{"ymdb_id":"YMDB16229","created_at":"2016-09-12T18:25:46.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"(Mannosyl)7-(N-acetylglucosaminyl)2-diphosphodolichol","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}[({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid","traditional_iupac":"[(2S,3R,4R,5S,6R)-5-{[(2S,3R,4R,5S,6R)-5-{[(2S,3S,4S,5R,6R)-6-({[(2S,3S,4S,5R,6R)-4-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2R,3S,4S,5S,6R)-3-{[(2R,3S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy({[(6E,10E,14E,18E,22E,26E,30E,34E,38E,42E,46E,50E,54E,58E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-hexadecamethyltetrahexaconta-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-pentadecaen-1-yl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid","logp":"8.663933677666673","pka":"3.1717817363756944","alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"49","donor_count":"30","rotatable_bond_count":"80","polar_surface_area":"843.3800000000007","refractivity":"719.1217000000007","polarizability":"308.439519060511","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.9477717037497753","pka_strongest_acidic":"1.7444953207602145","bioavailability":"0","number_of_rings":"9","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2016-09-09T22:47:57.000Z","updated_at":"2016-09-09T22:47:57.000Z","name":"Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase","uniprot_id":"P53730","uniprot_name":"ALG12","enzyme":true,"transporter":false,"gene_name":"ALG12","num_residues":551,"molecular_weight":"62671.87","theoretical_pi":null,"general_function":"protein N-linked glycosylation","specific_function":"Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.","reactions":[{"id":14879,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007069","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"3-23;62-82;90-110;137-157;179-199;203-223;228-248;276-296;304-324;332-352;366-386;418-438","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 12","Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase","Extracellular mutant protein 39","Mannosyltransferase ALG12"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"protein N-linked glycosylation"},{"category":"Function","description":"alpha-1,6-mannosyltransferase activity"},{"category":"Function","description":"dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"integral component of membrane"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGCGTTGGTCTGTCCTTGATACAGTGCTATTGACCGTGATTTCCTTTCATCTAATCCAAGCTCCATTCACCAAGGTGGAAGAGAGTTTTAATATTCAAGCCATTCATGATATTTTAACCTACAGCGTATTTGATATCTCCCAATATGACCACTTGAAATTTCCTGGAGTAGTCCCTAGAACATTCGTTGGTGCTGTGATTATTGCAATGCTTTCGAGACCTTATCTTTACTTGAGTTCTTTGATCCAAACTTCCAGGCCTACGTCTATAGATGTTCAATTGGTCGTTAGGGGGATTGTTGGCCTCACCAATGGGCTTTCTTTTATCTATTTAAAGAATTGTTTGCAAGATATGTTTGATGAAATCACTGAAAAGAAAAAGGAAGAAAATGAAGACAAGGATATATACATTTACGATAGCGCTGGTACATGGTTTCTTTTATTTTTAATTGGCAGTTTCCACCTCATGTTCTACAGCACTAGGACTCTGCCTAATTTTGTCATGACTCTGCCTCTAACCAACGTCGCATTGGGGTGGGTTTTATTGGGTCGTTATAATGCAGCTATATTCCTATCTGCGCTCGTGGCAATTGTATTTAGACTGGAAGTGTCAGCTCTCAGTGCTGGTATTGCTCTATTTAGCGTCATCTTCAAGAAGATTTCTTTATTCGATGCTATCAAATTCGGTATCTTTGGCTTGGGACTTGGTTCCGCCATCAGTATCACCGTTGATTCATATTTCTGGCAAGAATGGTGTCTACCTGAGGTAGATGGTTTCTTGTTCAACGTGGTTGCGGGTTACGCTTCCAAGTGGGGTGTGGAGCCAGTTACTGCTTATTTCACGCATTACTTGAGAATGATGTTTATGCCACCAACTGTTTTACTATTGAATTACTTCGGCTATAAATTAGCACCTGCAAAATTAAAAATTGTCTCACTAGCATCTCTTTTCCACATTATCGTCTTATCCTTTCAACCTCACAAAGAATGGAGATTCATCATCTACGCTGTTCCATCTATCATGTTGCTAGGTGCCACAGGAGCAGCACATCTATGGGAGAATATGAAAGTAAAAAAGATTACCAATGTTTTATGTTTGGCTATATTGCCCTTATCTATAATGACCTCCTTTTTCATTTCAATGGCGTTCTTGTATATATCAAGAATGAATTATCCAGGCGGCGAGGCTTTAACTTCTTTTAATGACATGATTGTGGAAAAAAATATTACAAACGCTACAGTTCATATCAGCATACCTCCTTGCATGACAGGTGTCACTTTATTTGGTGAATTGAACTACGGTGTGTACGGCATCAATTACGATAAGACTGAAAATACGACTTTACTGCAGGAAATGTGGCCCTCCTTTGATTTCTTGATCACCCACGAGCCAACCGCCTCTCAATTGCCATTCGAGAATAAGACTACCAACCATTGGGAGCTAGTTAACACAACAAAGATGTTTACTGGATTTGACCCAACCTACATTAAGAACTTTGTTTTCCAAGAGAGAGTGAATGTTTTGTCTCTACTCAAACAGATCATTTTCGACAAGACCCCTACCGTTTTTTTGAAAGAATTGACGGCCAATTCGATTGTTAAAAGCGATGTCTTCTTCACCTATAAGAGAATCAAACAAGATGAAAAAACTGATTGA","protein_sequence":"MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATVHISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQLPFENKTTNHWELVNTTKMFTGFDPTYIKNFVFQERVNVLSLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRIKQDEKTD"},{"created_at":"2016-09-09T22:48:16.000Z","updated_at":"2016-09-09T22:48:19.000Z","name":"Alpha-1,2-mannosyltransferase ALG9","uniprot_id":"P53868","uniprot_name":"ALG9","enzyme":true,"transporter":false,"gene_name":"ALG9","num_residues":555,"molecular_weight":"63776.03","theoretical_pi":null,"general_function":"protein glycosylation","specific_function":"Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.","reactions":[{"id":14877,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007068","source":"Smpdb"},{"id":14878,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007070","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"8-28;63-83;87-107;114-134;177-197;214-234;269-289;317-337;350-370","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 9","Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"endoplasmic reticulum"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"glycolipid mannosyltransferase activity"},{"category":"Function","description":"mannosyltransferase activity"},{"category":"Function","description":"integral component of membrane"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAATTGCAAGGCGGTAACCATTAGTTTATTACTGTTGTTATTTTTAACAAGAGTATATATTCAGCCGACATTCTCGTTAATTTCAGATTGCGATGAAACTTTTAATTATTGGGAACCATTAAATTTATTGGTACGTGGATTTGGTAAACAAACCTGGGAATATTCACCCGAGTATTCTATTAGATCATGGGCTTTCTTATTACCTTTTTACTGTATTCTTTATCCAGTAAACAAATTTACTGACCTAGAAAGTCATTGGAACTTTTTCATCACAAGAGCATGCTTAGGCTTTTTTAGTTTTATCATGGAATTTAAACTACATCGTGAAATTGCAGGCAGCTTGGCATTGCAAATCGCAAATATTTGGATTATTTTCCAATTGTTTAATCCGGGCTGGTTCCATGCATCTGTGGAATTATTGCCTTCTGCCGTTGCCATGTTGTTGTATGTAGGTGCCACCAGACACTCTCTACGCTATCTGTCCACTGGGTCTACTTCTAACTTTACGAAAAGTTTAGCGTACAATTTCCTGGCTAGTATACTAGGCTGGCCATTTGTTTTAATTTTAAGCTTGCCATTATGTTTACATTACCTTTTCAACCATAGAATTATTTCTACCATCAGAACCGCATTCGACTGCTGTTTGATATTTTCATTGACTGCATTTGCTGTGATTGTCACTGACAGTATATTTTACGGGAAGCTTGCTCCTGTATCATGGAACATCTTATTTTACAATGTCATTAATGCAAGTGAGGAATCTGGCCCAAATATTTTCGGGGTTGAGCCATGGTACTACTATCCACTAAATTTGTTACTGAATTTCCCACTGCCTGTGCTAGTTTTAGCTATTTTGGGAATTTTCCATTTGAGATTATGGCCATTATGGGCATCATTATTCACATGGATTGCCGTTTTCACTCAACAACCTCACAAAGAGGAAAGATTTCTCTATCCAATTTACGGGTTAATAACTTTGAGTGCAAGTATCGCCTTTTACAAAGTGTTGAATCTATTCAATAGAAAGCCGATTCTTAAAAAAGGTATAAAGTTGTCAGTTTTATTAATTGTTGCAGGCCAGGCAATGTCACGGATAGTGGCTTTGGTGAACAATTACACAGCTCCTATAGCCGTCTACGAGCAATTTTCTTCACTAAATCAAGGTGGTGTGAAGGCACCGGTAGTGAATGTATGTACGGGACGTGAATGGTATCACTTCCCAAGTTCTTTCCTGCTGCCAGATAATCATAGGCTAAAATTTGTTAAATCTGGATTTGATGGTCTTCTTCCAGGTGATTTTCCAGAGAGTGGTTCTATTTTCAAAAAGATTAGAACTTTACCTAAGGGAATGAATAACAAGAATATATATGATACCGGTAAAGAGTGGCCGATCACTAGATGTGATTATTTTATTGACATCGTCGCCCCAATAAATTTAACAAAAGACGTTTTCAACCCTCTACATCTGATGGATAACTGGAATAAGCTGGCATGTGCTGCATTCATCGACGGTGAAAATTCTAAGATTTTGGGTAGAGCATTTTACGTACCGGAGCCAATCAACCGAATCATGCAAATAGTTTTACCAAAACAATGGAATCAAGTGTACGGTGTTCGTTACATTGATTACTGTTTGTTTGAAAAACCAACTGAGACTACTAATTGA","protein_sequence":"MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKGMNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENSKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN"}]}