Peroxisomal long-chain fatty acid import protein 1 (P34230)

Identification

Name

Peroxisomal long-chain fatty acid import protein 1

Synonyms

Peroxisomal ABC transporter 2

Gene Name

PXA2

Enzyme Class

Not Available

Biological Properties

General Function

Involved in transport

Specific Function

Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix

Cellular Location

Peroxisome membrane; Multi-pass membrane protein

SMPDB Pathways

Not Available

KEGG Pathways

Not Available

SMPDB Reactions

Not Available

KEGG Reactions

Not Available

Metabolites

YMDB ID	Name	View
YMDB00109	Adenosine triphosphate	Show
YMDB00469	hexadec-2-enoyl-CoA	Show
YMDB00527	palmitoyl-CoA	Show
YMDB00528	myristoyl-CoA	Show
YMDB00538	stearoyl-CoA	Show
YMDB00539	oleoyl-CoA	Show
YMDB00862	hydron	Show
YMDB00890	water	Show
YMDB00914	ADP	Show

GO Classification

Component
cell part
membrane
membrane part
intrinsic to membrane
integral to membrane
Function
primary active transmembrane transporter activity
binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
nucleoside binding
ATPase activity, coupled to transmembrane movement of substances
purine nucleoside binding
pyrophosphatase activity
adenyl nucleotide binding
nucleoside-triphosphatase activity
adenyl ribonucleotide binding
ATPase activity
ATP binding
nucleotide binding
transporter activity
transmembrane transporter activity
active transmembrane transporter activity
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Process
transmembrane transport
establishment of localization
transport

Gene Properties

Chromosome Location

chromosome 11

Locus

YKL188C

Gene Sequence

>2562 bp ATGATCTCAACAGCTTCTGCATTTTATCAGAAGCATAGAGTAAATTTACTGCGTTCTTCA TACATAATATTGTTGCTAGCCACGCTTTACAATTCAAATTCCAGTTCTAGTAACAACAAA ACTGATAAGAAGGATTCTGAGTCAACGGTTTTAGAAAATAAGAAAATTGAAGAGGGAAAA GAAACCGCAGTAGATAGAGAGGAAGATGAAAGTAGCAAAGAAGAGTTAACGATAGTCTCC AAACATAGCACAGATTCAGAAGATGGTGCAATAATAATTGATAAAGAAAGCAAGACTAAT CATAAGGGGGGAGAGCGAAAAGGAAAGGTAGATTTTTTGTTCAAACTTTTGCTTCATGAT AAGAAGTGCCTCATTTTATTTATTACACAGGCTATTCTTCTGAACATCAGAACATTGCTG TCTCTTCGTGTGGCTACTTTAGATGGTCAATTAGTGTCCACACTAGTAAGAGCTCAATAC GCAAACTTCACAAAGATATTGTTGGGGAAATGGATGATCCTTGGAATTCCCGCCAGTTTT ATTAATTCACTGATCAGTTACACGACAAAACTTTGTGCTGTCACTATTAATAGGAAAGTT TCAGACTTTCTACTCTCAAAGTATCTATCTAATCACCATACTTTCTATTCCGTAGCTTCT GCTGAATCTGTTTCAGAAATTCAGGATAATTTGACAAAAGATATTTACACATTTTCAATG AACTCGTCATTATTACTGAATCAGCTATTAAAGCCAATGCTGGATTTGATCCTCTGTTCA TTCAAATTATTAACCTCAAACACTAGTGTTATGGGTGAAGGAACTTTGGCACTGGGCTTA ATTGTCTACGCCTCCAATTCATTACTAAAATTGATTCAACCGAATTTCACTAGGTTAACT ATGGCAAGCGCATCTTTGGAAAGTTGGTTCAGATCTTTACACTCGAATCTACATTCAAGC AATGAAGAAATTGCACTGCTAAGAGGGCAAAAGAGGGAACTAGAAAACGTTGATTATTCA TTTTACCGTTTGGTGCTATTTTTAAACAGAGAAATAAAGGCAAGAGCTATTTATGATGTT GCTACTGCATTTGTCATTAAATATACTTGGGGCGCAGCTGGCTTGGTACTATGCTCGATT CCAATATTTTTCAAAAACAAACCTAGTGAAGACACCTTACAGCTTAAGGAACCCGGGAAT GATATGACGGCTGATTTCATCACAAATAGAAGATTATTAGTCACTGCATCTAGCTCTATC GGAAGATTTGTGGAACTGAAGAGAAATATACAACAATTACGCGGTATCAGATTGAGATTG AACAAGTTCAATGATTTGTTGGATGCTAATAAAGGTGATGACGAAAAAGAACCAAGAGAT GAAAGGTGTATAGTGGAATATGATGATTCAAGGATAAAGTTTGAAAATATTCCTTTAATA ACACCTGCCAATCAAGTTCTAGTACCGGAGCTAAGTTTTGATCTGAAGCATGGAAATCAT CTACTAATTATTGGGCCCAACGGTTGCGGTAAATCTTCATTATTTCGTATTCTAGGCGGG CTTTGGCCGATAAGGGCGACTCCCAATAAAAATCATCAATCCAAGTTAATAATGCCGCGT AGAACTGTGGATAGAGATTGCGCAATATTTTATTTACCCCAAAGGCCGTATATGGGCAAT AGGTCGACATTCAGGGAACAGATTATTTATCCAGACAGTATTGAACAATTCAAAGAAAGA TATCACAATGATTATGATCTAGGCGATGCAGATTTAATAAAAATTCTGCAATTATTAGAT TTGGAGGATTTAGTCACTGAAAATATGTCACTTCTGCTGGCGCAAAGGACTTCCAAAAAT GATTCACAGCAGTTGTCGACGGAAGACAATCAGTCACCATGCGCCATTAAAGTTCGTGAT GCATTCAGTATAGTAAGAAATTGGTCCGAAGAATTAACAATTGGTGTCCAACAAAGGTTA GCTATGGCAAGGATGTACTATCATAAACCCAAGTTTGCTGTGCTCGACGAATGTACATCT GCAGTAGCCCCAGAAATGGAACAAAGGATGTACGAAAATGCGCAAAATTTTGGTATCTCG TTAATATCAGTTTGCCACAGGACAAGTTTATGGCATTTTCATAACTATCTGTTAAAATTT GATGGTAAAGGCGGATACCAATTTGGACCGTTTAACCCGAAGGAAAGGTTATGTAATGAA GAAAAACTTCTTGAACTAAATGCCATCTTGGATCAACAGGTGCCACTTTGGGAGCGGAAG TTGAAAGATCTGACAATTGCTAAAGAATCCAACATCATTCGTAAATCAGAAACTAACCTG AATCTTTTTGAAAAGATCGAAGATCCAAAAACGTCCAAATCTAATGCATTGTTTAATGCA AATAAAGGGCAGCGAATCACATCACCTACAGGGCAGGAGACTAGTAAGAGATTACCACTA TTTTCCCAACCATCTAGTTCAGCATCATCAAATTTACTAAGAAACAATAAAAGCTTGAAC AAAAAAGTTAAAACAAAAAAGGAAGAAGGAAAGGAGAGGTAA

Protein Properties

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane_2 (PF06472 )

Protein Residues

853

Protein Molecular Weight

97125.29688

Protein Theoretical pI

9.25

Signalling Regions

None

Transmembrane Regions

122-142
166-186
269-289
364-384

Protein Sequence

>Peroxisomal long-chain fatty acid import protein 1 MISTASAFYQKHRVNLLRSSYIILLLATLYNSNSSSSNNKTDKKDSESTVLENKKIEEGK ETAVDREEDESSKEELTIVSKHSTDSEDGAIIIDKESKTNHKGGERKGKVDFLFKLLLHD KKCLILFITQAILLNIRTLLSLRVATLDGQLVSTLVRAQYANFTKILLGKWMILGIPASF INSLISYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAESVSEIQDNLTKDIYTFSM NSSLLLNQLLKPMLDLILCSFKLLTSNTSVMGEGTLALGLIVYASNSLLKLIQPNFTRLT MASASLESWFRSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDV ATAFVIKYTWGAAGLVLCSIPIFFKNKPSEDTLQLKEPGNDMTADFITNRRLLVTASSSI GRFVELKRNIQQLRGIRLRLNKFNDLLDANKGDDEKEPRDERCIVEYDDSRIKFENIPLI TPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLIMPR RTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLD LEDLVTENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRL AMARMYYHKPKFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKF DGKGGYQFGPFNPKERLCNEEKLLELNAILDQQVPLWERKLKDLTIAKESNIIRKSETNL NLFEKIEDPKTSKSNALFNANKGQRITSPTGQETSKRLPLFSQPSSSASSNLLRNNKSLN KKVKTKKEEGKER

References

External Links

Resource	Link
Saccharomyces Genome Database	PXA2
Uniprot ID	P34230
Uniprot Name	PXA2_YEAST
GenBank Gene ID	U93584
Genebank Protein ID	1931633

General Reference

Shani, N., Valle, D. (1996). "A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters." Proc Natl Acad Sci U S A 93:11901-11906.8876235
Wiemann, S., Voss, H., Schwager, C., Rupp, T., Stegemann, J., Zimmermann, J., Grothues, D., Sensen, C., Erfle, H., Hewitt, N., et, a. l. .. (1993). "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Yeast 9:1343-1348.8154185
Bossier, P., Fernandes, L., Vilela, C., Rodrigues-Pousada, C. (1994). "The yeast YKL741 gene situated on the left arm of chromosome XI codes for a homologue of the human ALD protein." Yeast 10:681-686.7941751
Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
Hettema, E. H., van Roermund, C. W., Distel, B., van den Berg, M., Vilela, C., Rodrigues-Pousada, C., Wanders, R. J., Tabak, H. F. (1996). "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae." EMBO J 15:3813-3822.8670886