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Identification |
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Name | Phosphoribosylformylglycinamidine synthase |
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Synonyms | - FGAM synthase
- FGAMS
- Formylglycinamide ribotide amidotransferase
- FGARAT
- Formylglycinamide ribotide synthetase
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Gene Name | ADE6 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in catalytic activity |
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Specific Function | ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate |
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Cellular Location | Cytoplasm |
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SMPDB Pathways | Not Available |
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KEGG Pathways | |
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SMPDB Reactions | Not Available |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00001 | 5'-Phosphoribosyl-N-formylglycinamide | Show | YMDB00002 | L-Glutamine | Show | YMDB00109 | Adenosine triphosphate | Show | YMDB00271 | L-Glutamic acid | Show | YMDB00398 | 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine | Show | YMDB00758 | 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine | Show | YMDB00759 | N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide | Show | YMDB00862 | hydron | Show | YMDB00890 | water | Show | YMDB00907 | phosphate | Show | YMDB00914 | ADP | Show |
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GO Classification | Component |
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Not Available | Function |
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catalytic activity | ligase activity | ligase activity, forming carbon-nitrogen bonds | carbon-nitrogen ligase activity, with glutamine as amido-N-donor | phosphoribosylformylglycinamidine synthase activity | Process |
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purine nucleotide metabolic process | purine nucleotide biosynthetic process | purine nucleoside monophosphate biosynthetic process | purine ribonucleoside monophosphate biosynthetic process | IMP biosynthetic process | 'de novo' IMP biosynthetic process | metabolic process | nitrogen compound metabolic process | cellular nitrogen compound metabolic process | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | nucleobase, nucleoside and nucleotide metabolic process | nucleoside phosphate metabolic process | nucleotide metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 7 |
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Locus | YGR061C |
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Gene Sequence | >4077 bp
ATGACTGATTATATTTTGCCGGGTCCCAAGGCCTTATCTCAGTTCAGAGTCGATAATCTA
ATTAAAGATATAAACTCCTATACAAACAGTACTTCTGTCATCAATGAATTGCGTTCGTGT
TACATTCACTATGTCAACGGCATCGCTCAAAATTTGTCTGAACAGGACACTAAATTGCTA
GAAGTTTTGTTGACTTACGATTCTGCTTTAGATATTGCTAACGATCCATTAGCAAGACAA
TTAAACGATGCTGTCGCTAATAATTTACCCAGTTCAGCTCTTGGCGAAGACACATATTTG
ATTAGAGTTGTTCCTAGATCAGGCACTATCTCTCCTTGGTCTTCCAAGGCTACTAATATT
GCTCATGTATGCGGGCTACAAGACAAAGTTCAACGTATTGAAAGAGGTTTAGCCTTACTC
ATAAAGACTGTTCCAGGTTTCCCTCTTTTGGAAAATCTAAATGATATTTCATTGAAGTGT
GTCTACGATAGGATGACACAACAATTATATCTGACCGAACCACCAAATACGATGAGTATT
TTCACACATGAAGAGCCAAAGCCATTAGTTCACGTTCCTTTAACTCCTAAGGACACTAAA
CAGTCTCCAAAGGATATTTTATCCAAAGCTAATACGGAATTGGGTTTAGCTCTAGATAGT
GGAGAAATGGAATATTTGATTCATGCATTCGTCGAAACTATGAAAAGAGATCCTACTGAT
GTTGAGTTATTTATGTTCGCTCAAGTTAATTCTGAACATTGTCGTCACAAGATCTTCAAT
GCTGATTGGACCATTGATGGAATAAAACAACAATTCACCTTGTTTCAAATGATTAGAAAT
ACCCATAAATTAAACCCAGAATATACTATTAGCGCCTATTCTGATAATGCAGCCGTTTTG
GATAGTGAAAATGATGCCTTTTTCTTTGCACCAAATTCAACTACAAAGGAATGGACCTCT
ACAAAGGAAAGAATTCCATTACTTATCAAAGTCGAAACTCACAACCATCCAACAGCCGTG
TCTCCTTTCCCAGGTGCTGCTACAGGTTCTGGTGGTGAAATCAGAGACGAGGGTGCTACA
GGCAGAGGTTCCAAGACTAAGTGTGGTTTGAGTGGATTCTCTGTCAGCGACCTTTTGATA
CCAGGTAATGAACAACCTTGGGAGTTGAATATTGGTAAGCCTTACCATATTGCATCTGCA
TTAGATATTATGATTGAGGCTCCTTTGGGTTCAGCTGCATTTAACAATGAGTTTGGTAGA
CCTTGTATAAACGGTTACTTCAGAACTTTAACTACAAAGGTTTTGAATCACCAAGGGAAG
GAGGAAATCAGAGGGTTCCACAAGCCAATTATGATTGCGGGTGGTTTCGGTACTGTTAGA
CCTCAATTTGCTTTGAAGAACACCCCAATAACTCCAGGCTCTTGTTTAATTGTACTTGGT
GGTCAATCTATGCTGATTGGTTTAGGTGGTGGTGCTGCTTCTTCTGTAGCTTCCGGTGAA
GGTTCCGCCGATTTGGATTTTGCTTCTGTACAAAGAGGGAACCCCGAAATGGAACGTCGT
TGCCAACAAGTGATTGACGCTTGTGTTGCCTTAGGTAACAATAATCCTATCCAATCTATT
CACGATGTTGGTGCTGGTGGGTTATCCAACGCTTTGCCAGAATTGGTTCATGACAATGAC
TTGGGTGCTAAATTCGATATTAGAAAGGTCCTCTCCTTAGAACCTGGTATGTCACCAATG
GAAATTTGGTGTAATGAATCACAAGAACGTTATGTTCTTGGTGTTTCTCCTCAAGACTTA
TCCATTTTCGAGGAAATCTGTAAGAGAGAAAGAGCACCATTTGCTGTCGTCGGTCACGCA
ACCGCTGAACAAAAATTGATTGTAGAAGATCCTCTTTTGAAAACAACTCCAATTGATTTA
GAAATGCCAATTTTATTTGGTAAGCCTCCAAAGATGTCAAGAGAAACCATAACTGAAGCA
CTAAATCTACCAGAGGCAAATTTGAGCGAAATTCCTTCCCTACAAGATGCTATTCAAAGA
GTTCTAAACTTACCATCTGTTGGCTCAAAGTCATTTTTGATTACTATTGGTGACAGATCC
GTCACAGGTCTAATTGATAGGGATCAATTTGTTGGTCCTTGGCAAGTACCTGTTGCGGAT
GTCGGTGTTACCGGTACCTCTTTGGGTGAGACAATAATTTCCACAGGTGAAGCCATGGCT
ATGGGTGAAAAACCAGTTAACGCCCTAATCTCCGCATCTGCTTCCGCTAAATTATCTGTG
GCAGAATCTTTATTGAACATATTCGCTGCTGATGTGAAATCTTTAAATCATATCAAGCTA
TCTGCTAACTGGATGTCTCCAGCCTCTCATCAAGGTGAGGGTTCTAAGTTATATGAAGCC
GTTCAAGCATTAGGTCTGGATTTATGTCCTGCATTAGGTGTTGCTATCCCTGTTGGTAAG
GATTCCATGTCCATGAAGATGAAATGGGATGATAAGGAAGTTACTGCACCATTGTCATTG
AATATCACAGCATTTGCACCAGTTTTCAACACTAGTAAAACGTGGACTCCATTGCTAAAT
AGAAACACAGATGATTCTGTCCTTGTCTTGGTTGATCTATCAGCTAAACAAGAGACTAAG
TCACTAGGTGCCTCTGCTTTGTTGCAAGTTTACAACCAAGTTGGTAACAAGTCGCCTACT
GTGTATGATAACGCCATTTTGAAGGGTTTCTTGGAAAGTTTAATCCAATTGCATCAACAA
AAGGAGGATATAGTGCTTGCCTACCATGATAGGTCTGATGGTGGTCTACTAATCACTTTA
CTGGAAATGGCATTTGCTTCCAGATGCGGCTTAGAAATCAACATTGACGGTGGAGACCTA
GAAAGTCAATTAACAAACCTATTCAATGAAGAATTAGGTGCAGTATTCCAGATTTCTGCT
AAGAACTTGAGCAAGTTCGAAAAAATCTTGAACGAGAACGGAGTTGCTAAAGAATATATT
TCTATTGTTGGTAAGCCATCCTTCCAAAGCCAGGAAATCAAGATTATTAACTCCACAACA
AATGATGTAATTTACGCCAATTCGAGATCTGAATTGGAGCAAACTTGGAGTAAGACATCT
TACGAAATGCAGAAATTGAGAGACAATCCAAAAACAGCCGAAGAAGAGTTTGCCAGTATC
ACGGACGATAGAGATCCCGGTTTGCAGTATGCCCTAACATACAACCCAGCCGATGATATG
AAGATCGGATTAGAATTATCCAGTCAAAGGCCAAAGGTTGCTATCTTAAGAGAGCAAGGT
GTGAACGGTCAAATGGAAATGGCATGGTGCTTCCAACAAGCTGGATTCAACTCAGTGGAT
GTCACTATGACAGATTTGCTAGAAGGTAGGTTCCATTTGGATGACTTCATCGGTCTTGCC
GCATGTGGTGGTTTCTCTTATGGTGATGTCTTAGGTGCAGGTGCGGGTTGGGCTAAATCC
GTATTGTATCACGAAGGTGTGCGCTCGCAATTTTCTAAGTTCTTCAATGAAAGACAAGAT
ACATTTGCTTTTGGTGCTTGTAATGGTTGTCAATTCTTGAGTAGATTAAAAGATATCATA
CCCGGGTGTGAAAACTGGCCAAGTTTCGAAAGAAATGTTAGTGAACAATATGAAGCCCGT
GTATGTATGGTGCAAATATCTCAAGAAAAGGACAATTCTAGCGAGGAATCTGTTTTCTTG
AATGGCATGGCAGGATCCAAATTGCCAATTGCTGTCGCACATGGTGAAGGTAAAGCAACA
TTTTCTAAAAGCGCTGAACAACTGGAAAAGTTCGAAAAGGATGGTTTATGTTGTATAAGG
TATGTGGACAACTACGGTAACGTCACCGAAAGGTTCCCCTTCAACCCCAATGGGTCGACC
AATGGTATTGCCGGTATCAAGTCACCAAATGGTAGAGTGCTTGCCATGATGCCACATCCT
GAAAGAGTTTGCAGATTGGAGGCCAATTCCTGGTATCCAGAGGGCAAATACGAAGAGTGG
GGTGGATACGGTCCATGGATTAGATTATTCAGATCTGCCAGAAGATGGGTCGGTTGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 1358 |
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Protein Molecular Weight | 148904.0 |
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Protein Theoretical pI | 4.92 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Phosphoribosylformylglycinamidine synthase
MTDYILPGPKALSQFRVDNLIKDINSYTNSTSVINELRSCYIHYVNGIAQNLSEQDTKLL
EVLLTYDSALDIANDPLARQLNDAVANNLPSSALGEDTYLIRVVPRSGTISPWSSKATNI
AHVCGLQDKVQRIERGLALLIKTVPGFPLLENLNDISLKCVYDRMTQQLYLTEPPNTMSI
FTHEEPKPLVHVPLTPKDTKQSPKDILSKANTELGLALDSGEMEYLIHAFVETMKRDPTD
VELFMFAQVNSEHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVL
DSENDAFFFAPNSTTKEWTSTKERIPLLIKVETHNHPTAVSPFPGAATGSGGEIRDEGAT
GRGSKTKCGLSGFSVSDLLIPGNEQPWELNIGKPYHIASALDIMIEAPLGSAAFNNEFGR
PCINGYFRTLTTKVLNHQGKEEIRGFHKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLG
GQSMLIGLGGGAASSVASGEGSADLDFASVQRGNPEMERRCQQVIDACVALGNNNPIQSI
HDVGAGGLSNALPELVHDNDLGAKFDIRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDL
SIFEEICKRERAPFAVVGHATAEQKLIVEDPLLKTTPIDLEMPILFGKPPKMSRETITEA
LNLPEANLSEIPSLQDAIQRVLNLPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVAD
VGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLLNIFAADVKSLNHIKL
SANWMSPASHQGEGSKLYEAVQALGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSL
NITAFAPVFNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPT
VYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINIDGGDL
ESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTT
NDVIYANSRSELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDM
KIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLA
ACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDII
PGCENWPSFERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKAT
FSKSAEQLEKFEKDGLCCIRYVDNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHP
ERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWVG |
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References |
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External Links | |
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General Reference | - Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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