTAAGAGGATCTCGCAGGCTTTACGTAAAAGAGAGATATACTTTAAAATTGACGATTCC
AATACTTCAATTGGTAAAAAATACGCCCGTAACGATGAATTGGGAACACCATTTGGTATC
ACCATAGATTTCGAAACTATAAAAGACCAAACGGTGACGTTAAGAGAAAGAAATTCTATG
AGGCAAGTAAGAGGCACTATTACTGATGTGATTTCGACCATTGACAAAATGCTTCACAAC
CCTGATGAATCGGACTGGGATAAATCAACATTTGGACTGTCGCCTGTTAAGATATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 618 |
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| Protein Molecular Weight | 71017.89844 |
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| Protein Theoretical pI | 7.58 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Glycyl-tRNA synthetase 2
MPLMSNSERDKLESTLRRRFFYTPSFEIYGGVSGLFDLGPPGCQLQNNLIRLWREHFIME
ENMLQVDGPMLTPYDVLKTSGHVDKFTDWMCRNPKTGEYYRADHLIEQTLKKRLLDKDVN
PQDMKNMEKILTTIDGFSGPELNLVMQEYNINDPVTNDVLDALTSFNLMFETKIGASGQL
KAFLRPETAQGQFLNFNKLLEINQGKIPFASASIGKSFRNEISPRSGLLRVREFLMAEIE
HFVDPLNKSHAKFNEVLNEEIPLLSRRLQESGEVQLPVKMTIGEAVNSGMVENETLGYFM
ARVHQFLLNIGINKDKFRFRQHLKNEMAHYATDCWDGEILTSYGWIECVGCADRAAFDLT
VHSKKTGRSLTVKQKLDTPKERTEWVVEVNKKFFGSKFKQKAKLIESVLSKFSQDELIRR
HEELEKNGEFTCQVNGQIVKLDSSLVTIKMKTTLQHIREYIPNVIEPSFGLGRIIYCIFD
HCFQVRVDSESRGFFSFPLQIAPIKVFVTTISNNDGFPAILKRISQALRKREIYFKIDDS
NTSIGKKYARNDELGTPFGITIDFETIKDQTVTLRERNSMRQVRGTITDVISTIDKMLHN
PDESDWDKSTFGLSPVKI |
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| References |
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| External Links | |
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| General Reference | - Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
- Turner, R. J., Lovato, M., Schimmel, P. (2000). "One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions." J Biol Chem 275:27681-27688.10874035
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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