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Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (P53730)

Identification
NameDol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Synonyms
  • Asparagine-linked glycosylation protein 12
  • Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase
  • Extracellular mutant protein 39
  • Mannosyltransferase ALG12
Gene NameALG12
Enzyme ClassNot Available
Biological Properties
General Functionprotein N-linked glycosylation
Specific FunctionAdds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
Cellular LocationNot Available
SMPDB Pathways
N-Glycan biosynthesisPW002501 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
N-Glycan biosynthesisec00510 Map00510
SMPDB Reactions
(Mannosyl)7-(N-acetylglucosaminyl)2-diphosphodolichol + dolichyl β-D-mannosyl phosphate → (Mannosyl)8-(N-acetylglucosaminyl)2-diphosphodolichol + Dolichol phosphate + hydron
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00862hydronShow
YMDB00864Dolichol phosphateShow
YMDB16229(Mannosyl)7-(N-acetylglucosaminyl)2-diphosphodolicholShow
YMDB16230(Mannosyl)8-(N-acetylglucosaminyl)2-diphosphodolicholShow
YMDB16337dolichyl β-D-mannosyl phosphateShow
GO Classification
Function
protein glycosylation
integral component of membrane
endoplasmic reticulum membrane
dolichol-linked oligosaccharide biosynthetic process
protein N-linked glycosylation
alpha-1,6-mannosyltransferase activity
dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1656 bp ATGCGTTGGTCTGTCCTTGATACAGTGCTATTGACCGTGATTTCCTTTCATCTAATCCAA GCTCCATTCACCAAGGTGGAAGAGAGTTTTAATATTCAAGCCATTCATGATATTTTAACC TACAGCGTATTTGATATCTCCCAATATGACCACTTGAAATTTCCTGGAGTAGTCCCTAGA ACATTCGTTGGTGCTGTGATTATTGCAATGCTTTCGAGACCTTATCTTTACTTGAGTTCT TTGATCCAAACTTCCAGGCCTACGTCTATAGATGTTCAATTGGTCGTTAGGGGGATTGTT GGCCTCACCAATGGGCTTTCTTTTATCTATTTAAAGAATTGTTTGCAAGATATGTTTGAT GAAATCACTGAAAAGAAAAAGGAAGAAAATGAAGACAAGGATATATACATTTACGATAGC GCTGGTACATGGTTTCTTTTATTTTTAATTGGCAGTTTCCACCTCATGTTCTACAGCACT AGGACTCTGCCTAATTTTGTCATGACTCTGCCTCTAACCAACGTCGCATTGGGGTGGGTT TTATTGGGTCGTTATAATGCAGCTATATTCCTATCTGCGCTCGTGGCAATTGTATTTAGA CTGGAAGTGTCAGCTCTCAGTGCTGGTATTGCTCTATTTAGCGTCATCTTCAAGAAGATT TCTTTATTCGATGCTATCAAATTCGGTATCTTTGGCTTGGGACTTGGTTCCGCCATCAGT ATCACCGTTGATTCATATTTCTGGCAAGAATGGTGTCTACCTGAGGTAGATGGTTTCTTG TTCAACGTGGTTGCGGGTTACGCTTCCAAGTGGGGTGTGGAGCCAGTTACTGCTTATTTC ACGCATTACTTGAGAATGATGTTTATGCCACCAACTGTTTTACTATTGAATTACTTCGGC TATAAATTAGCACCTGCAAAATTAAAAATTGTCTCACTAGCATCTCTTTTCCACATTATC GTCTTATCCTTTCAACCTCACAAAGAATGGAGATTCATCATCTACGCTGTTCCATCTATC ATGTTGCTAGGTGCCACAGGAGCAGCACATCTATGGGAGAATATGAAAGTAAAAAAGATT ACCAATGTTTTATGTTTGGCTATATTGCCCTTATCTATAATGACCTCCTTTTTCATTTCA ATGGCGTTCTTGTATATATCAAGAATGAATTATCCAGGCGGCGAGGCTTTAACTTCTTTT AATGACATGATTGTGGAAAAAAATATTACAAACGCTACAGTTCATATCAGCATACCTCCT TGCATGACAGGTGTCACTTTATTTGGTGAATTGAACTACGGTGTGTACGGCATCAATTAC GATAAGACTGAAAATACGACTTTACTGCAGGAAATGTGGCCCTCCTTTGATTTCTTGATC ACCCACGAGCCAACCGCCTCTCAATTGCCATTCGAGAATAAGACTACCAACCATTGGGAG CTAGTTAACACAACAAAGATGTTTACTGGATTTGACCCAACCTACATTAAGAACTTTGTT TTCCAAGAGAGAGTGAATGTTTTGTCTCTACTCAAACAGATCATTTTCGACAAGACCCCT ACCGTTTTTTTGAAAGAATTGACGGCCAATTCGATTGTTAAAAGCGATGTCTTCTTCACC TATAAGAGAATCAAACAAGATGAAAAAACTGATTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues551
Protein Molecular Weight62671.87
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane Regions
  • 3-23
  • 62-82
  • 90-110
  • 137-157
  • 179-199
  • 203-223
  • 228-248
  • 276-296
  • 304-324
  • 332-352
  • 366-386
  • 418-438
Protein Sequence>Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPR TFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFD EITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWV LLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAIS ITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFG YKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKI TNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATVHISIPP CMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQLPFENKTTNHWE LVNTTKMFTGFDPTYIKNFVFQERVNVLSLLKQIIFDKTPTVFLKELTANSIVKSDVFFT YKRIKQDEKTD
References
External Links
ResourceLink
Saccharomyces Genome Database ALG12
Uniprot IDP53730
Uniprot NameALG12
General ReferenceNot Available